YU48197B - Derivati 4-aminopiridina i postupak za dobijanje njihovih smeša - Google Patents
Derivati 4-aminopiridina i postupak za dobijanje njihovih smešaInfo
- Publication number
- YU48197B YU48197B YU184988A YU184988A YU48197B YU 48197 B YU48197 B YU 48197B YU 184988 A YU184988 A YU 184988A YU 184988 A YU184988 A YU 184988A YU 48197 B YU48197 B YU 48197B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- quinoline
- amine
- present
- optional bond
- aminopyridine derivatives
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/61—Carboxylic acid nitriles containing cyano groups and nitrogen atoms being part of imino groups bound to the same carbon skeleton
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/08—Nitrogen atoms
- C07D219/10—Nitrogen atoms attached in position 9
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/36—Nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
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- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
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- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Ovaj pronalazak se odnosi na postupak za dobijanje derivata 4-aminopiridina, gde u formuli jeadn od CH ostataka u poližaju a, b, c i d formule 1, može biti zamenjen atomom azota ili svaki od CH ostataka u položaju a i d, a i c ili b i d može biti zamenjen atomom azota, pri čemu svaka isprekidana linija prestavlja opcionud vogubu vezu, R1 je H ili C1-C6 alkil, R3 je H, ili fluor, 1 B je gde isprekidana linija izmedju Y2 i Y3 predstavlja opcionu vezu, Y1 je CH2, O ili S; Y2 je CH2, CH, O ili S, a Y3 je CH2 ili CH, gde Y2 i Y3 predstavljaju CH kada je opciona veza prisutna, pod uslovom da kada R3 predstavlja H i nema atoma azota u položaju a, samo jedan od Y1 i Y2 može biti CH2 i najmanje jedan od Y1, Y2 i Y3 je različit od CH2, pri čemu Y1 predstavlja O ili S kada je opciona veza prisutna, a Y1 i Y2 su nezavisno O ili S kada Y3 predstavlja CH2; ili je naznačeno jedinjenje 9-amino-1,2,3,4-tetrahidro-1,4-metanoakridin; 9-amino-8-fluoro-1,2,3,4-tetrahidro-1,4-metanoakridin; 2,3-dihidrotieno /3,2-b/ hinolin-9-amin; 2,3-dihidro-8-fluorotieno /3,2-b/hinolin-9-amin, ili 1,3-dihidro-8-fluoro-tieno /3,4/ hinolin-9-amin, ili njihova farmacuetski prihvatljiva so. -Prijava sadrži još 1 nezavisan i 1 zavisan zahtev.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US1987/002546 WO1989002739A1 (en) | 1987-10-05 | 1987-10-05 | 4-aminopyridine derivatives |
PCT/US1988/001070 WO1989002740A1 (en) | 1987-10-05 | 1988-03-30 | 4-aminopyridine derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
YU184988A YU184988A (en) | 1990-04-30 |
YU48197B true YU48197B (sh) | 1997-08-22 |
Family
ID=26776287
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU184988A YU48197B (sh) | 1987-10-05 | 1988-10-04 | Derivati 4-aminopiridina i postupak za dobijanje njihovih smeša |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP0311303B1 (sh) |
JP (1) | JPH0692372B2 (sh) |
CN (1) | CN1032440A (sh) |
AU (1) | AU619213B2 (sh) |
DE (1) | DE3853863T2 (sh) |
DK (1) | DK553988A (sh) |
ES (1) | ES2072263T3 (sh) |
HU (1) | HU203082B (sh) |
IE (1) | IE60718B1 (sh) |
IL (1) | IL87861A0 (sh) |
NO (1) | NO176713C (sh) |
NZ (1) | NZ226445A (sh) |
YU (1) | YU48197B (sh) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4753950A (en) * | 1986-11-24 | 1988-06-28 | Hoechst-Roussel Pharmaceuticals, Inc. | Fused heterocyclic tetrahydroaminoquinolinols and related compounds |
US5013741A (en) * | 1987-09-08 | 1991-05-07 | Hoechst-Roussel Pharmaceuticals Incorporated | N-[substituted alkylidene]-1,2,3,4-tetrahydro-9-acridinamines useful for enhancing the cholinergic function in a mammal |
US4868177A (en) * | 1988-11-09 | 1989-09-19 | Hoechst-Roussel Pharmaceuticals, Inc. | 1,2,3,4-tetrahydro-1,9-acridinediamines, pharmaceutical compositions and use |
JPH02180871A (ja) * | 1988-11-16 | 1990-07-13 | Hoechst Roussel Pharmaceut Inc | ヒドロキシ―1,2,3,4―テトラヒドロアミノアクリジンおよびその製造法 |
US4999358A (en) * | 1989-06-26 | 1991-03-12 | Hoechst-Roussel Pharmaceuticals Inc. | (1,2,3,4-tetrahydro-9-acridinimino)cyclohexane carboxylic acid and related compounds |
JP2720549B2 (ja) * | 1989-11-08 | 1998-03-04 | 三菱化学株式会社 | 9―アミノアセチルアミノテトラヒドロアクリジン誘導体 |
US5112829A (en) * | 1989-11-28 | 1992-05-12 | Hoechst-Roussel Pharmaceuticals Inc. | Hexahydro-1H-quino[4,3,2-ef][1,4]benzoxazepines and related compounds |
US4994452A (en) * | 1989-11-28 | 1991-02-19 | Hoechst-Roussel Pharmaceuticals Inc. | Hexahydro-1H-quino[4,3,2-ef][1,4]benzoxazepines and related compounds |
EP0430485A3 (en) * | 1989-11-29 | 1992-01-22 | Ube Industries, Ltd. | Quinoline compound |
GB9010296D0 (en) * | 1990-05-08 | 1990-06-27 | Beecham Group Plc | Novel compounds |
US5210087A (en) * | 1991-02-13 | 1993-05-11 | Hoechst-Roussel Pharmaceuticals Inc. | 9-aminotetrahydroacridines and related compounds |
US5155226A (en) * | 1991-02-19 | 1992-10-13 | Hoechst-Roussel Pharmaceuticals Incorporated | Method for the preparation of 9-amino-1,2,3,4-tetrahydroacridine |
US5336675A (en) * | 1991-05-14 | 1994-08-09 | Ernir Snorrason | Method of treating mania in humans |
ES2042384B1 (es) * | 1991-12-26 | 1994-06-01 | Boehringer Ingelheim Espana | Procedimiento para obtener derivados bis-piridinicos. |
ES2059263B1 (es) * | 1992-10-27 | 1995-10-01 | Vita Invest Sa | Procedimiento para la obtencion del (+)-9-amino-1,2,3,4-tetrahidroacridin-1-ol. |
ES2100129B1 (es) * | 1995-10-11 | 1998-02-16 | Medichem Sa | Nuevos compuestos aminopiridinicos policiclicos inhibidores de acetilcolinesterasa, procedimiento para su preparacion y su utilizacion. |
GB9524346D0 (en) * | 1995-11-29 | 1996-01-31 | Univ Strathclyde | Polycyclic compounds |
DE19707655A1 (de) * | 1997-02-26 | 1998-08-27 | Hoechst Ag | Kombinationspräparat zur Anwendung bei Demenz |
CN102219740B (zh) * | 2010-09-10 | 2013-02-13 | 长春华洋高科技有限公司 | 1,2,3,4,5,6,7,8-八氢-9-苯乙酰胺基吖啶及制备方法和药用用途 |
KR20140143804A (ko) * | 2012-03-21 | 2014-12-17 | 메르크 파텐트 게엠베하 | 벤조[1,2―b;4,5―b′]디티오펜―4,8―디카르복실산 또는 이의 2,3―디히드로 유도체의 제조 방법 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1251764B (de) * | 1965-08-18 | 1967-10-12 | C H Boehnnger Sohn Ingelheim/ Rhein | Verfahren zur Herstellung von antimikrobiell wirksamen 12 3,4-Tetra hydro 9 -ammo acridmiumverbmdungen |
US3700673A (en) * | 1971-02-12 | 1972-10-24 | Morton Norwich Products Inc | 3-4-dihydrobenzo(b) (1,7)naphthyridin-1(2h)-ones |
US4550113A (en) * | 1982-08-19 | 1985-10-29 | Nauchno-Issledovatelsky Institut Po Biologicheskikm Ispytaniyam Khimicheskikh Soedineny | 9-Amino-2,3,5,6,7,8-hexahydro-1H-cyclopenta(b)quinoline monohydrate hydrochloride as stimulant of neuro-muscular transmission of smooth muscles |
GB2125696B (en) * | 1982-08-23 | 1985-11-06 | Nii Biolog Ispytaniam Khim Soe | Compositions containing quinoline derivatives |
EP0179383B1 (en) * | 1984-10-25 | 1991-05-29 | Hoechst-Roussel Pharmaceuticals Incorporated | 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds, a process for their preparation and their use as medicaments |
GB8610980D0 (en) * | 1986-05-06 | 1986-06-11 | Ici America Inc | Heterocyclic fused tricyclic compounds |
JPS63239271A (ja) * | 1986-11-05 | 1988-10-05 | Sumitomo Pharmaceut Co Ltd | シクロヘプタ〔b〕キノリン誘導体 |
JPS63225358A (ja) * | 1986-10-31 | 1988-09-20 | Sumitomo Pharmaceut Co Ltd | シクロペンタ〔b〕キノリン誘導体 |
JPS63264485A (ja) * | 1986-12-29 | 1988-11-01 | Sumitomo Pharmaceut Co Ltd | アミノキノリン誘導体 |
EP0268871A1 (en) * | 1986-10-31 | 1988-06-01 | Sumitomo Pharmaceuticals Company, Limited | Quinoline derivatives |
US4753950A (en) * | 1986-11-24 | 1988-06-28 | Hoechst-Roussel Pharmaceuticals, Inc. | Fused heterocyclic tetrahydroaminoquinolinols and related compounds |
US4897400A (en) * | 1987-02-13 | 1990-01-30 | Hoeschst-Roussel Pharmaceuticals, Inc. | 9-amino-1,4-ethano-1,2,3,4-tetrahydroacridine and related compounds useful for incresing the cholinergic function in a mammal |
EP0282959A3 (en) * | 1987-03-17 | 1989-05-31 | Hoechst-Roussel Pharmaceuticals Incorporated | Substituted 9-amino-tetrahydro-acridines and related compounds, a process for their preparation and their use as medicaments |
ES2056849T3 (es) * | 1987-04-23 | 1994-10-16 | Hoechst Roussel Pharma | Heteroalquilen-quinolinaminas condensadas, un procedimiento y productos intermedios para su preparacion y su uso como medicamentos. |
JP2510586B2 (ja) * | 1987-05-29 | 1996-06-26 | ゴスダルストベンヌイ、インスチツ−ト、アゾトノイ、プロムイシュレンノスチ(ギアプ) | 9−アミノ−2,3,5,6,7,8−ヘキサヒドロ−1H−シクロペンタ(b)キノリンの製造方法 |
-
1988
- 1988-09-28 IL IL87861A patent/IL87861A0/xx not_active IP Right Cessation
- 1988-09-29 DE DE3853863T patent/DE3853863T2/de not_active Expired - Fee Related
- 1988-09-29 ES ES88309040T patent/ES2072263T3/es not_active Expired - Lifetime
- 1988-09-29 EP EP88309040A patent/EP0311303B1/en not_active Expired - Lifetime
- 1988-10-04 IE IE300388A patent/IE60718B1/en not_active IP Right Cessation
- 1988-10-04 HU HU885131A patent/HU203082B/hu not_active IP Right Cessation
- 1988-10-04 YU YU184988A patent/YU48197B/sh unknown
- 1988-10-04 AU AU23370/88A patent/AU619213B2/en not_active Ceased
- 1988-10-04 DK DK553988A patent/DK553988A/da not_active Application Discontinuation
- 1988-10-04 NZ NZ226445A patent/NZ226445A/xx unknown
- 1988-10-04 CN CN88109023A patent/CN1032440A/zh active Pending
- 1988-10-04 NO NO884400A patent/NO176713C/no unknown
- 1988-10-05 JP JP63251742A patent/JPH0692372B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
YU184988A (en) | 1990-04-30 |
JPH0692372B2 (ja) | 1994-11-16 |
CN1032440A (zh) | 1989-04-19 |
DE3853863D1 (de) | 1995-06-29 |
EP0311303A3 (en) | 1990-09-12 |
DE3853863T2 (de) | 1995-09-21 |
ES2072263T3 (es) | 1995-07-16 |
NZ226445A (en) | 1991-11-26 |
DK553988D0 (da) | 1988-10-04 |
HU203082B (en) | 1991-05-28 |
NO172783B (no) | 1993-06-01 |
IE60718B1 (en) | 1994-08-10 |
NO176713C (no) | 1995-05-16 |
DK553988A (da) | 1989-04-06 |
NO884400A (no) | 1989-04-06 |
EP0311303A2 (en) | 1989-04-12 |
AU619213B2 (en) | 1992-01-23 |
AU2337088A (en) | 1989-04-06 |
NO884400D0 (no) | 1988-10-04 |
IL87861A0 (en) | 1989-03-31 |
NO176713B (no) | 1995-02-06 |
EP0311303B1 (en) | 1995-05-24 |
JPH01132566A (ja) | 1989-05-25 |
HUT50784A (en) | 1990-03-28 |
IE883003L (en) | 1989-04-05 |
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