YU68201A - Novi derivati morfolina, postupak za njihovo dobijanje i farmaceutske kompozicije koje ih sadrže - Google Patents

Novi derivati morfolina, postupak za njihovo dobijanje i farmaceutske kompozicije koje ih sadrže

Info

Publication number
YU68201A
YU68201A YU68201A YUP68201A YU68201A YU 68201 A YU68201 A YU 68201A YU 68201 A YU68201 A YU 68201A YU P68201 A YUP68201 A YU P68201A YU 68201 A YU68201 A YU 68201A
Authority
YU
Yugoslavia
Prior art keywords
derivatives
production
pharmaceutical preparations
preparations containing
novel morpholine
Prior art date
Application number
YU68201A
Other languages
English (en)
Inventor
Jean Philipe Ducoux
Xavier Edmonds-Alt
Patrick Gueule
Vincenzo Proietto
Original Assignee
Sanofi-Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Synthelabo filed Critical Sanofi-Synthelabo
Publication of YU68201A publication Critical patent/YU68201A/sh
Publication of RS50085B publication Critical patent/RS50085B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

Pronalazak se odnosi na jedinjenja formule (I), i na njihove soli sa neorganskim ili organskim kiselinama, na njihove solvate i/ili hidrate, koji imaju jak afinitet i visok stepen selektivnosti u odnosu na humane NK1 receptore supstance P. Pronalazak se takodje odnosi na postupak za proizvodnju pomenutih derivata, medjuproizvoda formule (IV), (VI) i (VIII) koji se koriste za njihovu proizvodnju, kao i na njihovu primenu za pripremanje medicinskih proizvoda koji su korisni kod lečenja bilo koje patologije u koju su uključeni supstanca P i/ili humani NK1 receptori.
YUP-682/01A 1999-03-25 2000-03-21 Novi derivati morfolina, postupak za njihovo dobijanje i farmaceutske kompozicije koje ih sadrže RS50085B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9903854A FR2791346B3 (fr) 1999-03-25 1999-03-25 Nouveaux derives de morpholine, procede pour leur preparation et compositions pharmaceutiques les contenant

Publications (2)

Publication Number Publication Date
YU68201A true YU68201A (sh) 2004-03-12
RS50085B RS50085B (sr) 2009-01-22

Family

ID=9543720

Country Status (41)

Country Link
US (1) US6506750B1 (sh)
EP (1) EP1165528B1 (sh)
JP (1) JP3853155B2 (sh)
KR (1) KR100696340B1 (sh)
CN (1) CN100422160C (sh)
AR (1) AR023139A1 (sh)
AT (1) ATE275136T1 (sh)
AU (1) AU756855B2 (sh)
BG (1) BG64623B1 (sh)
BR (1) BR0009281B1 (sh)
CA (1) CA2366829C (sh)
CO (1) CO5160340A1 (sh)
CZ (1) CZ300911B6 (sh)
DE (1) DE60013418T2 (sh)
DK (1) DK1165528T3 (sh)
EE (1) EE04525B1 (sh)
ES (1) ES2226794T3 (sh)
FR (1) FR2791346B3 (sh)
HK (1) HK1042092B (sh)
HR (1) HRP20010704B1 (sh)
HU (1) HUP0201863A3 (sh)
ID (1) ID29871A (sh)
IL (2) IL145041A0 (sh)
IS (1) IS2338B (sh)
ME (2) MEP12008A (sh)
MX (1) MXPA01009643A (sh)
NO (1) NO321576B1 (sh)
NZ (1) NZ513674A (sh)
PE (1) PE20001596A1 (sh)
PL (1) PL205318B1 (sh)
PT (1) PT1165528E (sh)
RS (1) RS50085B (sh)
RU (1) RU2222537C2 (sh)
SI (1) SI1165528T1 (sh)
SK (1) SK286977B6 (sh)
TR (1) TR200102639T2 (sh)
TW (1) TW534906B (sh)
UA (1) UA73931C2 (sh)
UY (1) UY26079A1 (sh)
WO (1) WO2000058292A1 (sh)
ZA (1) ZA200106981B (sh)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2234929T3 (es) * 2000-11-28 2005-07-01 Smithkline Beecham Plc Derivados de morfolina como antagonistas de los receptores de orexina.
FR2824828B1 (fr) * 2001-05-21 2005-05-20 Sanofi Synthelabo Nouveaux derives de piperidinecarboxamide, un procede pour leur preparation et les compositions pharmaceutiques les contenant
GB0228787D0 (en) * 2002-12-10 2003-01-15 Pfizer Ltd Morpholine dopamine agonists
ATE410426T1 (de) * 2002-12-13 2008-10-15 Smithkline Beecham Corp Heterocyclische verbindungen alsccr5-antagonisten
JO2485B1 (en) * 2002-12-23 2009-01-20 شركة جانسين فارماسوتيكا ان. في 1-Piperidine-3-Yl-4-Piperidine-4-Yl-Piperazine derivatives substituted and used as quinine antagonists
JP2007515425A (ja) * 2003-12-22 2007-06-14 シェーリング　コーポレイション 医薬組成物
FR2873373B1 (fr) * 2004-07-23 2006-09-08 Sanofi Synthelabo Derives de 4-arylmorpholin-3-one, leur preparation et leur application en therapeutique
CN103142569B (zh) * 2013-02-27 2016-01-20 南京医科大学 2,6-二异丙基苯甲酸及其衍生物作为神经保护剂的应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ3134U1 (cs) * 1995-01-10 1995-03-17 Pavel Ing. Janda Rotor universálního radiálního ventilátoru
FR2729954B1 (fr) 1995-01-30 1997-08-01 Sanofi Sa Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant
US5780466A (en) * 1995-01-30 1998-07-14 Sanofi Substituted heterocyclic compounds method of preparing them and pharmaceutical compositions in which they are present
HU224225B1 (hu) * 1995-12-01 2005-06-28 Sankyo Co. Ltd. Tachikinin receptor antagonista hatású heterociklusos vegyületek, ezek előállítási eljárása és alkalmazásuk gyógyszerkészítmények előállítására
JP3192631B2 (ja) * 1997-05-28 2001-07-30 三共株式会社 飽和複素環化合物からなる医薬
ATE297906T1 (de) * 1997-12-04 2005-07-15 Sankyo Co Alicyclische acylierte heterocyclenderivate

Also Published As

Publication number Publication date
IL145041A (en) 2010-11-30
HRP20010704B1 (en) 2005-04-30
ATE275136T1 (de) 2004-09-15
RU2222537C2 (ru) 2004-01-27
RS50085B (sr) 2009-01-22
FR2791346A1 (fr) 2000-09-29
BR0009281A (pt) 2002-01-22
AU3301600A (en) 2000-10-16
HUP0201863A2 (hu) 2002-12-28
DE60013418T2 (de) 2005-09-22
MXPA01009643A (es) 2002-05-14
US6506750B1 (en) 2003-01-14
CN100422160C (zh) 2008-10-01
ME00057B (me) 2010-10-10
CZ300911B6 (cs) 2009-09-09
AR023139A1 (es) 2002-09-04
CA2366829A1 (fr) 2000-10-05
EP1165528B1 (fr) 2004-09-01
WO2000058292A1 (fr) 2000-10-05
NO321576B1 (no) 2006-06-06
FR2791346B3 (fr) 2001-04-27
NZ513674A (en) 2003-05-30
SK286977B6 (sk) 2009-08-06
KR100696340B1 (ko) 2007-03-20
CO5160340A1 (es) 2002-05-30
HK1042092B (zh) 2005-04-22
ES2226794T3 (es) 2005-04-01
SI1165528T1 (en) 2005-02-28
TW534906B (en) 2003-06-01
BG64623B1 (bg) 2005-09-30
CZ20013365A3 (cs) 2002-01-16
PL205318B1 (pl) 2010-04-30
PL351317A1 (en) 2003-04-07
DK1165528T3 (da) 2005-01-10
TR200102639T2 (tr) 2002-02-21
BR0009281B1 (pt) 2011-05-17
JP3853155B2 (ja) 2006-12-06
NO20014632L (no) 2001-11-26
ZA200106981B (en) 2002-10-24
BG105923A (en) 2002-05-31
CA2366829C (fr) 2007-05-15
SK13462001A3 (sk) 2002-05-09
EP1165528A1 (fr) 2002-01-02
IS6063A (is) 2001-08-24
UY26079A1 (es) 2000-10-31
IL145041A0 (en) 2002-06-30
HRP20010704A2 (en) 2002-08-31
PE20001596A1 (es) 2001-04-01
EE200100499A (et) 2002-12-16
IS2338B (is) 2008-02-15
HK1042092A1 (en) 2002-08-02
JP2002540195A (ja) 2002-11-26
AU756855B2 (en) 2003-01-23
DE60013418D1 (de) 2004-10-07
KR20010108381A (ko) 2001-12-07
EE04525B1 (et) 2005-08-15
HUP0201863A3 (en) 2003-03-28
MEP12008A (en) 2010-06-10
CN1353698A (zh) 2002-06-12
NO20014632D0 (no) 2001-09-24
ID29871A (id) 2001-10-18
PT1165528E (pt) 2005-01-31
UA73931C2 (en) 2005-10-17

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