ZA200802252B - Conjugates of hydroxyalkyl starch and an active substance, prepared by chemical ligation via thiazolidine - Google Patents

Conjugates of hydroxyalkyl starch and an active substance, prepared by chemical ligation via thiazolidine

Info

Publication number
ZA200802252B
ZA200802252B ZA200802252A ZA200802252A ZA200802252B ZA 200802252 B ZA200802252 B ZA 200802252B ZA 200802252 A ZA200802252 A ZA 200802252A ZA 200802252 A ZA200802252 A ZA 200802252A ZA 200802252 B ZA200802252 B ZA 200802252B
Authority
ZA
South Africa
Prior art keywords
conjugates
active substance
hydroxyalkyl starch
prepared
chemical ligation
Prior art date
Application number
ZA200802252A
Other languages
English (en)
Inventor
Zander Norbert
Knoller Helmut
Original Assignee
Fresenius Kabi De Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fresenius Kabi De Gmbh filed Critical Fresenius Kabi De Gmbh
Publication of ZA200802252B publication Critical patent/ZA200802252B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B31/00—Preparation of derivatives of starch
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Polymers & Plastics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Materials Engineering (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA200802252A 2005-09-12 2006-09-12 Conjugates of hydroxyalkyl starch and an active substance, prepared by chemical ligation via thiazolidine ZA200802252B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05019768A EP1762250A1 (de) 2005-09-12 2005-09-12 Konjugate welche durch chemische Ligation zwischen Hydroxyalkylstärken und aktiven Substanzen mit Bildung eines Thiazolidin-Ringes entstehen

Publications (1)

Publication Number Publication Date
ZA200802252B true ZA200802252B (en) 2009-08-26

Family

ID=35426984

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200802252A ZA200802252B (en) 2005-09-12 2006-09-12 Conjugates of hydroxyalkyl starch and an active substance, prepared by chemical ligation via thiazolidine

Country Status (15)

Country Link
US (1) US20080207562A1 (de)
EP (2) EP1762250A1 (de)
JP (1) JP5242398B2 (de)
KR (1) KR20080065602A (de)
CN (2) CN102492047A (de)
AT (1) ATE543515T1 (de)
AU (1) AU2006291527B2 (de)
BR (1) BRPI0615732A2 (de)
CA (1) CA2619036A1 (de)
EA (1) EA013910B1 (de)
ES (1) ES2382303T3 (de)
HK (1) HK1119395A1 (de)
IL (1) IL189466A0 (de)
WO (1) WO2007031266A2 (de)
ZA (1) ZA200802252B (de)

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WO2004024761A1 (en) * 2002-09-11 2004-03-25 Fresenius Kabi Deutschland Gmbh Hasylated polypeptides, especially hasylated erythropoietin
BRPI0413450A (pt) * 2003-08-08 2006-10-17 Fresenius Kabi De Gmbh conjugados de hidroxialquil amido e g-csf
WO2005014655A2 (en) 2003-08-08 2005-02-17 Fresenius Kabi Deutschland Gmbh Conjugates of hydroxyalkyl starch and a protein
EP1732609B1 (de) * 2004-03-11 2012-07-11 Fresenius Kabi Deutschland GmbH Konjugate von hydroxyalkyl-stärke und einem protein
JP5191729B2 (ja) 2004-03-11 2013-05-08 フレゼニウス・カビ・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 還元的アミノ化によって製造される、ヒドロキシアルキルデンプンとタンパク質とのコンジュゲート
AU2006222187A1 (en) * 2005-03-11 2006-09-14 Fresenius Kabi Deutschland Gmbh Production of bioactive glycoproteins from inactive starting material by conjugation with hydroxyalkylstarch
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TWI518084B (zh) 2009-03-26 2016-01-21 鹽野義製藥股份有限公司 哌喃酮與吡啶酮衍生物之製造方法
TWI582097B (zh) 2010-03-23 2017-05-11 Ｖｉｉｖ醫療保健公司 製備胺甲醯吡啶酮衍生物及中間體之方法
JP2014521594A (ja) 2011-05-25 2014-08-28 アミリン・ファーマシューティカルズ，リミテッド・ライアビリティ・カンパニー 長持続期間デュアルホルモンコンジュゲート
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CN113214620B (zh) * 2021-05-25 2022-06-21 湖北工业大学 一种环氧基有机改性蒙脱土的制备方法及应用
CN115385973B (zh) * 2022-07-13 2023-06-06 康龙化成(宁波)科技发展有限公司 寡聚核酸-四氢噻唑类化合物在基因编码化合物库合成上的应用
CN116448996B (zh) * 2023-03-22 2023-11-21 卡秋(江苏)生物科技有限公司 一种串珠结构的多聚酶-抗体复合物的制备方法

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Also Published As

Publication number Publication date
WO2007031266A3 (en) 2007-09-20
JP5242398B2 (ja) 2013-07-24
ES2382303T3 (es) 2012-06-07
IL189466A0 (en) 2008-08-07
BRPI0615732A2 (pt) 2011-05-24
KR20080065602A (ko) 2008-07-14
ATE543515T1 (de) 2012-02-15
EP1933878B1 (de) 2012-02-01
CN102492047A (zh) 2012-06-13
EA200800822A1 (ru) 2008-08-29
WO2007031266A2 (en) 2007-03-22
CA2619036A1 (en) 2007-03-22
EA013910B1 (ru) 2010-08-30
CN101262889B (zh) 2013-02-06
CN101262889A (zh) 2008-09-10
HK1119395A1 (en) 2009-03-06
EP1762250A1 (de) 2007-03-14
JP2009507973A (ja) 2009-02-26
AU2006291527A1 (en) 2007-03-22
US20080207562A1 (en) 2008-08-28
AU2006291527B2 (en) 2012-03-22
EP1933878A2 (de) 2008-06-25

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