DE69132340T2 - Kondensiertes pyrazinderivat - Google Patents
Kondensiertes pyrazinderivatInfo
- Publication number
- DE69132340T2 DE69132340T2 DE69132340T DE69132340T DE69132340T2 DE 69132340 T2 DE69132340 T2 DE 69132340T2 DE 69132340 T DE69132340 T DE 69132340T DE 69132340 T DE69132340 T DE 69132340T DE 69132340 T2 DE69132340 T2 DE 69132340T2
- Authority
- DE
- Germany
- Prior art keywords
- represent
- alkyl
- pyrazine derivative
- nitro
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Liquid Crystal Substances (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP30087990 | 1990-11-06 | ||
JP6959291 | 1991-01-11 | ||
JP13382891 | 1991-03-29 | ||
JP18324891 | 1991-06-27 | ||
PCT/JP1991/001498 WO1992007847A1 (en) | 1990-11-06 | 1991-11-01 | Fused pyrazine derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69132340D1 DE69132340D1 (de) | 2000-08-31 |
DE69132340T2 true DE69132340T2 (de) | 2001-02-08 |
Family
ID=27465151
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69132340T Expired - Fee Related DE69132340T2 (de) | 1990-11-06 | 1991-11-01 | Kondensiertes pyrazinderivat |
Country Status (14)
Country | Link |
---|---|
US (1) | US5283244A (de) |
EP (1) | EP0556393B1 (de) |
JP (1) | JP2550456B2 (de) |
KR (1) | KR0132903B1 (de) |
AT (1) | ATE194985T1 (de) |
AU (1) | AU656154B2 (de) |
CA (1) | CA2095444C (de) |
DE (1) | DE69132340T2 (de) |
DK (1) | DK0556393T3 (de) |
ES (1) | ES2150417T3 (de) |
GR (1) | GR3034629T3 (de) |
HU (2) | HU221425B (de) |
RU (1) | RU2095352C1 (de) |
WO (1) | WO1992007847A1 (de) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK162491D0 (da) * | 1991-09-20 | 1991-09-20 | Novo Nordisk As | Heterocycliske forbindelser, deres fremstilling og farmaceutiske praeparater indeholdende forbindelserne |
US6057304A (en) * | 1992-10-26 | 2000-05-02 | Schering Aktiengesellschaft | Quinoxaline-phosphonic acid derivatives |
DE4217952A1 (de) * | 1992-05-30 | 1993-12-02 | Basf Ag | Chinoxalin-2,3(1H,4H)-dione |
AU672617B2 (en) * | 1992-06-22 | 1996-10-10 | Regents Of The University Of California, The | Glycine receptor antagonists and the use thereof |
EP0664807B1 (de) | 1992-10-13 | 1997-09-10 | Warner-Lambert Company | Chinoxalinderivate als eaa antagonisten |
PH31122A (en) * | 1993-03-31 | 1998-02-23 | Eisai Co Ltd | Nitrogen-containing fused-heterocycle compounds. |
IL109397A0 (en) * | 1993-04-28 | 1994-07-31 | Schering Ag | Quinoxalinedione derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same |
US5631373A (en) | 1993-11-05 | 1997-05-20 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon | Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones |
DE4340045A1 (de) * | 1993-11-24 | 1995-06-01 | Basf Ag | Neue Chinoxaline und Arzneimittel daraus |
JPH09510695A (ja) * | 1994-01-03 | 1997-10-28 | エイシア・ファーマシュウティカルズ,インコーポレイテッド | 8−アザ、6−アザ、および6,8−ジアザ−1,4−ジヒドロキノキサリン−2,3−ジオン類およびそのグリシン/nmdaリセプターに対するアンタゴニストとしての使用 |
AU688459B2 (en) * | 1994-04-08 | 1998-03-12 | Shionogi & Co., Ltd. | Oxopyridinylquinoxaline derivative |
DE4428152A1 (de) * | 1994-06-22 | 1996-01-04 | Basf Ag | Neue Amido-chinoxalindione, ihrer Herstellung und Verwendung |
GB9419318D0 (en) * | 1994-09-24 | 1994-11-09 | Pfizer Ltd | Therapeutic agents |
US6096743A (en) * | 1994-09-27 | 2000-08-01 | Yamanouchi Pharmaceuticals Co., Ltd. | 1,2,3,4-tetrahydroquinoxalinedione derivative |
DE4436852A1 (de) * | 1994-10-14 | 1996-04-18 | Basf Ag | Pyrrolyl-tetrahydrobenzochinoxalindione, ihre Herstellung und Verwendung |
US5801183A (en) * | 1995-01-27 | 1998-09-01 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon | Aza and aza (N-oxy) analogs of glycine/NMDA receptor antagonists |
US6110911A (en) * | 1995-06-07 | 2000-08-29 | Warner-Lambert Company | Cyclic amine derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists |
DE19521058A1 (de) * | 1995-06-09 | 1996-12-12 | Basf Ag | Verfahren zur Herstellung von Aromaten enthaltenden Polyetherpolyolen |
DE19532050A1 (de) * | 1995-08-31 | 1997-03-06 | Basf Ag | Pyrrolyl-tetrahydrochinoxalindione, ihre Herstellung und Verwendung zur Bekämpfung von Krankheiten |
GB9605027D0 (en) * | 1996-03-09 | 1996-05-08 | Pfizer Ltd | Quinoxalinediones |
ZA973884B (en) | 1996-05-23 | 1998-11-06 | Du Pont Merck Pharma | Tetrahydropteridines and pyridylpiperazines for treatment of neurological disorders |
TW448171B (en) * | 1996-06-06 | 2001-08-01 | Yamanouchi Pharma Co Ltd | Imidazole-substituted quinoxalinedione derivatives |
US6017903A (en) | 1996-09-27 | 2000-01-25 | Guilford Pharmaceuticals Inc. | Pharmaceutical compositions and methods of treating a glutamate abnormality and effecting a neuronal activity in an animal using NAALADase inhibitors |
US5824662A (en) * | 1996-09-27 | 1998-10-20 | Guilford Pharmaceuticals Inc. | Treatment of global and focal ischemia using naaladase inhibitors |
DE19624808A1 (de) | 1996-06-21 | 1998-01-02 | Basf Ag | Pyrrolylchinoxalindione, ihre Herstellung und Verwendung |
HUP0001062A3 (en) | 1996-09-27 | 2001-09-28 | Guilford Pharmaceuticals Inc B | Pharmaceutical compositions of phosphinic acid derivatives having naaladase inhibitor acivity |
ES2264171T3 (es) * | 1996-10-24 | 2006-12-16 | Novartis Ag | Acidos aminoalcanofosfonicos sustituidos. |
WO1998038186A1 (en) * | 1997-02-27 | 1998-09-03 | Pfizer Limited | Quinoxalinediones |
AP982A (en) * | 1997-02-27 | 2001-07-16 | Pfizer | Quinoxalinediones. |
TW526195B (en) | 1997-06-10 | 2003-04-01 | Novartis Ag | Crystal modifications of 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide and their use |
US6015800A (en) * | 1997-09-03 | 2000-01-18 | Warner-Lambert Company | Substituted quinoxaline-2-ones as glutamate receptor antagonists |
TR200001728T2 (tr) | 1997-11-11 | 2000-09-21 | Ono Pharmaceutical Co., Ltd. | Birleşik pirazin türevleri |
US7282511B2 (en) * | 2000-01-24 | 2007-10-16 | Neurosearch A/S | Isatine derivatives with neurotrophic activity |
BRPI0611993B1 (pt) | 2005-06-23 | 2023-11-28 | Array Biopharma, Inc. | Compostos de benzimidazol e seu processo de preparação |
WO2007122466A1 (en) * | 2006-04-21 | 2007-11-01 | Pfizer Products Inc. | Pyridine[3,4-b]pyrazinones |
US7601716B2 (en) * | 2006-05-01 | 2009-10-13 | Cephalon, Inc. | Pyridopyrazines and derivatives thereof as ALK and c-Met inhibitors |
DE602008002690D1 (de) * | 2007-01-16 | 2010-11-04 | Purdue Pharma Lp | Heterozyklische substituierte piperidine als orl-1-liganden |
WO2008088820A2 (en) | 2007-01-16 | 2008-07-24 | The Johns Hopkins University | Glutamate receptor antagonists and methods of use |
RU2488585C2 (ru) * | 2007-08-31 | 2013-07-27 | Пэдью Фарма Л.П. | Замещенные пиперидиновые соединения хиноксалинового типа и их применение |
WO2010053757A1 (en) | 2008-10-29 | 2010-05-14 | Gilead Palo Alto, Inc. | 2 -oxoquinoxalin blockers of the late sodium channel |
WO2010074807A1 (en) | 2008-10-30 | 2010-07-01 | Gilead Palo Alto, Inc. | 3, 4-dihydroquinolin-2 ( 1h ) -one derivatives as sodium channel modulators |
EP2338492A1 (de) | 2009-12-24 | 2011-06-29 | Universidad del Pais Vasco | Verfahren und Zusammensetzung zur Behandlung von Alzheimer |
WO2023042887A1 (ja) | 2021-09-15 | 2023-03-23 | 国立大学法人 琉球大学 | 認知機能低下、または過体重もしくは肥満症を処置することに用いるための医薬組成物 |
WO2023042888A1 (ja) | 2021-09-15 | 2023-03-23 | 国立大学法人 琉球大学 | 認知機能低下、または過体重もしくは肥満症を処置することに用いるための医薬組成物 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE66149B1 (en) * | 1986-09-16 | 1995-12-13 | Novo Nordisk As | Quinoxaline compounds and their preparation and use |
NO179551C (no) * | 1987-11-10 | 1996-10-30 | Novo Nordisk As | Analogifremgangsmåte for fremstilling av terapeutisk virksomme kinoxalinforbindelser |
GB8827822D0 (en) * | 1988-11-29 | 1988-12-29 | Janssen Pharmaceutica Nv | (1h-azol-1-ylmethyl)substituted quinoline derivatives |
CA2002864C (en) * | 1988-11-29 | 1999-11-16 | Eddy J. E. Freyne | (1h-azol-1-ylmethyl) substituted quinoline, quinazoline or quinoxaline derivatives |
DK715888D0 (da) * | 1988-12-22 | 1988-12-22 | Ferrosan As | Quinoxalinforbindelser, deres fremstilling og anvendelse |
-
1991
- 1991-11-01 AT AT91918943T patent/ATE194985T1/de not_active IP Right Cessation
- 1991-11-01 CA CA002095444A patent/CA2095444C/en not_active Expired - Fee Related
- 1991-11-01 ES ES91918943T patent/ES2150417T3/es not_active Expired - Lifetime
- 1991-11-01 JP JP3517229A patent/JP2550456B2/ja not_active Expired - Fee Related
- 1991-11-01 RU RU93033484/04A patent/RU2095352C1/ru not_active IP Right Cessation
- 1991-11-01 US US08/050,225 patent/US5283244A/en not_active Expired - Lifetime
- 1991-11-01 DK DK91918943T patent/DK0556393T3/da active
- 1991-11-01 AU AU87666/91A patent/AU656154B2/en not_active Ceased
- 1991-11-01 DE DE69132340T patent/DE69132340T2/de not_active Expired - Fee Related
- 1991-11-01 HU HU9301298A patent/HU221425B/hu unknown
- 1991-11-01 WO PCT/JP1991/001498 patent/WO1992007847A1/ja active IP Right Grant
- 1991-11-01 EP EP91918943A patent/EP0556393B1/de not_active Expired - Lifetime
-
1993
- 1993-05-04 KR KR1019930701342A patent/KR0132903B1/ko not_active IP Right Cessation
-
1995
- 1995-06-30 HU HU95P/P00644P patent/HU211310A9/hu unknown
-
2000
- 2000-10-16 GR GR20000402315T patent/GR3034629T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DK0556393T3 (da) | 2000-10-16 |
AU656154B2 (en) | 1995-01-27 |
HU211310A9 (en) | 1995-11-28 |
KR0132903B1 (ko) | 1998-04-17 |
RU2095352C1 (ru) | 1997-11-10 |
JP2550456B2 (ja) | 1996-11-06 |
DE69132340D1 (de) | 2000-08-31 |
EP0556393B1 (de) | 2000-07-26 |
HU221425B (en) | 2002-10-28 |
EP0556393A1 (de) | 1993-08-25 |
ES2150417T3 (es) | 2000-12-01 |
AU8766691A (en) | 1992-05-26 |
WO1992007847A1 (en) | 1992-05-14 |
EP0556393A4 (en) | 1994-04-13 |
CA2095444C (en) | 2001-06-19 |
CA2095444A1 (en) | 1992-05-07 |
US5283244A (en) | 1994-02-01 |
ATE194985T1 (de) | 2000-08-15 |
GR3034629T3 (en) | 2001-01-31 |
HUT64324A (en) | 1993-12-28 |
HU9301298D0 (en) | 1993-09-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: ASTELLAS PHARMA INC., TOKIO/TOKYO, JP |
|
8339 | Ceased/non-payment of the annual fee |