ZA200404811B - Alpha-(N-sulfonamido)acetamide derivatives as beta-amyloid inhibitors. - Google Patents

Alpha-(N-sulfonamido)acetamide derivatives as beta-amyloid inhibitors. Download PDF

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Publication number
ZA200404811B
ZA200404811B ZA200404811A ZA200404811A ZA200404811B ZA 200404811 B ZA200404811 B ZA 200404811B ZA 200404811 A ZA200404811 A ZA 200404811A ZA 200404811 A ZA200404811 A ZA 200404811A ZA 200404811 B ZA200404811 B ZA 200404811B
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South Africa
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alkyl
halogen
group
optionally substituted
phenyl
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ZA200404811A
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English (en)
Inventor
Michael F Parker
Robert A Mate
Yonghua Gai
Lawrence R Marcin
Katharine E Mcelhone
Joanne J Bronson
Carl P Bergstrom
John F Macor
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Bristol Myers Squibb Co
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Publication of ZA200404811B publication Critical patent/ZA200404811B/en

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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/18—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms, not being part of nitro or nitroso groups
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    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
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    • C07C2601/14—The ring being saturated

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