ES2137862B1 - Preparacion farmaceutica oral que comprende un compuesto de actividad antiulcerosa y procedimiento para su obtencion. - Google Patents
Preparacion farmaceutica oral que comprende un compuesto de actividad antiulcerosa y procedimiento para su obtencion.Info
- Publication number
- ES2137862B1 ES2137862B1 ES009701816A ES9701816A ES2137862B1 ES 2137862 B1 ES2137862 B1 ES 2137862B1 ES 009701816 A ES009701816 A ES 009701816A ES 9701816 A ES9701816 A ES 9701816A ES 2137862 B1 ES2137862 B1 ES 2137862B1
- Authority
- ES
- Spain
- Prior art keywords
- procedure
- solution
- ulcer activity
- obtaining
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Abstract
Preparación farmacéutica oral que comprende un compuesto de actividad antiulcerosa y procedimiento para su obtención. Comprende un núcleo inerte; una capa activa soluble o de desintegración rápida en agua obtenida a partir de una única solución-suspensión acuosa o hidroalcohólica que comprende: un principio activo de actividad antiulcerosa de fórmula I, II ó III, y por lo menos un excipiente; y una capa de recubrimiento externa gastrorresistente obtenida a partir de una solución que comprende: un polímero de recubrimiento entérico; y por lo menos un excipiente. El procedimiento se lleva a cabo mediante 1) un recubrimiento de los núcleos inertes mediante la nebulización de la única suspensión-solución acuosa o hidroalcohólica; 2) un secado de la capa activa formada durante la nebulización de la etapa anterior; y 3) un recubrimiento de los núcleos cargados mediante la nebulización de una solución que comprende un polímero de recubrimiento entérico con por lo menos un excipiente para obteneruna capa de recubrimiento externa gastrorresistente.
Priority Applications (35)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES009701816A ES2137862B1 (es) | 1997-07-31 | 1997-07-31 | Preparacion farmaceutica oral que comprende un compuesto de actividad antiulcerosa y procedimiento para su obtencion. |
TW087110962A TW533201B (en) | 1997-07-31 | 1998-07-07 | Oral pharmaceutical preparation which includes a benzimidazole compound of anti-ulcer activity and procedure for making same |
PT98932185T PT1010423E (pt) | 1997-07-31 | 1998-07-13 | Preparacao farmaceutica oral que contem um derivado benzimidazolico com accao anti-ulcerosa e processo para a sua producao |
IL13415898A IL134158A (en) | 1997-07-31 | 1998-07-13 | Oral pharmacy preparations containing active compounds against gastric ulcer and process for their manufacture |
ES98932185T ES2256943T4 (es) | 1997-07-31 | 1998-07-13 | Preparacion farmaceutica oral que comprende un compuesto de actividad antiulcerosa y procedimiento para su obtencion. |
CZ20000344A CZ298700B6 (cs) | 1997-07-31 | 1998-07-13 | Orální farmaceutický postredek obsahující slouceninu s protivredovou aktivitou a zpusob jeho prípravy |
AU82173/98A AU751609B2 (en) | 1997-07-31 | 1998-07-13 | Oral pharmaceutical preparation comprising an antiulcer activity compound, and process for its production |
RU2000104866/14A RU2207114C2 (ru) | 1997-07-31 | 1998-07-13 | Пероральный фармацевтический препарат, содержащий соединение, обладающее противоязвенным действием, и способ получения указанного препарата |
SK103-2000A SK284892B6 (sk) | 1997-07-31 | 1998-07-13 | Orálny farmaceutický prostriedok obsahujúci zlúčeninu s protivredovou aktivitou a spôsob jeho prípravy |
NZ502590A NZ502590A (en) | 1997-07-31 | 1998-07-13 | Anti-ulcer oral pharmaceutical preparation produced in a fluidized bed coater |
DK98932185T DK1010423T3 (da) | 1997-07-31 | 1998-07-13 | Oralt farmaceutisk præparat indeholdende et benzimidazolderivat med antiulcusvirkning og fremgangsmåde til dets fremstilling |
KR1020007001023A KR100591488B1 (ko) | 1997-07-31 | 1998-07-13 | 항궤양 활성 화합물을 포함하는 경구용 약제학적 제제의 제조방법 |
TR2000/00264T TR200000264T2 (tr) | 1997-07-31 | 1998-07-13 | Anti-ülser özelliğine sahip bileşik içeren oral ilaç preparatı ve bunu elde etmenin yöntemi. |
UA2000020750A UA66800C2 (uk) | 1997-07-31 | 1998-07-13 | Фармацевтична форма препарату для перорального прийому, що містить сполуку з противиразковою активністю, і спосіб її одержання |
PL338613A PL192961B1 (pl) | 1997-07-31 | 1998-07-13 | Sposób wytwarzania doustnej kompozycji farmaceutycznej i doustna kompozycja farmaceutyczna |
JP2000504847A JP3961217B2 (ja) | 1997-07-31 | 1998-07-13 | 抗潰瘍活性化合物を含んでなる経口医薬製剤およびその製造方法 |
AT98932185T ATE317688T1 (de) | 1997-07-31 | 1998-07-13 | Orale pharmazeutische zusammensetzung enthaltend ein benzimidazolderivat mit antiulcus wirkung und verfahren zu seiner herstellung |
PCT/ES1998/000204 WO1999006032A2 (es) | 1997-07-31 | 1998-07-13 | Preparacion farmaceutica oral que comprende un compuesto de actividad antiulcerosa y procedimiento para su obtencion |
CA002307037A CA2307037C (en) | 1997-07-31 | 1998-07-13 | Oral pharmaceutical preparation comprising an antiulcer activity compound, and process for its production |
DE69833490T DE69833490T2 (de) | 1997-07-31 | 1998-07-13 | Orale pharmazeutische zusammensetzung enthaltend ein benzimidazolderivat mit antiulcus wirkung und verfahren zu seiner herstellung |
HU0002524A HU230635B1 (hu) | 1997-07-31 | 1998-07-13 | Eljárás fekélyellenes hatóanyagot tartalmazó orális gyógyászati készítmények előállítására |
EP98932185A EP1010423B1 (en) | 1997-07-31 | 1998-07-13 | Oral pharmaceutical preparation comprising an antiulcer benzimidazole derivative, and process for its production |
ARP980103576A AR013242A1 (es) | 1997-07-31 | 1998-07-22 | Preparacion farmaceutica oral que comprende un compuesto de actividad antiulcerosa y procedimiento para su obtencion |
HN1998000113A HN1998000113A (es) | 1997-07-31 | 1998-07-23 | Preparacion farmaceutica oral que comprende un compuesto de actividad antiulcerosa y procedimiento para su obtencion. |
PE1998000660A PE105199A1 (es) | 1997-07-31 | 1998-07-23 | Preparacion farmaceutica oral que comprende un compuesto de actividad antiulcerosa y procedimiento para su obtencion |
CR5826A CR5826A (es) | 1997-07-31 | 1998-07-24 | Preparacion farmaceutica oral que comprende un compuesto de actividad antiulcerosa y procedimiento para su obtencion |
GT199800113A GT199800113A (es) | 1997-07-31 | 1998-07-27 | Preparacion farmaceutica oral que comprende un compuesto de actividad antiulcerosa y procedimiento para su obtencion. |
MYPI98003435A MY121353A (en) | 1997-07-31 | 1998-07-28 | Oral pharmaceutical preparation which includes a compound of anti-ulcer activity and procedure for making same. |
PA19988456401A PA8456401A1 (es) | 1997-07-31 | 1998-07-30 | Preparacion farmaceutica oral que comprende un compuesto de actividad antiulcerosa y procedimiento para su obtencion |
ZA986893A ZA986893B (en) | 1997-07-31 | 1998-07-31 | Oral pharmaceutical preparation which includes a compound of anti-ulcer activity and procedure for making same |
ES009900157A ES2156699B1 (es) | 1997-07-31 | 1999-01-27 | "preparacion farmaceutica oral que comprende un compuesto de actividad antiulcerosa y procedimiento para su obtencion". |
US09/491,624 US20020098242A1 (en) | 1997-07-31 | 2000-01-26 | Oral pharmaceutical preparation comprising an antiulcer activity compound, and process for its production |
NO20000435A NO20000435L (no) | 1997-07-31 | 2000-01-27 | Oralt farmasoytisk preparat omfattende en forbindelse med anti-ulceraktivitet og fremgangsmate for dets fremstilling |
HR20000053A HRP20000053B1 (en) | 1997-07-31 | 2000-01-31 | Oral pharmaceutical preparation comprising an antiulcer activity compound, and process for its production |
BG104193A BG64967B1 (bg) | 1997-07-31 | 2000-02-25 | Метод за получаване на орален фармацевтичен препарат, включващ съединение с противоязвена активност |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES009701816A ES2137862B1 (es) | 1997-07-31 | 1997-07-31 | Preparacion farmaceutica oral que comprende un compuesto de actividad antiulcerosa y procedimiento para su obtencion. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2137862A1 ES2137862A1 (es) | 1999-12-16 |
ES2137862B1 true ES2137862B1 (es) | 2000-09-16 |
Family
ID=8300432
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES009701816A Expired - Fee Related ES2137862B1 (es) | 1997-07-31 | 1997-07-31 | Preparacion farmaceutica oral que comprende un compuesto de actividad antiulcerosa y procedimiento para su obtencion. |
ES98932185T Expired - Lifetime ES2256943T4 (es) | 1997-07-31 | 1998-07-13 | Preparacion farmaceutica oral que comprende un compuesto de actividad antiulcerosa y procedimiento para su obtencion. |
ES009900157A Expired - Fee Related ES2156699B1 (es) | 1997-07-31 | 1999-01-27 | "preparacion farmaceutica oral que comprende un compuesto de actividad antiulcerosa y procedimiento para su obtencion". |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES98932185T Expired - Lifetime ES2256943T4 (es) | 1997-07-31 | 1998-07-13 | Preparacion farmaceutica oral que comprende un compuesto de actividad antiulcerosa y procedimiento para su obtencion. |
ES009900157A Expired - Fee Related ES2156699B1 (es) | 1997-07-31 | 1999-01-27 | "preparacion farmaceutica oral que comprende un compuesto de actividad antiulcerosa y procedimiento para su obtencion". |
Country Status (33)
Country | Link |
---|---|
US (1) | US20020098242A1 (es) |
EP (1) | EP1010423B1 (es) |
JP (1) | JP3961217B2 (es) |
KR (1) | KR100591488B1 (es) |
AR (1) | AR013242A1 (es) |
AT (1) | ATE317688T1 (es) |
AU (1) | AU751609B2 (es) |
BG (1) | BG64967B1 (es) |
CA (1) | CA2307037C (es) |
CR (1) | CR5826A (es) |
CZ (1) | CZ298700B6 (es) |
DE (1) | DE69833490T2 (es) |
DK (1) | DK1010423T3 (es) |
ES (3) | ES2137862B1 (es) |
GT (1) | GT199800113A (es) |
HN (1) | HN1998000113A (es) |
HR (1) | HRP20000053B1 (es) |
HU (1) | HU230635B1 (es) |
IL (1) | IL134158A (es) |
MY (1) | MY121353A (es) |
NO (1) | NO20000435L (es) |
NZ (1) | NZ502590A (es) |
PA (1) | PA8456401A1 (es) |
PE (1) | PE105199A1 (es) |
PL (1) | PL192961B1 (es) |
PT (1) | PT1010423E (es) |
RU (1) | RU2207114C2 (es) |
SK (1) | SK284892B6 (es) |
TR (1) | TR200000264T2 (es) |
TW (1) | TW533201B (es) |
UA (1) | UA66800C2 (es) |
WO (1) | WO1999006032A2 (es) |
ZA (1) | ZA986893B (es) |
Families Citing this family (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8071128B2 (en) | 1996-06-14 | 2011-12-06 | Kyowa Hakko Kirin Co., Ltd. | Intrabuccally rapidly disintegrating tablet and a production method of the tablets |
US6096340A (en) * | 1997-11-14 | 2000-08-01 | Andrx Pharmaceuticals, Inc. | Omeprazole formulation |
US6733778B1 (en) | 1999-08-27 | 2004-05-11 | Andrx Pharmaceuticals, Inc. | Omeprazole formulation |
US6723342B1 (en) | 1999-02-08 | 2004-04-20 | Fmc Corporation | Edible coating composition |
US6432448B1 (en) | 1999-02-08 | 2002-08-13 | Fmc Corporation | Edible coating composition |
FR2793688B1 (fr) * | 1999-05-21 | 2003-06-13 | Ethypharm Lab Prod Ethiques | Microgranules gastroproteges, procede d'obtention et preparations pharmaceutiques |
IL130602A0 (en) * | 1999-06-22 | 2000-06-01 | Dexcel Ltd | Stable benzimidazole formulation |
US6228400B1 (en) * | 1999-09-28 | 2001-05-08 | Carlsbad Technology, Inc. | Orally administered pharmaceutical formulations of benzimidazole derivatives and the method of preparing the same |
US6500462B1 (en) | 1999-10-29 | 2002-12-31 | Fmc Corporation | Edible MCC/PGA coating composition |
IT1319655B1 (it) | 2000-11-15 | 2003-10-23 | Eurand Int | Microsfere di enzimi pancreatici con elevata stabilita' e relativometodo di preparazione. |
IL155959A0 (en) | 2000-11-28 | 2003-12-23 | Fmc Corp | Edible pga (propylene glycol alginate) coating composition |
US9358214B2 (en) | 2001-10-04 | 2016-06-07 | Adare Pharmaceuticals, Inc. | Timed, sustained release systems for propranolol |
KR100447085B1 (ko) * | 2001-11-08 | 2004-09-04 | 바램제약주식회사 | 마그네슘이온, 칼슘이온 또는 철이온이 고농도로 결합된알긴산의 제조 방법 |
CN101982199A (zh) * | 2001-11-21 | 2011-03-02 | 卫材R&D管理有限公司 | 含有对酸不稳定的生理活性化合物的制剂组合物及其制法 |
US20050163846A1 (en) * | 2001-11-21 | 2005-07-28 | Eisai Co., Ltd. | Preparation composition containing acid-unstable physiologically active compound, and process for producing same |
US6663888B2 (en) | 2001-12-14 | 2003-12-16 | Eurand Pharmaceuticals Ltd. | Pulsatile release histamine H2 antagonist dosage form |
CA2494716A1 (en) * | 2002-08-02 | 2004-02-19 | Ratiopharm Gmbh | Pharmaceutical preparation containing a benzimidazole compound mixed with microcrystalline cellulose and a method for its preparation |
EP1556010A4 (en) * | 2002-10-31 | 2007-12-05 | Supergen Inc | PHARMACEUTICAL FORMULATIONS TARGETING SPECIFIC REGIONS OF THE GASTROINTESTINAL TRACT |
US8367111B2 (en) | 2002-12-31 | 2013-02-05 | Aptalis Pharmatech, Inc. | Extended release dosage forms of propranolol hydrochloride |
ES2665464T3 (es) * | 2003-03-28 | 2018-04-25 | Sigmoid Pharma Limited | Forma de dosificación oral sólida que contiene microcápsulas sin costuras |
AR045062A1 (es) * | 2003-07-18 | 2005-10-12 | Santarus Inc | Formulaciones farmaceuticas para inhibir la secrecion de acido y metodos para preparar y utilizarlas |
CA2560613C (en) | 2004-03-22 | 2015-11-24 | Solvay Pharmaceuticals Gmbh | Oral pharmaceutical compositions of lipase-containing products, in particular of pancreatin, containing surfactants |
CN1938026A (zh) * | 2004-03-26 | 2007-03-28 | 卫材R&D管理有限公司 | 控释制剂及其制造方法 |
BRPI0508075A (pt) | 2004-03-31 | 2007-07-17 | Bpsi Holdings Inc | revestimentos entéricos para substratos de ingestão oral |
US8747895B2 (en) | 2004-09-13 | 2014-06-10 | Aptalis Pharmatech, Inc. | Orally disintegrating tablets of atomoxetine |
CA2581775A1 (en) * | 2004-09-27 | 2006-04-06 | Sigmoid Biotechnologies Limited | Dihydropyrimidine microcapsule - formulations |
US9884014B2 (en) | 2004-10-12 | 2018-02-06 | Adare Pharmaceuticals, Inc. | Taste-masked pharmaceutical compositions |
CA2584957C (en) | 2004-10-21 | 2015-08-25 | Eurand Pharmaceuticals Limited | Taste-masked pharmaceutical compositions with gastrosoluble pore-formers |
BRPI0500586A (pt) * | 2005-02-21 | 2006-10-10 | Fundacao Oswaldo Cruz | composição farmacêutica, processo para preparar dita composição, uso da respectiva composição no tratamento da imunodeficiência causada por infecção pelo hiv e respectivo método de tratamento |
WO2006111980A2 (en) * | 2005-04-20 | 2006-10-26 | Ideal Cures Pvt. Ltd. | Pva based film coating and film coating compositions |
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GB201020032D0 (en) | 2010-11-25 | 2011-01-12 | Sigmoid Pharma Ltd | Composition |
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US10953025B2 (en) * | 2011-07-14 | 2021-03-23 | Able Cerebral, Llc | Composition, device and method for delayed and sustained release of brain energy molecules |
EP2987499B1 (en) | 2011-08-08 | 2019-05-08 | Allergan Pharmaceuticals International Limited | Method for dissolution testing of solid compositions containing digestive enzymes |
GB201212010D0 (en) | 2012-07-05 | 2012-08-22 | Sigmoid Pharma Ltd | Formulations |
US10184121B2 (en) | 2013-06-28 | 2019-01-22 | Allergan Pharmaceuticals International Limited | Methods for removing viral contaminants from pancreatic extracts |
RU2679832C2 (ru) | 2013-08-09 | 2019-02-13 | Аллерган Фармасьютикалз Интернэйшнл Лимитед | Композиция пищеварительных ферментов, подходящая для энтерального введения |
GB201319791D0 (en) | 2013-11-08 | 2013-12-25 | Sigmoid Pharma Ltd | Formulations |
MX2014008314A (es) * | 2014-07-07 | 2016-01-06 | Andres Abelino Choza Romero | Procedimiento para mezclar sustancias, mediante nebulizacion. |
TWI535784B (zh) | 2014-08-26 | 2016-06-01 | 財團法人工業技術研究院 | 剪切增稠配方、及包含其之複合材料 |
CN107106644B (zh) | 2014-11-07 | 2022-04-15 | 卓越治疗有限公司 | 包含环孢菌素的组合物 |
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US2799241A (en) * | 1949-01-21 | 1957-07-16 | Wisconsin Alumni Res Found | Means for applying coatings to tablets or the like |
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CA1327010C (en) * | 1986-02-13 | 1994-02-15 | Tadashi Makino | Stabilized solid pharmaceutical composition containing antiulcer benzimidazole compound and its production |
GB2189698A (en) * | 1986-04-30 | 1987-11-04 | Haessle Ab | Coated omeprazole tablets |
GB2189699A (en) * | 1986-04-30 | 1987-11-04 | Haessle Ab | Coated acid-labile medicaments |
US5026560A (en) * | 1987-01-29 | 1991-06-25 | Takeda Chemical Industries, Ltd. | Spherical granules having core and their production |
KR930000861B1 (ko) * | 1990-02-27 | 1993-02-08 | 한미약품공업 주식회사 | 오메프라졸 직장투여 조성물 |
US5232706A (en) * | 1990-12-31 | 1993-08-03 | Esteve Quimica, S.A. | Oral pharmaceutical preparation containing omeprazol |
YU48263B (sh) * | 1991-06-17 | 1997-09-30 | Byk Gulden Lomberg Chemische Fabrik Gmbh. | Postupak za dobijanje farmaceutskog preparata na bazi pantoprazola |
DE69127275T2 (de) * | 1991-06-21 | 1998-03-12 | Ilsan Ilac Ve Hammaddeleri San | Neues galenisches Verfahren für Omeprazol enthaltende Pellets |
FR2692146B1 (fr) * | 1992-06-16 | 1995-06-02 | Ethypharm Sa | Compositions stables de microgranules d'omeprazole gastro-protégés et leur procédé d'obtention. |
ATE192932T1 (de) * | 1993-09-09 | 2000-06-15 | Takeda Chemical Industries Ltd | Formulierung enthaltend einen antibakteriellen und einen antiulcus wirkstoff |
SE9402431D0 (sv) * | 1994-07-08 | 1994-07-08 | Astra Ab | New tablet formulation |
ES2094694B1 (es) * | 1995-02-01 | 1997-12-16 | Esteve Quimica Sa | Nueva formulacion farmaceuticamente estable de un compuesto de bencimidazol y su proceso de obtencion. |
US5945124A (en) * | 1995-07-05 | 1999-08-31 | Byk Gulden Chemische Fabrik Gmbh | Oral pharmaceutical composition with delayed release of active ingredient for pantoprazole |
SE9600072D0 (sv) * | 1996-01-08 | 1996-01-08 | Astra Ab | New oral formulation of two active ingredients II |
SE9600070D0 (sv) * | 1996-01-08 | 1996-01-08 | Astra Ab | New oral pharmaceutical dosage forms |
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1999
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2000
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