WO2017101151A1 - Composition de médecine traditionnelle chinoise pour le traitement de la goutte et procédé de préparation de cette dernière - Google Patents

Composition de médecine traditionnelle chinoise pour le traitement de la goutte et procédé de préparation de cette dernière Download PDF

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Publication number
WO2017101151A1
WO2017101151A1 PCT/CN2015/098982 CN2015098982W WO2017101151A1 WO 2017101151 A1 WO2017101151 A1 WO 2017101151A1 CN 2015098982 W CN2015098982 W CN 2015098982W WO 2017101151 A1 WO2017101151 A1 WO 2017101151A1
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parts
chinese medicine
medicine composition
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traditional chinese
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PCT/CN2015/098982
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华坚
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华坚
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/756—Phellodendron, e.g. corktree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/884—Alismataceae (Water-plantain family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8966—Fritillaria, e.g. checker lily or mission bells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/898—Orchidaceae (Orchid family)
    • A61K36/8984—Dendrobium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9064—Amomum, e.g. round cardamom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger

Definitions

  • the present invention relates to a traditional Chinese medicine composition.
  • Gout is a crystal-associated joint disease caused by deposition of monosodium urate (MSU), which is directly related to hyperuricemia caused by a decrease in sputum metabolism and/or uric acid excretion, especially acute characteristic arthritis. Chronic tophi stone disease.
  • MSU monosodium urate
  • the pace of life is accelerating, the pressure of life is increasing, and the diet structure is changing, the number of patients with gout is also increasing.
  • Gout is more common in middle-aged men, and women account for only 5%, mainly postmenopausal women. At present, gout is younger.
  • the natural course of gout can be divided into four phases, namely, asymptomatic hyperuricemia, acute phase, intermittent phase, and chronic phase.
  • the onset of gout causes great pain to the patient.
  • western medicine for treating gout will have more or less side effects, and it is easy to relapse, which makes the gout cure.
  • the present invention provides a traditional Chinese medicine composition for treating gout and a preparation method thereof.
  • the traditional Chinese medicine composition for treating gout of the present invention is composed of the following components by weight: 20-40 parts of sea breeze, 2-7 parts of sea sand, 8-15 parts of Lysimachia, 8-15 parts of Phellodendron, and 8-15 of Magnolia.
  • the traditional Chinese medicine composition for treating gout of the present invention is composed of the following parts by weight: 25 to 35 parts of sea breeze, 4 to 6 parts of sea sand, 9 to 12 parts of Lysimachia, 9 to 12 parts of Phellodendron, and Magnolia 9 to 12 parts, 9 to 12 parts of black beans, 4 to 6 parts of medlar, 4 to 6 parts of schisandra, 4 to 6 parts of licorice, 4 to 6 parts of pulsatilla, 4 to 6 parts of Chuanpu, 4 to 6 parts of medlar, 4 to 6 parts of scorpion, 4 ⁇ 6 parts, Alisma 4 to 6 parts, tangerine peel 9 to 12 parts, chicken inner gold 4 to 6 parts, Sichuan Fritillaria 4 to 6 parts, Amomum villosum 4 to 6 parts, Dendrobium 4 to 6 parts, Myrrh 4 to 6 parts, 9-12 parts of spatholobus.
  • the traditional Chinese medicine composition for treating gout of the present invention is composed of the following parts by weight: 30 parts of sea breeze, 5 parts of sea sand, 10 parts of Lysimachia, 10 parts of Phellodendron, 10 parts of Magnolia, 10 parts of black beans, and medlar.
  • the preparation method of the traditional Chinese medicine composition for treating gout of the present invention is as follows: according to the above formula amount, the raw materials are washed, dried and pulverized, added to 4 to 7 times by weight of water, and boiled for 40 minutes to 2 hours to separate the extract and the insoluble matter. Add the insoluble matter to 4 to 7 times the weight of water again, decoct for 2 to 5 hours, discard the insoluble matter, and combine the extracts to obtain.
  • each raw material is washed, dried and pulverized, added to 6 times by weight of water, and boiled for 1 hour, and the extract and the insoluble matter are separated, and the insoluble matter is again added to 5 times by weight of water and boiled for 3 hours. Discard the insoluble matter and combine the extracts. That is.
  • Money grass is sweet, salty, and slightly cold. Liver, gallbladder, kidney, bladder. Lee dampness, diuretic pass, detoxification and swelling. For damp heat jaundice, biliary hypochondriac pain, stone shower, hot shower, urinary pain, swollen hemorrhoids, snake bites.
  • the spatholobus sinensis is sweet, bitter, and warm, and it can be transferred to the liver and kidney, to promote blood circulation, to relieve pain, and to relax the muscles.
  • dysmenorrhea amenorrhea
  • rheumatism numbness
  • blood deficiency and chlorosis.
  • Black beans are sweet, slightly cold, flat, into the spleen, kidney. Bushen Yiyin, spleen and dampness, in addition to heat and detoxification.
  • the traditional Chinese medicine composition for treating gout of the present invention uses Haifeng vine as a monarch medicine, and money grass, phellodendron, tangerine peel, magnolia, spatholobus, black bean as a medicine, sea gold sand, medlar, schisandra, pulsatilla, chuanpu, scorpion, turtle shell , Alisma, Chicken Jin, Chuan Fritillaria, Amomum, Dendrobium, Myrrh is the adjuvant, licorice is the medicine.
  • the whole side has rheumatoid pain, swollen sore, clearing heat and detoxification, phlegm dampness, promoting blood circulation and collaterals, reducing swelling and relieving pain, can be used to treat various types of gout attacks, and The side effects are small.
  • the preparation process is simple and the curative effect is remarkable.
  • the preparation method of the traditional Chinese medicine composition for treating gout of the invention is:
  • the preparation method of the traditional Chinese medicine composition for treating gout of the invention is:
  • the preparation method of the traditional Chinese medicine composition for treating gout of the invention is:
  • the preparation method of the traditional Chinese medicine composition for treating gout of the invention is:
  • the preparation method of the traditional Chinese medicine composition for treating gout of the invention is:
  • the clinical manifestations were: the first metatarsophalangeal joint pain was progressively exacerbated, and it was tear-like, knife-cut or bite-like, unbearable, red, swollen, hot, painful and affected joints and surrounding tissues. Limited functionality, etc.
  • the rats were divided into 6 groups and treated with the traditional Chinese medicine composition for treating gout prepared in Examples 1 to 5 of the present invention and the commercially available traditional Chinese medicine gout drugs, respectively, 3 times a day, 200 to 300 ml each time, for a total of 3 months.
  • the statistical analysis by systematic clinical observation is summarized as follows:
  • the traditional Chinese medicine composition for treating gout of the present invention can alleviate various gout symptoms, and the therapeutic effect thereof is significantly different from that of the commercially available product, and has an unexpected technical effect, and is suitable for general gout patients.
  • Example 2 of the present invention Zhang, male, 33 years old, gout history for 3 years, the clinical manifestation is redness and swelling of the thumb joint of the finger.
  • the traditional Chinese medicine composition for treating gout prepared in Example 2 of the present invention was started, 3 times a day. After 200ml, the symptoms disappeared after 3 days, and there was no side effect during the whole medication.
  • Example 3 of the present invention Wang, male, 57 years old, 8 years of gout history, the clinical manifestations of the right foot lateral big toe swelling and pain, joint deformation, fever and other symptoms.
  • the traditional Chinese medicine composition for treating gout prepared in Example 3 of the present invention was started, 3 times a day, 300 ml each time, the symptoms disappeared after 4 months, and the drug was stopped after 3 months of continuous use, and there was no recurrence so far. There is no side effect during the medication.

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

L'invention concerne une composition de médecine traditionnelle chinoise pour le traitement de la goutte et un procédé de préparation de cette dernière. La composition de médecine chinoise est préparée en séchant, puis broyant les ingrédients suivants, en parties en poids : 20 à 40 parties de tige de poivrier kadsura, 2 à 7 parties de spores de Lygodium japonicum, 8 à 15 parties de Lysimachia christinae Hance, 8 à 15 parties de feuilles de Phellodendron amurense, 8 à 15 parties d'écorce de Magnolia officinalis, 8 à 15 parties de Glycine Semen Nigra, 2 à 7 parties de Wolfiporia extensa, 2 à 7 parties de fruit de Schisandra chinensis, 2 à 7 parties de Glycyrrhiza glabra, 2 à 7 parties de racine de Pulsatilla chinensis, de 2 à 7 parties de Magnolia obovata, 2 à 7 parties de rhizome de Curcuma zedoaria, 2 à 7 parties de plastron de tortue terrestre, 2 à 7 parties de rhizome d'Alisma orientale, 8 à 15 parties de zeste séché de Citrus reticulata, 2 à 7 parties d'Endothelium corneum gigeriae galli, 2 à 7 parties de bulbe de Fritillaria cirrhosa, 2 à 7 parties de fruit d'Amomum villosum, 2 à 7 parties de Dendrobium, 2 à 7 parties de myrrhe, et 8 à 15 parties de tige de Spatholobus suberectus Dunn, et en réalisant une décoction de ces derniers dans de l'eau.
PCT/CN2015/098982 2015-12-14 2015-12-25 Composition de médecine traditionnelle chinoise pour le traitement de la goutte et procédé de préparation de cette dernière WO2017101151A1 (fr)

Applications Claiming Priority (2)

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CN201510926932.3 2015-12-14
CN201510926932.3A CN105288518A (zh) 2015-12-14 2015-12-14 一种治疗痛风的中药组合物及其制备方法

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109420117A (zh) * 2017-08-23 2019-03-05 临泽县锐翔科技开发有限责任公司 一组用于治疗痛风的中药
CN111068043A (zh) * 2019-12-23 2020-04-28 武汉轻工大学 一种富含菊苣菊糖的组合物及制备方法和预防痛风的制剂
CN112826888A (zh) * 2021-02-26 2021-05-25 中国中医科学院中医临床基础医学研究所 一种用于痛风的中药组合物及其制备方法和应用
CN113261666A (zh) * 2021-05-07 2021-08-17 云南品斛堂生物科技有限公司 一种石斛干片的提香方法及其石斛干片提香设备
CN115040581A (zh) * 2022-07-27 2022-09-13 山东创新腐植酸科技股份有限公司 一种痛风浴液及其制备方法
CN116059154A (zh) * 2021-10-29 2023-05-05 李宏亮 一种藏药八味泷沐组合物
CN118021897A (zh) * 2024-04-12 2024-05-14 山东新时代药业有限公司 一种药物组合物及其在治疗冠心病药物中的用途

Families Citing this family (1)

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Publication number Priority date Publication date Assignee Title
CN105288518A (zh) * 2015-12-14 2016-02-03 华坚 一种治疗痛风的中药组合物及其制备方法

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CN102240378A (zh) * 2010-05-10 2011-11-16 张金荣 一种治疗痛风的药物组合物及制法
CN105288518A (zh) * 2015-12-14 2016-02-03 华坚 一种治疗痛风的中药组合物及其制备方法

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CN104740424A (zh) * 2013-12-30 2015-07-01 魏修彦 一种治疗痛风的方法

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CN102240378A (zh) * 2010-05-10 2011-11-16 张金荣 一种治疗痛风的药物组合物及制法
CN105288518A (zh) * 2015-12-14 2016-02-03 华坚 一种治疗痛风的中药组合物及其制备方法

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KUANG, HUITAO: "Research Overview on Treating Gout in Traditional Chinese Medicine", HUNAN JOURNAL OF TRADITIONAL CHINESE MEDICINE, vol. 21, no. 02, 25 March 2005 (2005-03-25), pages 79 - 83 *

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109420117A (zh) * 2017-08-23 2019-03-05 临泽县锐翔科技开发有限责任公司 一组用于治疗痛风的中药
CN111068043A (zh) * 2019-12-23 2020-04-28 武汉轻工大学 一种富含菊苣菊糖的组合物及制备方法和预防痛风的制剂
CN112826888A (zh) * 2021-02-26 2021-05-25 中国中医科学院中医临床基础医学研究所 一种用于痛风的中药组合物及其制备方法和应用
CN113261666A (zh) * 2021-05-07 2021-08-17 云南品斛堂生物科技有限公司 一种石斛干片的提香方法及其石斛干片提香设备
CN113261666B (zh) * 2021-05-07 2022-08-16 云南品斛堂生物科技有限公司 一种石斛干片的提香方法及其石斛干片提香设备
CN116059154A (zh) * 2021-10-29 2023-05-05 李宏亮 一种藏药八味泷沐组合物
CN115040581A (zh) * 2022-07-27 2022-09-13 山东创新腐植酸科技股份有限公司 一种痛风浴液及其制备方法
CN118021897A (zh) * 2024-04-12 2024-05-14 山东新时代药业有限公司 一种药物组合物及其在治疗冠心病药物中的用途
CN118021897B (zh) * 2024-04-12 2024-06-11 山东新时代药业有限公司 一种药物组合物及其在治疗冠心病药物中的用途

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