WO2017101595A1 - Composition de médecine traditionnelle chinoise pour le traitement de la goutte et procédé de préparation de cette dernière - Google Patents
Composition de médecine traditionnelle chinoise pour le traitement de la goutte et procédé de préparation de cette dernière Download PDFInfo
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- WO2017101595A1 WO2017101595A1 PCT/CN2016/103703 CN2016103703W WO2017101595A1 WO 2017101595 A1 WO2017101595 A1 WO 2017101595A1 CN 2016103703 W CN2016103703 W CN 2016103703W WO 2017101595 A1 WO2017101595 A1 WO 2017101595A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/58—Reptiles
- A61K35/586—Turtles; Tortoises, e.g. terrapins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
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- A—HUMAN NECESSITIES
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/486—Millettia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/57—Magnoliaceae (Magnolia family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
- A61K36/575—Magnolia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/884—Alismataceae (Water-plantain family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8966—Fritillaria, e.g. checker lily or mission bells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8967—Lilium, e.g. tiger lily or Easter lily
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8984—Dendrobium
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9064—Amomum, e.g. round cardamom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Definitions
- the present invention relates to a traditional Chinese medicine composition.
- Gout is a crystal-associated joint disease caused by deposition of monosodium urate (MSU), which is directly related to hyperuricemia caused by a decrease in sputum metabolism and/or uric acid excretion, especially acute characteristic arthritis. Chronic tophi stone disease.
- MSU monosodium urate
- the pace of life is accelerating, the pressure of life is increasing, and the diet structure is changing, the number of patients with gout is also increasing.
- Gout is more common in middle-aged men, and women account for only 5%, mainly postmenopausal women. At present, gout is younger.
- the natural course of gout can be divided into four phases, namely, asymptomatic hyperuricemia, acute phase, intermittent phase, and chronic phase.
- the onset of gout causes great pain to the patient.
- western medicine for treating gout will have more or less side effects, and it is easy to relapse, which makes the gout cure.
- the present invention provides a traditional Chinese medicine composition for treating gout and a preparation method thereof.
- the traditional Chinese medicine composition for treating gout of the present invention is composed of the following components by weight: 20 to 40 parts, 2 to 7 parts of sea sand, 8 to 15 parts of Lysimachia, 8 to 15 parts of Phellodendron, 8 to 15 parts of Magnolia.
- the traditional Chinese medicine composition for treating gout of the present invention is composed of the following components by weight: 25 to 35 parts of living, 4 to 6 parts of sea sand, 9 to 12 parts of Lysimachia, 9 to 12 parts of Phellodendron, and Magnolia 9 ⁇ 12 parts, black beans 9-12 parts, ⁇ 4-6 parts, schisandra 4-6 parts, licorice 4-6 parts, Pulsatilla 4-6 parts, Chuanpu 4-6 parts, ⁇ 4-6 parts, turtle shell 4 ⁇ 6 parts, 4 to 6 parts of Alisma, 9 to 12 parts of dried tangerine peel, 4 to 6 parts of chicken inner gold, 4 to 6 parts of Fritillaria, 4 to 6 parts of Amomum villosum, 4 to 6 parts of Dendrobium, 4 to 6 parts of Dendrobium, 4 to 6 Serve, 9 to 12 parts of spatholobus.
- the traditional Chinese medicine composition for treating gout of the present invention is composed of the following parts by weight: 30 parts of solo, 5 parts of sea sand, 10 parts of Lysimachia, 10 parts of Phellodendron, 10 parts of Magnolia, 10 parts of black beans, and 5 parts of ⁇ 5. 5 parts of Schisandra, 5 parts of licorice, 5 parts of licorice, 5 parts of Pulsatilla, 5 parts of Chuanpu, 5 parts of medlar, 5 parts of turtle shell, 5 parts of Alisma, 10 parts of dried tangerine peel, 5 parts of chicken inner gold, 5 parts of Fritillaria, 5 parts of Amomum villosum L. 5 parts, 5 parts of Dendrobium, 5 parts of myrrh, and 10 parts of Spatholobus.
- the preparation method of the traditional Chinese medicine composition for treating gout of the present invention is as follows: according to the above formula amount, the raw materials are washed, dried and pulverized, added to 4 to 7 times by weight of water, and boiled for 40 minutes to 2 hours to separate the extract and the insoluble matter. Add the insoluble matter to 4 to 7 times the weight of water again, decoct for 2 to 5 hours, discard the insoluble matter, and combine the extracts to obtain.
- each raw material is washed, dried and pulverized, added to 6 times by weight of water, and boiled for 1 hour, and the extract and the insoluble matter are separated, and the insoluble matter is again added to 5 times by weight of water and boiled for 3 hours. Discard the insoluble matter and combine the extracts. That is.
- Money grass is sweet, salty, and slightly cold. Liver, gallbladder, kidney, bladder. Lee dampness, diuretic pass, detoxification and swelling. For damp heat jaundice, biliary hypochondriac pain, stone shower, hot shower, urinary pain, swollen hemorrhoids, snake bites.
- the spatholobus sinensis is sweet, bitter, and warm, and it can be transferred to the liver and kidney, to promote blood circulation, to relieve pain, and to relax the muscles.
- dysmenorrhea amenorrhea
- rheumatism numbness
- blood deficiency and chlorosis.
- Black beans are sweet, slightly cold, flat, into the spleen, kidney. Bushen Yiyin, spleen and dampness, in addition to heat and detoxification.
- the traditional Chinese medicine composition for treating gout of the present invention is a medicinal herb, a medicinal herb, a medicinal herb, a yellow peony, a tangerine peel, a magnolia, a spatholobus, a black bean as a medicine, a sea sand, a scorpion, a schisandra, a pulsatilla, a chuanpu, a scorpion, a turtle shell, Alisma, chicken, gold, Fritillaria, Amomum, Dendrobium, Myrrh is an adjuvant, and licorice is a drug.
- the whole side has rheumatoid pain, swollen sore, clearing heat and detoxification, phlegm dampness, promoting blood circulation and collaterals, reducing swelling and relieving pain, can be used to treat various types of gout attacks, and The side effects are small.
- the preparation process is simple and the curative effect is remarkable.
- the preparation method of the traditional Chinese medicine composition for treating gout of the invention is:
- the preparation method of the traditional Chinese medicine composition for treating gout of the invention is:
- the preparation method of the traditional Chinese medicine composition for treating gout of the invention is:
- the preparation method of the traditional Chinese medicine composition for treating gout of the invention is:
- wash, dry and pulverize add 5 times the weight of water, decoct for 1.5h, separate the extract and insoluble matter, add the insoluble matter to 5 times the weight of water again, decoct for 2.5h, discard the insoluble matter, combine and extract Liquid, that is.
- the preparation method of the traditional Chinese medicine composition for treating gout of the invention is:
- Example 2 of the present invention The traditional Chinese medicine composition for treating gout prepared in Example 2 of the present invention was started on the third day of the onset, 3 times a day. After 200ml, the symptoms disappeared after 3 days, and there was no side effect during the whole medication.
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Abstract
L'invention concerne une composition de médecine traditionnelle chinoise pour le traitement de la goutte et un procédé de préparation de cette dernière. La composition de médecine traditionnelle chinoise comprend les composants suivants, en parties en poids : 20 à 40 parties de Radix Angelicae Pubescentis, 2 à 7 parties de Lygodium japonicum, 8 à 15 parties de Lysimachia christinae Hance, 8 à 15 parties d'écorce de Phellodendron, 8 à 15 parties de Magnolia officinalis, 8 à 15 parties de Glycine Semen Nigra, 2 à 7 parties de Wolfiporia extensa, 2 à 7 parties de fruit de Schisandra chinensis, 2 à 7 parties de Glycyrrhiza glabra, 2 à 7 parties de racine de Pulsatilla chinensis, de 2 à 7 parties de Magnolia obovata, 2 à 7 parties de Curcuma zedoaria, 2 à 7 parties de plastron de tortue terrestre, 2 à 7 parties de rhizome d'Alisma orientale, 8 à 15 parties de zeste de Citrus reticulata, 2 à 7 parties d'Endothelium corneum gigeriae galli, 2 à 7 parties de bulbe de Fritillaria cirrhosa, 2 à 7 parties de fruit d'Amomum villosum, 2 à 7 parties de Dendrobium, 2 à 7 parties de myrrhe, et 8 à 15 parties de tige de Spatholobus suberectus Dunn.
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CN201510927051.3 | 2015-12-14 | ||
CN201510927051.3A CN105343802A (zh) | 2015-12-14 | 2015-12-14 | 一种治疗痛风的中药组合物及其制备方法 |
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Citations (2)
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CN104257779A (zh) * | 2014-08-06 | 2015-01-07 | 蚌埠丰原涂山制药有限公司 | 一种抗痛风的药物组合物及其制备方法 |
CN104706856A (zh) * | 2015-04-01 | 2015-06-17 | 淄博夸克医药技术有限公司 | 一种用于治疗痛风的中药 |
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CN102240378A (zh) * | 2010-05-10 | 2011-11-16 | 张金荣 | 一种治疗痛风的药物组合物及制法 |
CN102579913A (zh) * | 2011-01-14 | 2012-07-18 | 天津市中宝制药有限公司 | 一种治疗痛风性关节炎的中药组合物 |
CN104721645A (zh) * | 2015-03-03 | 2015-06-24 | 刘正菊 | 一种治疗痛风症的中药组合物及制备方法 |
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2015
- 2015-12-14 CN CN201510927051.3A patent/CN105343802A/zh active Pending
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- 2016-10-28 WO PCT/CN2016/103703 patent/WO2017101595A1/fr active Application Filing
Patent Citations (2)
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CN104257779A (zh) * | 2014-08-06 | 2015-01-07 | 蚌埠丰原涂山制药有限公司 | 一种抗痛风的药物组合物及其制备方法 |
CN104706856A (zh) * | 2015-04-01 | 2015-06-17 | 淄博夸克医药技术有限公司 | 一种用于治疗痛风的中药 |
Non-Patent Citations (3)
Title |
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"The medication regularity of traditional chinese meddiineand medicine against arthritis, gout and ostteoarthritis", MODERNIZATION OF TRADITIONAL CHINESE MEDICINE, vol. 12, no. 5, 31 May 2010 (2010-05-31), pages 835 * |
FU HANSHENG: "Treatment of gouty arthritis by strenthening spleen and eliminating dampmess and blood stasis", SHAANXI JOURNAL OF TRADITIONAL CHINESE MEDICINE, vol. 24, no. 12, 31 December 2013 (2013-12-31), pages 1065 - 1066 * |
XU YUANZHEN ET AL.: "Radix Angelicae Pubescentis", CHINESE MEDICINE COLLECTION, 31 March 2012 (2012-03-31), pages 173 * |
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