ZA812448B - Pyridoxine derivatives, process for preparing them and use in therapeutics - Google Patents

Pyridoxine derivatives, process for preparing them and use in therapeutics

Info

Publication number
ZA812448B
ZA812448B ZA00812448A ZA812448A ZA812448B ZA 812448 B ZA812448 B ZA 812448B ZA 00812448 A ZA00812448 A ZA 00812448A ZA 812448 A ZA812448 A ZA 812448A ZA 812448 B ZA812448 B ZA 812448B
Authority
ZA
South Africa
Prior art keywords
therapeutics
preparing
pyridoxine derivatives
pyridoxine
derivatives
Prior art date
Application number
ZA00812448A
Other languages
English (en)
Inventor
M Descamps
M Urbain
Original Assignee
Labaz Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Labaz Nv filed Critical Labaz Nv
Publication of ZA812448B publication Critical patent/ZA812448B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C07D213/66—One oxygen atom attached in position 3 or 5 having in position 3 an oxygen atom and in each of the positions 4 and 5 a carbon atom bound to an oxygen, sulphur, or nitrogen atom, e.g. pyridoxal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
ZA00812448A 1980-05-19 1981-04-13 Pyridoxine derivatives, process for preparing them and use in therapeutics ZA812448B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8016516 1980-05-19

Publications (1)

Publication Number Publication Date
ZA812448B true ZA812448B (en) 1982-04-28

Family

ID=10513518

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA00812448A ZA812448B (en) 1980-05-19 1981-04-13 Pyridoxine derivatives, process for preparing them and use in therapeutics

Country Status (32)

Country Link
US (1) US4374841A (es)
EP (1) EP0040591B1 (es)
JP (1) JPS5711966A (es)
AR (1) AR226356A1 (es)
AT (1) ATE3859T1 (es)
AU (1) AU542463B2 (es)
BG (1) BG35327A3 (es)
CA (1) CA1152080A (es)
CS (1) CS223842B2 (es)
DD (1) DD159071A5 (es)
DE (1) DE3160480D1 (es)
DK (1) DK217481A (es)
EG (1) EG15890A (es)
ES (1) ES502276A0 (es)
FI (1) FI811525L (es)
GR (1) GR82343B (es)
HU (1) HU183441B (es)
IE (1) IE51179B1 (es)
IL (1) IL62602A (es)
IN (1) IN151915B (es)
IS (1) IS1183B6 (es)
MA (1) MA19147A1 (es)
NO (1) NO811680L (es)
NZ (1) NZ196766A (es)
OA (1) OA06811A (es)
PL (1) PL129213B1 (es)
PT (1) PT72992B (es)
RO (1) RO81943A (es)
SU (1) SU1077566A3 (es)
YU (1) YU126281A (es)
ZA (1) ZA812448B (es)
ZW (1) ZW9681A1 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4663354A (en) * 1984-04-26 1987-05-05 Klinge Pharma Gmbh Use of etilefrin and etilefrin pivalate in the long term treatment of circulatory disorders not due to hypotonia
DE3519693A1 (de) * 1985-06-01 1987-01-02 Basf Ag Pyridin-derivate, ihre herstellung und verwendung
US6051587A (en) * 1998-04-16 2000-04-18 Medicure, Inc. Treatment of iatrogenic and age-related hypertension and pharmaceutical compositions useful therein
US6043259A (en) * 1998-07-09 2000-03-28 Medicure Inc. Treatment of cardiovascular and related pathologies
US6339085B1 (en) 1999-03-08 2002-01-15 The University Of Manitoba Therapeutics for cardiovascular and related diseases
US6489345B1 (en) 1999-07-13 2002-12-03 Medicure, Inc. Treatment of diabetes and related pathologies
EP1872797A3 (en) * 1999-08-24 2008-04-02 Medicure International Inc. Treatment of cardiovascular and related pathologies
US7442689B2 (en) * 2000-02-29 2008-10-28 Medicure International Inc. Cardioprotective phosphonates and malonates
JP2003525303A (ja) 2000-02-29 2003-08-26 メディキュア インターナショナル インコーポレイテッド 心臓保護ホスホン酸塩およびマロン酸塩
EP1278526A2 (en) 2000-03-28 2003-01-29 Medicure International Inc. Treatment of cerebrovascular disease
ATE364595T1 (de) 2000-07-07 2007-07-15 Medicure Int Inc Pyridoxin- und pyridoxalanaloga als cardiovasculäre therapeutika
US6548519B1 (en) 2001-07-06 2003-04-15 Medicure International Inc. Pyridoxine and pyridoxal analogues: novel uses
US6897228B2 (en) * 2000-07-07 2005-05-24 Medicure International Inc. Pyridoxine and pyridoxal analogues: new uses
US20040121988A1 (en) * 2001-03-28 2004-06-24 Medicure International Inc. Treatment of cerebrovascular disease
JP4048166B2 (ja) * 2002-11-18 2008-02-13 三井製糖株式会社 血糖値上昇抑制剤及び体脂肪蓄積抑制剤並びに食用材料
US20040186077A1 (en) * 2003-03-17 2004-09-23 Medicure International Inc. Novel heteroaryl phosphonates as cardioprotective agents
AU2004224566A1 (en) * 2003-03-27 2004-10-07 Medicure Inc. Compositions for treating angina
EP1773370A1 (en) * 2004-07-07 2007-04-18 Medicure International Inc. Combination therapies employing platelet aggregation drugs
US20070060549A1 (en) * 2004-08-10 2007-03-15 Friesen Albert D Combination therapies employing ace inhibitors and uses thereof for the treatment of diabetic disorders
WO2006050598A1 (en) * 2004-10-28 2006-05-18 Medicure International Inc. Dual antiplatelet/anticoagulant pyridoxine analogs
US20060094749A1 (en) * 2004-10-28 2006-05-04 Medicure International Inc. Substituted pyridoxines as anti-platelet agents
US7459468B2 (en) * 2004-10-28 2008-12-02 Medicure International, Inc. Aryl sulfonic pyridoxines as antiplatelet agents
WO2007059631A1 (en) * 2005-11-28 2007-05-31 Medicure International Inc. Selected dosage for the treatment of cardiovascular and related pathologies

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4115575A (en) * 1973-02-20 1978-09-19 Ciba-Geigy Corporation 2-(3-Amino-2-hydroxy-propoxy)-pyrazines
AR207133A1 (es) * 1973-02-20 1976-09-15 Ciba Geigy Ag Procedimiento para la elaboracion de derivados de 1-piridiloxi 1-pirimidiniloxi y 1-piraziniloxi-2-hidroxi-3-amino-propano
GB1485919A (en) * 1975-08-12 1977-09-14 Grindstedvaerket As Pyridine derivatives
DE2711655A1 (de) * 1977-03-17 1978-09-21 Basf Ag Pyridinyl-aminoalkylaether
US4210653A (en) * 1978-06-27 1980-07-01 Merck & Co., Inc. Pyridyloxypropanolamines

Also Published As

Publication number Publication date
PT72992A (en) 1981-06-01
NO811680L (no) 1981-11-20
DE3160480D1 (en) 1983-07-28
AR226356A1 (es) 1982-06-30
OA06811A (fr) 1982-12-31
IE811085L (en) 1981-11-19
IL62602A (en) 1984-06-29
DD159071A5 (de) 1983-02-16
NZ196766A (en) 1984-02-03
SU1077566A3 (ru) 1984-02-29
ATE3859T1 (de) 1983-07-15
AU542463B2 (en) 1985-02-21
YU126281A (en) 1984-02-29
IL62602A0 (en) 1981-06-29
HU183441B (en) 1984-05-28
AU7053581A (en) 1981-11-26
PL129213B1 (en) 1984-04-30
RO81943B (ro) 1983-05-30
FI811525L (fi) 1981-11-20
PT72992B (en) 1982-07-01
IN151915B (es) 1983-09-03
MA19147A1 (fr) 1981-12-31
RO81943A (ro) 1983-06-01
DK217481A (da) 1981-11-20
IE51179B1 (en) 1986-10-29
ES8203845A1 (es) 1982-04-01
CA1152080A (en) 1983-08-16
US4374841A (en) 1983-02-22
CS223842B2 (en) 1983-11-25
ZW9681A1 (en) 1982-01-20
JPS5711966A (en) 1982-01-21
ES502276A0 (es) 1982-04-01
PL231193A1 (es) 1982-07-05
GR82343B (es) 1984-12-13
EP0040591A1 (fr) 1981-11-25
BG35327A3 (en) 1984-03-15
IS1183B6 (is) 1985-05-13
IS2631A7 (is) 1981-11-11
EP0040591B1 (fr) 1983-06-22
EG15890A (en) 1987-03-30

Similar Documents

Publication Publication Date Title
EG15890A (en) Pyridoxine derivatives,process for preparing them and use in therapeutics
ZA817675B (en) New nor-tropane and granatane derivatives,the process for preparing the same and their application in therapeutics
ZA834704B (en) New 3-amino quinuclidine derivatives,the process for preparing same and the application thereof in therapeutics
ZA801081B (en) Polyol derivatives,processes for preparing the same and their uses in therapeutics
ZA831134B (en) New derivatives of piperazine,the method of preparing same and their application in therapeutics
EP0029912A3 (en) Mould-half, in particular laminating mould-half, and process for making it
ZA813567B (en) Novel n-aryl azolone derivatives,the process for preparing the same and their application in therapeutics
EG18150A (en) Process for preparing furo-(3,4-c)-pyridine derivatives
DE3065163D1 (en) New 4-fluoro-3-phenoxy-benzyl-ethers, process for their preparation and their use
MY8600008A (en) Thieno-pyridine derivatives, their preparation process and their therapeutic use
GB2053196B (en) Derivatives of 5h-furanone-2 and of 3h-dihydrofuranone-2,the process for preparing the same and their application in therapeutics
DE2860858D1 (en) Indolacetoxyacetylaminoacid derivatives, process for their preparation and their use in drugs
DE3162203D1 (en) Isoindoline derivatives, process for their preparation and their use
YU44113B (en) Process for preparing glyoxale, alkylglyoxales and their acethales
DE3463041D1 (en) Tributylphenolether-glycidyl-sulphonates, process for their preparation and their use
DE3477662D1 (en) 3-phenyl-4-cyanopyrrole derivatives, process for their preparation and their use as microbicides
ZA818847B (en) New heterocyclic aminoalcoyl derivatives,the process for preparing same and the therapeutical use thereof
DE2860981D1 (en) 4-hydroxy-2-benzimidazolinone derivatives, process for their preparation and their use in medicaments
ZA802673B (en) Novel derivatives of 5h-furanone-2 and of 3h-dihydrofuranone-2, the process for preparing the same and their application in therapeutics
ZA80160B (en) Novel nor-tropane derivatives,a process for preparing same and their application in therapeutics
DE3168442D1 (en) Tetrazolylcoumarin derivatives, process for preparing the same and composition containing the same
DE3362189D1 (en) 14-amino-steroid derivatives, process for their preparation and their use in therapy
ZA821823B (en) 4-fluoro-3-phenoxy-benzyl 3-alken-1-yl-2,2-dimethyl-cyclopro-panecarboxylates, a process for their preparation and their use in pest-combating agents
ZA847640B (en) Cinnamoic compounds,process for preparing same and use in therapeutics
GB2075983B (en) Pyridoxine derivatives process for preparing them and use in therapeutics