WO2014023096A1 - Composition capable de réguler la flore intestinale chez le sujet humain et de renforcer ses défenses immunitaires - Google Patents

Composition capable de réguler la flore intestinale chez le sujet humain et de renforcer ses défenses immunitaires Download PDF

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Publication number
WO2014023096A1
WO2014023096A1 PCT/CN2013/072131 CN2013072131W WO2014023096A1 WO 2014023096 A1 WO2014023096 A1 WO 2014023096A1 CN 2013072131 W CN2013072131 W CN 2013072131W WO 2014023096 A1 WO2014023096 A1 WO 2014023096A1
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WO
WIPO (PCT)
Prior art keywords
parts
polysaccharide
immune function
vegetable
human flora
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Application number
PCT/CN2013/072131
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English (en)
Chinese (zh)
Inventor
肖天存
李丽
张鹏飞
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广州博能生物科技有限公司
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Publication of WO2014023096A1 publication Critical patent/WO2014023096A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/02—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation containing fruit or vegetable juices
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
    • A23L19/01—Instant products; Powders; Flakes; Granules
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives

Definitions

  • the present invention relates to a health care product, and in particular to a method for preparing a composition capable of regulating a human flora and an immune function. Background technique
  • Immunity is the body's own defense mechanism. It is the body that recognizes and destroys any foreign bodies (viruses, bacteria, etc.) that invade. It treats aging, disease, injury, death, degeneration of self-cells, and recognizes and processes mutant cells and virus-infected cells in vivo. Ability. Modern immunology believes that immunity is the physiological response of the human body to recognize and eliminate "dissidents.”
  • Intestinal diseases and immunity The two lower diseases are intertwined, causing intestinal dysfunction and failing to function normally, resulting in many complications such as low immunity, intestinal cancer, breast cancer, diabetes, hypertension, and hyperlipidemia.
  • the intestinal disease is very harmful and involves a wide population. It is one of the fierce killers in modern diseases today.
  • Immunity is closely related to the population of human flora. In addition to mental factors, human immunity is closely related to the body's intake of various substances in the body. It is generally believed that the substances that enhance immunity are as follows: 1. Protein, protein is the basic element that constitutes human cells, and is also the main component of white blood cells and antibodies; if the body is seriously deficient in protein, it will reduce the number of lymphocytes. , causing serious decline in immune function, so eat more high-protein foods, such as: fresh meat, chicken, duck, fish, eggs, milk and dairy products, rich animal protein, containing globulin can help you improve immunity . 2. Vitamin A Vitamin A is related to the integrity of cells. It can help cells fight against oxidation.
  • Vitamin C has the function of promoting the immune system, and increases the ability of white blood cells to phagocytose bacteria, as well as the ability to enhance the thymus and lymphocytes, help the body increase the resistance content and increase the interferon content in the blood. It is an effective antioxidant. It is resistant to destructive molecules and is one of the vitamins that enhance immunity. Vegetables and fruits rich in vitamin C (eg apple, lemon, orange, etc.) are good sources of food for improving immunity. IV.
  • Vitamin E Vitamin E As a free radical, the nemesis can also promote antibody production. From the point of view of anti-virus, it has anti-oxidation effect and enhances the function of immune cells. Generally, foods such as beans, wheat germ, fruits and vegetables, vegetable oil, and stone fruits are more common. Many levels of vitamin E, however, due to changes in modern people's eating habits, the diet is not balanced, so the amount of vitamin E that can be taken from food is very low.
  • the object of the present invention is to provide a composition capable of regulating human flora and immune function, which can be processed into tablets or oral liquids for foods or beverages, to improve immunity and change.
  • the human flora can prevent or treat digestive tract diseases, protect the gastrointestinal environment, prevent obesity, reduce acne, and promote and maintain health.
  • a composition capable of regulating human flora and immune function comprising the following components in parts by weight: a) vegetable or vegetable dry powder or water extract 1-100 parts
  • composition for regulating human flora and immune function of the present invention comprises the following components in parts by weight.
  • the vegetable and fruit water extract and the natural active polysaccharide are respectively extracted by the following steps: 1) Select raw materials: Choose fresh raw materials for fruits and vegetables;
  • Raw material processing Wash the above selected raw materials to remove impurities, cut into silk or block;
  • Drying Spray drying or heating to static drying for 5-40 seconds, save for use.
  • the dried fruit and vegetable powder is a powder of 20-80 ⁇ which is directly pulverized by a ball mill after washing and dehydrating fresh fruits and vegetables, wherein the rotation speed of the barrel of the ball mill is 18-38 r/min.
  • the drying method can be naturally air-dried or high-temperature drying or freeze-drying.
  • the method is a conventional method which can be grasped by those skilled in the art, and will not be described in detail herein; in order to facilitate subsequent processing into tablets, capsules, sprays, etc. Different preparations.
  • the preferred vegetable or vegetable plant in the present invention is one or more of vegetables or/and melons and fruits; wherein the vegetables are roots or/and leaves of cabbage, cabbage, mustard, aquatic vegetables, radishes , one or more of celery, asparagus, pepper, etc., wherein the cabbage is selected from the group consisting of pakchoi, cabbage, Chinese cabbage, seaweed, spinach, rape, broccoli, celery, red cabbage Or two or more; the cabbage is selected from one or more of broccoli, broccoli, kale, broccoli, broccoli, etc.; mustard is leaf mustard, stem mustard (head dish), root mustard (kohlrabi) One or two or more, aquatic vegetables, and radishes.
  • the melon fruit is one or a mixture of two or more of apple, pear, orange, watermelon, blueberry, tomato, eggplant, raspberry, papaya, etc., and the present invention is not limited to the above.
  • a composition capable of regulating human flora and immune function comprising the following components in parts by weight: a) fried whole grain dry powder or coarse grain water extract 1-100 parts
  • the coarse grain extract described in the present invention is obtained by extracting a concentrate by the following steps:
  • Raw material processing Wash the above selected raw materials to remove impurities, cut into silk or block;
  • the coarse grain described in the present invention is one or more of corn, millet, purple rice, sorghum, oat, buckwheat, wheat bran, soybean, green bean, red bean, mung bean, sweet potato, etc., but is not limited to the above
  • the powder of 20-80 ⁇ ⁇ is directly pulverized by a ball mill, wherein the rotation speed of the ball mill cylinder is 18-38 r/min.
  • the drying method can be carried out by natural air drying or high temperature drying or freeze drying. The method is a conventional method which can be grasped by those skilled in the art and will not be described in detail herein.
  • a composition capable of regulating human flora and immune function comprising the following components in parts by weight: a) juice or / and vegetable juice 1-100 parts
  • the fruit juice is fresh juice of one or both of apple, orange, pear, blueberry, strawberry, and tomato.
  • the natural active polysaccharide of the present invention is obtained by extracting a concentrate by the following steps: 1) Select raw materials: Astragalus membranaceus chooses raw materials that are free of insects and mildews and meet Chinese Pharmacopoeia standards;
  • Raw material processing Wash the above selected raw materials to remove impurities, cut into silk or block;
  • the composition for regulating human flora and immune function of the present invention further comprises 0-50 parts of edible algae in parts by weight, and the edible algae are seaweed, asparagus, and wakame. , one or more of Mani, kelp, or more.
  • the natural active polysaccharide mentioned in the present invention is a polysaccharide substance capable of improving immunity; preferably from Astragalus polysaccharide, Jujube polysaccharide, bamboo leaf polysaccharide, Gynostemma, Cordyceps polysaccharide, black bean crude polysaccharide, fig polysaccharide, monkey One or more of the polysaccharides of Pleurotus ostreatus, Chinese kiwifruit polysaccharide, Atractylodes polysaccharide, Rehmannia polysaccharide, Lycium barbarum polysaccharide, Spirulina polysaccharide, Eucommia polysaccharide, and Ligustrum lucidum polysaccharide.
  • Natural active polysaccharides have activated cells, inhibit aging, enhance immune function, prevent diseases, promote disease healing, regulate human physiology, anti-tumor, anti-radiation, anti-oxidation, anti-hypoxia, anti-allergy, anti-inflammatory, hypolipidemic, lower blood Viscosity, hypoglycemic effect
  • Vitamin C promotes the biosynthesis of collagen, facilitates faster healing of tissue wounds, promotes the metabolism of tyrosine and tryptophan in amino acids, prolongs the life of the body, improves the utilization of iron, calcium and folic acid, and improves fats and Lipids, especially cholesterol metabolism, prevent cardiovascular disease, promote the growth of teeth and bones, prevent gum bleeding, and enhance the body's ability to resist stress and immunity to the external environment.
  • the invention adopts the flavonoid water extract and the propolis and the vitamin C to cooperate with each other to make the antibacterial and the immune enhancement effect
  • add the dried fruit/water extract or the dried fruit powder/or water extract or juice to the formula to improve the human flora and immunity, and to help the body's balanced diet.
  • the invention has the beneficial effects that: the composition of the invention can regulate the imbalance of the human flora and enhance the immune function of the human body, has the functions of mediating the stomach, increasing gastrointestinal motility, aeration, and protecting the gastric membrane, and has the functions of hangover and protecting the digestive system. Better effect.
  • the product containing the composition of the present invention can prevent or treat oral ulcers, and has certain auxiliary effects on gum bleeding, bad breath or stomach acid and stomach pain.
  • the invention has the advantages of simple and convenient raw materials, can greatly improve the bioavailability of the material, and can harmoniously distribute and combine the material components to exert the best effect. It can effectively regulate human flora and immune function and create good conditions for human health.
  • Scheme 1 The composition for regulating human flora and immune function, comprising the following components in parts by weight:
  • Examples 1-6 were prepared according to the formulation of Scheme 1, and the specific formulation choices of Examples 1-6 are shown in Table 1:
  • Example 2 Example 3
  • Example 4 Example 5
  • Example 6 Group of cauliflower dried broccoli dried broccoli dried spinach extract spinach dry powder Chinese cabbage dried a) powder 1 part powder 80 parts powder 100 parts 80 parts 80 100 parts of powder b) 20 parts 1 part 20 parts 20 parts 10 parts 20 parts ⁇ c c) 1 part 20 parts 10 parts 20 parts 10 parts square d) 0 5 parts 10 parts 5 parts 5 parts 5 parts application example 1
  • Example 4 10 g of the composition of Example 4 was added, 5 g of white sugar was added, and the mixture was uniformly mixed to prepare a beverage. Drink once a day. 20 cases of constipation patients were examined, 10 males and 10 females. The patients used this product after constipation, and healed 17 times every day for 3 days, reaching 85%, and all of them healed after five days.
  • Scheme 2 A composition capable of regulating human flora and immune function, comprising the following components in parts by weight:
  • the examples 7-12 are prepared according to the formula of the second embodiment, and the specific formula selection of the examples 7-12 is shown in the table.
  • Example 7 Example 8
  • Example 9 Example 10
  • Example 12 Group of cooked soybean dry cooked soybean dry cooked soybean dry millet extract cooked millet dry oatmeal dry powder a) powder 1 part powder 80 parts powder 100 parts 80 parts of powder 80 parts 100 parts b) 20 parts 1 part 20 parts 20 parts 10 parts 20 parts ⁇ c) 1 part 20 parts 10 parts 20 parts 10 parts square d) 0 5 parts 10 parts 5 parts 5 parts 5 parts Application Example 3
  • Example 10 10 g of the composition of Example 10 was added, 5 g of white sugar was added, and the mixture was uniformly mixed to prepare a beverage. 30 patients with gastric acid were enrolled, 10 males and 20 females. They insisted on taking the products of the invention twice a day, and the number of people who recovered after 7 days was 18.
  • Scheme 3 A composition capable of modulating human flora and immune function, comprising the following components in parts by weight:
  • Examples 13-18 were prepared according to the formulation of Scheme 2, and the specific formulation choices of Examples 13-18 are shown in Table 2:
  • Example 13 Example 14
  • Example 15 Example 16
  • Example 17 Freshly squeezed apple freshly squeezed apple freshly squeezed apple apple juice + spinach juice + freshly squeezed strawberry a) juice 1 part juice 80 parts Juice 100 parts of vegetable juice 80 parts of tomato juice 80 parts of juice 100 parts b) 20 parts 1 part 20 parts 20 parts 10 parts 20 parts ⁇ c c) 1 part 20 parts 10 parts 20 parts 10 parts square d) 0 5 parts 10 parts 5 parts 5 parts 5 parts application examples

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Cette invention concerne une composition capable de réguler la flore intestinale chez le sujet humain et de renforcer ses défenses immunitaires. L'invention concerne également un procédé de préparation de la composition, ladite composition comprenant une poudre de légumes et de fruits séchés ou un extrait aqueux desdits légumes et desdits fruits, une poudre de céréales secondaires séchées et frites ou l'extrait aqueux desdites céréales secondaires, un jus de fruits ou un jus de légumes avec un polysaccharide actif naturel, de la propolis, etc. La composition permet de réguler le déséquilibre de la flore intestinale chez le sujet humain et de renforcer les défenses immunitaires dudit sujet humain.
PCT/CN2013/072131 2012-08-06 2013-03-04 Composition capable de réguler la flore intestinale chez le sujet humain et de renforcer ses défenses immunitaires WO2014023096A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201210278247.0 2012-08-06
CN201210278247.0A CN102813113B (zh) 2012-08-06 2012-08-06 一种能调节人体菌群和免疫功能的组合物

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WO2014023096A1 true WO2014023096A1 (fr) 2014-02-13

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WO (1) WO2014023096A1 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102813113B (zh) * 2012-08-06 2014-06-25 广州博能生物科技有限公司 一种能调节人体菌群和免疫功能的组合物
CN103125802B (zh) * 2013-03-11 2014-07-30 宁夏原野蜂业有限公司 一种以蜂胶膏、枸杞膏、蜂蜜、沙漠人参粉为原料的营养品及其制备方法
CN103190626B (zh) * 2013-04-17 2014-12-03 肖天存 治疗口腔溃疡的果蔬食品及其制备方法
CN103461612A (zh) * 2013-10-09 2013-12-25 北京绿源求证科技发展有限责任公司 一种保护胃黏膜的食品养胃茶冲剂
CN104543811B (zh) * 2013-10-21 2018-05-15 广州博能生物科技有限公司 提高免疫力的天然复合粉及其制备方法和应用
CN103637268B (zh) * 2013-12-25 2015-09-09 山东金诃药物研究开发有限公司 一种具有改善记忆功能的即食枸杞海苔
CN103704796B (zh) * 2014-01-14 2015-07-08 广西南宁桂景大酒店有限责任公司 螺旋藻玛卡汤及其制作方法
CN104207121B (zh) * 2014-07-07 2016-01-06 郑州乐嫒商贸有限公司 一种提高免疫力降低三高的食疗保健品
CN104630005B (zh) * 2015-01-26 2016-09-14 云南省热带作物科学研究所 一种诺丽果保健酒原料和诺丽果保健酒及其制备方法
CN105029166A (zh) * 2015-06-10 2015-11-11 周爱民 一种复合型多功能食品及制备方法
CN107019144A (zh) * 2017-04-12 2017-08-08 山东菌芝堂生物科技发展有限公司 一种恢复肺癌患者肠道菌群平衡的速食粥及其制备方法
CN106962900A (zh) * 2017-04-12 2017-07-21 山东菌芝堂生物科技发展有限公司 一种恢复经期不调患者肠道菌群平衡的速食粥及其制备方法
CN106993750A (zh) * 2017-04-12 2017-08-01 山东菌芝堂生物科技发展有限公司 一种恢复慢性结肠炎患者肠道菌群平衡的速食粥及其制备方法
CN106974280A (zh) * 2017-04-12 2017-07-25 山东菌芝堂生物科技发展有限公司 一种恢复乳腺结节患者肠道菌群平衡的速食粥及其制备方法
CN107019143A (zh) * 2017-04-12 2017-08-08 山东菌芝堂生物科技发展有限公司 一种恢复2型糖尿病患者肠道菌群平衡的速食粥及其制备方法
CN106983143A (zh) * 2017-04-12 2017-07-28 山东菌芝堂生物科技发展有限公司 一种恢复银屑病患者肠道菌群平衡的速食粥及其制备方法
CN106993749A (zh) * 2017-04-12 2017-08-01 山东菌芝堂生物科技发展有限公司 一种恢复慢性肾炎患者肠道菌群平衡的速食粥及其制备方法
CN107006850A (zh) * 2017-04-12 2017-08-04 山东菌芝堂生物科技发展有限公司 一种恢复原发性高血压患者肠道菌群平衡的速食粥及其制备方法
CN107048199A (zh) * 2017-04-12 2017-08-18 山东菌芝堂生物科技发展有限公司 一种恢复高尿酸血症患者肠道菌群平衡的速食粥及其制备方法
CN112167580A (zh) * 2020-10-10 2021-01-05 拜里待西·哈赛音 一种提高免疫力的果蔬酱

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1669475A (zh) * 2004-03-17 2005-09-21 张晓红 一种能防病抗衰老的保健酥果
CN101297683A (zh) * 2007-05-06 2008-11-05 张晓红 具有防病抗衰延寿功能的酥果
CN102228242A (zh) * 2011-06-17 2011-11-02 肖天存 一种复合蔬菜保健品及其制备方法
CN102326727A (zh) * 2011-05-31 2012-01-25 大连海尔思科技有限公司 蜂胶保健品及其制备方法
CN102813113A (zh) * 2012-08-06 2012-12-12 广州博能生物科技有限公司 一种能调节人体菌群和免疫功能的组合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1265725C (zh) * 2003-11-13 2006-07-26 上海奥医高科技实业有限公司 具有延缓衰老和增加骨密度功能的保健食品
CN101361757B (zh) * 2008-09-01 2013-06-12 北京世纪博康医药科技有限公司 一种含有褐藻多糖硫酸酯和蜂胶的组合物和其应用
CN101971988B (zh) * 2010-10-11 2012-05-23 孙羽蒙 一种用于对妇女更年期进行治疗的组合物

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1669475A (zh) * 2004-03-17 2005-09-21 张晓红 一种能防病抗衰老的保健酥果
CN101297683A (zh) * 2007-05-06 2008-11-05 张晓红 具有防病抗衰延寿功能的酥果
CN102326727A (zh) * 2011-05-31 2012-01-25 大连海尔思科技有限公司 蜂胶保健品及其制备方法
CN102228242A (zh) * 2011-06-17 2011-11-02 肖天存 一种复合蔬菜保健品及其制备方法
CN102813113A (zh) * 2012-08-06 2012-12-12 广州博能生物科技有限公司 一种能调节人体菌群和免疫功能的组合物

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