ZA968808B - Production of analgesic synergy by co-administration of sub-analgesic doses of a mu opioid agoinst and a kappa-2 opioid agonist - Google Patents
Production of analgesic synergy by co-administration of sub-analgesic doses of a mu opioid agoinst and a kappa-2 opioid agonistInfo
- Publication number
- ZA968808B ZA968808B ZA968808A ZA968808A ZA968808B ZA 968808 B ZA968808 B ZA 968808B ZA 968808 A ZA968808 A ZA 968808A ZA 968808 A ZA968808 A ZA 968808A ZA 968808 B ZA968808 B ZA 968808B
- Authority
- ZA
- South Africa
- Prior art keywords
- analgesic
- opioid
- sub
- agoinst
- kappa
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AUPN6038A AUPN603895A0 (en) | 1995-10-19 | 1995-10-19 | Production of analgesic synergy by co-administration of sub-analgesic doses of two strong opioids |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA968808B true ZA968808B (en) | 1997-05-27 |
Family
ID=3790365
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA968808A ZA968808B (en) | 1995-10-19 | 1996-10-19 | Production of analgesic synergy by co-administration of sub-analgesic doses of a mu opioid agoinst and a kappa-2 opioid agonist |
Country Status (13)
Country | Link |
---|---|
US (1) | US6310072B1 (de) |
EP (1) | EP0871488B1 (de) |
JP (1) | JP4571236B2 (de) |
CN (1) | CN1104910C (de) |
AT (1) | ATE292982T1 (de) |
AU (2) | AUPN603895A0 (de) |
CA (1) | CA2235375C (de) |
DE (1) | DE69634609T2 (de) |
DK (1) | DK0871488T3 (de) |
ES (1) | ES2241003T3 (de) |
NZ (1) | NZ319531A (de) |
WO (1) | WO1997014438A1 (de) |
ZA (1) | ZA968808B (de) |
Families Citing this family (59)
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---|---|---|---|---|
US6375957B1 (en) | 1997-12-22 | 2002-04-23 | Euro-Celtique, S.A. | Opioid agonist/opioid antagonist/acetaminophen combinations |
PT2266564E (pt) | 1997-12-22 | 2013-06-20 | Euro Celtique Sa | Forma de dosagem farmacêutica por via oral compreendendo uma combinação de um agonista opióide e de um antagonista opióide |
US6759520B1 (en) * | 1999-10-28 | 2004-07-06 | The New England Medical Center Hospitals, Inc. | Chimeric analgesic peptides |
CN100346788C (zh) * | 2000-07-31 | 2007-11-07 | 尼科梅德丹麦有限公司 | 用于鼻内给药的芬太尼组合物 |
WO2002092060A1 (en) | 2001-05-11 | 2002-11-21 | Endo Pharmaceuticals, Inc. | Abuse-resistant controlled-release opioid dosage form |
US20030004177A1 (en) * | 2001-05-11 | 2003-01-02 | Endo Pharmaceuticals, Inc. | Abuse-resistant opioid dosage form |
WO2003002100A1 (en) * | 2001-06-26 | 2003-01-09 | Farrell John J | Tamper-proof narcotic delivery system |
DE10141650C1 (de) | 2001-08-24 | 2002-11-28 | Lohmann Therapie Syst Lts | Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen |
US20040024005A1 (en) * | 2002-01-23 | 2004-02-05 | The Regents Of The University Of California | Methods and compositions for reducing the development of drug tolerance and/or physical dependence |
US20060177381A1 (en) * | 2002-02-15 | 2006-08-10 | Howard Brooks-Korn | Opiopathies |
PT2425821T (pt) | 2002-04-05 | 2017-08-23 | Mundipharma Farmacêutica Lda | Preparação farmacêutica contendo oxicodona e naloxona |
US20030199496A1 (en) * | 2002-04-22 | 2003-10-23 | Simon David Lew | Pharmaceutical compositions containing alpha3beta4 nicotinic receptor antagonists and methods of their use |
US6881829B2 (en) * | 2002-04-26 | 2005-04-19 | Chimeracom, L.L.C. | Chimeric hybrid analgesics |
US10004729B2 (en) | 2002-07-05 | 2018-06-26 | Collegium Pharmaceutical, Inc. | Tamper-resistant pharmaceutical compositions of opioids and other drugs |
US8557291B2 (en) | 2002-07-05 | 2013-10-15 | Collegium Pharmaceutical, Inc. | Abuse-deterrent pharmaceutical compositions of opioids and other drugs |
US8840928B2 (en) | 2002-07-05 | 2014-09-23 | Collegium Pharmaceutical, Inc. | Tamper-resistant pharmaceutical compositions of opioids and other drugs |
AU2003247876B2 (en) * | 2002-07-05 | 2006-10-05 | Collegium Pharmaceutical, Inc | Abuse-deterrent pharmaceutical compositions of opiods and other drugs |
US20040096089A1 (en) * | 2002-08-16 | 2004-05-20 | David Borsook | Non-invasive functional imaging of peripheral nervous system activation in humans and animals |
WO2004075832A2 (en) * | 2003-02-27 | 2004-09-10 | Lucas John M | Methods and compositions for the treatment of chronic pain using dhea and derivatives thereof |
US20040202717A1 (en) | 2003-04-08 | 2004-10-14 | Mehta Atul M. | Abuse-resistant oral dosage forms and method of use thereof |
US20050053659A1 (en) * | 2003-09-10 | 2005-03-10 | Pace Gary W. | Methods and compositions for reducing the risk associated with the administration of opioid analgesics in patients with diagnosed or undiagnosed respiratory illness |
US7201920B2 (en) * | 2003-11-26 | 2007-04-10 | Acura Pharmaceuticals, Inc. | Methods and compositions for deterring abuse of opioid containing dosage forms |
US20050251442A1 (en) * | 2004-05-07 | 2005-11-10 | Joseph Ficalora | Consumer incentive system and business method |
EP1604666A1 (de) | 2004-06-08 | 2005-12-14 | Euro-Celtique S.A. | Opioide zur Behandlung der chronischen obstruktiven Lungenkrankheit |
WO2005123039A1 (en) | 2004-06-12 | 2005-12-29 | Collegium Pharmaceutical, Inc. | Abuse-deterrent drug formulations |
EP1702558A1 (de) | 2005-02-28 | 2006-09-20 | Euro-Celtique S.A. | Verfahren und Vorrichtung zur Darmtätigkeitserfassung |
WO2007005716A2 (en) * | 2005-06-30 | 2007-01-11 | Cinergen, Llc | Methods of treatment and compositions for use thereof |
US9066847B2 (en) * | 2007-01-05 | 2015-06-30 | Aceirx Pharmaceuticals, Inc. | Storage and dispensing devices for administration of oral transmucosal dosage forms |
US9289583B2 (en) | 2006-01-06 | 2016-03-22 | Acelrx Pharmaceuticals, Inc. | Methods for administering small volume oral transmucosal dosage forms using a dispensing device |
US8865743B2 (en) | 2006-01-06 | 2014-10-21 | Acelrx Pharmaceuticals, Inc. | Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain |
US8252328B2 (en) * | 2006-01-06 | 2012-08-28 | Acelrx Pharmaceuticals, Inc. | Bioadhesive drug formulations for oral transmucosal delivery |
US8535714B2 (en) | 2006-01-06 | 2013-09-17 | Acelrx Pharmaceuticals, Inc. | Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain |
US8753308B2 (en) | 2006-01-06 | 2014-06-17 | Acelrx Pharmaceuticals, Inc. | Methods for administering small volume oral transmucosal dosage forms using a dispensing device |
US8357114B2 (en) | 2006-01-06 | 2013-01-22 | Acelrx Pharmaceuticals, Inc. | Drug dispensing device with flexible push rod |
US8202535B2 (en) | 2006-01-06 | 2012-06-19 | Acelrx Pharmaceuticals, Inc. | Small-volume oral transmucosal dosage forms |
US8252329B2 (en) | 2007-01-05 | 2012-08-28 | Acelrx Pharmaceuticals, Inc. | Bioadhesive drug formulations for oral transmucosal delivery |
US8217000B2 (en) * | 2006-05-26 | 2012-07-10 | Cara Therapeutics, Inc. | Method for elevating prolactin in mammals |
WO2008051527A2 (en) * | 2006-10-23 | 2008-05-02 | Psivida, Inc. | Sustained release of agents for localized pain management |
KR101445891B1 (ko) * | 2007-01-05 | 2014-10-02 | 아셀알엑스 파마슈티컬스 인코퍼레이티드 | 경구 경점막 제형의 투여를 위한 저장 및 분배 장치 |
US10736850B2 (en) * | 2007-08-13 | 2020-08-11 | Ohemo Life Sciences Inc. | Abuse resistant oral opioid formulations |
US20090291975A1 (en) * | 2008-05-20 | 2009-11-26 | Warren Stern | Dual opioid pain therapy |
US8945592B2 (en) | 2008-11-21 | 2015-02-03 | Acelrx Pharmaceuticals, Inc. | Sufentanil solid dosage forms comprising oxygen scavengers and methods of using the same |
TWI630208B (zh) | 2008-12-08 | 2018-07-21 | 歐陸斯迪公司 | 二氫羥戊甲嗎啡 |
ES2706407T3 (es) | 2009-03-10 | 2019-03-28 | Euro Celtique Sa | Composiciones farmacéuticas de liberación inmediata que comprenden oxicodona y naloxona |
WO2010107761A1 (en) | 2009-03-18 | 2010-09-23 | Acelrx Pharmaceuticals, Inc. | Improved storage and dispensing devices for administration of oral transmucosal dosage forms |
US20110046173A1 (en) * | 2009-08-24 | 2011-02-24 | Warren Charles Stern | Combination analgesic opioid pain therapy |
US7923453B1 (en) | 2009-10-14 | 2011-04-12 | QRxPharma Ltd. | Methods of converting a patient's treatment regimen from intravenous administration of an opioid to oral co-administration of morphine and oxycodone using a dosing algorithm to provide analgesia |
US8012990B2 (en) * | 2009-10-14 | 2011-09-06 | QRxPharma Ltd. | Methods of converting a patient's treatment regimen from intravenous administration of an opioid to oral co-administration of morphine and oxycodone using a dosing algorithm to provide analgesia |
US8222267B2 (en) | 2009-10-14 | 2012-07-17 | QRxPharma Ltd. | Methods of converting a patient's treatment regimen from intravenous administration of an opioid to oral co-administration of morphine and oxycodone using a dosing algorithm to provide analgesia |
US10668060B2 (en) | 2009-12-10 | 2020-06-02 | Collegium Pharmaceutical, Inc. | Tamper-resistant pharmaceutical compositions of opioids and other drugs |
US8461171B2 (en) | 2010-02-09 | 2013-06-11 | QRxPharma Ltd. | Hybrid opioid compounds and compositions |
JP2013537232A (ja) | 2010-09-14 | 2013-09-30 | キューアールエックスファーマ リミテッド | 鎮痛をもたらすために、オピオイドの静脈内投与から、投薬アルゴリズムを用いたモルヒネおよびオキシコドンの経口共投与へと、患者の処置レジメンを変換する方法 |
US20140275038A1 (en) | 2013-03-15 | 2014-09-18 | Inspirion Delivery Technologies, Llc | Abuse deterrent compositions and methods of use |
GB201309654D0 (en) | 2013-05-30 | 2013-07-17 | Euro Celtique Sa | Method |
NZ716267A (en) | 2013-07-23 | 2017-05-26 | Euro Celtique Sa | A combination of oxycodone and naloxone for use in treating pain in patients suffering from pain and a disease resulting in intestinal dysbiosis and/or increasing the risk for intestinal bacterial translocation |
US10729685B2 (en) | 2014-09-15 | 2020-08-04 | Ohemo Life Sciences Inc. | Orally administrable compositions and methods of deterring abuse by intranasal administration |
WO2016106329A1 (en) | 2014-12-23 | 2016-06-30 | Acelrx Pharmaceuticals, Inc. | Systems, devices and methods for dispensing oral transmucosal dosage forms |
WO2017222575A1 (en) | 2016-06-23 | 2017-12-28 | Collegium Pharmaceutical, Inc. | Process of making more stable abuse-deterrent oral formulations |
US20210128549A1 (en) * | 2018-02-28 | 2021-05-06 | Celista Pharmaceuticals Llc | Oxycodone and methylnaltrexone multiparticulates and suspensions containing them |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993002707A1 (de) * | 1991-08-06 | 1993-02-18 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Neue antidiarrhoica |
US5273760A (en) * | 1991-12-24 | 1993-12-28 | Euroceltigue, S.A. | Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer |
US5286493A (en) * | 1992-01-27 | 1994-02-15 | Euroceltique, S.A. | Stabilized controlled release formulations having acrylic polymer coating |
IL110014A (en) * | 1993-07-01 | 1999-11-30 | Euro Celtique Sa | Solid controlled-release oral dosage forms of opioid analgesics |
IE940292A1 (en) * | 1994-04-06 | 1995-10-18 | Elan Corp Plc | Biodegradable microcapsules and method for their manufacture |
-
1995
- 1995-10-19 AU AUPN6038A patent/AUPN603895A0/en not_active Abandoned
-
1996
- 1996-10-19 ZA ZA968808A patent/ZA968808B/xx unknown
- 1996-10-21 WO PCT/AU1996/000656 patent/WO1997014438A1/en active IP Right Grant
- 1996-10-21 JP JP51535797A patent/JP4571236B2/ja not_active Expired - Fee Related
- 1996-10-21 NZ NZ319531A patent/NZ319531A/xx not_active IP Right Cessation
- 1996-10-21 AU AU72076/96A patent/AU706691B2/en not_active Expired
- 1996-10-21 CA CA002235375A patent/CA2235375C/en not_active Expired - Lifetime
- 1996-10-21 ES ES96933277T patent/ES2241003T3/es not_active Expired - Lifetime
- 1996-10-21 CN CN96199071A patent/CN1104910C/zh not_active Expired - Lifetime
- 1996-10-21 AT AT96933277T patent/ATE292982T1/de not_active IP Right Cessation
- 1996-10-21 EP EP96933277A patent/EP0871488B1/de not_active Expired - Lifetime
- 1996-10-21 DK DK96933277T patent/DK0871488T3/da active
- 1996-10-21 DE DE69634609T patent/DE69634609T2/de not_active Expired - Lifetime
-
1997
- 1997-08-29 US US08/921,187 patent/US6310072B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0871488B1 (de) | 2005-04-13 |
CN1204264A (zh) | 1999-01-06 |
DE69634609T2 (de) | 2006-02-02 |
CA2235375C (en) | 2008-01-08 |
NZ319531A (en) | 1999-11-29 |
ATE292982T1 (de) | 2005-04-15 |
JP2000511158A (ja) | 2000-08-29 |
CA2235375A1 (en) | 1997-04-24 |
JP4571236B2 (ja) | 2010-10-27 |
EP0871488A4 (de) | 2001-04-04 |
DE69634609D1 (de) | 2005-05-19 |
AU706691B2 (en) | 1999-06-24 |
ES2241003T3 (es) | 2005-10-16 |
DK0871488T3 (da) | 2005-08-15 |
AU7207696A (en) | 1997-05-07 |
EP0871488A1 (de) | 1998-10-21 |
US6310072B1 (en) | 2001-10-30 |
WO1997014438A1 (en) | 1997-04-24 |
CN1104910C (zh) | 2003-04-09 |
AUPN603895A0 (en) | 1995-11-09 |
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