YU47689B - Postupak za pravljenje 1,4-dihidro-piridinskih derivata - Google Patents
Postupak za pravljenje 1,4-dihidro-piridinskih derivataInfo
- Publication number
- YU47689B YU47689B YU46689A YU46689A YU47689B YU 47689 B YU47689 B YU 47689B YU 46689 A YU46689 A YU 46689A YU 46689 A YU46689 A YU 46689A YU 47689 B YU47689 B YU 47689B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- formula
- dihydro
- group
- iii
- correction
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
- C07C251/24—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to carbon atoms of six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Abstract
Postupak za pravljenje dimetil-1,4-dihidro-,2,6-dimetil-4-(2'-nitro-fenil)-piridin-3,5-dikarboksilata I: naznačen time, što obuhvata reakciju jedinjenja opšte formule II: gde n je 1 i R je grupa formule ili n je 3 i R je vodonik, sa metilacetatom formule III: CH3-CO-CH2-COOCH3 (III) i opciono sa amino jedinjenjem opšte formule IV: gde Z je grupa formule CH3-C=CH-COOCH3; p je 0; k je 1; ili Z predstavlja C1-5alkanoiloksi grupu pravog ili račvastog niza ili karbonatni, bikarbonatni ili hidroksi anjon; p je 1; k je 1; ili k je 0 i jedan, p je 0 dok je drugi 1, u inertnom rastvaraču na temperaturi od -10 do 120В°C; ili reakciju 2-nitro-benzaldehida i metilacetoacetata formule III i vodenog amonijum hidroksida u prisustvu inertnog rastvarača u jednoj fazi na temperaturi od 101 do 120В°C, na pritisku 0,2-0,6 MPa. Prijava sadrži još 26 zavisnih zahteva.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU881112A HU200320B (en) | 1988-03-08 | 1988-03-08 | Process for production of derivatives of azometine |
HU111188A HU201912B (en) | 1988-03-08 | 1988-03-08 | Process for producing dihydropyridine-carboxylic acid esters |
HU405588A HUT54647A (en) | 1988-08-02 | 1988-08-02 | Process for producing nifedipine |
Publications (2)
Publication Number | Publication Date |
---|---|
YU46689A YU46689A (en) | 1990-12-31 |
YU47689B true YU47689B (sh) | 1996-01-08 |
Family
ID=27269951
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU46689A YU47689B (sh) | 1988-03-08 | 1989-03-06 | Postupak za pravljenje 1,4-dihidro-piridinskih derivata |
Country Status (22)
Country | Link |
---|---|
US (1) | US5126457A (sh) |
JP (1) | JPH01316358A (sh) |
KR (1) | KR0131338B1 (sh) |
AT (1) | AT395586B (sh) |
AU (1) | AU615521B2 (sh) |
BE (1) | BE1003199A5 (sh) |
CA (1) | CA1340193C (sh) |
CH (1) | CH677490A5 (sh) |
CY (1) | CY1760A (sh) |
CZ (1) | CZ285313B6 (sh) |
DE (1) | DE3907508A1 (sh) |
DK (1) | DK113189A (sh) |
ES (1) | ES2012687A6 (sh) |
FI (1) | FI92056C (sh) |
FR (1) | FR2628421B1 (sh) |
GB (2) | GB2216521B (sh) |
GR (1) | GR1002248B (sh) |
IL (1) | IL89536A0 (sh) |
NL (1) | NL8900569A (sh) |
PL (1) | PL159098B1 (sh) |
SE (1) | SE469659B (sh) |
YU (1) | YU47689B (sh) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4011695A1 (de) * | 1990-04-11 | 1991-10-17 | Bayer Ag | Verwendung von n-alkylierten 1,4-dihydropyridindicarbonsaeureestern als arzneimittel, neue verbindungen und verfahren zu ihrer herstellung |
AU640019B2 (en) * | 1990-05-22 | 1993-08-12 | Unichema Chemie Bv | Lubricants |
DE19727350C1 (de) * | 1997-06-27 | 1999-01-21 | Bayer Ag | Verfahren zur Herstellung von Nifedipin |
LV12200B (lv) * | 1997-07-03 | 1999-04-20 | Gunārs DUBURS | Antidiabētisks līdzeklis |
HUP9900353A3 (en) * | 1999-02-15 | 2002-01-28 | Egis Gyogyszergyar Nyilvanosan | Process for producing asymmetric esters of 1,4-dihydropyridine-dicarboxylic acids |
CN103204814A (zh) * | 2010-09-02 | 2013-07-17 | 常州市第四制药厂有限公司 | 硝苯地平的制备及其杂质分离方法与应用 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2863920A (en) * | 1956-07-26 | 1958-12-09 | Gen Aniline & Film Corp | Process of preparing hydrobenzamide |
DE1670827C3 (de) * | 1967-03-20 | 1974-10-24 | Bayer Ag, 5090 Leverkusen | 4-(2'-Nitrophenyl)-2,6-dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridin |
DE2210667A1 (de) * | 1972-03-06 | 1973-09-20 | Bayer Ag | Kondensiert aromatisch substituierte 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
JPS4936682A (sh) * | 1972-08-16 | 1974-04-05 | ||
GB1409865A (en) * | 1973-02-13 | 1975-10-15 | Science Union & Cie | Dihydropyridines derivatives their preparation and pharmaceu tical compositions containing them |
DE2335466A1 (de) * | 1973-07-12 | 1975-01-30 | Bayer Ag | Alkoxyalkyl-1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
DD120019A1 (sh) * | 1975-04-11 | 1976-05-20 | ||
US4012032A (en) * | 1975-11-28 | 1977-03-15 | International Business Machines Corporation | Document reproduction having output means with plural outputs operable in a plurality of modes |
DE2639257A1 (de) * | 1976-09-01 | 1978-03-02 | Bayer Ag | Aminoalkylidenamino-1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
ES537914A0 (es) * | 1984-11-23 | 1985-11-01 | Coma Julia Concepcio | Procedimiento de obtencion del dimetil ester del acido 1,4-dihidro-2,6-dimetil-4-(2-nitrofenil)-3,5-piridindicarboxilico |
EP0191724A3 (de) * | 1985-01-15 | 1986-12-03 | Sandoz Ag | 1,4-Dihydropyridine, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen |
DE3501855A1 (de) * | 1985-01-22 | 1986-07-24 | Bayer Ag, 5090 Leverkusen | 5-aryl-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
PL141347B1 (en) * | 1985-10-10 | 1987-07-31 | Inst Przemyslu Farmaceutic | Method of obtaining chromatographically pure 4-/2-nitrophenyl/-2,6-dimethyl-3,5-dicarbomethoxy-1,4-dihydropyridine |
-
1989
- 1989-02-28 GR GR890100133A patent/GR1002248B/el unknown
- 1989-03-03 CH CH799/89A patent/CH677490A5/de not_active IP Right Cessation
- 1989-03-06 YU YU46689A patent/YU47689B/sh unknown
- 1989-03-08 CZ CS891454A patent/CZ285313B6/cs unknown
- 1989-03-08 BE BE8900247A patent/BE1003199A5/fr not_active IP Right Cessation
- 1989-03-08 PL PL1989278134A patent/PL159098B1/pl unknown
- 1989-03-08 JP JP1053968A patent/JPH01316358A/ja active Pending
- 1989-03-08 FR FR8903043A patent/FR2628421B1/fr not_active Expired - Fee Related
- 1989-03-08 NL NL8900569A patent/NL8900569A/nl not_active Application Discontinuation
- 1989-03-08 US US07/321,293 patent/US5126457A/en not_active Expired - Fee Related
- 1989-03-08 CA CA000593128A patent/CA1340193C/en not_active Expired - Fee Related
- 1989-03-08 DE DE3907508A patent/DE3907508A1/de not_active Withdrawn
- 1989-03-08 FI FI891111A patent/FI92056C/fi not_active IP Right Cessation
- 1989-03-08 GB GB8905270A patent/GB2216521B/en not_active Expired - Lifetime
- 1989-03-08 KR KR1019890002844A patent/KR0131338B1/ko not_active IP Right Cessation
- 1989-03-08 IL IL89536A patent/IL89536A0/xx not_active IP Right Cessation
- 1989-03-08 SE SE8900813A patent/SE469659B/sv not_active IP Right Cessation
- 1989-03-08 AT AT0052589A patent/AT395586B/de not_active IP Right Cessation
- 1989-03-08 DK DK113189A patent/DK113189A/da unknown
- 1989-03-08 ES ES8900848A patent/ES2012687A6/es not_active Expired - Lifetime
- 1989-03-08 AU AU31129/89A patent/AU615521B2/en not_active Ceased
-
1991
- 1991-04-24 GB GB9108770A patent/GB2243608B/en not_active Expired - Lifetime
-
1994
- 1994-07-15 CY CY176094A patent/CY1760A/xx unknown
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