ZA200105580B - Ketolide antibiotics. - Google Patents

Ketolide antibiotics. Download PDF

Info

Publication number: ZA200105580B
Authority: ZA; South Africa
Prior art keywords: alkyl; aryl; groups; halo; independently selected
Prior art date: 1999-01-27

Application number

ZA200105580A

Other languages

English (en)

Inventor

Takushi Keneko

Mcmillen William Thomas

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-01-27

Filing date

2001-07-06

Publication date

2003-02-17

2001-07-06 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2003-02-17 Publication of ZA200105580B publication Critical patent/ZA200105580B/en

Links

239000003242 anti bacterial agent Substances 0.000 title description 4
229940088710 antibiotic agent Drugs 0.000 title description 4
239000003835 ketolide antibiotic agent Substances 0.000 title description 2
125000000217 alkyl group Chemical group 0.000 claims description 38
125000000623 heterocyclic group Chemical group 0.000 claims description 28
125000003118 aryl group Chemical group 0.000 claims description 24
150000001875 compounds Chemical class 0.000 claims description 23
229910052799 carbon Inorganic materials 0.000 claims description 18
-1 trifiuoromethoxy Chemical group 0.000 claims description 17
208000035143 Bacterial infection Diseases 0.000 claims description 15
208000022362 bacterial infectious disease Diseases 0.000 claims description 15
125000005843 halogen group Chemical group 0.000 claims description 15
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 13
125000004093 cyano group Chemical group *C#N 0.000 claims description 12
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 10
125000003342 alkenyl group Chemical group 0.000 claims description 9
125000000304 alkynyl group Chemical group 0.000 claims description 9
241000251468 Actinopterygii Species 0.000 claims description 8
241000124008 Mammalia Species 0.000 claims description 8
229910052739 hydrogen Inorganic materials 0.000 claims description 8
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 8
208000028172 protozoa infectious disease Diseases 0.000 claims description 7
150000003839 salts Chemical class 0.000 claims description 6
239000012453 solvate Substances 0.000 claims description 6
125000001424 substituent group Chemical group 0.000 claims description 6
125000003545 alkoxy group Chemical group 0.000 claims description 5
125000004432 carbon atom Chemical group C* 0.000 claims description 5
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 4
125000001153 fluoro group Chemical group F* 0.000 claims description 4
238000000034 method Methods 0.000 claims description 4
239000008194 pharmaceutical composition Substances 0.000 claims description 4
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 4
125000005842 heteroatom Chemical group 0.000 claims description 3
229910052760 oxygen Inorganic materials 0.000 claims description 3
229910052717 sulfur Inorganic materials 0.000 claims description 3
125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims description 2
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 2
125000001589 carboacyl group Chemical group 0.000 claims description 2
239000003937 drug carrier Substances 0.000 claims description 2
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
101100460702 Aspergillus sp. (strain MF297-2) notH gene Proteins 0.000 claims 1
125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 claims 1
239000003795 chemical substances by application Substances 0.000 claims 1
239000003814 drug Substances 0.000 claims 1
230000002140 halogenating effect Effects 0.000 claims 1
238000004519 manufacturing process Methods 0.000 claims 1
UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 claims 1
208000015181 infectious disease Diseases 0.000 description 38
241000283690 Bos taurus Species 0.000 description 8
208000035475 disorder Diseases 0.000 description 7
206010037075 Protozoal infections Diseases 0.000 description 6
241000193996 Streptococcus pyogenes Species 0.000 description 6
125000004122 cyclic group Chemical group 0.000 description 6
239000003120 macrolide antibiotic agent Substances 0.000 description 6
230000001580 bacterial effect Effects 0.000 description 5
241000271566 Aves Species 0.000 description 4
241000588724 Escherichia coli Species 0.000 description 4
241000282472 Canis lupus familiaris Species 0.000 description 3
241000282326 Felis catus Species 0.000 description 3
241000606768 Haemophilus influenzae Species 0.000 description 3
241000606856 Pasteurella multocida Species 0.000 description 3
241000191967 Staphylococcus aureus Species 0.000 description 3
241000191963 Staphylococcus epidermidis Species 0.000 description 3
125000006615 aromatic heterocyclic group Chemical group 0.000 description 3
125000004429 atom Chemical group 0.000 description 3
241001148536 Bacteroides sp. Species 0.000 description 2
241001647372 Chlamydia pneumoniae Species 0.000 description 2
241000193403 Clostridium Species 0.000 description 2
241000194033 Enterococcus Species 0.000 description 2
241000194032 Enterococcus faecalis Species 0.000 description 2
241000194031 Enterococcus faecium Species 0.000 description 2
241000191992 Peptostreptococcus Species 0.000 description 2
206010062255 Soft tissue infection Diseases 0.000 description 2
241000193985 Streptococcus agalactiae Species 0.000 description 2
241000193998 Streptococcus pneumoniae Species 0.000 description 2
241001312524 Streptococcus viridans Species 0.000 description 2
241000282898 Sus scrofa Species 0.000 description 2
230000000844 anti-bacterial effect Effects 0.000 description 2
125000002393 azetidinyl group Chemical group 0.000 description 2
229960004099 azithromycin Drugs 0.000 description 2
MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 description 2
125000001246 bromo group Chemical group Br* 0.000 description 2
201000010099 disease Diseases 0.000 description 2
229940047650 haemophilus influenzae Drugs 0.000 description 2
208000028774 intestinal disease Diseases 0.000 description 2
208000023504 respiratory system disease Diseases 0.000 description 2
206010040872 skin infection Diseases 0.000 description 2
229940031000 streptococcus pneumoniae Drugs 0.000 description 2
208000019206 urinary tract infection Diseases 0.000 description 2
JPRPJUMQRZTTED-UHFFFAOYSA-N 1,3-dioxolanyl Chemical group [CH]1OCCO1 JPRPJUMQRZTTED-UHFFFAOYSA-N 0.000 description 1
125000001698 2H-pyranyl group Chemical group O1C(C=CC=C1)* 0.000 description 1
125000004364 3-pyrrolinyl group Chemical group [H]C1=C([H])C([H])([H])N(*)C1([H])[H] 0.000 description 1
125000001963 4 membered heterocyclic group Chemical group 0.000 description 1
125000001826 4H-pyranyl group Chemical group O1C(=CCC=C1)* 0.000 description 1
125000002373 5 membered heterocyclic group Chemical group 0.000 description 1
241000606750 Actinobacillus Species 0.000 description 1
201000001320 Atherosclerosis Diseases 0.000 description 1
241001518086 Bartonella henselae Species 0.000 description 1
241000588807 Bordetella Species 0.000 description 1
241000588832 Bordetella pertussis Species 0.000 description 1
241000180135 Borrelia recurrentis Species 0.000 description 1
241000589969 Borreliella burgdorferi Species 0.000 description 1
241001148534 Brachyspira Species 0.000 description 1
241000589875 Campylobacter jejuni Species 0.000 description 1
239000004215 Carbon black (E152) Substances 0.000 description 1
208000024172 Cardiovascular disease Diseases 0.000 description 1
241000606161 Chlamydia Species 0.000 description 1
241000606153 Chlamydia trachomatis Species 0.000 description 1
241000193468 Clostridium perfringens Species 0.000 description 1
108010065152 Coagulase Proteins 0.000 description 1
241000224483 Coccidia Species 0.000 description 1
206010010741 Conjunctivitis Diseases 0.000 description 1
208000031973 Conjunctivitis infective Diseases 0.000 description 1
241000186216 Corynebacterium Species 0.000 description 1
241000186227 Corynebacterium diphtheriae Species 0.000 description 1
241001518260 Corynebacterium minutissimum Species 0.000 description 1
206010011224 Cough Diseases 0.000 description 1
208000008953 Cryptosporidiosis Diseases 0.000 description 1
241000605721 Dichelobacter nodosus Species 0.000 description 1
241000588914 Enterobacter Species 0.000 description 1
241000520130 Enterococcus durans Species 0.000 description 1
ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical class O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 1
241000186394 Eubacterium Species 0.000 description 1
206010016952 Food poisoning Diseases 0.000 description 1
208000019331 Foodborne disease Diseases 0.000 description 1
241000605909 Fusobacterium Species 0.000 description 1
241000605952 Fusobacterium necrophorum Species 0.000 description 1
201000000628 Gas Gangrene Diseases 0.000 description 1
208000005577 Gastroenteritis Diseases 0.000 description 1
206010018364 Glomerulonephritis Diseases 0.000 description 1
206010018612 Gonorrhoea Diseases 0.000 description 1
241000589989 Helicobacter Species 0.000 description 1
241000590002 Helicobacter pylori Species 0.000 description 1
241000588748 Klebsiella Species 0.000 description 1
241001469654 Lawsonia <weevil> Species 0.000 description 1
241000589242 Legionella pneumophila Species 0.000 description 1
241000186781 Listeria Species 0.000 description 1
208000016604 Lyme disease Diseases 0.000 description 1
241001293418 Mannheimia haemolytica Species 0.000 description 1
208000010315 Mastoiditis Diseases 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
241000588622 Moraxella bovis Species 0.000 description 1
241000588655 Moraxella catarrhalis Species 0.000 description 1
241000186367 Mycobacterium avium Species 0.000 description 1
241000187482 Mycobacterium avium subsp. paratuberculosis Species 0.000 description 1
241000187478 Mycobacterium chelonae Species 0.000 description 1
241000186363 Mycobacterium kansasii Species 0.000 description 1
241000186362 Mycobacterium leprae Species 0.000 description 1
241000187479 Mycobacterium tuberculosis Species 0.000 description 1
241000204031 Mycoplasma Species 0.000 description 1
241001138504 Mycoplasma bovis Species 0.000 description 1
241000202934 Mycoplasma pneumoniae Species 0.000 description 1
241000588652 Neisseria gonorrhoeae Species 0.000 description 1
206010031252 Osteomyelitis Diseases 0.000 description 1
201000007100 Pharyngitis Diseases 0.000 description 1
206010035664 Pneumonia Diseases 0.000 description 1
241000605894 Porphyromonas Species 0.000 description 1
241000605861 Prevotella Species 0.000 description 1
206010037294 Puerperal pyrexia Diseases 0.000 description 1
101150088095 RTM2 gene Proteins 0.000 description 1
206010057190 Respiratory tract infections Diseases 0.000 description 1
241000607142 Salmonella Species 0.000 description 1
206010040070 Septic Shock Diseases 0.000 description 1
208000019802 Sexually transmitted disease Diseases 0.000 description 1
241000295644 Staphylococcaceae Species 0.000 description 1
241000191940 Staphylococcus Species 0.000 description 1
241000191980 Staphylococcus intermedius Species 0.000 description 1
241000194042 Streptococcus dysgalactiae Species 0.000 description 1
206010044248 Toxic shock syndrome Diseases 0.000 description 1
231100000650 Toxic shock syndrome Toxicity 0.000 description 1
241000589884 Treponema pallidum Species 0.000 description 1
208000025865 Ulcer Diseases 0.000 description 1
241000202921 Ureaplasma urealyticum Species 0.000 description 1
208000006374 Uterine Cervicitis Diseases 0.000 description 1
206010046793 Uterine inflammation Diseases 0.000 description 1
108010059993 Vancomycin Proteins 0.000 description 1
241000606834 [Haemophilus] ducreyi Species 0.000 description 1
206010000210 abortion Diseases 0.000 description 1
231100000176 abortion Toxicity 0.000 description 1
206010000269 abscess Diseases 0.000 description 1
201000001028 acute contagious conjunctivitis Diseases 0.000 description 1
230000001154 acute effect Effects 0.000 description 1
229940126575 aminoglycoside Drugs 0.000 description 1
238000011203 antimicrobial therapy Methods 0.000 description 1
239000003904 antiprotozoal agent Substances 0.000 description 1
150000004945 aromatic hydrocarbons Chemical class 0.000 description 1
HONIICLYMWZJFZ-UHFFFAOYSA-N azetidine Chemical compound C1CNC1 HONIICLYMWZJFZ-UHFFFAOYSA-N 0.000 description 1
229940092524 bartonella henselae Drugs 0.000 description 1
235000013405 beer Nutrition 0.000 description 1
210000004369 blood Anatomy 0.000 description 1
239000008280 blood Substances 0.000 description 1
206010006451 bronchitis Diseases 0.000 description 1
239000011203 carbon fibre reinforced carbon Substances 0.000 description 1
206010008323 cervicitis Diseases 0.000 description 1
229940038705 chlamydia trachomatis Drugs 0.000 description 1
229960005091 chloramphenicol Drugs 0.000 description 1
WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 1
125000001309 chloro group Chemical group Cl* 0.000 description 1
235000013365 dairy product Nutrition 0.000 description 1
125000002576 diazepinyl group Chemical group N1N=C(C=CC=C1)* 0.000 description 1
125000005043 dihydropyranyl group Chemical group O1C(CCC=C1)* 0.000 description 1
125000005057 dihydrothienyl group Chemical group S1C(CC=C1)* 0.000 description 1
125000000532 dioxanyl group Chemical group 0.000 description 1
125000005411 dithiolanyl group Chemical group S1SC(CC1)* 0.000 description 1
230000000694 effects Effects 0.000 description 1
206010014665 endocarditis Diseases 0.000 description 1
229940032049 enterococcus faecalis Drugs 0.000 description 1
208000010801 foot rot Diseases 0.000 description 1
208000001786 gonorrhea Diseases 0.000 description 1
229940037467 helicobacter pylori Drugs 0.000 description 1
229930195733 hydrocarbon Natural products 0.000 description 1
239000001257 hydrogen Substances 0.000 description 1
125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
125000002636 imidazolinyl group Chemical group 0.000 description 1
125000003387 indolinyl group Chemical group N1(CCC2=CC=CC=C12)* 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
230000000968 intestinal effect Effects 0.000 description 1
125000002346 iodo group Chemical group I* 0.000 description 1
206010023332 keratitis Diseases 0.000 description 1
229940115932 legionella pneumophila Drugs 0.000 description 1
229940041033 macrolides Drugs 0.000 description 1
208000004396 mastitis Diseases 0.000 description 1
125000001624 naphthyl group Chemical group 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
125000003551 oxepanyl group Chemical group 0.000 description 1
125000003566 oxetanyl group Chemical group 0.000 description 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
125000004193 piperazinyl group Chemical group 0.000 description 1
230000002028 premature Effects 0.000 description 1
125000003072 pyrazolidinyl group Chemical group 0.000 description 1
125000002755 pyrazolinyl group Chemical group 0.000 description 1
125000000719 pyrrolidinyl group Chemical group 0.000 description 1
150000007660 quinolones Chemical class 0.000 description 1
150000003254 radicals Chemical class 0.000 description 1
208000020029 respiratory tract infectious disease Diseases 0.000 description 1
201000003068 rheumatic fever Diseases 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
241000894007 species Species 0.000 description 1
229940115920 streptococcus dysgalactiae Drugs 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
208000011580 syndromic disease Diseases 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
125000004853 tetrahydropyridinyl group Chemical group N1(CCCC=C1)* 0.000 description 1
125000005958 tetrahydrothienyl group Chemical group 0.000 description 1
125000004632 tetrahydrothiopyranyl group Chemical group S1C(CCCC1)* 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
125000005308 thiazepinyl group Chemical group S1N=C(C=CC=C1)* 0.000 description 1
125000000335 thiazolyl group Chemical group 0.000 description 1
125000001583 thiepanyl group Chemical group 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
206010044008 tonsillitis Diseases 0.000 description 1
239000003053 toxin Substances 0.000 description 1
231100000765 toxin Toxicity 0.000 description 1
125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 description 1
231100000397 ulcer Toxicity 0.000 description 1
208000000143 urethritis Diseases 0.000 description 1
229960003165 vancomycin Drugs 0.000 description 1
MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 description 1
MYPYJXKWCTUITO-LYRMYLQWSA-O vancomycin(1+) Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C([O-])=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)[NH2+]C)[C@H]1C[C@](C)([NH3+])[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-O 0.000 description 1
150000003952 β-lactams Chemical class 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Communicable Diseases (AREA)
Gynecology & Obstetrics (AREA)
Molecular Biology (AREA)
Pulmonology (AREA)
Genetics & Genomics (AREA)
Oncology (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Urology & Nephrology (AREA)
Pregnancy & Childbirth (AREA)
Dermatology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Otolaryngology (AREA)
Ophthalmology & Optometry (AREA)
Heart & Thoracic Surgery (AREA)
Tropical Medicine & Parasitology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Cephalosporin Compounds (AREA)

ZA200105580A 1999-01-27 2001-07-06 Ketolide antibiotics. ZA200105580B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US11734299P	1999-01-27	1999-01-27

Publications (1)

Publication Number	Publication Date
ZA200105580B true ZA200105580B (en)	2003-02-17

Family

ID=22372371

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200105580A ZA200105580B (en)	1999-01-27	2001-07-06	Ketolide antibiotics.

Country Status (39)

Country	Link
US (1)	US6833444B2 (hu)
EP (1)	EP1147121B1 (hu)
JP (1)	JP3947360B2 (hu)
KR (1)	KR20020002380A (hu)
CN (1)	CN1342163A (hu)
AP (1)	AP2001002222A0 (hu)
AT (1)	ATE256694T1 (hu)
AU (1)	AU1675400A (hu)
BG (1)	BG105730A (hu)
BR (1)	BR9916969A (hu)
CA (1)	CA2359708C (hu)
CO (1)	CO5150229A1 (hu)
CZ (1)	CZ20012675A3 (hu)
DE (1)	DE69913738T2 (hu)
DK (1)	DK1147121T3 (hu)
DZ (1)	DZ3000A1 (hu)
EA (1)	EA200100623A1 (hu)
EE (1)	EE200100394A (hu)
ES (1)	ES2212655T3 (hu)
HK (1)	HK1042707A1 (hu)
HN (1)	HN2000000003A (hu)
HR (1)	HRP20010559A2 (hu)
HU (1)	HUP0105190A3 (hu)
ID (1)	ID30233A (hu)
IL (1)	IL144178A0 (hu)
IS (1)	IS5984A (hu)
MA (1)	MA26717A1 (hu)
NO (1)	NO20013680L (hu)
OA (1)	OA11753A (hu)
PA (1)	PA8489501A1 (hu)
PE (1)	PE20001422A1 (hu)
PT (1)	PT1147121E (hu)
SI (1)	SI1147121T1 (hu)
SK (1)	SK10172001A3 (hu)
TN (1)	TNSN00007A1 (hu)
TR (1)	TR200102128T2 (hu)
UY (1)	UY25990A1 (hu)
WO (1)	WO2000044761A2 (hu)
ZA (1)	ZA200105580B (hu)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AP1060A (en)	1998-01-02	2002-04-23	Pfizer Prod Inc	Novel erythromycin derivatives.
TR200102128T2 (tr)	1999-01-27	2001-12-21	Pfizer Products Inc.	Ketolid antibiyotikler
ATE340183T1 (de)	1999-04-16	2006-10-15	Kosan Biosciences Inc	Antiinfektiöse makrolidderivate
US6451768B1 (en)	1999-04-16	2002-09-17	Kosan Biosciences, Inc.	Macrolide antiinfective agents
AU4354900A (en)	1999-04-16	2000-11-02	Kosan Biosciences, Inc.	Ketolide antibacterials
US6514944B2 (en)	1999-04-16	2003-02-04	Kosan Biosciences, Inc.	Macrolide antiinfective agents
US6590083B1 (en)	1999-04-16	2003-07-08	Ortho-Mcneil Pharmaceutical, Inc.	Ketolide antibacterials
US6939861B2 (en)	1999-04-16	2005-09-06	Kosan Biosciences, Inc.	Amido macrolides
CA2373117C (en)	1999-05-24	2006-02-28	Pfizer Products Inc.	13-methyl-erythromycin derivatives
ATE271062T1 (de)	2000-06-30	2004-07-15	Pfizer Prod Inc	Makrolid-antibiotika
US20020115621A1 (en)	2000-08-07	2002-08-22	Wei-Gu Su	Macrolide antibiotics
AU2002217277B2 (en) *	2000-12-21	2005-06-16	Glaxo Group Limited	Macrolide antibiotics
PE20030438A1 (es) *	2001-09-05	2003-07-03	Hokuriku Pharmaceutical	Medicamento que comprende un derivado de eritromicina como agente antituberculoso
ES2552682T3 (es)	2003-03-10	2015-12-01	Merck Sharp & Dohme Corp.	Agentes antibacterianos novedosos
BRPI0513903A (pt) *	2004-07-28	2008-05-20	Ranbaxy Lab Ltd	derivados de cetolìdeos úteis como agentes antimicrobianos, seus processos de preparação e composições farmacêuticas compreendendo os mesmos
BRPI0519135A2 (pt)	2004-12-21	2008-12-23	Pfizer Prod Inc	macrolÍdeos
RU2455308C2 (ru) *	2006-05-01	2012-07-10	Тайсо Фармасьютикал Ко., Лтд.	Макролидные производные
CN105732745A (zh)	2007-10-25	2016-07-06	森普拉制药公司	大环内酯类抗菌剂的制备方法
ES2565083T3 (es)	2008-10-24	2016-03-31	Cempra Pharmaceuticals, Inc.	Biodefensas usando macrólidos que contienen triazol
US9937194B1 (en)	2009-06-12	2018-04-10	Cempra Pharmaceuticals, Inc.	Compounds and methods for treating inflammatory diseases
CN102724874B (zh)	2009-09-10	2018-06-01	森普拉制药公司	治疗疟疾、结核病和mac疾病的方法
MY162411A (en)	2010-03-22	2017-06-15	Cempra Pharmaceuticals Inc	Crystalline forms of a macrolide, and uses therefor
JP6184319B2 (ja)	2010-05-20	2017-08-23	センプラファーマシューティカルズ，インコーポレイテッド	マクロライド類およびケトライド類ならびにその中間体を調製するための工程
EP2613630A4 (en)	2010-09-10	2014-01-15	Cempra Pharmaceuticals Inc	FLUOROCETOLIDES FORMING HYDROGEN LINKS TO TREAT DISEASES
KR20140139083A (ko)	2012-03-27	2014-12-04	셈프라 파마슈티컬스, 인크.	마크롤라이드계 항생제를 투여하기 위한 비경구 제제
JP6426696B2 (ja)	2013-03-14	2018-11-21	センプラファーマシューティカルズ，インコーポレイテッド	呼吸器疾患の治療のための方法および製剤
WO2014145210A1 (en)	2013-03-15	2014-09-18	Cempra Pharmaceuticals, Inc.	Convergent processes for preparing macrolide antibacterial agents
WO2014156549A1 (ja)	2013-03-28	2014-10-02	不二製油株式会社	緑豆蛋白ゲル状組成物及びチーズ様食品
CN106518939B (zh) *	2015-09-14	2019-12-31	江苏奥赛康药业有限公司	一种制备Solithromycin化合物的方法
WO2018067663A2 (en) *	2016-10-04	2018-04-12	Biopharmati Sa	Ketolides having antibacterial activity

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
YU43006B (en)	1981-03-06	1989-02-28	Pliva Pharm & Chem Works	Process for preparing n-methyl-11-aza-10-deoxo-10-dihydro erythromycin and derivatives thereof
US4474768A (en)	1982-07-19	1984-10-02	Pfizer Inc.	N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
US5141926A (en)	1990-04-18	1992-08-25	Abbott Laboratories	Erythromycin derivatives
IL114589A (en)	1990-11-21	1999-12-22	Roussel Uclaf	Intermediates for the preparation of the history of erythromycin
US5527780A (en)	1992-11-05	1996-06-18	Roussel Uclaf	Erythromycin derivatives
FR2697524B1 (fr)	1992-11-05	1994-12-23	Roussel Uclaf	Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2719587B1 (fr) *	1994-05-03	1996-07-12	Roussel Uclaf	Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2727969B1 (fr) *	1994-12-09	1997-01-17	Roussel Uclaf	Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
US5747466A (en)	1995-11-08	1998-05-05	Abbott Laboratories	3-deoxy-3-descladinose derivatives of erythromycins A and B
FR2742757B1 (fr) *	1995-12-22	1998-01-30	Roussel Uclaf	Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2745290B1 (fr)	1996-02-28	1998-04-03	Roussel Uclaf	Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2748746B1 (fr)	1996-05-14	1998-08-14	Hoechst Marion Roussel Inc	Nouveau procede d'isomerisation du radical methyle en 10 de derives de l'erythromycine
TR199900006T2 (xx)	1996-07-05	1999-04-21	Biotica Technology Limited	Eritromisinler ve bunlar�n haz�rlanmas� i�in i�lem.
FR2751656B1 (fr)	1996-07-24	1998-10-16	Hoechst Marion Roussel Inc	Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
UA51730C2 (uk)	1996-09-04	2002-12-16	Ебботт Лабораторіз	6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
FR2757168B1 (fr)	1996-12-12	1999-06-11	Hoechst Marion Roussel Inc	Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2760017B1 (fr)	1997-02-27	1999-04-30	Hoechst Marion Roussel Inc	Nouveaux derives de l'erytromycine, leur procede de preparation et leur application comme medicaments
US6165986A (en)	1997-03-10	2000-12-26	Taisho Pharmaceutical Co., Ltd.	Erythromycin a derivatives
US20020025937A1 (en)	2000-03-20	2002-02-28	Yong-Jin Wu	9-oxime erythromycin derivatives
ZA987689B (en)	1997-09-02	1999-02-24	Abbott Lab	3-descladinose 6-O substituted erythromycin derivatives
HN1998000159A (es)	1997-10-29	1999-02-09	Monsanto Co	Derivados de 9- amino - 3 ceto eritromicina
ZA989835B (en)	1997-10-29	1999-05-05	Taisho Pharmaceutical Co Ltd	Erythromycin a derivatives
FR2771008B1 (fr) *	1997-11-17	2000-04-28	Hoechst Marion Roussel Inc	Utilisation des ketolides pour la preparation de compositions pharmaceutiques destinees a prevenir les complications thrombotiques arterielles liees a l'atherosclerose
AU1390699A (en)	1997-11-17	1999-06-07	Imarx Pharmaceutical Corp.	A method of increasing nucleic acid synthesis with ultrasound
AP1060A (en)	1998-01-02	2002-04-23	Pfizer Prod Inc	Novel erythromycin derivatives.
FR2777282B1 (fr)	1998-04-08	2001-04-20	Hoechst Marion Roussel Inc	Nouveaux derives de la 2-fluoro 3-de((2,6-dideoxy 3-c-methyl 3-0-methyl-alpha-l-ribohexopyranosyl) oxyl) 6-o-methyl 3-oxo erythromycine, leur procede de preparation et leur application a la synthese de principes actifs de medicaments
ES2243066T3 (es)	1998-09-22	2005-11-16	Pfizer Products Inc.	Antibioticos de carbamato y carbazato cetolida.
US6100240A (en)	1998-10-09	2000-08-08	Pfizer Inc	Macrolide derivatives
FR2785612A1 (fr)	1998-11-10	2000-05-12	Hoechst Marion Roussel Inc	Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
ID28286A (id)	1998-11-03	2001-05-10	Pfizer Prod Inc	Antibiotik-antibiotik makrolida baru
FR2786188B1 (fr)	1998-11-24	2002-10-31	Hoechst Marion Roussel Inc	Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments
AU6484199A (en)	1998-12-10	2000-06-26	Pfizer Products Inc.	Carbamate and carbazate ketolide antibiotics
TR200102128T2 (tr)	1999-01-27	2001-12-21	Pfizer Products Inc.	Ketolid antibiyotikler
FR2789392B1 (fr) *	1999-02-04	2001-10-05	Hoechst Marion Roussel Inc	Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
AU4354900A (en)	1999-04-16	2000-11-02	Kosan Biosciences, Inc.	Ketolide antibacterials
ATE340183T1 (de)	1999-04-16	2006-10-15	Kosan Biosciences Inc	Antiinfektiöse makrolidderivate
US6355620B1 (en)	1999-05-14	2002-03-12	Abbott Laboratories	C-2 modified erythromycin derivatives
CA2373117C (en)	1999-05-24	2006-02-28	Pfizer Products Inc.	13-methyl-erythromycin derivatives
EP1114826A3 (en)	1999-12-29	2001-10-31	Pfizer Products Inc.	Novel antibacterial and prokinetic macrolides
EP1122261A3 (en)	2000-01-31	2001-09-26	Pfizer Products Inc.	13 and 14-membered antibacterial macrolides
US20020061856A1 (en)	2000-04-24	2002-05-23	Yong-Jin Wu	Novel tricyclic erythromycin derivatives
ATE271062T1 (de)	2000-06-30	2004-07-15	Pfizer Prod Inc	Makrolid-antibiotika

1999
- 1999-12-28 TR TR2001/02128T patent/TR200102128T2/xx unknown
- 1999-12-28 EA EA200100623A patent/EA200100623A1/ru unknown
- 1999-12-28 WO PCT/IB1999/002051 patent/WO2000044761A2/en active IP Right Grant
- 1999-12-28 CN CN99815909A patent/CN1342163A/zh active Pending
- 1999-12-28 AU AU16754/00A patent/AU1675400A/en not_active Abandoned
- 1999-12-28 EP EP99959627A patent/EP1147121B1/en not_active Expired - Lifetime
- 1999-12-28 JP JP2000596017A patent/JP3947360B2/ja not_active Expired - Fee Related
- 1999-12-28 OA OA1200100191A patent/OA11753A/en unknown
- 1999-12-28 KR KR1020017009382A patent/KR20020002380A/ko not_active Application Discontinuation
- 1999-12-28 BR BR9916969-0A patent/BR9916969A/pt not_active Application Discontinuation
- 1999-12-28 HU HU0105190A patent/HUP0105190A3/hu unknown
- 1999-12-28 CZ CZ20012675A patent/CZ20012675A3/cs unknown
- 1999-12-28 ES ES99959627T patent/ES2212655T3/es not_active Expired - Lifetime
- 1999-12-28 ID IDW00200101637A patent/ID30233A/id unknown
- 1999-12-28 EE EEP200100394A patent/EE200100394A/xx unknown
- 1999-12-28 DK DK99959627T patent/DK1147121T3/da active
- 1999-12-28 IL IL14417899A patent/IL144178A0/xx unknown
- 1999-12-28 PT PT99959627T patent/PT1147121E/pt unknown
- 1999-12-28 SI SI9930486T patent/SI1147121T1/xx unknown
- 1999-12-28 SK SK1017-2001A patent/SK10172001A3/sk unknown
- 1999-12-28 CA CA002359708A patent/CA2359708C/en not_active Expired - Fee Related
- 1999-12-28 DE DE69913738T patent/DE69913738T2/de not_active Expired - Lifetime
- 1999-12-28 AP APAP/P/2001/002222A patent/AP2001002222A0/en unknown
- 1999-12-28 AT AT99959627T patent/ATE256694T1/de not_active IP Right Cessation
2000
- 2000-01-05 TN TNTNSN00007A patent/TNSN00007A1/fr unknown
- 2000-01-05 DZ DZ000002A patent/DZ3000A1/xx active
- 2000-01-06 PA PA20008489501A patent/PA8489501A1/es unknown
- 2000-01-06 HN HN2000000003A patent/HN2000000003A/es unknown
- 2000-01-06 PE PE2000000013A patent/PE20001422A1/es not_active Application Discontinuation
- 2000-01-06 MA MA25883A patent/MA26717A1/fr unknown
- 2000-01-21 CO CO00003460A patent/CO5150229A1/es unknown
- 2000-01-27 UY UY25990A patent/UY25990A1/es unknown
2001
- 2001-06-28 IS IS5984A patent/IS5984A/is unknown
- 2001-07-06 ZA ZA200105580A patent/ZA200105580B/en unknown
- 2001-07-25 BG BG105730A patent/BG105730A/xx unknown
- 2001-07-25 HR HR20010559A patent/HRP20010559A2/hr not_active Application Discontinuation
- 2001-07-26 NO NO20013680A patent/NO20013680L/no not_active Application Discontinuation
2002
- 2002-04-05 US US10/116,969 patent/US6833444B2/en not_active Expired - Fee Related
- 2002-05-31 HK HK02104131.0A patent/HK1042707A1/zh unknown

Also Published As

Publication number	Publication date
AU1675400A (en)	2000-08-18
CN1342163A (zh)	2002-03-27
UY25990A1 (es)	2000-09-29
JP2002535414A (ja)	2002-10-22
PA8489501A1 (es)	2000-09-29
KR20020002380A (ko)	2002-01-09
ATE256694T1 (de)	2004-01-15
HUP0105190A3 (en)	2003-03-28
ID30233A (id)	2001-11-15
TNSN00007A1 (fr)	2005-11-10
US6833444B2 (en)	2004-12-21
EP1147121A2 (en)	2001-10-24
CZ20012675A3 (cs)	2002-04-17
PE20001422A1 (es)	2000-12-18
IL144178A0 (en)	2002-05-23
HN2000000003A (es)	2001-02-02
EA200100623A1 (ru)	2002-02-28
OA11753A (en)	2005-07-19
PT1147121E (pt)	2004-04-30
EP1147121B1 (en)	2003-12-17
CA2359708A1 (en)	2000-08-03
ES2212655T3 (es)	2004-07-16
DZ3000A1 (fr)	2004-03-27
HRP20010559A2 (en)	2002-08-31
CA2359708C (en)	2005-10-25
BG105730A (en)	2002-03-29
MA26717A1 (fr)	2004-12-20
WO2000044761A2 (en)	2000-08-03
EE200100394A (et)	2002-10-15
DE69913738T2 (de)	2004-06-17
AP2001002222A0 (en)	2001-09-30
IS5984A (is)	2001-06-28
US20020156027A1 (en)	2002-10-24
DK1147121T3 (da)	2004-04-13
WO2000044761A3 (en)	2001-01-04
SK10172001A3 (sk)	2002-06-04
NO20013680L (no)	2001-09-19
NO20013680D0 (no)	2001-07-26
DE69913738D1 (de)	2004-01-29
JP3947360B2 (ja)	2007-07-18
CO5150229A1 (es)	2002-04-29
HK1042707A1 (zh)	2002-08-23
HUP0105190A2 (hu)	2002-04-29
TR200102128T2 (tr)	2001-12-21
BR9916969A (pt)	2001-11-06
SI1147121T1 (en)	2004-04-30

Publication	Publication Date	Title
ZA200105580B (en)	2003-02-17	Ketolide antibiotics.
EP1250343B1 (en)	2003-06-25	Azalide antibiotic compositions
HRP980571A2 (en)	1999-08-31	9-amino-3-keto erythromycin derivatives
CA2286511C (en)	2003-07-08	Novel macrolide derivatives
EP1132392B1 (en)	2004-03-03	Ketolide antibiotics
US6291656B1 (en)	2001-09-18	Tricyclic erythromycin derivatives
US6727352B2 (en)	2004-04-27	Methods of making macrolides
EP1114826A2 (en)	2001-07-11	Novel antibacterial and prokinetic macrolides
EP1167376B1 (en)	2004-07-14	Macrolide antibiotics
CA2332686C (en)	2005-06-07	Novel 13 and 14-membered antibacterial and prokinetic macrolides and their intermediates
EP1262186B1 (en)	2004-04-21	Azalide antibiotic compositions
US20030100742A1 (en)	2003-05-29	Erythromycin a derivatives
US20020061856A1 (en)	2002-05-23	Novel tricyclic erythromycin derivatives
US20020077302A1 (en)	2002-06-20	Tricyclic erythromycin derivatives
US20030171307A1 (en)	2003-09-11	Azalide antibiotic compositions
US10485812B2 (en)	2019-11-26	Stable antibacterial composition
EP0952157B1 (en)	2003-06-18	9A, 11B-Dehydro derivatives of 9-oxime-3-keto-6-0-methylerythromycin
US20020061857A1 (en)	2002-05-23	9-amino-3-oxo erythromycin derivatives
EP1439186A2 (en)	2004-07-21	Intermediates for novel antibacterial and prokinetic macrolides
MXPA01001212A (en)	2002-06-05	13 and 14-membered antibacterial macrolides
MXPA99009269A (en)	2000-10-01	New derivatives of macroli