ZA200603590B - Strains of microorganisms optimized for biosynthetic pathways consuming NADPH - Google Patents
Strains of microorganisms optimized for biosynthetic pathways consuming NADPH Download PDFInfo
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- ZA200603590B ZA200603590B ZA200603590A ZA200603590A ZA200603590B ZA 200603590 B ZA200603590 B ZA 200603590B ZA 200603590 A ZA200603590 A ZA 200603590A ZA 200603590 A ZA200603590 A ZA 200603590A ZA 200603590 B ZA200603590 B ZA 200603590B
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- coli
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- 238000011160 research Methods 0.000 description 1
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- 239000013605 shuttle vector Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 229940063673 spermidine Drugs 0.000 description 1
- 230000028070 sporulation Effects 0.000 description 1
- 229940031439 squalene Drugs 0.000 description 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 125000000185 sucrose group Chemical group 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-L sulfite Chemical compound [O-]S([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-L 0.000 description 1
- 101150003389 tdh2 gene Proteins 0.000 description 1
- 229960003604 testosterone Drugs 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 235000019149 tocopherols Nutrition 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
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- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
- QUEDXNHFTDJVIY-UHFFFAOYSA-N γ-tocopherol Chemical class OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
- C12N9/92—Glucose isomerase (5.3.1.5; 5.3.1.9; 5.3.1.18)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/005—Amino acids other than alpha- or beta amino acids, e.g. gamma amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
- C12P33/12—Acting on D ring
- C12P33/16—Acting at 17 position
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
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- General Health & Medical Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Molecular Biology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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FR0313056A FR2862068B1 (fr) | 2003-11-06 | 2003-11-06 | Souches de microorganismes optimisees pour des voies de biosyntheses consommatrices de nadph |
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ZA200603590B true ZA200603590B (en) | 2007-07-25 |
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ZA200603590A ZA200603590B (en) | 2003-11-06 | 2006-05-05 | Strains of microorganisms optimized for biosynthetic pathways consuming NADPH |
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US (1) | US8088620B2 (ja) |
EP (1) | EP1680504B1 (ja) |
JP (1) | JP5553956B2 (ja) |
KR (1) | KR101149566B1 (ja) |
CN (2) | CN103952335B (ja) |
AT (1) | ATE529504T1 (ja) |
AU (1) | AU2004289859B2 (ja) |
BR (1) | BRPI0415774B1 (ja) |
CA (1) | CA2544507A1 (ja) |
DK (1) | DK1680504T3 (ja) |
ES (1) | ES2371648T3 (ja) |
FR (1) | FR2862068B1 (ja) |
IL (1) | IL174890A0 (ja) |
RU (1) | RU2006119625A (ja) |
WO (1) | WO2005047498A1 (ja) |
ZA (1) | ZA200603590B (ja) |
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RU2004124226A (ru) | 2004-08-10 | 2006-01-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) | Использование фосфокетолазы для продукции полезных метаболитов |
WO2007140816A1 (en) | 2006-06-09 | 2007-12-13 | Metabolic Explorer | Glycolic acid production by fermentation from renewable resources |
WO2008013996A2 (en) * | 2006-07-27 | 2008-01-31 | Gevo Inc. | Engineered microorganisms for increasing product yield in biotransformations, related methods and systems |
EP2126042A4 (en) * | 2007-01-12 | 2010-08-04 | Univ Colorado Regents | COMPOSITIONS AND METHODS FOR IMPROVING THE PRODUCTION TOLERANCE OF ORGANIC CHEMICALS FROM MICROORGANISMS |
WO2008091627A2 (en) * | 2007-01-22 | 2008-07-31 | Genomatica, Inc. | Methods and organisms for growth-coupled production of 3-hydroxypropionic acid |
WO2009059253A2 (en) * | 2007-10-31 | 2009-05-07 | Gevo, Inc. | Methods for the economical production of biofuel from biomass |
US8048624B1 (en) | 2007-12-04 | 2011-11-01 | Opx Biotechnologies, Inc. | Compositions and methods for 3-hydroxypropionate bio-production from biomass |
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US7977084B2 (en) | 2008-03-05 | 2011-07-12 | Genomatica, Inc. | Primary alcohol producing organisms |
AU2009242615A1 (en) | 2008-05-01 | 2009-11-05 | Genomatica, Inc. | Microorganisms for the production of methacrylic acid |
WO2010022763A1 (en) * | 2008-08-25 | 2010-03-04 | Metabolic Explorer | Method for the preparation of 2-hydroxy-isobutyrate |
US8647642B2 (en) | 2008-09-18 | 2014-02-11 | Aviex Technologies, Llc | Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment |
BRPI0914521A2 (pt) * | 2008-10-27 | 2016-07-26 | Butamax Advanced Biofuels Llc | célula hospedeira microbiana recombinante, método de aumento da produção de isobutanol e método de produção de isobutanol |
BRPI0921734A2 (pt) | 2008-10-31 | 2019-01-08 | California Inst Of Techn | micro-organismos criados geneticamente capazes de produzir compostos-alvo sob condições anaeróbicas |
ES2549003T3 (es) | 2008-12-31 | 2015-10-22 | Metabolic Explorer | Método para la preparación de dioles |
EP2425006A4 (en) | 2009-04-30 | 2013-01-23 | Genomatica Inc | ORGANISMS FOR THE MANUFACTURE OF ISOPROPANOL, N-BUTANOL AND ISOBUTANOL |
WO2010127319A2 (en) | 2009-04-30 | 2010-11-04 | Genomatica, Inc. | Organisms for the production of 1,3-butanediol |
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US8809027B1 (en) | 2009-09-27 | 2014-08-19 | Opx Biotechnologies, Inc. | Genetically modified organisms for increased microbial production of 3-hydroxypropionic acid involving an oxaloacetate alpha-decarboxylase |
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JPWO2011052482A1 (ja) * | 2009-10-29 | 2013-03-21 | 三井化学株式会社 | イソプロピルアルコール生産細菌及びイソプロピルアルコール生産方法 |
CA2781400A1 (en) * | 2009-11-20 | 2011-05-26 | Opx Biotechnologies, Inc. | Production of an organic acid and/or related chemicals |
SG182686A1 (en) | 2010-01-29 | 2012-08-30 | Genomatica Inc | Microorganisms and methods for the biosynthesis of p-toluate and terephthalate |
CN103189513A (zh) * | 2010-03-31 | 2013-07-03 | 纳幕尔杜邦公司 | 上调磷酸戊糖途径以提高转基因微生物中受关注的非天然产物的产量 |
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US11408013B2 (en) | 2013-07-19 | 2022-08-09 | Cargill, Incorporated | Microorganisms and methods for the production of fatty acids and fatty acid derived products |
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KR20160037194A (ko) * | 2013-08-05 | 2016-04-05 | 그린라이트 바이오사이언시스, 아이엔씨. | 프로테아제 분열 위치를 갖는 엔지니어링된 프로테인 |
CN103710396A (zh) * | 2013-12-30 | 2014-04-09 | 南京工业大学 | 一种提高厌氧发酵目标产物转化率的方法 |
CN106559997B (zh) * | 2014-05-12 | 2021-04-09 | 代谢探索者公司 | 基于nadph依赖型丙酮醇还原酶和改进的nadph供给用于生产1,2-丙二醇的新微生物和方法 |
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CN107771214B (zh) | 2015-04-07 | 2022-01-18 | 代谢探索者公司 | 用于具有增加的2,4-二羟基丁酸外排物的优化的2,4-二羟基丁酸产生的修饰的微生物 |
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CN106086082B (zh) * | 2016-06-01 | 2019-11-15 | 苏州华赛生物工程技术有限公司 | 一种改良重组大肠杆菌生产9-癸烯醇的方法 |
US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
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EP3342873A1 (en) | 2016-12-29 | 2018-07-04 | Metabolic Explorer | Conversion of methylglyoxal into hydroxyacetone using enzymes and applications thereof |
CN110494566A (zh) | 2017-02-02 | 2019-11-22 | 嘉吉公司 | 产生c6-c10脂肪酸衍生物的经遗传修饰的细胞 |
EP3428282A1 (en) * | 2017-07-11 | 2019-01-16 | Alderys | Ectoine-producing yeast |
KR101894984B1 (ko) * | 2017-07-14 | 2018-09-05 | 한국과학기술원 | 환원력이 증가된 캔디다 속 변이 균주 및 이의 용도 |
CN115747240A (zh) * | 2022-08-05 | 2023-03-07 | 华熙生物科技股份有限公司 | 一种生产雌马酚的重组大肠杆菌工程菌株及应用 |
CN117487681A (zh) * | 2023-11-16 | 2024-02-02 | 湖南农业大学 | 一种生产角鲨烯的酵母工程菌及其应用 |
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GB9614618D0 (en) * | 1996-07-11 | 1996-09-04 | Animal Health Inst | Vaccine compositions |
JP4380029B2 (ja) * | 2000-07-05 | 2009-12-09 | 味の素株式会社 | 微生物を利用した物質の製造法 |
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ES2371648T3 (es) | 2012-01-05 |
CN103952335A (zh) | 2014-07-30 |
JP5553956B2 (ja) | 2014-07-23 |
KR101149566B1 (ko) | 2012-07-05 |
KR20060132577A (ko) | 2006-12-21 |
BRPI0415774B1 (pt) | 2019-12-31 |
EP1680504B1 (fr) | 2011-10-19 |
US8088620B2 (en) | 2012-01-03 |
WO2005047498A1 (fr) | 2005-05-26 |
AU2004289859A1 (en) | 2005-05-26 |
ATE529504T1 (de) | 2011-11-15 |
FR2862068A1 (fr) | 2005-05-13 |
US20070087403A1 (en) | 2007-04-19 |
DK1680504T3 (da) | 2011-11-21 |
AU2004289859B2 (en) | 2009-03-26 |
CN1875096A (zh) | 2006-12-06 |
EP1680504A1 (fr) | 2006-07-19 |
IL174890A0 (en) | 2006-08-20 |
RU2006119625A (ru) | 2007-12-27 |
CN103952335B (zh) | 2016-08-31 |
JP2007510411A (ja) | 2007-04-26 |
BRPI0415774A (pt) | 2006-12-26 |
FR2862068B1 (fr) | 2007-10-12 |
CA2544507A1 (fr) | 2005-05-26 |
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