YU42357B - Process for obtaining (6r-7r)-7-/(z)-2-(2-aminothiazole)-4-yl)-2-(carboxiprop-2-oxiimino) acetamido/-3-(1-pyridinium-methyl)-cef-3-em-4-carboxilate pentahydrate - Google Patents

Process for obtaining (6r-7r)-7-/(z)-2-(2-aminothiazole)-4-yl)-2-(carboxiprop-2-oxiimino) acetamido/-3-(1-pyridinium-methyl)-cef-3-em-4-carboxilate pentahydrate

Info

Publication number: YU42357B
Authority: YU; Yugoslavia
Prior art keywords: carboxiprop; oxiimino; carboxilate; aminothiazole; cef
Prior art date: 1979-10-02

Application number

YU2497/80A

Other languages

English (en)

Other versions

YU249780A (en

Inventor

A C Brodie

A Wetherill

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-10-02

Filing date

1980-10-01

Publication date

1988-08-31

1980-10-01 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

1980-10-01 Priority to SI8012497A priority Critical patent/SI8012497A8/sl

1983-02-28 Publication of YU249780A publication Critical patent/YU249780A/xx

1988-08-31 Publication of YU42357B publication Critical patent/YU42357B/xx

Links

125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 title 1
238000000034 method Methods 0.000 title 1
150000004686 pentahydrates Chemical class 0.000 title 1
230000008569 process Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Cephalosporin Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

YU2497/80A 1979-10-02 1980-10-01 Process for obtaining (6r-7r)-7-/(z)-2-(2-aminothiazole)-4-yl)-2-(carboxiprop-2-oxiimino) acetamido/-3-(1-pyridinium-methyl)-cef-3-em-4-carboxilate pentahydrate YU42357B (en)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
SI8012497A SI8012497A8 (sl)	1979-10-02	1980-10-01	Postopek za pridobivanje (6r,7r)-7-/(z)-2- (2-aminotiazol)-4-il-)-2-(karboksiprop-2-okiimino) acetamido/-3- (1-piridinium-metil)-cef-3-em-4-karboksilat pentahidratov

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB7934204		1979-10-02

Publications (2)

Publication Number	Publication Date
YU249780A YU249780A (en)	1983-02-28
YU42357B true YU42357B (en)	1988-08-31

Family

ID=10508246

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
YU2497/80A YU42357B (en)	1979-10-02	1980-10-01	Process for obtaining (6r-7r)-7-/(z)-2-(2-aminothiazole)-4-yl)-2-(carboxiprop-2-oxiimino) acetamido/-3-(1-pyridinium-methyl)-cef-3-em-4-carboxilate pentahydrate

Country Status (36)

Country	Link
US (1)	US4329453A (xx)
JP (1)	JPS5657791A (xx)
KR (1)	KR840001776B1 (xx)
AT (1)	AT368161B (xx)
AU (1)	AU539519B2 (xx)
BE (1)	BE885489A (xx)
BG (1)	BG33586A3 (xx)
CA (1)	CA1142919A (xx)
CH (1)	CH645118A5 (xx)
CS (1)	CS214721B2 (xx)
CY (1)	CY1338A (xx)
DD (1)	DD153376A5 (xx)
DE (1)	DE3037102C2 (xx)
DK (1)	DK155525C (xx)
EC (1)	ECSP941099A (xx)
ES (1)	ES8106908A1 (xx)
FI (1)	FI71157C (xx)
FR (1)	FR2466467A1 (xx)
GB (1)	GB2063871B (xx)
GR (1)	GR69123B (xx)
HK (1)	HK78686A (xx)
HU (1)	HU184835B (xx)
IT (1)	IT1144006B (xx)
KE (1)	KE3641A (xx)
MX (1)	MX6545E (xx)
MY (1)	MY8500315A (xx)
NL (1)	NL190329C (xx)
NO (1)	NO156246C (xx)
PL (1)	PL126606B1 (xx)
PT (1)	PT71860B (xx)
RO (1)	RO82721B (xx)
SE (1)	SE449614B (xx)
SU (1)	SU942599A3 (xx)
UA (1)	UA7208A1 (xx)
YU (1)	YU42357B (xx)
ZA (1)	ZA806081B (xx)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4443444A (en) *	1980-08-11	1984-04-17	Fujisawa Pharmaceutical Co., Ltd.	Cephem compounds
US4427677A (en)	1980-12-31	1984-01-24	Fujisawa Pharmaceutical Co., Ltd.	Cephem compounds
US4394503A (en)	1981-12-07	1983-07-19	Bristol-Myers Company	Cephalosporin derivatives
US4474954A (en) *	1981-12-07	1984-10-02	Bristol-Myers Company	Intermediates for cephalosporin derivatives
JPS58198489A (ja) *	1982-05-14	1983-11-18	Meiji Seika Kaisha Ltd	７β−（２Ｄ−２−アミノ−２−カルボキシエチルチオアセトアミド）−７α−メトキシ−３−（１−メチル−１Ｈ−テトラゾ−ル−５−イル）−チオメチル−３−セフエム−４−カルボン酸ナトリウム塩の七水和物及びその製造方法
ES525492A0 (es) *	1982-09-10	1985-02-01	Glaxo Group Ltd	Un procedimiento para la produccion de un recipiente hermeticamente cerrado que contiene al menos un antibiotico de beta-lactama.
DE3313818A1 (de) *	1983-04-16	1984-10-18	Hoechst Ag, 6230 Frankfurt	Neue kristallmodifikation von ceftazidim
DE3313816A1 (de) *	1983-04-16	1984-10-18	Hoechst Ag, 6230 Frankfurt	Neue kristallmodifikation von ceftazidim
GB8406218D0 (en) *	1984-03-09	1984-04-11	Glaxo Group Ltd	Process
US4537959A (en) *	1984-03-26	1985-08-27	Eli Lilly And Company	Crystalline cephalosporin antibiotic salt
JPS60231683A (ja) *	1984-05-02	1985-11-18	Teijin Ltd	セフアロスポリン誘導体その製造法及びそれを有効成分とする抗菌剤
US4616080A (en) *	1984-07-02	1986-10-07	Eli Lilly And Company	Simplified process of forming crystalline ceftazidime pentahydrate
EP0169700B1 (en) *	1984-07-23	1990-05-16	Eli Lilly And Company	Improved pharmaceutical formulations for ceftazidime
US4626534A (en) *	1984-07-23	1986-12-02	Eli Lilly And Company	Pharmaceutical formulation
CA1239389A (en) *	1984-11-08	1988-07-19	Melvin G. Pleiss, Jr.	Crystallization process
US4659813A (en) *	1984-11-08	1987-04-21	Eli Lilly And Company	Crystallization process for ceftazidime derivative
US4910301A (en) *	1985-08-05	1990-03-20	Bristol-Myers Company	Cefepime cephalosporin salts
US4994451A (en) *	1988-01-19	1991-02-19	Bristol-Myers Company	Cephalosporin salts and injectable compositions
US5244891A (en) *	1985-08-05	1993-09-14	Bristol-Myers Squibb Company	Injectable compositions of cefepime dihydrochloride hydrate
AT387390B (de) *	1986-10-07	1989-01-10	Biochemie Gmbh	Verfahren zur herstellung des antibiotikums (6r,7r)-7-(2-(2-amino-4-thiazolyl)-2-(2-carboxy
US4954624A (en) *	1986-10-07	1990-09-04	Sandoz Ltd.	Process for the production of cephalosporin derivatives
JP2533151B2 (ja) *	1987-02-02	1996-09-11	イーライ・リリー・アンド・カンパニー	抗生物質製造の改良法
US5021564A (en) *	1987-02-02	1991-06-04	Eli Lilly And Company	Process for preparing ceftazidime pentahydrate
EP0321562B1 (en) *	1987-06-25	1993-11-24	Banyu Pharmaceutical Co., Ltd.	Crystalline cephalosporin compounds, process for their preparation, and intermediates for their preparation
WO1988010262A1 (fr) *	1987-06-25	1988-12-29	Banyu Pharmaceutical Co., Ltd.	Compose cristallin de cephalosporine
GB8802622D0 (en) *	1988-02-05	1988-03-02	Glaxo Group Ltd	Chemical compound
KR940000112B1 (ko) *	1990-07-05	1994-01-05	주식회사 대웅제약	신규의 3-치환 세펨화합물 및 그의 제조방법
US5831085A (en) *	1997-01-16	1998-11-03	Lupin Laboratories Limited	Process for manufacture of cephalosporin such as ceftazidime and intermediate thereof
CN1328281C (zh) *	2004-11-16	2007-07-25	广州白云山制药股份有限公司	头孢他啶的纯化方法
CN102875576A (zh) *	2012-10-31	2013-01-16	苏州致君万庆药业有限公司	一种抗菌素头孢他啶的合成、注射用头孢他啶及其制备方法
CN102924483B (zh) *	2012-10-31	2015-06-17	海南合瑞制药股份有限公司	一种头孢他啶晶体化合物、其制备方法及其无菌混合粉形式的药物组合物
CN104876949A (zh) *	2015-05-28	2015-09-02	浙江长典医药有限公司	一种小儿用头孢他啶化合物实体及其制剂
CN106420658A (zh) *	2016-09-23	2017-02-22	临沂草之美医药科技有限公司	一种治疗外科手术感染的药物头孢他啶胶囊
CN109111467A (zh) *	2017-06-22	2019-01-01	宁应	一种51/4水头孢他啶化合物及其药物组合物制剂

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR229883A1 (es) *	1978-05-26	1983-12-30	Glaxo Group Ltd	Procedimiento para la preparacion de antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)-acetamido)-3-(1-piridinometil)-cef-3-em-4-carboxilato

1980
- 1980-09-09 US US06/185,883 patent/US4329453A/en not_active Expired - Lifetime
- 1980-10-01 NO NO802913A patent/NO156246C/no unknown
- 1980-10-01 GR GR63023A patent/GR69123B/el unknown
- 1980-10-01 FR FR8021033A patent/FR2466467A1/fr active Granted
- 1980-10-01 AT AT0490080A patent/AT368161B/de not_active IP Right Cessation
- 1980-10-01 PT PT71860A patent/PT71860B/pt unknown
- 1980-10-01 CH CH734180A patent/CH645118A5/de not_active IP Right Cessation
- 1980-10-01 JP JP13822480A patent/JPS5657791A/ja active Granted
- 1980-10-01 NL NLAANVRAGE8005443,A patent/NL190329C/xx not_active IP Right Cessation
- 1980-10-01 RO RO102255A patent/RO82721B/ro unknown
- 1980-10-01 CY CY1338A patent/CY1338A/xx unknown
- 1980-10-01 CS CS806627A patent/CS214721B2/cs unknown
- 1980-10-01 AU AU62882/80A patent/AU539519B2/en not_active Expired
- 1980-10-01 YU YU2497/80A patent/YU42357B/xx unknown
- 1980-10-01 UA UA2987392A patent/UA7208A1/uk unknown
- 1980-10-01 SU SU802987392A patent/SU942599A3/ru active
- 1980-10-01 BE BE0/202301A patent/BE885489A/fr not_active IP Right Cessation
- 1980-10-01 HU HU802393A patent/HU184835B/hu unknown
- 1980-10-01 MX MX809068U patent/MX6545E/es unknown
- 1980-10-01 BG BG8049206A patent/BG33586A3/xx unknown
- 1980-10-01 ES ES495534A patent/ES8106908A1/es not_active Expired
- 1980-10-01 FI FI803126A patent/FI71157C/fi not_active IP Right Cessation
- 1980-10-01 DK DK414780A patent/DK155525C/da not_active IP Right Cessation
- 1980-10-01 SE SE8006861A patent/SE449614B/sv not_active IP Right Cessation
- 1980-10-01 IT IT49783/80A patent/IT1144006B/it active Protection Beyond IP Right Term
- 1980-10-01 CA CA000361346A patent/CA1142919A/en not_active Expired
- 1980-10-01 DD DD80224266A patent/DD153376A5/de not_active IP Right Cessation
- 1980-10-01 PL PL1980227019A patent/PL126606B1/pl unknown
- 1980-10-01 DE DE3037102A patent/DE3037102C2/de not_active Expired
- 1980-10-01 ZA ZA00806081A patent/ZA806081B/xx unknown
- 1980-10-01 GB GB8031703A patent/GB2063871B/en not_active Expired
- 1980-10-02 KR KR1019800003810A patent/KR840001776B1/ko active
1985
- 1985-12-30 MY MY315/85A patent/MY8500315A/xx unknown
1986
- 1986-05-29 KE KE3641A patent/KE3641A/xx unknown
- 1986-10-16 HK HK786/86A patent/HK78686A/xx not_active IP Right Cessation
1994
- 1994-05-26 EC EC1994001099A patent/ECSP941099A/es unknown

Also Published As

Publication number	Publication date
GB2063871B (en)	1983-06-02
DE3037102A1 (de)	1981-04-23
BG33586A3 (en)	1983-03-15
AU6288280A (en)	1981-04-09
FI71157B (fi)	1986-08-14
BE885489A (fr)	1981-04-01
JPH0128036B2 (xx)	1989-05-31
DK414780A (da)	1981-04-03
CA1142919A (en)	1983-03-15
PL126606B1 (en)	1983-08-31
SU942599A3 (ru)	1982-07-07
ATA490080A (de)	1982-01-15
ES495534A0 (es)	1981-09-01
RO82721A (ro)	1984-09-29
FR2466467A1 (fr)	1981-04-10
DD153376A5 (de)	1982-01-06
NO156246C (no)	1987-08-19
US4329453A (en)	1982-05-11
KR830004317A (ko)	1983-07-09
NO802913L (no)	1981-04-03
NO156246B (no)	1987-05-11
KE3641A (en)	1986-07-11
FI71157C (fi)	1986-11-24
DK155525B (da)	1989-04-17
DK155525C (da)	1989-09-04
DE3037102C2 (de)	1986-04-10
ECSP941099A (es)	1995-01-16
PT71860B (en)	1982-04-02
IT1144006B (it)	1986-10-29
AT368161B (de)	1982-09-27
CH645118A5 (de)	1984-09-14
NL190329C (nl)	1994-01-17
CY1338A (en)	1987-01-16
HK78686A (en)	1986-10-24
FI803126L (fi)	1981-04-03
FR2466467B1 (xx)	1984-02-10
MY8500315A (en)	1985-12-31
HU184835B (en)	1984-10-29
ZA806081B (en)	1982-05-26
MX6545E (es)	1985-07-10
UA7208A1 (uk)	1995-06-30
RO82721B (ro)	1984-10-30
JPS5657791A (en)	1981-05-20
SE449614B (sv)	1987-05-11
KR840001776B1 (ko)	1984-10-19
AU539519B2 (en)	1984-10-04
PT71860A (en)	1980-11-01
CS214721B2 (en)	1982-05-28
SE8006861L (sv)	1981-04-03
PL227019A1 (xx)	1981-06-05
NL8005443A (nl)	1981-04-06
NL190329B (nl)	1993-08-16
ES8106908A1 (es)	1981-09-01
GR69123B (xx)	1982-05-03
GB2063871A (en)	1981-06-10
IT8049783A0 (it)	1980-10-01
YU249780A (en)	1983-02-28

Publication	Publication Date	Title
YU42357B (en)	1988-08-31	Process for obtaining (6r-7r)-7-/(z)-2-(2-aminothiazole)-4-yl)-2-(carboxiprop-2-oxiimino) acetamido/-3-(1-pyridinium-methyl)-cef-3-em-4-carboxilate pentahydrate
YU43097B (en)	1989-02-28	Process for obtaining cephalosporanic antibiotics
YU128879A (en)	1982-10-31	Process for obtaining new aminothiazoles
YU3180A (en)	1983-10-31	Process for obtaining 2-penem compounds
YU11380A (en)	1983-04-30	Process for obtaining n-benzyl-imidazole
YU90978A (en)	1983-01-21	Process for obtaining cephalosporin compounds
YU156080A (en)	1983-10-31	Process for obtaining cephalosporin compounds
YU33578A (en)	1983-06-30	Process for obtaining 1-oxadethia cepham compounds
YU300278A (en)	1982-10-31	Process for preparing cephalosporin compounds
YU171080A (en)	1983-06-30	Process for obtaining new substituted heterocyclic phenoxyamines
YU76080A (en)	1983-04-30	Process for obtaining new isothiocarbamide compounds
YU177880A (en)	1983-12-31	Process for obtaining acyl-carbamides
YU10777A (en)	1982-06-30	Process for obtaining beta-lactam comprising compounds
YU43217B (en)	1989-06-30	Process for preparing agent for hydroformilation from used up agent for hydroformilation
YU116380A (en)	1983-02-28	Process for obtaining thiazolylidene-oxo-propionitrile
YU125780A (en)	1983-04-30	Process for obtaining 7-aminodeacetoxy cephalosporanic acid derivatives
YU80780A (en)	1983-02-28	Process for obtaining benzothiazole compounds
YU93880A (en)	1983-02-28	Process for obtaining beta-lactamase inhibitors
PH18215A (en)	1985-04-30	Cephalosporin reduction process
GB2058769B (en)	1984-04-18	Cephalosporin compounds and process for preparing same
YU51478A (en)	1982-10-31	Process for obtaining cephalosporin compounds
YU13180A (en)	1983-01-21	Process for obtaining spiro-quinolyl-hydantoin
YU91079A (en)	1984-10-31	Process for the stabilization of 4-methyl-(2-chloroethyl)thiazole
PT69884A (en)	1979-08-01	Process for preparing aminothiazole compounds
CY1193A (en)	1983-10-07	Process for preparing thiazoles