WO2017101151A1 - 一种治疗痛风的中药组合物及其制备方法 - Google Patents

一种治疗痛风的中药组合物及其制备方法 Download PDF

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WO2017101151A1
WO2017101151A1 PCT/CN2015/098982 CN2015098982W WO2017101151A1 WO 2017101151 A1 WO2017101151 A1 WO 2017101151A1 CN 2015098982 W CN2015098982 W CN 2015098982W WO 2017101151 A1 WO2017101151 A1 WO 2017101151A1
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华坚
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华坚
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/756—Phellodendron, e.g. corktree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/884—Alismataceae (Water-plantain family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8966—Fritillaria, e.g. checker lily or mission bells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/898—Orchidaceae (Orchid family)
    • A61K36/8984—Dendrobium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9064—Amomum, e.g. round cardamom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger

Definitions

  • the present invention relates to a traditional Chinese medicine composition.
  • Gout is a crystal-associated joint disease caused by deposition of monosodium urate (MSU), which is directly related to hyperuricemia caused by a decrease in sputum metabolism and/or uric acid excretion, especially acute characteristic arthritis. Chronic tophi stone disease.
  • MSU monosodium urate
  • the pace of life is accelerating, the pressure of life is increasing, and the diet structure is changing, the number of patients with gout is also increasing.
  • Gout is more common in middle-aged men, and women account for only 5%, mainly postmenopausal women. At present, gout is younger.
  • the natural course of gout can be divided into four phases, namely, asymptomatic hyperuricemia, acute phase, intermittent phase, and chronic phase.
  • the onset of gout causes great pain to the patient.
  • western medicine for treating gout will have more or less side effects, and it is easy to relapse, which makes the gout cure.
  • the present invention provides a traditional Chinese medicine composition for treating gout and a preparation method thereof.
  • the traditional Chinese medicine composition for treating gout of the present invention is composed of the following components by weight: 20-40 parts of sea breeze, 2-7 parts of sea sand, 8-15 parts of Lysimachia, 8-15 parts of Phellodendron, and 8-15 of Magnolia.
  • the traditional Chinese medicine composition for treating gout of the present invention is composed of the following parts by weight: 25 to 35 parts of sea breeze, 4 to 6 parts of sea sand, 9 to 12 parts of Lysimachia, 9 to 12 parts of Phellodendron, and Magnolia 9 to 12 parts, 9 to 12 parts of black beans, 4 to 6 parts of medlar, 4 to 6 parts of schisandra, 4 to 6 parts of licorice, 4 to 6 parts of pulsatilla, 4 to 6 parts of Chuanpu, 4 to 6 parts of medlar, 4 to 6 parts of scorpion, 4 ⁇ 6 parts, Alisma 4 to 6 parts, tangerine peel 9 to 12 parts, chicken inner gold 4 to 6 parts, Sichuan Fritillaria 4 to 6 parts, Amomum villosum 4 to 6 parts, Dendrobium 4 to 6 parts, Myrrh 4 to 6 parts, 9-12 parts of spatholobus.
  • the traditional Chinese medicine composition for treating gout of the present invention is composed of the following parts by weight: 30 parts of sea breeze, 5 parts of sea sand, 10 parts of Lysimachia, 10 parts of Phellodendron, 10 parts of Magnolia, 10 parts of black beans, and medlar.
  • the preparation method of the traditional Chinese medicine composition for treating gout of the present invention is as follows: according to the above formula amount, the raw materials are washed, dried and pulverized, added to 4 to 7 times by weight of water, and boiled for 40 minutes to 2 hours to separate the extract and the insoluble matter. Add the insoluble matter to 4 to 7 times the weight of water again, decoct for 2 to 5 hours, discard the insoluble matter, and combine the extracts to obtain.
  • each raw material is washed, dried and pulverized, added to 6 times by weight of water, and boiled for 1 hour, and the extract and the insoluble matter are separated, and the insoluble matter is again added to 5 times by weight of water and boiled for 3 hours. Discard the insoluble matter and combine the extracts. That is.
  • Money grass is sweet, salty, and slightly cold. Liver, gallbladder, kidney, bladder. Lee dampness, diuretic pass, detoxification and swelling. For damp heat jaundice, biliary hypochondriac pain, stone shower, hot shower, urinary pain, swollen hemorrhoids, snake bites.
  • the spatholobus sinensis is sweet, bitter, and warm, and it can be transferred to the liver and kidney, to promote blood circulation, to relieve pain, and to relax the muscles.
  • dysmenorrhea amenorrhea
  • rheumatism numbness
  • blood deficiency and chlorosis.
  • Black beans are sweet, slightly cold, flat, into the spleen, kidney. Bushen Yiyin, spleen and dampness, in addition to heat and detoxification.
  • the traditional Chinese medicine composition for treating gout of the present invention uses Haifeng vine as a monarch medicine, and money grass, phellodendron, tangerine peel, magnolia, spatholobus, black bean as a medicine, sea gold sand, medlar, schisandra, pulsatilla, chuanpu, scorpion, turtle shell , Alisma, Chicken Jin, Chuan Fritillaria, Amomum, Dendrobium, Myrrh is the adjuvant, licorice is the medicine.
  • the whole side has rheumatoid pain, swollen sore, clearing heat and detoxification, phlegm dampness, promoting blood circulation and collaterals, reducing swelling and relieving pain, can be used to treat various types of gout attacks, and The side effects are small.
  • the preparation process is simple and the curative effect is remarkable.
  • the preparation method of the traditional Chinese medicine composition for treating gout of the invention is:
  • the preparation method of the traditional Chinese medicine composition for treating gout of the invention is:
  • the preparation method of the traditional Chinese medicine composition for treating gout of the invention is:
  • the preparation method of the traditional Chinese medicine composition for treating gout of the invention is:
  • the preparation method of the traditional Chinese medicine composition for treating gout of the invention is:
  • the clinical manifestations were: the first metatarsophalangeal joint pain was progressively exacerbated, and it was tear-like, knife-cut or bite-like, unbearable, red, swollen, hot, painful and affected joints and surrounding tissues. Limited functionality, etc.
  • the rats were divided into 6 groups and treated with the traditional Chinese medicine composition for treating gout prepared in Examples 1 to 5 of the present invention and the commercially available traditional Chinese medicine gout drugs, respectively, 3 times a day, 200 to 300 ml each time, for a total of 3 months.
  • the statistical analysis by systematic clinical observation is summarized as follows:
  • the traditional Chinese medicine composition for treating gout of the present invention can alleviate various gout symptoms, and the therapeutic effect thereof is significantly different from that of the commercially available product, and has an unexpected technical effect, and is suitable for general gout patients.
  • Example 2 of the present invention Zhang, male, 33 years old, gout history for 3 years, the clinical manifestation is redness and swelling of the thumb joint of the finger.
  • the traditional Chinese medicine composition for treating gout prepared in Example 2 of the present invention was started, 3 times a day. After 200ml, the symptoms disappeared after 3 days, and there was no side effect during the whole medication.
  • Example 3 of the present invention Wang, male, 57 years old, 8 years of gout history, the clinical manifestations of the right foot lateral big toe swelling and pain, joint deformation, fever and other symptoms.
  • the traditional Chinese medicine composition for treating gout prepared in Example 3 of the present invention was started, 3 times a day, 300 ml each time, the symptoms disappeared after 4 months, and the drug was stopped after 3 months of continuous use, and there was no recurrence so far. There is no side effect during the medication.

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Abstract

一种治疗痛风的中药组合物及其制备方法，由以下重量份的原料组分：海风藤20-40份、海金沙2-7份、金钱草8-15份、黄柏8-15份、厚朴8-15份、黑豆8-15份、茯苓2-7份、五味子2-7份、甘草2-7份、白头翁2-7份、川朴2-7份、莪术2-7份、龟板2-7份、泽泻2-7份、陈皮8-15份、鸡内金2-7份、川贝母2-7份、砂仁2-7份、石斛2-7份、没药2-7份、鸡血藤8-15份，经烘干、粉碎后加水煎煮制得。

Description

一种治疗痛风的中药组合物及其制备方法 技术领域
本发明涉及一种中药组合物。
背景技术
痛风是由单钠尿酸盐(MSU)沉积所致的晶体相关性关节病，与嘌呤代谢紊乱和(或)尿酸***减少所致的高尿酸血症直接相关，特指急性特征性关节炎和慢性痛风石疾病。随着社会的发展，生活节奏的加快、生活压力的增大，饮食结构的改变，痛风患者人数也在增加。痛风多见于中年男性，女性仅占5％，主要是绝经后女性，目前痛风发生有年轻化趋势。痛风的自然病程可分为四期，即无症状高尿酸血症期、急性期、间歇期、慢性期。痛风的发作给患者带来极大痛苦。一般治疗痛风的西药会有或多或少的副作用，而且易复发，使得痛风根治。
发明内容
针对上述技术问题，本发明提供一种治疗痛风的中药组合物及其制备方法。本发明的治疗痛风的中药组合物由以下重量份的组分组成：海风藤20～40份、海金沙2～7份、金钱草8～15份、黄柏8～15份、厚朴8～15份、黑豆8～15份、茯苓2～7份、五味子2～7份、甘草2～7份、白头翁2～7份、川朴2～7份、莪术2～7份、龟板2～7份、泽泻2～7份、陈皮8～15份、鸡内金2～7份、川贝母2～7份、砂仁2～7份、石斛2～7份、没药2～7份、鸡血藤8～15份。
进一步地，本发明的治疗痛风的中药组合物由以下重量份的组分组成：海风藤25～35份、海金沙4～6份、金钱草9～12份、黄柏9～12份、厚朴9～12份、黑豆9～12份、茯苓4～6份、五味子4～6份、甘草4～6份、白头翁4～6份、川朴4～6份、莪术4～6份、龟板4～6份、泽泻4～6份、陈皮9～12份、鸡内金4～6份、川贝母4～6份、砂仁4～6份、石斛4～6份、没药4～6份、鸡血藤9～12份。
具体地，本发明的治疗痛风的中药组合物由以下重量份的组分组成：海风藤30份、海金沙5份、金钱草10份、黄柏10份、厚朴10份、黑豆10份、茯苓5份、五味子5份、甘草5份、白头翁5份、川朴5份、莪术5份、龟板5份、泽泻5份、陈皮10份、鸡内金5份、川贝母5份、砂仁5份、石斛5份、没药5份、鸡血藤10份。
本发明的治疗痛风的中药组合物的制备方法为：按上述配方量，将各原料洗净、烘干粉碎后加入4～7倍重量的水中，煎煮40min～2h，分离提取液与不溶物，将不溶物再次加入4～7倍重量的水中，煎煮2h～5h，弃去不溶物，合并提取液，即得。
具体地，按上述配方量，将各原料洗净、烘干粉碎后加入6倍重量的水中，煎煮1h，分离提取液与不溶物，将不溶物再次加入5倍重量的水中，煎煮3h，弃去不溶物，合并提取液， 即得。
本发明的主要组分中：
海风藤味辛、苦，性微温。归肝经。祛风湿，通经络，止痹痛。用于风寒湿痹，肢节疼痛，筋脉拘挛，屈伸不利。
金钱草味甘、咸，性微寒。归肝、胆、肾、膀胱经。利湿退黄，利尿通淋，解毒消肿。用于湿热黄疸，胆胀胁痛，石淋，热淋，小便涩痛，痈肿疔疮，蛇虫咬伤。
黄柏味苦，性寒。归肾、膀胱经。有清热燥湿，泻火除蒸，解毒疗疮的功效。用于湿热泻痢，黄疸尿赤，带***痒，热淋涩痛，脚气痿蹙，骨蒸劳热，盗汗，遗精，疮疡肿毒，湿疹湿疮。盐黄柏滋阴降火。用于阴虚火旺，盗汗骨蒸。
厚朴味苦、辛，性温，归脾、胃、肺、大肠经。燥湿消痰，下气除满。用于湿滞伤中，脘痞吐泻，食积气滞，腹胀便秘，痰饮喘咳。
鸡血藤味甘、苦，性温，归肝、肾经，活血补血，调经止痛，舒筋活络。用于***，痛经，经闭，风湿痹痛，麻木瘫痪，血虚萎黄。
黑豆味甘，性微寒，性平、入脾、肾经。补肾益阴，健脾利湿，除热解毒。
陈皮：味苦、辛，性温。归肺、脾经。理气健脾，燥湿化痰。用于脘腹胀满，食少吐泻，咳嗽痰多。
本发明的治疗痛风的中药组合物以海风藤为君药，金钱草、黄柏、陈皮、厚朴、鸡血藤、黑豆为臣药，海金沙、茯苓、五味子、白头翁、川朴、莪术、龟板、泽泻、鸡内金、川贝母、砂仁、石斛、没药为佐药，甘草为使药。通过科学配伍，各药味协同作用，全方具有风湿痹痛，痈肿疮毒，清热解毒，化瘀祛湿，活血通络，消肿止痛之功，可用于治疗各种类型的痛风发作，并且副作用小。制备工艺简单，疗效显著。
为了更好地理解和实施，下面详细说明本发明。
具体实施方式
制备实施例1
本发明的治疗痛风的中药组合物制备方法为：
按重量份，海风藤20份、海金沙2份、金钱草8份、黄柏8份、厚朴8份、黑豆8份、茯苓2份、五味子2份、甘草2份、白头翁2份、川朴2份、莪术2份、龟板2份、泽泻2份、陈皮8份、鸡内金2份、川贝母2份、砂仁2份、石斛2份、没药2份、鸡血藤8份洗净、烘干粉碎后加入4倍重量的水中，煎煮40min，分离提取液与不溶物，将不溶物再次加入4倍重量的水中，煎煮2h，弃去不溶物，合并提取液，即得。
制备实施例2
本发明的治疗痛风的中药组合物制备方法为：
按重量份，海风藤40份、海金沙7份、金钱草15份、黄柏15份、厚朴15份、黑豆15份、茯苓7份、五味子7份、甘草7份、白头翁7份、川朴7份、莪术7份、龟板7份、泽泻7份、陈皮15份、鸡内金7份、川贝母7份、砂仁7份、石斛7份、没药7份、鸡血藤15份洗净、烘干粉碎后加入7倍重量的水中，煎煮2h，分离提取液与不溶物，将不溶物再次加入7倍重量的水中，煎煮5h，弃去不溶物，合并提取液，即得。
制备实施例3
本发明的治疗痛风的中药组合物制备方法为：
按重量份，将海风藤25份、海金沙4份、金钱草9份、黄柏9份、厚朴9份、黑豆9份、茯苓4份、五味子4份、甘草4份、白头翁4份、川朴4份、莪术4份、龟板4份、泽泻4份、陈皮9份、鸡内金4份、川贝母4份、砂仁4份、石斛4份、没药4份、鸡血藤9份洗净、烘干粉碎后加入6倍重量的水中，煎煮1h，分离提取液与不溶物，将不溶物再次加入6倍重量的水中，煎煮4h，弃去不溶物，合并提取液，即得。
制备实施例4
本发明的治疗痛风的中药组合物制备方法为：
按重量份，将海风藤35份、海金沙6份、金钱草12份、黄柏12份、厚朴12份、黑豆12份、茯苓6份、五味子6份、甘草6份、白头翁6份、川朴6份、莪术6份、龟板6份、泽泻6份、陈皮12份、鸡内金6份、川贝母6份、砂仁6份、石斛6份、没药6份、鸡血藤12份洗净、烘干粉碎后加入5倍重量的水中，煎煮1.5h，分离提取液与不溶物，将不溶物再次加入5倍重量的水中，煎煮2.5h，弃去不溶物，合并提取液，即得。
制备实施例5
本发明的治疗痛风的中药组合物制备方法为：
按重量份，将海风藤30份、海金沙5份、金钱草10份、黄柏10份、厚朴10份、黑豆10份、茯苓5份、五味子5份、甘草5份、白头翁5份、川朴5份、莪术5份、龟板5份、泽泻5份、陈皮10份、鸡内金5份、川贝母5份、砂仁5份、石斛5份、没药5份、鸡血藤10份洗净、烘干粉碎后加入6倍重量的水中，煎煮1h，分离提取液与不溶物，将不溶物再次加入5倍重量的水中，煎煮3h，弃去不溶物，合并提取液，即得。
临床试验实施例
入选120例痛风患者，临床表现为：第一跖趾关节疼痛并进行性加剧，呈撕裂样、刀割样或咬噬样，难以忍受，受累关节及周围组织红、肿、热、痛和功能受限等。平均分成6组，分别使用本发明实施例1～5所制得的治疗痛风的中药组合物和市售中药痛风药物进行治疗，一日3次，每次200～300ml，共治疗3个月。经***临床观察进行统计分析总结如下：
疗效判定标准：临床治愈—各种症状均消失；显效—各种症状明显改善；有效—各种症状有所改善；无效—各种症状无改变。
<表1效果考察>
Figure PCTCN2015098982-appb-000001
由本临床试验可知，本发明的治疗痛风的中药组合物能缓解多种痛风症状，经检验其治疗效果与市售品之间有明显差异，具有意料不到的技术效果，适合一般痛风患者服用。
病例实施例
1.卫某，男，41岁，痛风史5年，临床表现为第一跖趾关节红肿热痛，关节屈伸不利，关节内有结节，2015年1月开始服用本发明实施例1制得的治疗痛风的中药组合物，每日2次，每次200ml，3月后症状消失，继续服用3个月后停药，至今无复发，全部服药过程无任何副作用。
2.张某，男，33岁，痛风史3年，临床表现为手指拇指关节红肿，发病第三天开始服用本发明实施例2制得的治疗痛风的中药组合物，每日3次，每次200ml，3天后症状消失，全部服药过程无任何副作用。
3.王某，男，57岁，痛风史8年，临床表现为右脚外侧大脚趾红肿疼痛，关节变形，发热等症状。2015年1月开始服用本发明实施例3制得的治疗痛风的中药组合物，每日3次，每次300ml，4月后症状消失，继续服用3个月后停药，至今无复发，全部服药过程无任何副作用。
本发明并不局限于上述实施方式，如果对本发明的各种改动或变形不脱离本发明的精神 和范围，倘若这些改动和变形属于本发明的权利要求和等同技术范围之内，则本发明也意图包含这些改动和变形。

Claims (5)

  1. 一种治疗痛风的中药组合物，其特征在于由以下重量份的组分组成：海风藤20～40份、海金沙2～7份、金钱草8～15份、黄柏8～15份、厚朴8～15份、黑豆8～15份、茯苓2～7份、五味子2～7份、甘草2～7份、白头翁2～7份、川朴2～7份、莪术2～7份、龟板2～7份、泽泻2～7份、陈皮8～15份、鸡内金2～7份、川贝母2～7份、砂仁2～7份、石斛2～7份、没药2～7份、鸡血藤8～15份。
  2. 根据权利要求1所述的治疗痛风的中药组合物，其特征在于由以下重量份的组分组成：海风藤25～35份、海金沙4～6份、金钱草9～12份、黄柏9～12份、厚朴9～12份、黑豆9～12份、茯苓4～6份、五味子4～6份、甘草4～6份、白头翁4～6份、川朴4～6份、莪术4～6份、龟板4～6份、泽泻4～6份、陈皮9～12份、鸡内金4～6份、川贝母4～6份、砂仁4～6份、石斛4～6份、没药4～6份、鸡血藤9～12份。
  3. 根据权利要求2所述的治疗痛风的中药组合物，其特征在于由以下重量份的组分组成：海风藤30份、海金沙5份、金钱草10份、黄柏10份、厚朴10份、黑豆10份、茯苓5份、五味子5份、甘草5份、白头翁5份、川朴5份、莪术5份、龟板5份、泽泻5份、陈皮10份、鸡内金5份、川贝母5份、砂仁5份、石斛5份、没药5份、鸡血藤10份。
  4. 制备权利要求1～3任意一项所述的治疗痛风的中药组合物的方法，其特征在于：按上述配方量，将各原料洗净、烘干粉碎后加入4～7倍重量的水中，煎煮40min～2h，分离提取液与不溶物，将不溶物再次加入4～7倍重量的水中，煎煮2h～5h，弃去不溶物，合并提取液，即得。
  5. 根据权利要求4所述的治疗痛风的中药组合物的制备方法，其特征在于：按上述配方量，将各原料洗净、烘干粉碎后加入6倍重量的水中，煎煮1h，分离提取液与不溶物，将不溶物再次加入5倍重量的水中，煎煮3h，弃去不溶物，合并提取液，即得。
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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109420117A (zh) * 2017-08-23 2019-03-05 临泽县锐翔科技开发有限责任公司 一组用于治疗痛风的中药
CN111068043A (zh) * 2019-12-23 2020-04-28 武汉轻工大学 一种富含菊苣菊糖的组合物及制备方法和预防痛风的制剂
CN112826888A (zh) * 2021-02-26 2021-05-25 中国中医科学院中医临床基础医学研究所 一种用于痛风的中药组合物及其制备方法和应用
CN113261666A (zh) * 2021-05-07 2021-08-17 云南品斛堂生物科技有限公司 一种石斛干片的提香方法及其石斛干片提香设备
CN115040581A (zh) * 2022-07-27 2022-09-13 山东创新腐植酸科技股份有限公司 一种痛风浴液及其制备方法
CN116059154A (zh) * 2021-10-29 2023-05-05 李宏亮 一种藏药八味泷沐组合物
CN118021897A (zh) * 2024-04-12 2024-05-14 山东新时代药业有限公司 一种药物组合物及其在治疗冠心病药物中的用途

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105288518A (zh) * 2015-12-14 2016-02-03 华坚 一种治疗痛风的中药组合物及其制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102240378A (zh) * 2010-05-10 2011-11-16 张金荣 一种治疗痛风的药物组合物及制法
CN105288518A (zh) * 2015-12-14 2016-02-03 华坚 一种治疗痛风的中药组合物及其制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104740424A (zh) * 2013-12-30 2015-07-01 魏修彦 一种治疗痛风的方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102240378A (zh) * 2010-05-10 2011-11-16 张金荣 一种治疗痛风的药物组合物及制法
CN105288518A (zh) * 2015-12-14 2016-02-03 华坚 一种治疗痛风的中药组合物及其制备方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHAI, LIANMING ET AL.: "The Treatment of Gout", FUJIAN JOURNAL OF TRADITIONAL CHINESE MEDICINE, vol. 31, no. 06, 18 December 2000 (2000-12-18), pages 46 - 47 *
KUANG, HUITAO: "Research Overview on Treating Gout in Traditional Chinese Medicine", HUNAN JOURNAL OF TRADITIONAL CHINESE MEDICINE, vol. 21, no. 02, 25 March 2005 (2005-03-25), pages 79 - 83 *

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CN112826888A (zh) * 2021-02-26 2021-05-25 中国中医科学院中医临床基础医学研究所 一种用于痛风的中药组合物及其制备方法和应用
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