YU46421B - Postupak za dobijanje farmaceutskog preparata kiselinski labilnih supstanci za oralnu upotrebu - Google Patents

Postupak za dobijanje farmaceutskog preparata kiselinski labilnih supstanci za oralnu upotrebu

Info

Publication number
YU46421B
YU46421B YU68087A YU68087A YU46421B YU 46421 B YU46421 B YU 46421B YU 68087 A YU68087 A YU 68087A YU 68087 A YU68087 A YU 68087A YU 46421 B YU46421 B YU 46421B
Authority
YU
Yugoslavia
Prior art keywords
compound
acid
lower alkyl
preparation
alkaline
Prior art date
Application number
YU68087A
Other languages
English (en)
Other versions
YU68087A (en
Inventor
K.I. Lövgren
A.G. Pilbrant
M. Yasumura
S. Morigaki
M. Oda
N. Ohishi
Original Assignee
Aktiebolaget Hässle
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10597119&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=YU46421(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aktiebolaget Hässle filed Critical Aktiebolaget Hässle
Priority to SI8710680A priority Critical patent/SI8710680B/sl
Publication of YU68087A publication Critical patent/YU68087A/xx
Priority to HRP-680/87A priority patent/HRP920855B1/xx
Publication of YU46421B publication Critical patent/YU46421B/sh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

POSTUPAK ZA DOBIJANJE FARMACEUTSKOG PREPARATA KISELINSKI LABILNIH SUPSTANCI ZA ORALNU UPOTREBU, stabilnog na obezbojavanje, koji sadrži kiselinski labilno jedinjenje opšte formule (I) u kojoj je A po potrebi supstituisana heterociklična grupa, R1, R2, R3 i R4 su isti ili različiti i poželjno su vodonik, niži alkil, niži alkoksi, -CF3-, - niži alkil ili halogen i R5 je H ili niža alkil grupa, gde "niža" označava 1-6 atoma ugljenika izuzev kada je jedinjenje omerpazol, 5-metoksi-2//-(metoksi-3,5- dimetil-2-piridinil)metil/sul-finil/-1H-benzimidazol; ili je kiselinski labilno jedinjenje 2-/(2-dimetilaminozil)sulfinil/benzimidazol, kao aktivan sastojak, naz načen time, što se kiselinski labilno aktivno jedinjenje, pomešano sa jedinjenjem koje reaguje alkalno, ili alkalna so aktivnog jedinjenja po potrebi pomešana sa jedinjenjem koje reaguje alkalno, formira u jezgra u obliku malih čestica ili tableta, što se ova jezgra oblažu sa jednim ili više slojeva inertne pod prevlake koji se sastoje od ekcipijenata za tablete koji se rastvaraju ili brzo dezintegrišu u vodi, ili polimernih, u vodi rastvornih jedinjenja koja obrazuju film, kojima se po potrebi dodaju alkalna puferska sredstva, i što se jezgra prevučena slojem pod-prevlake dalje oblažu slojem intestinalne prevlake. Prijava sadrži još 8 zavisnih zahteva.
YU68087A 1986-04-30 1987-04-15 Postupak za dobijanje farmaceutskog preparata kiselinski labilnih supstanci za oralnu upotrebu YU46421B (sh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
SI8710680A SI8710680B (sl) 1986-04-30 1987-04-15 Farmacevtski pripravki kislinsko labilnih substanc za oralno uporabo
HRP-680/87A HRP920855B1 (en) 1986-04-30 1992-10-02 Pharmaceutical formulations of acid labile substances for oral use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB08610573A GB2189699A (en) 1986-04-30 1986-04-30 Coated acid-labile medicaments

Publications (2)

Publication Number Publication Date
YU68087A YU68087A (en) 1988-08-31
YU46421B true YU46421B (sh) 1993-10-20

Family

ID=10597119

Family Applications (1)

Application Number Title Priority Date Filing Date
YU68087A YU46421B (sh) 1986-04-30 1987-04-15 Postupak za dobijanje farmaceutskog preparata kiselinski labilnih supstanci za oralnu upotrebu

Country Status (33)

Country Link
US (1) US4853230A (sh)
EP (3) EP0565210B1 (sh)
JP (1) JPH0667837B2 (sh)
KR (1) KR950004886B1 (sh)
CN (1) CN1025151C (sh)
AR (1) AR243377A1 (sh)
AT (2) ATE186639T1 (sh)
AU (1) AU603568B2 (sh)
CA (1) CA1302891C (sh)
CS (1) CS268535B2 (sh)
CY (1) CY1860A (sh)
DD (1) DD260222B5 (sh)
DE (3) DE3751851T2 (sh)
DK (1) DK169987B1 (sh)
DZ (1) DZ1078A1 (sh)
EG (1) EG18517A (sh)
ES (2) ES2010648T3 (sh)
FI (1) FI91708C (sh)
GB (1) GB2189699A (sh)
GR (2) GR890300156T1 (sh)
HK (2) HK104095A (sh)
HU (1) HU198385B (sh)
IE (1) IE61837B1 (sh)
IS (1) IS1918B (sh)
MY (1) MY102675A (sh)
NO (1) NO174952C (sh)
NZ (1) NZ220097A (sh)
PH (1) PH24440A (sh)
PL (1) PL265417A1 (sh)
PT (1) PT84786B (sh)
SU (1) SU1709894A3 (sh)
YU (1) YU46421B (sh)
ZA (1) ZA872379B (sh)

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