YU45815B - Postopek za pripravo novih dušikarilmetoksitiofenskih derivatov - Google Patents
Postopek za pripravo novih dušikarilmetoksitiofenskih derivatovInfo
- Publication number
- YU45815B YU45815B YU3487A YU3487A YU45815B YU 45815 B YU45815 B YU 45815B YU 3487 A YU3487 A YU 3487A YU 3487 A YU3487 A YU 3487A YU 45815 B YU45815 B YU 45815B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- preparation
- derivatives
- group
- metholoxythiophene
- procedure
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pyridine Compounds (AREA)
Abstract
POSTOPEK ZA PRIPRAVO NOVIH DUSIKARILMETOKSITIOFENSKIH DERIVATOV, s splosno formulo I v kateri stoji skupina R-CH2O- v legi 4 ali 5 tiofenskega obroca, pomenita R skupino 2-piridinil ali 2-kinolinil in R1 skupino -COO-C1-C4-alkil, -CO(CH2)n ali -CH(OH)-(CH2)n-CH3, pri cemer n predstavlja celo stevilo 2 do 6, kot tudi njihovih hidratov in/ali njihovih farmacevtsko prenesljivih kislinskih adicijskih soli, oz nacen s tem, da spojino s splosno formulo II v kateri stoji hidroksilna skupina v legi 4 ali 5 tiofenskega obroca in pomeni R2 skupino -COO-C1-C4-alkil ali -CO-(CH2)nCH3, pri cemer n predstavlja celo stevilo 2 do 6, presnovimo v prisotnosti alkalijskega karbonata v polarnem organskem topilu z nizkim vreliscem s spojino s formulo III R-CH2-Cl III v kateri ima R v formuli I navedeni pomen, ali z njenim hidrokloridom in ce R2 pomeni skupino -CO-(CH2)n-CH3, v danem primeru reduciramo z redukcijskim sredstvom v spojino s formulo I, v kateri R1 pomeni skupino -CH(OH)-(CH2)n-CH3, in v danem primeru dobljene spojine s formulo I prevedemo v njihove farmacevtsko prenesljive kislinske adicijske soli. Postopek po enem od zahtevku 1 do 3 za pripravo spojin s splosno formulo I, oznacen s tem, da izvedemo presnovo spojin s formulo II s spojinami s formulo III v vrelem 2-botanonu v prisotnosti vsaj 1 mola brezvodnega natrijevega ali kalijevega karbonata. Postopek po enem od zahtevkov 1 ali 3 za pripravo spojin s splosno formulo I, v kateri R1 pomeni skupino -CH(OH)-(CH2)n-CH3, oznacen s tem, da za redukcijo spojin s formulo I, v kateri R1 pomeni skupino -CO-(CH2)n-CH3, uporabimo litijev aluminijev hidrid ali natrijev borov hidrid. Prijava vsebuje se 4 patentne zahtevke.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT10786 | 1986-01-17 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU3487A YU3487A (en) | 1988-06-30 |
| YU45815B true YU45815B (sh) | 1992-07-20 |
Family
ID=3481700
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU3487A YU45815B (sh) | 1986-01-17 | 1987-01-12 | Postopek za pripravo novih dušikarilmetoksitiofenskih derivatov |
| YU2356/87A YU45479B (en) | 1986-01-17 | 1987-12-22 | Process for preparing new nitrogen aryl metoxithiophenic derivatives |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU2356/87A YU45479B (en) | 1986-01-17 | 1987-12-22 | Process for preparing new nitrogen aryl metoxithiophenic derivatives |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US4778803A (sh) |
| EP (1) | EP0229660B1 (sh) |
| JP (1) | JPH0784465B2 (sh) |
| KR (1) | KR950009826B1 (sh) |
| AT (1) | ATE56971T1 (sh) |
| AU (1) | AU588960B2 (sh) |
| CA (1) | CA1297109C (sh) |
| CS (2) | CS264287B2 (sh) |
| DD (1) | DD259865A1 (sh) |
| DE (1) | DE3765124D1 (sh) |
| DK (1) | DK21787A (sh) |
| ES (1) | ES2031833T3 (sh) |
| FI (1) | FI86063C (sh) |
| GR (1) | GR3002512T3 (sh) |
| HU (1) | HU200604B (sh) |
| NO (1) | NO165677C (sh) |
| NZ (1) | NZ218892A (sh) |
| SG (1) | SG39992G (sh) |
| YU (2) | YU45815B (sh) |
| ZA (1) | ZA87311B (sh) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT391316B (de) * | 1988-09-15 | 1990-09-25 | Ebewe Arzneimittel | Neue thienyloxy-alkylamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| AT394045B (de) * | 1989-07-05 | 1992-01-27 | Chem Pharm Forsch Gmbh | Neue sulfamoyl-thiophene, verfahren zu ihrer herstellung und ihre verwendung |
| DE10234527A1 (de) * | 2002-07-25 | 2004-02-05 | Infineon Technologies Ag | Polymerisierbare Zusammensetzung, Resist und Verfahren zur Elektronenstrahllithographie |
| TWI675033B (zh) * | 2015-01-05 | 2019-10-21 | 日商綜研化學股份有限公司 | 含有雜環的化合物、使用該化合物的聚合物及其用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5734275B2 (sh) * | 1973-07-30 | 1982-07-22 | ||
| CA1134828A (en) * | 1978-12-28 | 1982-11-02 | Tadao Tanouchi | Pyridine derivatives |
| DE2950064A1 (de) * | 1979-12-13 | 1981-06-19 | Basf Ag, 6700 Ludwigshafen | Piperidinderivate von 3-hydroxythiophen-2-carbonsaeure und -estern, ihre herstellung und diese enthaltende pharmazeutische zubereitungen |
| GB2065121A (en) * | 1979-12-13 | 1981-06-24 | Pfizer Ltd | Isoquinoline Derivatives |
| GB2068950A (en) * | 1980-02-06 | 1981-08-19 | Pfizer Ltd | Pyridine Derivatives |
| GR75101B (sh) * | 1980-10-23 | 1984-07-13 | Pfizer | |
| NZ213986A (en) * | 1984-10-30 | 1989-07-27 | Usv Pharma Corp | Heterocyclic or aromatic compounds, and pharmaceutical compositions containing such |
| US4631287A (en) * | 1985-04-16 | 1986-12-23 | Usv Pharmaceutical Corp. | Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments |
-
1986
- 1986-12-23 CA CA000526227A patent/CA1297109C/en not_active Expired - Fee Related
- 1986-12-24 US US06/947,418 patent/US4778803A/en not_active Expired - Fee Related
-
1987
- 1987-01-07 FI FI870045A patent/FI86063C/fi not_active IP Right Cessation
- 1987-01-12 YU YU3487A patent/YU45815B/sh unknown
- 1987-01-13 AT AT87100347T patent/ATE56971T1/de not_active IP Right Cessation
- 1987-01-13 ES ES198787100347T patent/ES2031833T3/es not_active Expired - Lifetime
- 1987-01-13 EP EP87100347A patent/EP0229660B1/de not_active Expired - Lifetime
- 1987-01-13 DE DE8787100347T patent/DE3765124D1/de not_active Expired - Fee Related
- 1987-01-15 NO NO870162A patent/NO165677C/no unknown
- 1987-01-15 DD DD87299272A patent/DD259865A1/de unknown
- 1987-01-15 CS CS87280A patent/CS264287B2/cs unknown
- 1987-01-16 KR KR1019870000296A patent/KR950009826B1/ko not_active IP Right Cessation
- 1987-01-16 HU HU87133A patent/HU200604B/hu not_active IP Right Cessation
- 1987-01-16 ZA ZA87311A patent/ZA87311B/xx unknown
- 1987-01-16 DK DK021787A patent/DK21787A/da not_active Application Discontinuation
- 1987-01-16 JP JP62006291A patent/JPH0784465B2/ja not_active Expired - Lifetime
- 1987-01-16 AU AU67638/87A patent/AU588960B2/en not_active Ceased
- 1987-06-12 NZ NZ218892A patent/NZ218892A/xx unknown
- 1987-10-17 CS CS877505A patent/CS264298B2/cs unknown
- 1987-12-22 YU YU2356/87A patent/YU45479B/xx unknown
-
1990
- 1990-10-30 GR GR90400478T patent/GR3002512T3/el unknown
-
1992
- 1992-04-11 SG SG399/92A patent/SG39992G/en unknown
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