WO2021155751A1 - 一种具有清肺排毒功能的中药复方及其应用 - Google Patents
一种具有清肺排毒功能的中药复方及其应用 Download PDFInfo
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Definitions
- the invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine compound with functions of clearing lungs and detoxification.
- Viral pneumonia is the inflammation of the upper respiratory tract that spreads down to the lower respiratory tract, until the bronchi and lungs. Influenza virus infection is the most common.
- 2019-nCoV 2019-nCoV
- 2019-nCoV World Health Organization
- Symptoms of the virus are generally fever, fatigue, dry cough, and gradual dyspnea and other viral pneumonia symptoms. In severe cases, it manifests as acute respiratory distress syndrome, septic shock, and difficult to correct metabolic acidosis and coagulation dysfunction.
- the virus has been confirmed to have human-to-human transmission, the incubation period is infectious, and the disease caused by it has no specific treatment.
- the purpose of the present invention is to provide a traditional Chinese medicine compound with functions of clearing lungs and detoxification and its application, so as to realize the treatment of viral pneumonia, especially for the 2019 new coronavirus and its mutant viruses.
- the resulting viral pneumonia provides an effective treatment plan.
- the present invention provides a traditional Chinese medicine compound with functions of clearing lungs and detoxification. Its raw materials include the following Chinese medicinal materials by weight:
- the prescriptions of the traditional Chinese medicine compound of the present invention refer to Zhang Zhongjing's "Treatise on Febrile and Miscellaneous Diseases" in Han Dynasty, a classic work of traditional Chinese medicine, consisting of Mahuang Almond Gancao Gypsum Decoction (referred to as Maxing Shigan Decoction, Treatise on Febrile Diseases 63) and Xiao Chaihu Decoction (Treatise on Febrile Diseases 96) , Wulingsan (Treatise on Febrile Diseases 71), Shegan Mahuang Decoction (Synopsis of the Golden Chamber. Lung wilt, Lung carbuncle, Cough, Shangqi disease, pulse syndrome and treatment seventh).
- the Chinese yam, Citrus aurantium, tangerine peel and Huoxiang in the recipe are for the addition and subtraction of the clinical symptoms of pneumonia caused by the new coronavirus infection.
- Maxing Shigan Decoction to promote the lungs through evil Wuling powder to dispel dampness and turbidity, to benefit the triple burn, wet urine, so that moisture from the pores and urine is removed; Xiao Chaihu Decoction to comb Shaoyang cardinal; Shegan Mahuang Decoction Phenomenon drink the qi to relieve cough; Huoxiang, Zhishi, and tangerine peel regulate the spleen and stomach qi, the aroma promotes qi and turbidity, so that the turbidity in the chest and abdomen is eliminated and the breathing is smooth; there are more yam to replenish the spleen and kidney, and support the right qi.
- the whole prescription has the effects of dispelling dampness and turbidity, clearing the lungs through evil, and reconciling qi.
- the raw materials of the traditional Chinese medicine compound include the following Chinese medicinal materials in parts by weight: 9 parts of ephedra, 6 parts of roasted licorice, 9 parts of almonds, 15-30 parts of raw gypsum, 9 parts of cinnamon sticks, 9 parts of Alisma, 9 parts of Polyporus umbellatus , 9 parts of Atractylodes macrocephala, 15 parts of Poria cocos, 16 parts of Bupleurum, 6 parts of Scutellaria baicalensis, 9 parts of Ginger Pinellia 9 parts, 9 parts of Ginger, 9 parts of Asters, 9 parts of Winter Flower, 9 parts of Shegan, 6 parts of Asarum, 12 parts of Chinese Yam, Citrus aurantium 6 parts, 6 parts of tangerine peel, 9 parts of Huoxiang.
- Chinese medicinal materials in parts by weight: 9 parts of ephedra, 6 parts of roasted licorice, 9 parts of almonds, 15-30 parts of raw gypsum, 9 parts of cinnamon sticks, 9 parts of A
- the amount of gypsum can be adjusted according to whether the patient has a fever. If the patient does not have a fever, the dosage of the gypsum should be small, and if the patient has a fever or strong heat, the dosage of the gypsum should be increased.
- the dosage form of the traditional Chinese medicine compound can be decoction (decoction), granule, ointment, pill, powder, pill or tablet, but it is not limited thereto.
- the specific preparation method of the above dosage forms can be carried out by conventional preparation methods in the art, and it is preferable to use water decoctions and granules to exert the therapeutic effect of the medicine.
- the present invention takes water decoction (decoction) and granules as examples in the optional dosage forms of the above-mentioned Chinese medicine compound to further illustrate the preparation of a Qingfei Paidu Decoction and a Qingfei Paidu Granule method.
- a Qingfei Paidu Granule preparation method includes the following steps:
- Decoction Weigh various Chinese medicinal materials according to the above-mentioned Chinese medicine compound, first take the raw gypsum, add water to decoct, then add the remaining 20 Chinese medicinal materials, and then add water to decoct to obtain a decoction liquid;
- the Chinese medicinal materials used are Chinese medicinal pieces.
- the present invention provides the application of the traditional Chinese medicine compound in the preparation of drugs with the efficacy of clearing lungs and detoxification, especially in the preparation of drugs for the treatment of pneumonia caused by novel coronavirus infection.
- the present invention further provides the use of the traditional Chinese medicine compound as a medicine for treating pneumonia caused by virus infection.
- the present invention provides the application of the traditional Chinese medicine compound in the preparation of medicines for the treatment of pneumonia caused by viral infections.
- the present invention provides the application of the Chinese medicine compound (and the aforementioned Qingfei Paidu Decoction or the aforementioned Qingfei Paidu Granules) in the treatment of viral pneumonia, especially in the treatment of infection caused by the new coronavirus 2019-nCoV Application in pneumonia.
- the method of use of the traditional Chinese medicine compound is: decocting in water, one pair a day, twice in the morning and evening (forty minutes after a meal), and taking it warmly. If possible, take half a bowl of rice soup after each pair of medicines, and up to one bowl for those with dry tongue and body fluid deficiency. Three pairs of a course of treatment. It is recommended that patients take a full course of treatment according to the original prescription, and take a second course of treatment if symptoms improve but not cured. If the patient has special conditions or other underlying diseases, the second course of treatment can be modified according to the actual situation, and the drug will be discontinued if the symptoms disappear.
- the raw materials of Chinese medicinal materials involved in the present invention are all common commercially available products, and the operations involved are routine operations in the field unless otherwise specified.
- the present invention combines the disease symptoms of the "new coronavirus pneumonia” this time, and believes that pneumonia infected by the new coronavirus (2019-nCoV) belongs to the category of "cold disease” in traditional Chinese medicine, and damp pathogens prevail.
- the main disease is in the lungs, followed by the surface guard, spleen and stomach; the main cause is the combination of Fuzao and dampness and cold.
- the main pathogenesis is the dampness and coldness of the epidemic virus and the congestion of Fuzao, leading to blockage of the Qi machine and abnormal movements.
- the present invention provides the aforementioned Chinese medicine compound, which utilizes a variety of Chinese medicines to optimize fusion and co-administer the treatment. Judging from the current treatment of diagnosed patients of different ages in many provinces and places, the curative effect is definite. Related clinical observation and research are ongoing.
- the Chinese medicine compound (Qingfei Paidu Decoction) provided by the present invention is used in the emergency scientific research project of the State Administration of Traditional Chinese Medicine "Clinical Screening Study of Effective Chinese Medicine Compounds for Preventing and Treating New Coronavirus Pneumonia", and is currently being carried out in conjunction with clinical treatment Clinical observation work and related research are continuing to advance.
- This prescription is suitable for light, common, and heavy patients. It can also be used reasonably in combination with the actual conditions of the patients in the treatment of critically ill patients, and has good social benefits.
- This example is used to illustrate Qingfei Paidu Decoction (water decoction) and its preparation method.
- the dosage of raw gypsum is adjusted within the above dosage range according to whether the patient has a fever. If the patient does not have a fever, the dosage of the raw gypsum should be small, and if the patient has a fever or strong heat, the dosage of the raw gypsum should be increased.
- This example is used to illustrate Qingfei Paidu Granules and the preparation method thereof.
- Decoction Weigh each Chinese medicinal material according to the above-mentioned Chinese medicine compound, first take the raw gypsum, add water to decoc, then add the remaining 20 Chinese medicinal materials, and then add water to decoc to obtain the decoction liquid;
- the Qingfei Paidu granules prepared in this embodiment have a better industrial production prospect, are conducive to storage and transportation, and are easy to achieve a wider range of popularization and application.
- the Qingfei Paidu Decoction was prepared by the preparation method described in Example 1. In a pair of medicine, each Chinese medicinal material was weighed at 1 g per part by weight.
- the Qingfei Paidu Decoction was prepared by the preparation method described in Example 1. In a pair of medicine, each Chinese medicinal material was weighed at 1 g per part by weight.
- This experimental example uses the Qingfei Paidu Granules prepared in Example 5 to conduct a drug safety test to prove the safety of the traditional Chinese medicine compound of the present invention.
- the acute toxicity of Qingfei Paidu Granules administered to mice was evaluated. Observe the death of the animal after the test substance is given, and determine its maximum tolerable dose; and continuously observe the toxicity symptoms and their degree, and the time when the toxicity appears and disappear within 14 days, so as to provide references for other safety evaluation tests and clinical trials.
- ICR mice weighing 18-21g were randomly divided into 7 groups according to fasting weight: the control group and Qingfei Paidu Granules 104.5, 122.9, 144.6, 170.1, 20.2, 235.5g crude drug/kg 6 dose groups, each Group of 20 animals, half male and half male. After fasting for about 15 hours, each administration group was given intragastrically once with a volume of 40mL/kg, and the control group was given intragastrically with equal volume of purified water once a day. After administration, the observation was continued for 14 days, on the 15th day. After fasting, the surviving animals were subjected to necropsy.
- mice were weighed on the 1, 2, 3, 5, 7, 10, and 14 days after the administration, and the mice were fasted after the observation period on the 14th day, and the surviving animals were subjected to necropsy as above.
- Qingfei Paidu Granules were administered to animals at a dose of 104.5, 122.9, 144.6, 170.1, 200.2, 235.5g crude drug/kg, once a day, and the main toxic reactions that could be observed were diarrhea and abnormal activity (including reduction of spontaneous activity). Or increase, lying still, etc.), startle reflex, tremor and acute death.
- the Chinese medicine compound with the functions of clearing lungs and detoxification disclosed in the present invention with reference to Zhang Zhongjing's "Treatise on Febrile and Miscellaneous Diseases" in the Han Dynasty classic of Chinese medicine, consists of Mahuang Almond Gancao Gypsum Decoction (referred to as Maxing Shigan Decoction, Treatise on Febrile Diseases 63) and Xiao Chaihu Decoction (Treatise on Febrile Diseases) Lun 96), Wuling San (Shanghan Lun 71), Shegan Mahuang Decoction (Golden Chamber Synopsis. Lung wilt, Lung carbuncle, Cough, Cough, Shangqi disease, pulse treatment seventh). The treatment has obvious effect on the symptoms of the new type of coronavirus pneumonia COVID-19.
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Abstract
Description
Claims (10)
- 一种具有清肺排毒功能的中药复方,其特征在于,由如下重量份的中药材制成:麻黄8-10份、炙甘草5-8份、杏仁8-10份、生石膏15-30份、桂枝8-10份、泽泻8-10份、猪苓8-10份、白术8-10份、茯苓15份、柴胡15-18份、黄芩5-8份、姜半夏8-10份、生姜8-10份、紫苑8-10份、冬花8-10份、射干8-10份、细辛5-8份、山药10-14份、枳实5-8份、陈皮5-8份、藿香8-10份。
- 根据权利要求1所述的中药复方,其特征在于,所述中药材的重量份为:麻黄9份、炙甘草6份、杏仁9份、生石膏15-30份、桂枝9份、泽泻9份、猪苓9份、白术9份、茯苓15份、柴胡16份、黄芩6份、姜半夏9份、生姜9份、紫苑9份、冬花9份、射干9份、细辛6份、山药12份、枳实6份、陈皮6份、藿香9份。
- 根据权利要求1或2所述的中药复方,其特征在于,所述中药复方的剂型为水煎剂、颗粒剂、膏剂、丸剂、散剂、丹剂或片剂。
- 一种清肺排毒汤剂,其特征在于,按照权利要求1或2所述的中药复方称取各味中药材,将其中的生石膏先加水煎煮,再将其余中药材投入合并煎煮,获得煎煮液,即得。
- 一种清肺排毒颗粒剂,其特征在于,其制备方法包括如下步骤:(1)煎煮:按照权利要求1或2所述的中药复方称取各味中药材,先取其中的生石膏,加水煎煮,再加入其余二十味中药材,再加水煎煮,得到煎煮液;(2)浓缩:将所得煎煮液滤过,浓缩得到水提浓缩膏;(3)制粒成型:以水提浓缩膏为原料,加入甜菊糖苷及适量糊精,一步制粒,即得清肺排毒颗粒剂。
- 权利要求1-3任一项所述的中药复方在制备具有清肺排毒药效的药物 中的应用。
- 权利要求1-3任一项所述的中药复方在制备治疗新型冠状病毒感染的肺炎的药物中的应用。
- 权利要求1~3任一项所述的中药复方在作为治疗由病毒感染导致的肺炎的药物中的用途。
- 权利要求1~3任一项所述的中药复方在制备治疗由病毒感染导致的肺炎的药物中的应用。
- 权利要求1~3任一项所述的中药复方,或权利要求4所述的清肺排毒汤剂,或权利要求5所述的清肺排毒颗粒剂在治疗病毒性肺炎方面的应用。
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