WO2017134685A3 - Novel hydrazino compounds as btk inhibitors - Google Patents

Novel hydrazino compounds as btk inhibitors Download PDF

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Publication number
WO2017134685A3
WO2017134685A3 PCT/IN2017/050048 IN2017050048W WO2017134685A3 WO 2017134685 A3 WO2017134685 A3 WO 2017134685A3 IN 2017050048 W IN2017050048 W IN 2017050048W WO 2017134685 A3 WO2017134685 A3 WO 2017134685A3
Authority
WO
WIPO (PCT)
Prior art keywords
novel
btk inhibitors
compounds
hydrazino compounds
hydrazino
Prior art date
Application number
PCT/IN2017/050048
Other languages
French (fr)
Other versions
WO2017134685A2 (en
Inventor
V.S.N. Murty KADIYALA
Virendra Narendra RAUT
Pratit SAVANT
Chetana Kaushal SHETH
Umesh Vishnu CHAUDHARI
Rajendrasinh Jashvantsinh RATHOD
Tushar Bhupendrabhai BHATT
Trinadha Rao Chitturi
Original Assignee
Sun Pharma Advanced Research Company Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sun Pharma Advanced Research Company Limited filed Critical Sun Pharma Advanced Research Company Limited
Publication of WO2017134685A2 publication Critical patent/WO2017134685A2/en
Publication of WO2017134685A3 publication Critical patent/WO2017134685A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

The present invention relates to novel hydrazino compounds of Formula (I) as Bruton tyrosine kinase inhibitors, process of preparation thereof, and to the use of the compounds in the preparation of pharmaceutical compositions for the therapeutic treatment of disorders involving mediation of Bruton tyrosine kinase in humans.
PCT/IN2017/050048 2016-02-02 2017-02-02 Novel hydrazino compounds as btk inhibitors WO2017134685A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201621003737 2016-02-02
IN201621003737 2016-02-02

Publications (2)

Publication Number Publication Date
WO2017134685A2 WO2017134685A2 (en) 2017-08-10
WO2017134685A3 true WO2017134685A3 (en) 2018-06-28

Family

ID=59500779

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Application Number Title Priority Date Filing Date
PCT/IN2017/050048 WO2017134685A2 (en) 2016-02-02 2017-02-02 Novel hydrazino compounds as btk inhibitors

Country Status (1)

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WO (1) WO2017134685A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109111446B (en) * 2017-06-22 2021-11-30 上海度德医药科技有限公司 Heteroaryl compound with pharmaceutical activity
CA3108065A1 (en) 2018-07-31 2020-02-06 Loxo Oncology, Inc. Spray-dried dispersions, formulations, and polymorphs of (s)-5-amino-3-(4-((5-fluoro-2-methoxybenzamido)methyl)phenyl)-1-(1,1,1-trifluoropropan-2-yl)-1h-pyrazole-4-carboxamide
CA3133004A1 (en) 2019-05-31 2020-12-03 Sichuan Haisco Pharmaceutical Co., Ltd. Btk inhibitor ring derivative, preparation method therefor and pharmaceutical application thereof
CN111018865B (en) * 2019-10-17 2021-01-15 山东大学 1-substituted benzyl pyrazolopyrimidine derivative and preparation method and application thereof
EP4253384A1 (en) * 2020-11-25 2023-10-04 Haisco Pharmaceuticals Pte. Ltd. Method for preparing btk degrading agent
WO2022111448A1 (en) * 2020-11-25 2022-06-02 四川海思科制药有限公司 Method for preparing btk degrading agent
US20230137175A1 (en) * 2021-08-17 2023-05-04 Endotarget Inc. Compounds and methods for the targeted degradation of bruton's tyrosine kinase

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008039218A2 (en) * 2006-09-22 2008-04-03 Pharmacyclics, Inc. Inhibitors of bruton's tyrosine kinase
WO2013177668A1 (en) * 2012-05-31 2013-12-05 Pharmascience, Inc. Protein kinase inhibitors
WO2014005217A1 (en) * 2012-07-06 2014-01-09 Pharmascience Inc. Protein kinase inhibitors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008039218A2 (en) * 2006-09-22 2008-04-03 Pharmacyclics, Inc. Inhibitors of bruton's tyrosine kinase
WO2013177668A1 (en) * 2012-05-31 2013-12-05 Pharmascience, Inc. Protein kinase inhibitors
WO2014005217A1 (en) * 2012-07-06 2014-01-09 Pharmascience Inc. Protein kinase inhibitors

Also Published As

Publication number Publication date
WO2017134685A2 (en) 2017-08-10

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