WO2015039612A8 - 抑制btk和/或jak3激酶活性的化合物 - Google Patents

抑制btk和/或jak3激酶活性的化合物 Download PDF

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Publication number
WO2015039612A8
WO2015039612A8 PCT/CN2014/086820 CN2014086820W WO2015039612A8 WO 2015039612 A8 WO2015039612 A8 WO 2015039612A8 CN 2014086820 W CN2014086820 W CN 2014086820W WO 2015039612 A8 WO2015039612 A8 WO 2015039612A8
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Prior art keywords
btk
compound
jak3
compound inhibiting
inhibiting activities
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PCT/CN2014/086820
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English (en)
French (fr)
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WO2015039612A1 (zh
Inventor
刘金明
车美英
李功
李占梅
邱红娟
金孟燮
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北京韩美药品有限公司
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Publication date
Priority to US15/022,248 priority Critical patent/US9840517B2/en
Priority to MX2016003582A priority patent/MX368781B/es
Application filed by 北京韩美药品有限公司 filed Critical 北京韩美药品有限公司
Priority to EP14846251.8A priority patent/EP3048105A4/en
Priority to NZ718728A priority patent/NZ718728A/en
Priority to AU2014323777A priority patent/AU2014323777C1/en
Priority to SG11201601980XA priority patent/SG11201601980XA/en
Priority to RU2016110755A priority patent/RU2650512C2/ru
Priority to KR1020167009680A priority patent/KR101879422B1/ko
Priority to CA2924362A priority patent/CA2924362C/en
Priority to BR112016005881A priority patent/BR112016005881A2/pt
Priority to JP2016543306A priority patent/JP6458039B2/ja
Publication of WO2015039612A1 publication Critical patent/WO2015039612A1/zh
Publication of WO2015039612A8 publication Critical patent/WO2015039612A8/zh
Priority to IL24461116A priority patent/IL244611B/en
Priority to PH12016500531A priority patent/PH12016500531B1/en
Priority to US15/799,315 priority patent/US10273242B2/en

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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • C07D491/04—Ortho-condensed systems
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Abstract

本发明涉及抑制BTK（布鲁顿酪氨酸激酶）和/或JAK3（Janus酪氨酸激酶3）激酶活性的化合物、其药物组合物、其在制药中的用途、使用其抑制BTK和/或JAK3活性的方法以及使用其治疗和/或预防哺乳动物（尤其是人）中BTK和/或JAK3介导的疾病或病症的方法。所述化合物具有结构式（I）。
PCT/CN2014/086820 2013-09-18 2014-09-18 抑制btk和/或jak3激酶活性的化合物 WO2015039612A1 (zh)

Priority Applications (14)

Application Number Priority Date Filing Date Title
CA2924362A CA2924362C (en) 2013-09-18 2014-09-18 Compound inhibiting activities of btk and/or jak3 kinases
KR1020167009680A KR101879422B1 (ko) 2013-09-18 2014-09-18 Btk 및/또는 jak3 키나제의 활성을 억제하는 화합물
EP14846251.8A EP3048105A4 (en) 2013-09-18 2014-09-18 Compound inhibiting activities of btk and/or jak3 kinases
MX2016003582A MX368781B (es) 2013-09-18 2014-09-18 Compuesto inhibidor de las actividades de las cinasas btk y/o jak3.
AU2014323777A AU2014323777C1 (en) 2013-09-18 2014-09-18 Compound inhibiting activities of BTK and/or JAK3 kinases
SG11201601980XA SG11201601980XA (en) 2013-09-18 2014-09-18 Compound inhibiting activities of btk and/or jak3 kinases
BR112016005881A BR112016005881A2 (pt) 2013-09-18 2014-09-18 composto, composição farmacêutica e uso do composto
US15/022,248 US9840517B2 (en) 2013-09-18 2014-09-18 Compound inhibiting activities of BTK and/or JAK3 kinases
NZ718728A NZ718728A (en) 2013-09-18 2014-09-18 Compound inhibiting activities of btk and/or jak3 kinases
RU2016110755A RU2650512C2 (ru) 2013-09-18 2014-09-18 Соединение, ингибирующее активности киназ ВТК и/или JAK3
JP2016543306A JP6458039B2 (ja) 2013-09-18 2014-09-18 Ｂｔｋ及び／又はｊａｋ３キナーゼの活性を抑制する化合物
IL24461116A IL244611B (en) 2013-09-18 2016-03-15 Compounds containing compressed pyrimidine/4,2,1-triazine two-ring systems as inhibitors of jak3 and/or btk kinase activity
PH12016500531A PH12016500531B1 (en) 2013-09-18 2016-03-18 Compound inhibiting activities of btk and/or jak3 kinases
US15/799,315 US10273242B2 (en) 2013-09-18 2017-10-31 Compound inhibiting activities of BTK and/or JAK3 kinases

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
CN201310429844 2013-09-18
CN201310429844.3 2013-09-18
CN201310430071 2013-09-18
CN201310430071.0 2013-09-18
CN201310430761 2013-09-18
CN201310430761.6 2013-09-18

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US15/022,248 A-371-Of-International US9840517B2 (en) 2013-09-18 2014-09-18 Compound inhibiting activities of BTK and/or JAK3 kinases
US15/799,315 Division US10273242B2 (en) 2013-09-18 2017-10-31 Compound inhibiting activities of BTK and/or JAK3 kinases

Publications (2)

Publication Number Publication Date
WO2015039612A1 WO2015039612A1 (zh) 2015-03-26
WO2015039612A8 true WO2015039612A8 (zh) 2016-03-03

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US (2) US9840517B2 (zh)
EP (1) EP3048105A4 (zh)
JP (1) JP6458039B2 (zh)
KR (1) KR101879422B1 (zh)
CN (3) CN106083887B (zh)
AU (1) AU2014323777C1 (zh)
BR (1) BR112016005881A2 (zh)
CA (1) CA2924362C (zh)
IL (1) IL244611B (zh)
MX (1) MX368781B (zh)
NZ (1) NZ718728A (zh)
PH (1) PH12016500531B1 (zh)
RU (1) RU2650512C2 (zh)
SG (1) SG11201601980XA (zh)
WO (1) WO2015039612A1 (zh)

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PH12016500531A1 (en) 2016-05-16
BR112016005881A2 (pt) 2017-09-12
AU2014323777A1 (en) 2016-04-28
IL244611B (en) 2019-10-31
SG11201601980XA (en) 2016-04-28
WO2015039612A1 (zh) 2015-03-26
JP2016530335A (ja) 2016-09-29
JP6458039B2 (ja) 2019-01-23
AU2014323777B2 (en) 2017-03-09
KR20160054014A (ko) 2016-05-13
CA2924362A1 (en) 2015-03-26
PH12016500531B1 (en) 2016-05-16
RU2650512C2 (ru) 2018-04-16
IL244611A0 (en) 2016-04-21
CN106065017B (zh) 2018-06-01
EP3048105A4 (en) 2017-05-17
EP3048105A1 (en) 2016-07-27
US9840517B2 (en) 2017-12-12
CN106065017A (zh) 2016-11-02
CA2924362C (en) 2018-12-18
US20160229865A1 (en) 2016-08-11
CN104311573A (zh) 2015-01-28
AU2014323777C1 (en) 2018-04-26
CN106083887B (zh) 2018-11-20
MX2016003582A (es) 2016-06-02
CN106083887A (zh) 2016-11-09
RU2016110755A (ru) 2017-10-23
MX368781B (es) 2019-10-16
CN104311573B (zh) 2017-12-15

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