ZA200604234B - Useful immunotherapeutic agent for the combined treatment of tuberculosis in association with other drugs - Google Patents
Useful immunotherapeutic agent for the combined treatment of tuberculosis in association with other drugs Download PDFInfo
- Publication number
- ZA200604234B ZA200604234B ZA200604234A ZA200604234A ZA200604234B ZA 200604234 B ZA200604234 B ZA 200604234B ZA 200604234 A ZA200604234 A ZA 200604234A ZA 200604234 A ZA200604234 A ZA 200604234A ZA 200604234 B ZA200604234 B ZA 200604234B
- Authority
- ZA
- South Africa
- Prior art keywords
- immunotherapeutic agent
- tuberculosis
- drugs
- treatment
- weeks
- Prior art date
Links
- 239000002955 immunomodulating agent Substances 0.000 title claims abstract description 54
- 238000011282 treatment Methods 0.000 title claims abstract description 42
- 239000003814 drug Substances 0.000 title claims abstract description 28
- 229940079593 drug Drugs 0.000 title claims abstract description 26
- 201000008827 tuberculosis Diseases 0.000 title claims abstract description 25
- 238000000034 method Methods 0.000 claims abstract description 23
- 210000002421 cell wall Anatomy 0.000 claims abstract description 19
- 239000012634 fragment Substances 0.000 claims abstract description 19
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 3
- 239000002502 liposome Substances 0.000 claims description 18
- 229960003350 isoniazid Drugs 0.000 claims description 17
- QRXWMOHMRWLFEY-UHFFFAOYSA-N isoniazide Chemical compound NNC(=O)C1=CC=NC=C1 QRXWMOHMRWLFEY-UHFFFAOYSA-N 0.000 claims description 17
- 150000001875 compounds Chemical class 0.000 claims description 16
- 239000000872 buffer Substances 0.000 claims description 12
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- 210000004027 cell Anatomy 0.000 claims description 9
- 238000005119 centrifugation Methods 0.000 claims description 5
- JQXXHWHPUNPDRT-WLSIYKJHSA-N rifampicin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C([O-])=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CC[NH+](C)CC1 JQXXHWHPUNPDRT-WLSIYKJHSA-N 0.000 claims description 5
- 229960001225 rifampicin Drugs 0.000 claims description 5
- 229920002113 octoxynol Polymers 0.000 claims description 4
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical class OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 claims description 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 2
- 238000004113 cell culture Methods 0.000 claims description 2
- 238000004108 freeze drying Methods 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 abstract description 8
- 238000002360 preparation method Methods 0.000 abstract description 3
- 241000187479 Mycobacterium tuberculosis Species 0.000 abstract description 2
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- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical group CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 description 3
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- KGTSLTYUUFWZNW-PPJQWWMSSA-N [(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[(E)-(4-methylpiperazin-1-yl)iminomethyl]-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl] acetate pyridine-4-carbohydrazide Chemical compound NNC(=O)c1ccncc1.CO[C@H]1\C=C\O[C@@]2(C)Oc3c(C2=O)c2c(O)c(\C=N\N4CCN(C)CC4)c(NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)c(O)c2c(O)c3C KGTSLTYUUFWZNW-PPJQWWMSSA-N 0.000 description 3
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- 239000000243 solution Substances 0.000 description 3
- 229940083466 soybean lecithin Drugs 0.000 description 3
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 3
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- NHBKXEKEPDILRR-UHFFFAOYSA-N 2,3-bis(butanoylsulfanyl)propyl butanoate Chemical compound CCCC(=O)OCC(SC(=O)CCC)CSC(=O)CCC NHBKXEKEPDILRR-UHFFFAOYSA-N 0.000 description 2
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- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 238000011765 DBA/2 mouse Methods 0.000 description 1
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 1
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 description 1
- 241000186366 Mycobacterium bovis Species 0.000 description 1
- 241000187919 Mycobacterium microti Species 0.000 description 1
- 241001302239 Mycobacterium tuberculosis complex Species 0.000 description 1
- 241000187644 Mycobacterium vaccae Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- QCWXUUIWCKQGHC-UHFFFAOYSA-N Zirconium Chemical compound [Zr] QCWXUUIWCKQGHC-UHFFFAOYSA-N 0.000 description 1
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- 229940072185 drug for treatment of tuberculosis Drugs 0.000 description 1
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- 230000036541 health Effects 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200302551A ES2231037B1 (es) | 2003-10-31 | 2003-10-31 | Agente inmunoterapico util para el tratamiento combinado de la tuberculosis en asociacion con otros farmacos. |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200604234B true ZA200604234B (en) | 2007-11-28 |
Family
ID=34530979
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200604234A ZA200604234B (en) | 2003-10-31 | 2006-05-25 | Useful immunotherapeutic agent for the combined treatment of tuberculosis in association with other drugs |
Country Status (21)
Country | Link |
---|---|
US (1) | US8246944B2 (es) |
EP (1) | EP1690549B1 (es) |
JP (1) | JP4998988B2 (es) |
KR (1) | KR101146469B1 (es) |
CN (1) | CN100490894C (es) |
AT (1) | ATE428442T1 (es) |
AU (1) | AU2004285305B2 (es) |
BR (1) | BRPI0415695B8 (es) |
CA (1) | CA2543659C (es) |
DE (1) | DE602004020663D1 (es) |
DK (1) | DK1690549T3 (es) |
ES (2) | ES2231037B1 (es) |
HK (1) | HK1098362A1 (es) |
IL (1) | IL175030A (es) |
MA (1) | MA28121A1 (es) |
NZ (1) | NZ546715A (es) |
PL (1) | PL1690549T3 (es) |
PT (1) | PT1690549E (es) |
RU (1) | RU2341287C2 (es) |
WO (1) | WO2005042013A1 (es) |
ZA (1) | ZA200604234B (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2231037B1 (es) | 2003-10-31 | 2005-12-16 | Archivel Technologies, Sl | Agente inmunoterapico util para el tratamiento combinado de la tuberculosis en asociacion con otros farmacos. |
EP2027865A4 (en) * | 2006-05-12 | 2010-08-18 | Univ Hokkaido Nat Univ Corp | LIPOSOME HAVING A LIPIDIC MEMBRANE CONTAINING A BACTERIAL CELLULAR COMPONENT |
ES2307402B1 (es) | 2006-10-30 | 2009-09-30 | Archivel Farma, S.L. | Vacuna profilactica contra la tuberculosis. |
ES2335177B1 (es) * | 2008-09-19 | 2011-02-28 | Archivel Farma, S.L. | Agente inmunoterapeutico apropiado para la profilaxis primaria de la tuberculosis. |
EP2471511A1 (en) | 2011-01-04 | 2012-07-04 | Archivel Farma, SL | Liposome formulation suitable for treating or preventing tuberculosis |
WO2012093137A1 (en) * | 2011-01-04 | 2012-07-12 | Archivel Farma, Sl | Liposome formulation suitable for treating or preventing tuberculosis |
EP2802345B1 (en) | 2012-01-12 | 2018-03-07 | Archivel Farma, S.l. | Mtb-c vaccine against allergic responses |
ES2758400B2 (es) | 2018-11-02 | 2021-01-20 | Univ Granada | Nanoparticulas biomimeticas mediadas por mamc |
WO2023062066A1 (en) | 2021-10-14 | 2023-04-20 | Archivel Farma, S.L. | Liposome formulations for treatment of active tuberculosis |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3125598A1 (de) * | 1981-06-30 | 1983-01-13 | Mahle Gmbh, 7000 Stuttgart | Einrichtung zur druckbeaufschlagung des presszylinders einer druckgiessmaschine |
JPS59161320A (ja) * | 1983-03-04 | 1984-09-12 | Maruyama Chisato | リポ多糖体およびその製造法 |
GB8404280D0 (en) | 1984-02-17 | 1984-03-21 | Stanford J L | Biological preparations |
JPS624701A (ja) * | 1985-06-29 | 1987-01-10 | Maruyama Chisato | リポ多糖体及びその製造法 |
US4744984A (en) * | 1985-10-08 | 1988-05-17 | Vetrepharm Research, Inc. | Antiviral immunotherapeutic agent and preparation thereof |
US5542935A (en) * | 1989-12-22 | 1996-08-06 | Imarx Pharmaceutical Corp. | Therapeutic delivery systems related applications |
US6641814B1 (en) * | 1997-04-02 | 2003-11-04 | Statens Serum Institut | Nucleic acids fragments and polypeptide fragments derived from M. tuberculosis |
US5785975A (en) * | 1995-06-26 | 1998-07-28 | Research Triangle Pharmaceuticals | Adjuvant compositions and vaccine formulations comprising same |
US6284255B1 (en) | 1996-08-29 | 2001-09-04 | Genesis Research & Development Corporation Limited | Compounds and methods for treatment and diagnosis of mycobacterial infections |
US6982085B2 (en) * | 1997-04-02 | 2006-01-03 | Statens Serum Institut | TB diagnostic based on antigens from M. tuberculosis |
CA2346218A1 (en) * | 1998-10-08 | 2000-04-20 | Statens Serum Institut | Tuberculosis vaccine and diagnostic reagents based on antigens from the mycobacterium tuberculosis cell |
RU2153354C1 (ru) * | 1999-03-31 | 2000-07-27 | Московский городской научно-практический центр борьбы с туберкулезом | Вакцина против туберкулеза |
AU2002239485A1 (en) * | 2000-12-08 | 2002-06-18 | The Johns Hopkins University | Methods for improved diagnosis and treatment of mycobacterial infections |
JP3944452B2 (ja) * | 2001-01-08 | 2007-07-11 | アメリカ合衆国 | 潜伏性ヒト結核モデル、診断用抗原、および使用法 |
EP1379529A2 (en) * | 2001-03-16 | 2004-01-14 | Sarawak Medichem Pharmaceuticals, Inc. | Pyranocoumarin compounds as a novel pharmacophore with anti-tb activity |
US7393540B2 (en) | 2001-07-04 | 2008-07-01 | Health Protection Agency | Mycobacterial antigens expressed during latency |
WO2003018053A1 (en) | 2001-08-22 | 2003-03-06 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Vaccine against mycobacterial-induced diseases |
CA2474794A1 (en) | 2002-01-29 | 2003-08-07 | Modi, Rajiv Indravadan | Method of providing prophylaxis for tuberculosis in hiv positive individuals |
ES2231037B1 (es) | 2003-10-31 | 2005-12-16 | Archivel Technologies, Sl | Agente inmunoterapico util para el tratamiento combinado de la tuberculosis en asociacion con otros farmacos. |
DE102004053141A1 (de) * | 2004-11-03 | 2006-05-04 | Schülke & Mayr GmbH | Desinfektionsmittel mit verbesserter Wirksamkeit gegen Mykobakterien |
-
2003
- 2003-10-31 ES ES200302551A patent/ES2231037B1/es not_active Expired - Fee Related
-
2004
- 2004-10-29 RU RU2006118795/13A patent/RU2341287C2/ru active
- 2004-10-29 EP EP04791401A patent/EP1690549B1/en active Active
- 2004-10-29 DE DE602004020663T patent/DE602004020663D1/de active Active
- 2004-10-29 US US10/577,840 patent/US8246944B2/en active Active
- 2004-10-29 BR BRPI0415695A patent/BRPI0415695B8/pt active IP Right Grant
- 2004-10-29 JP JP2006537326A patent/JP4998988B2/ja not_active Expired - Fee Related
- 2004-10-29 WO PCT/ES2004/000482 patent/WO2005042013A1/es active Application Filing
- 2004-10-29 CN CNB2004800322762A patent/CN100490894C/zh active Active
- 2004-10-29 DK DK04791401T patent/DK1690549T3/da active
- 2004-10-29 AT AT04791401T patent/ATE428442T1/de not_active IP Right Cessation
- 2004-10-29 KR KR1020067008014A patent/KR101146469B1/ko active IP Right Grant
- 2004-10-29 NZ NZ546715A patent/NZ546715A/en unknown
- 2004-10-29 PT PT04791401T patent/PT1690549E/pt unknown
- 2004-10-29 PL PL04791401T patent/PL1690549T3/pl unknown
- 2004-10-29 CA CA2543659A patent/CA2543659C/en active Active
- 2004-10-29 ES ES04791401T patent/ES2325835T3/es active Active
- 2004-10-29 AU AU2004285305A patent/AU2004285305B2/en not_active Ceased
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2006
- 2006-04-20 IL IL175030A patent/IL175030A/en active IP Right Grant
- 2006-04-28 MA MA28985A patent/MA28121A1/fr unknown
- 2006-05-25 ZA ZA200604234A patent/ZA200604234B/en unknown
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2007
- 2007-05-04 HK HK07104774.7A patent/HK1098362A1/xx not_active IP Right Cessation
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