ATE3859T1 - Pyridoxin-derivate, verfahren zu ihrer herstellung und ihre therapeutische verwendung. - Google Patents

Pyridoxin-derivate, verfahren zu ihrer herstellung und ihre therapeutische verwendung.

Info

Publication number
ATE3859T1
ATE3859T1 AT81870023T AT81870023T ATE3859T1 AT E3859 T1 ATE3859 T1 AT E3859T1 AT 81870023 T AT81870023 T AT 81870023T AT 81870023 T AT81870023 T AT 81870023T AT E3859 T1 ATE3859 T1 AT E3859T1
Authority
AT
Austria
Prior art keywords
processes
production
therapeutic use
pyridoxine derivatives
pyridoxine
Prior art date
Application number
AT81870023T
Other languages
English (en)
Inventor
Marcel Descamps
Marcel Urbain
Original Assignee
S.A. Labaz - Sanofi N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by S.A. Labaz - Sanofi N.V. filed Critical S.A. Labaz - Sanofi N.V.
Application granted granted Critical
Publication of ATE3859T1 publication Critical patent/ATE3859T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C07D213/66—One oxygen atom attached in position 3 or 5 having in position 3 an oxygen atom and in each of the positions 4 and 5 a carbon atom bound to an oxygen, sulphur, or nitrogen atom, e.g. pyridoxal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
AT81870023T 1980-05-19 1981-05-15 Pyridoxin-derivate, verfahren zu ihrer herstellung und ihre therapeutische verwendung. ATE3859T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8016516 1980-05-19
EP81870023A EP0040591B1 (de) 1980-05-19 1981-05-15 Pyridoxin-Derivate, Verfahren zu ihrer Herstellung und ihre therapeutische Verwendung

Publications (1)

Publication Number Publication Date
ATE3859T1 true ATE3859T1 (de) 1983-07-15

Family

ID=10513518

Family Applications (1)

Application Number Title Priority Date Filing Date
AT81870023T ATE3859T1 (de) 1980-05-19 1981-05-15 Pyridoxin-derivate, verfahren zu ihrer herstellung und ihre therapeutische verwendung.

Country Status (32)

Country Link
US (1) US4374841A (de)
EP (1) EP0040591B1 (de)
JP (1) JPS5711966A (de)
AR (1) AR226356A1 (de)
AT (1) ATE3859T1 (de)
AU (1) AU542463B2 (de)
BG (1) BG35327A3 (de)
CA (1) CA1152080A (de)
CS (1) CS223842B2 (de)
DD (1) DD159071A5 (de)
DE (1) DE3160480D1 (de)
DK (1) DK217481A (de)
EG (1) EG15890A (de)
ES (1) ES502276A0 (de)
FI (1) FI811525L (de)
GR (1) GR82343B (de)
HU (1) HU183441B (de)
IE (1) IE51179B1 (de)
IL (1) IL62602A (de)
IN (1) IN151915B (de)
IS (1) IS1183B6 (de)
MA (1) MA19147A1 (de)
NO (1) NO811680L (de)
NZ (1) NZ196766A (de)
OA (1) OA06811A (de)
PL (1) PL129213B1 (de)
PT (1) PT72992B (de)
RO (1) RO81943A (de)
SU (1) SU1077566A3 (de)
YU (1) YU126281A (de)
ZA (1) ZA812448B (de)
ZW (1) ZW9681A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4663354A (en) * 1984-04-26 1987-05-05 Klinge Pharma Gmbh Use of etilefrin and etilefrin pivalate in the long term treatment of circulatory disorders not due to hypotonia
DE3519693A1 (de) * 1985-06-01 1987-01-02 Basf Ag Pyridin-derivate, ihre herstellung und verwendung
US6051587A (en) * 1998-04-16 2000-04-18 Medicure, Inc. Treatment of iatrogenic and age-related hypertension and pharmaceutical compositions useful therein
US6043259A (en) * 1998-07-09 2000-03-28 Medicure Inc. Treatment of cardiovascular and related pathologies
US6339085B1 (en) 1999-03-08 2002-01-15 The University Of Manitoba Therapeutics for cardiovascular and related diseases
US6489345B1 (en) 1999-07-13 2002-12-03 Medicure, Inc. Treatment of diabetes and related pathologies
EP1872797A3 (de) * 1999-08-24 2008-04-02 Medicure International Inc. Behandlung kardiovaskulärer und verwandter Leiden
US7442689B2 (en) * 2000-02-29 2008-10-28 Medicure International Inc. Cardioprotective phosphonates and malonates
JP2003525303A (ja) 2000-02-29 2003-08-26 メディキュア インターナショナル インコーポレイテッド 心臓保護ホスホン酸塩およびマロン酸塩
EP1278526A2 (de) 2000-03-28 2003-01-29 Medicure International Inc. Behandlung von zerebrovaskulären erkrankungen
ATE364595T1 (de) 2000-07-07 2007-07-15 Medicure Int Inc Pyridoxin- und pyridoxalanaloga als cardiovasculäre therapeutika
US6548519B1 (en) 2001-07-06 2003-04-15 Medicure International Inc. Pyridoxine and pyridoxal analogues: novel uses
US6897228B2 (en) * 2000-07-07 2005-05-24 Medicure International Inc. Pyridoxine and pyridoxal analogues: new uses
US20040121988A1 (en) * 2001-03-28 2004-06-24 Medicure International Inc. Treatment of cerebrovascular disease
JP4048166B2 (ja) * 2002-11-18 2008-02-13 三井製糖株式会社 血糖値上昇抑制剤及び体脂肪蓄積抑制剤並びに食用材料
US20040186077A1 (en) * 2003-03-17 2004-09-23 Medicure International Inc. Novel heteroaryl phosphonates as cardioprotective agents
AU2004224566A1 (en) * 2003-03-27 2004-10-07 Medicure Inc. Compositions for treating angina
EP1773370A1 (de) * 2004-07-07 2007-04-18 Medicure International Inc. Kombinationstherapien mit thrombozytenaggregations-arzneimitteln
US20070060549A1 (en) * 2004-08-10 2007-03-15 Friesen Albert D Combination therapies employing ace inhibitors and uses thereof for the treatment of diabetic disorders
WO2006050598A1 (en) * 2004-10-28 2006-05-18 Medicure International Inc. Dual antiplatelet/anticoagulant pyridoxine analogs
US20060094749A1 (en) * 2004-10-28 2006-05-04 Medicure International Inc. Substituted pyridoxines as anti-platelet agents
US7459468B2 (en) * 2004-10-28 2008-12-02 Medicure International, Inc. Aryl sulfonic pyridoxines as antiplatelet agents
WO2007059631A1 (en) * 2005-11-28 2007-05-31 Medicure International Inc. Selected dosage for the treatment of cardiovascular and related pathologies

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4115575A (en) * 1973-02-20 1978-09-19 Ciba-Geigy Corporation 2-(3-Amino-2-hydroxy-propoxy)-pyrazines
AR207133A1 (es) * 1973-02-20 1976-09-15 Ciba Geigy Ag Procedimiento para la elaboracion de derivados de 1-piridiloxi 1-pirimidiniloxi y 1-piraziniloxi-2-hidroxi-3-amino-propano
GB1485919A (en) * 1975-08-12 1977-09-14 Grindstedvaerket As Pyridine derivatives
DE2711655A1 (de) * 1977-03-17 1978-09-21 Basf Ag Pyridinyl-aminoalkylaether
US4210653A (en) * 1978-06-27 1980-07-01 Merck & Co., Inc. Pyridyloxypropanolamines

Also Published As

Publication number Publication date
PT72992A (en) 1981-06-01
NO811680L (no) 1981-11-20
DE3160480D1 (en) 1983-07-28
AR226356A1 (es) 1982-06-30
OA06811A (fr) 1982-12-31
IE811085L (en) 1981-11-19
IL62602A (en) 1984-06-29
DD159071A5 (de) 1983-02-16
NZ196766A (en) 1984-02-03
SU1077566A3 (ru) 1984-02-29
AU542463B2 (en) 1985-02-21
ZA812448B (en) 1982-04-28
YU126281A (en) 1984-02-29
IL62602A0 (en) 1981-06-29
HU183441B (en) 1984-05-28
AU7053581A (en) 1981-11-26
PL129213B1 (en) 1984-04-30
RO81943B (ro) 1983-05-30
FI811525L (fi) 1981-11-20
PT72992B (en) 1982-07-01
IN151915B (de) 1983-09-03
MA19147A1 (fr) 1981-12-31
RO81943A (ro) 1983-06-01
DK217481A (da) 1981-11-20
IE51179B1 (en) 1986-10-29
ES8203845A1 (es) 1982-04-01
CA1152080A (en) 1983-08-16
US4374841A (en) 1983-02-22
CS223842B2 (en) 1983-11-25
ZW9681A1 (en) 1982-01-20
JPS5711966A (en) 1982-01-21
ES502276A0 (es) 1982-04-01
PL231193A1 (de) 1982-07-05
GR82343B (de) 1984-12-13
EP0040591A1 (de) 1981-11-25
BG35327A3 (en) 1984-03-15
IS1183B6 (is) 1985-05-13
IS2631A7 (is) 1981-11-11
EP0040591B1 (de) 1983-06-22
EG15890A (en) 1987-03-30

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee