WO2011152521A1 - 分包包装体 - Google Patents
分包包装体 Download PDFInfo
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- WO2011152521A1 WO2011152521A1 PCT/JP2011/062801 JP2011062801W WO2011152521A1 WO 2011152521 A1 WO2011152521 A1 WO 2011152521A1 JP 2011062801 W JP2011062801 W JP 2011062801W WO 2011152521 A1 WO2011152521 A1 WO 2011152521A1
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- adsorbent
- layer
- package
- internal use
- packaging
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
- B65D83/06—Containers or packages with special means for dispensing contents for dispensing powdered or granular material
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D77/00—Packages formed by enclosing articles or materials in preformed containers, e.g. boxes, cartons, sacks or bags
- B65D77/10—Container closures formed after filling
- B65D77/12—Container closures formed after filling by collapsing and flattening the mouth portion of the container and securing without folding, e.g. by pressure-sensitive adhesive, heat-sealing, welding or applying separate securing members
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/03—Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
- A61J7/0015—Devices specially adapted for taking medicines
- A61J7/003—Sticks, e.g. lollipops with drug release
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B15/00—Layered products comprising a layer of metal
- B32B15/04—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material
- B32B15/08—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
- B32B15/085—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin comprising polyolefins
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/32—Layered products comprising a layer of synthetic resin comprising polyolefins
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/36—Layered products comprising a layer of synthetic resin comprising polyesters
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B1/00—Packaging fluent solid material, e.g. powders, granular or loose fibrous material, loose masses of small articles, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D65/00—Wrappers or flexible covers; Packaging materials of special type or form
- B65D65/38—Packaging materials of special type or form
- B65D65/40—Applications of laminates for particular packaging purposes
- B65D65/403—Applications of laminates for particular packaging purposes with at least one corrugated layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/10—Bag-type containers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2439/00—Containers; Receptacles
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/13—Hollow or container type article [e.g., tube, vase, etc.]
- Y10T428/1334—Nonself-supporting tubular film or bag [e.g., pouch, envelope, packet, etc.]
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/13—Hollow or container type article [e.g., tube, vase, etc.]
- Y10T428/1352—Polymer or resin containing [i.e., natural or synthetic]
Definitions
- the present invention relates to a package body. More specifically, the internal adsorbent should be hermetically packaged with a packaging material having an inner surface specific resistance average value of 4.4 ⁇ 10 9 ⁇ or more and 1.0 ⁇ 10 16 ⁇ or less in a heated state.
- the present invention relates to a package for packaging. According to the present invention, it is possible to obtain a packaging package in which the adsorbent for internal use is not bitten in the heat-sealed portion of the package and the internal adsorbent is less scattered at the time of opening.
- An internal use adsorbent adsorbs poisonous substances that have entered the body or harmful substances metabolized in the body in the digestive tract, and excretes these toxic substances outside the body.
- an oral use adsorbent that can be taken orally and can treat renal or liver dysfunction has been developed and used (Patent Document 1).
- the adsorbent for oral administration consists of a porous spherical carbonaceous material having a specific functional group (ie, spherical activated carbon), and is highly safe and stable to the living body, and at the same time in the presence of bile acids in the intestine.
- the adsorbent for oral administration described in Patent Document 1 was produced by preparing spherical activated carbon using pitches such as petroleum pitch as a carbon source, and then performing oxidation treatment and reduction treatment. Recently, an adsorbent for oral administration has been developed, which is made of spherical activated carbon produced using a thermosetting resin such as a phenol resin described in Patent Document 2 as a carbon source.
- This adsorbent for oral administration has been shown to have an even better selective adsorption than the adsorbent for oral administration described in Patent Document 1. Furthermore, it is important for an adsorbent for oral administration to adsorb as much toxic substances as possible within the in-vivo period from oral ingestion to elimination from the body. According to the description in Patent Documents 3 and 4, by using an orally administered adsorbent composed of spherical activated carbon with a small average particle size, a large amount of toxic substances are adsorbed within the in vivo retention period from ingestion to extracorporeal discharge. Can do.
- an airtight container is a daily handling or in the normal storage state, liquid or solid foreign matter or moisture does not invade, the content medicine is lost, deflated, deliquescent.
- a container that can be protected from evaporation For example, a tube, can, sachet, or plastic container.
- Packaging forms used for air-tight packaging of adsorbents for internal use include can packaging, bottle packaging using a lid with packing, and packaging such as three-side seal packaging, four-side seal packaging, and stick packaging.
- the packaging is an excellent packaging form in that it can package the adsorbent for internal use to be taken at one time.
- the package of the adsorbent for internal use can be produced, for example, by hermetically packaging the internal use adsorbent in a composite film having a sealant layer on the inner surface.
- the packaging material which has the sealant layer which can be used for the package of the internal use adsorption agent is disclosed by patent inventor of this application, for example.
- the internal packaging adsorbent is packed with a stick made of a composite film, and the upper part of the stick is heat-sealed, whereby the heat seal portion and the unsealing portion are formed.
- the packaging body which has can be produced.
- the adsorbent for internal use has the property of adsorbing and desorbing air in addition to the physical properties expected to be adsorbed. Specifically, by increasing the temperature of the surrounding environment, the air adsorbed by the internal use adsorbent is desorbed or released, or by reducing the pressure of the surrounding environment, the internal use adsorbent is similarly applied. The air adsorbed on is desorbed or released. This phenomenon is reversible. When the temperature of the surrounding environment is lowered, the surrounding air is adsorbed by the adsorbent for internal use, or the surrounding air is also increased by increasing the pressure of the surrounding environment. Adsorbed on the adsorbent.
- the packaging package when airtight packaging is performed at a low temperature, when the packaging package becomes high temperature, the air adsorbed on the internal adsorbent is desorbed or released, and the volume expansion of the packaging package occurs.
- the volume expansion of the packaging package may cause damage to the seal part, bag breakage, and formation of pinholes, and may also hinder storage and transportation.
- a method of filling at a temperature 5 ° C. to 300 ° C. higher than room temperature or filling under reduced pressure has been performed.
- Japanese Patent Publication No.62-11611 International Publication No. 2004/039331 Patent No. 3835698 JP 2005-314415 A (Patent No. 3865399) JP 2005-314416 A (Patent No. 3865400) Japanese Patent Laid-Open No. 2005-7827 Japanese Patent Application No. 5-246036 (Japanese Patent No. 2607422) JP 2004-244414 A
- the package body manufactured by the above method does not cause breakage of the seal portion, bag breakage, or formation of pinholes, and is very advantageous in storage and transportation.
- the internal use adsorbent made of spherical activated carbon is bitten into the heat seal part, and the heat seal becomes insufficient, or the internal use is near the top and bottom of the opening part.
- the adsorbent may adhere and the adsorbent for internal use may scatter when opened. Such a phenomenon is not observed in a normal powdered medicine package.
- an object of the present invention is to provide a packaged packaging body for internal use adsorbents that does not bite the internal use adsorbent at a heat seal portion.
- Another object of the present invention is to provide a packaged package in which the adsorbent for internal use is less likely to adhere in the vicinity of the opened portion in a vacuum state and the internal adsorbent is not scattered at the time of opening.
- the present inventor used a packaging material having an inner surface specific resistance average value ranging from 4.4 ⁇ 10 9 ⁇ to 1.0 ⁇ 10 16 ⁇ .
- the solution to the above problem is particularly related to the inner surface specific resistance average value of the packaging material and the surface charging characteristics of the internal use adsorbent.
- the internal use adsorbent is 0.028 to 0.707 ⁇ C / This was conspicuous in the case of spherical activated carbon having surface charging characteristics of g.
- the present invention is based on such knowledge.
- an internal use adsorbent is packaged in the range of 4.4 ⁇ 10 9 ⁇ or more to 1.0 ⁇ 10 16 ⁇ or less in the inner surface specific resistance value in a heated state and / or under reduced pressure.
- the present invention relates to a wrapping package characterized by being hermetically packaged with a material.
- the adsorbent for internal use is composed of spherical activated carbon having a surface charging property of 0.028 to 0.707 ⁇ C / g, and the surface charging property is enclosed in a fluororesin container. This is the charge amount after rotating the spherical activated carbon at 120 rpm for 5 minutes.
- the internal use adsorbent is an adsorbent for oral administration.
- the packaging material is a composite film including an outer layer, an intermediate layer, and an inner layer, and more preferably, the intermediate layer includes an aluminum layer.
- the packaging material comprises, from the outside, an outer layer comprising a polyethylene terephthalate layer and a polyethylene layer, an intermediate layer comprising an aluminum layer, and a polyethylene containing a polyethylene layer and an antistatic agent. It consists of an inner layer consisting of layers.
- the packaged shape has a width of 1 cm to 6 cm and a length of 6 to 15 cm.
- the internal adsorbent is packaged in the range of 4.4 ⁇ 10 9 ⁇ or more to 1.0 ⁇ 10 16 ⁇ or less in the heated state and / or under reduced pressure.
- the present invention relates to a method for manufacturing a packaged package, characterized by being hermetically packaged with a material.
- the packaging package of the present invention it is possible to provide a packaging package in which the internal adsorbent is not caught in the heat seal part and the internal adsorbent is very little scattered when opened.
- FIG. 1 It is a schematic diagram which shows 1 aspect of the packaging body of this invention.
- A shows the side view of the package body immediately after heat-sealing in a heated state after filling with an internal-use adsorbent.
- B shows the side view of the package body cooled to room temperature after heat sealing.
- C shows the front view of the packaging body cooled to room temperature after heat sealing.
- It is a schematic diagram of the electrode of an inner surface specific resistance (surface resistivity) measuring device. It is a graph which shows the surface charge characteristic of the spherical activated carbon manufactured by manufacture example 1 and 2, and the internal use adsorption agent of a commercial item. It is a schematic diagram which shows fixation to the agitator rotating shaft of the container holder which accommodated the sample container in the case of measuring surface charging characteristics.
- the package of the present invention is a hermetically sealed packaging material having an inner surface specific resistance average value of not less than 4.4 ⁇ 10 9 ⁇ and not more than 1.0 ⁇ 10 16 ⁇ when the adsorbent for internal use is heated. It is to be packaged.
- the internal use adsorbent used in the package of the present invention is not particularly limited as long as it is an internal use adsorbent that adsorbs harmful substances in the body.
- the internal use adsorbent is preferably composed of spherical activated carbon having a surface charging property of 0.028 to 0.707 ⁇ C / g.
- the surface charge characteristic of the internal use adsorbent is more preferably 0.142 to 0.594 ⁇ C / g, and most preferably 0.225 to 0.481 ⁇ C / g. *
- the “surface charge characteristics” of the adsorbent for internal use are measured as follows. Under an atmospheric condition of a temperature of 20 to 23 ° C. and a humidity of 45 to 60% RH, a cylindrical fluororesin container (hereinafter referred to as PFA) having a capacity of 60 mL with about 0.1 g of an adsorbent for internal use and an aluminum tape attached to the outer surface of the container Put in a container) and cover. Set the PFA container at 30 degrees on a rotary stirrer, and rotate at 120 rpm for 5 minutes.
- PFA cylindrical fluororesin container
- the PFA container is opened, and the adsorbent for internal use is sucked into the filter capsule in the charge measuring unit from the sample collection nozzle of the charge amount measuring device to measure the charge amount.
- the filter capsule is weighed, the tare weight of the filter capsule is removed, and the charge amount per unit mass (charge amount ⁇ C / g) of the internal use adsorbent is calculated individually. The average value and standard deviation of 10 repetitions are obtained. Let the average value be the charge amount (charge amount ⁇ C / g).
- Examples of the adsorbent for internal use include the adsorbent for oral administration composed of spherical activated carbon described in Patent Documents 1 to 4, and the adsorbent for pharmaceuticals described in Patent Document 7.
- an adsorbent for oral administration described in Patent Document 1 has a diameter of 0.05 to 1 mm, a pore volume of 0.2 to 1.0 mL / g with a pore radius of 80 angstroms or less, and both an acidic group and a basic group. It is a porous spherical carbonaceous material.
- the preferred ranges of acidic groups and basic groups are: total acidic group (A) 0.30 to 1.20 meq / g, total basic group (B) 0.20 to 0.70 meq / g, A / B 0.40. ⁇ 2.5.
- the adsorbent for oral administration described in Patent Document 2 is produced using a phenol resin or an ion exchange resin as a carbon source, has a diameter of 0.01 to 1 mm, and has a specific surface area of 1000 m 2 / g determined by the Langmuir adsorption formula.
- the adsorbent for oral administration is characterized by the above, and the main feature is that the pore volume with a pore diameter of 7.5 to 15000 nm is less than 0.25 mL / g.
- the adsorbent for oral administration described in Patent Document 3 is mainly composed of spherical activated carbon having an average particle size of 50 to 200 ⁇ m and a specific surface area determined by the BET method of 700 m 2 / g or more. Orally administered adsorbent. Furthermore, the adsorbent for oral administration described in Patent Document 4 has an average particle size of 50 to 200 ⁇ m, a specific surface area determined by the BET method of 700 m 2 / g or more, and a total acidic group of 0.30 meq / g.
- An orally administered adsorbent characterized in that it consists of surface-modified spherical activated carbon with a total basic group of ⁇ 1.20 meq / g and total basic groups of 0.20 meq / g to 0.9 meq / g.
- the packaging material used for the package of the present invention has an average value of the inner surface specific resistance in the range of 4.4 ⁇ 10 9 ⁇ to 1.0 ⁇ 10 16 ⁇ .
- the lower the inner surface specific resistance average value the better the sliding property.
- the filled adsorbent for adhering will stick to the vicinity of the unsealed portion of the wrapping package. It is not preferable because the adsorbent for internal use is scattered.
- the slipping property is poor, and the adsorbent for internal use adheres to the entire inner surface of the packaging material, and the internal adsorbent is caught in the heat seal portion and used at the time of opening.
- the average value of the inner surface specific resistance is preferably 4.5 ⁇ 10 9 ⁇ to 7.5 ⁇ 10 15 ⁇ , and most preferably 5.2 ⁇ 10 9 ⁇ to 5.1 ⁇ 10 15 ⁇ .
- the “average inner surface resistivity” of the packaging material is measured as follows in accordance with JIS K 6911.
- An inner surface specific resistance (surface resistivity) measuring instrument for example, a superinsulator R-503 and a measuring electrode P-616 (manufactured by Kawaguchi Electric Co., Ltd.)
- FIG. 2 shows a schematic diagram of the packaging material and the electrode at the time of measurement.
- the packaging material is sandwiched between a circular front electrode and a back electrode, a voltage of 500 V is applied, and a resistance value after 1 minute is measured.
- the surface resistance value is obtained by the following formula.
- the individual measured values are repeatedly obtained three times, and the average value is defined as the inner surface specific resistance average value.
- the packaging material is not limited as long as it has the above-mentioned inner surface specific resistance average value, and any of a composite film (laminated film) and a single layer film can be used, but it has good workability and moisture resistance. Because of this, a composite film is more preferable.
- a composite film what contains an outer layer, an intermediate
- An intermediate layer composed of an aluminum layer and the like excellent in gas barrier properties and moisture-proof properties
- an inner layer composed of a sealant layer having heat sealing properties and ultrasonic sealing properties.
- aluminum vapor deposition or silica vapor deposition may be used as an outer layer and an intermediate layer.
- the packaging material is antistatic on at least one of the outer layer, the intermediate layer, and the inner layer in order to obtain an inner surface specific resistance average value in the range of 4.4 ⁇ 10 9 ⁇ to 1.0 ⁇ 10 16 ⁇ .
- An agent can be included.
- the antistatic agent can be contained in the packaging material as an antistatic agent layer, but can also be applied or kneaded into the layers constituting the outer layer, the intermediate layer, and the inner layer. Preferably, it is applied or kneaded into any of the layers constituting the inner layer that comes into contact with the adsorbent for internal use.
- Antistatic agents include, but are not limited to, antistatic resins (for example, cationic acrylic resins or resins containing conductive inorganic particles); alkyl quaternary ammonium salts; polyoxyethylene ether charging Inhibitors (eg, polyoxyethylene sorbitan fatty acid esters or polyoxyethylene sorbitan fatty acid esters); anionic antistatic agents; nonionic surfactants; fatty acid amines (eg, laurylamine, myristylamine, palmitylamine, stearylamine, Or oleylamine); fatty acid glycerides (for example, fatty acid monoglycerides in which the acyl group has 10 to 22 carbon atoms); or higher alcohols (for example, saturated or unsaturated aliphatic alcohols having 8 to 36 carbon atoms). , Especially fatty acid amines, fatty acid groups Ceilidh, or higher alcohols are preferred.
- antistatic resins for example, cationic acrylic resins or resins containing conductive
- the outer layer, the intermediate layer, and the inner layer constituting the packaging material may be, for example, a plastic coating layer when the intermediate layer has a high elastic modulus and good dimensional stability. Furthermore, a plastic film layer, a plastic coating layer, a cellophane layer, a paper layer, or the like can be formed between these layers. Depending on the purpose, the outer layer or the intermediate layer may be omitted.
- the sealant layer can be formed on either the entire inner surface or the seal portion. Moreover, you may use the sealant layer which has many small holes. It is also possible to form a container for a package by using a normal adhesive without a sealant layer.
- plastics used in plastic films and plastic coating layers are polyester (eg, polyethylene terephthalate), polyvinylidene chloride, polyvinyl chloride, ethylene / vinyl alcohol copolymer, ethylene vinyl acetate copolymer, stretched polypropylene, polypropylene, stretched Polyethylene, high density polyethylene, medium density polyethylene, linear low density polyethylene, low density polyethylene, ethylene / propylene copolymer, ethylene / butene copolymer, polybutene-1, ionomer, ethylene acrylic alkylate copolymer, ethylene / methacrylic Acid copolymer, polychlorotrifluoroethylene, Teflon (registered trademark), polyvinyl alcohol, polyacrylonitrile, acrylonitrile / budadiene / styrene copolymer, cellulose Scan, polystyrene, polycarbonate, nylon (polyamide) or the like.
- polyester eg, polyethylene tere
- Polyester for example, polyethylene terephthalate
- polyvinylidene chloride various polyethylenes
- various polypropylenes are preferable.
- heat resistant polymers are preferred. Examples of heat resistant polymers are hydroxybenzoic acid polyester, polypropylene, poly-4-methylpentene-1, polyester (eg polyethylene terephthalate), polycarbonate, polyetherimide, polyarylate and the like.
- Examples of paper are glassine, milk white glassine, cormorant paper, cellophane, hatron paper, fine paper, imitation paper, sulfuric acid paper and the like, and glassine, milk white glassine, cormorant paper and cellophane are particularly preferable.
- Examples of intermediate layers with excellent gas barrier properties and moisture-proof properties include aluminum layers such as aluminum foil and aluminum vapor deposition layers, polychlorotrifluoroethylene layers, polyvinylidene chloride layers, polyvinylidene chloride copolymer layers, ethylene / vinyl alcohol copolymer A coalesced layer, a silica deposited layer, an alumina deposited layer, and the like.
- an aluminum layer, a polychlorotrifluoroethylene layer, a polyvinylidene chloride layer, or an ethylene / vinyl alcohol copolymer layer is preferable, and an aluminum layer is more preferable.
- sealant layers include various olefin polymers, olefin copolymers, polyvinyl acetate, vinyl chloride / vinyl acetate copolymers, polyvinylidene chloride, ethylene acrylic alkylate copolymers, polybutadiene, polyesters (eg, polyethylene terephthalate), or copolymers. Polyester polymers and the like. Particularly preferred are polyvinylidene chloride, various polyethylenes, and ethylene acrylic alkylate copolymers.
- heat resistant polymers are preferred.
- heat resistant polymers are hydroxybenzoic acid polyesters, polypropylene, poly-4-methylpentene-1, polyesters (eg polyethylene terephthalate), polycarbonates, polyetherimides, polyarylates, etc., especially hydroxybenzoic acid polyesters or polyethers An imide is preferred.
- a particularly preferable configuration example is as follows.
- Outer layer glassine, milk white glassine, cormorant paper, cellophane, polyester (eg, polyethylene terephthalate), nylon, polyethylene, fine paper, or heat-resistant polymer
- Intermediate layer aluminum layer (foil or vapor deposition)
- Inner layer polyvinylidene chloride, polyethylene, ethylene acrylic An alkylate copolymer or a heat-resistant polymer If necessary, an ethylene-vinyl acetate copolymer layer or a polyethylene layer is provided as an adhesive layer between the layers.
- the configuration of each layer itself is not limited to the configuration using one kind of material, and two or more kinds of materials can be combined.
- the composite film (a) has an inner surface specific resistance average value of 5.1 ⁇ 10 15 ⁇ , and the composite film (b) has an inner surface specific resistance average value of 5.2 ⁇ 10 9 ⁇ . ing.
- a numerical value with “about” means a numerical value in a range of ⁇ 10%.
- the packaged package of the present invention can be produced by air-tightly packaging the adsorbent for internal use with the packaging material (A) in a heated state and / or (B) under reduced pressure.
- hermetic packaging in the heated state (A) and reduced pressure (B) include the following methods.
- a packing bag is filled with an adsorbent for internal use at a temperature of 5 ° C. to 300 ° C. higher than room temperature and then sealed.
- the packaging material and the internal use adsorbent are heated to a temperature 5 ° C. to 300 ° C. higher than room temperature and sealed.
- the lower limit temperature is preferably 10 ° C higher than room temperature, more preferably 15 ° C higher than room temperature.
- the upper limit temperature is preferably 200 ° C, more preferably 130 ° C.
- the two methods of the method (A) in a warmed state and the method (B) under reduced pressure can be simultaneously performed.
- an adsorbent for internal use at a temperature higher than room temperature to 300 ° C. is filled in a packaging bag and sealed under a pressure of atmospheric pressure or lower.
- the two methods since the two methods are performed simultaneously, it is not necessary to raise the filling temperature by 5 ° C. or more from room temperature.
- room temperature means the temperature at the filling place, and the range is 1 to 30 ° C. as stipulated by the Japanese Pharmacopoeia.
- the “adsorbent for internal use at a temperature of 5 ° C. to 300 ° C. higher than room temperature” when filling is, for example, when the temperature of the filling place is 15 ° C.
- the temperature of the place is 30 ° C.
- the temperature of the adsorbent for internal use at filling is less than 5 ° C. higher than room temperature, the internal use adsorbent in the package can move.
- the package body is greatly deformed by the change in the amount of air contained in the internal use adsorbent due to external temperature fluctuations.
- the temperature of the adsorbent for internal use at filling is 5 ° C. to 300 ° C. higher than room temperature
- the internal adsorbent adsorbs the air in the bag until the temperature drops to room temperature after sealing.
- the pressure in the bag is lowered, the package is rapidly squeezed, and the adsorbent for internal use does not move and is in a vacuum state. And the packaging body is hardly deformed by a temperature change near room temperature.
- the package package filled at a temperature of 5 ° C. to 300 ° C. above the room temperature is suitable for short-term storage up to several months, and a package package packed at 30 to 300 ° C. is preferable for year-round storage. . More preferably, it is 35 to 200 ° C, and still more preferably 40 to 130 ° C.
- the packaging shape of the packaging body of the present invention is not particularly limited, but those having a width of 1 cm to 6 cm and a length of 6 to 15 cm are preferable.
- an adsorbent for oral administration used for kidney disease patients it is suitable for filling an adsorbent for internal use of about 1 to 4 g, which is a single dose.
- the surface resistivity average value of the packaging material and the surface charge characteristics of the internal use adsorbent were measured by the following methods.
- the inner surface specific resistance average value was measured in accordance with JIS K 6911.
- a superinsulator R-503 and a measuring electrode P-616 are used as an internal surface specific resistance (surface resistivity) measuring instrument.
- the packaging material (100 mm ⁇ 100 mm) is sandwiched between the front electrode and the back electrode so that the inner surface of the packaging material is on the front electrode side.
- a is 80 ⁇ 0.5 mm
- D is 70 ⁇ 0.5 mm
- d is 50 ⁇ 0.5 mm
- a in the back electrode is 83 ⁇ 2 mm.
- a voltage of 500 V is applied to the positive electrode and negative electrode of the surface electrode, and the resistance value after 1 minute is measured.
- the surface resistivity ( ⁇ ) was calculated by the following formula. Three individual measurement values (three measurements for the same lot) were determined repeatedly, and the average value was defined as the inner surface specific resistance average value.
- Container inner surface treatment before use When the sample to be measured is switched, clean it thoroughly with a detergent and then dry it thoroughly. Before use, remove dirt and the like in the container using isopropanol, and perform static elimination sufficiently using a static elimination blower (MIDORI CT & ESD MI200S). When repeatedly measuring the same sample, wipe off dirt in the container using isopropanol before use, and sufficiently remove the charge using a charge removal blower (MIDORI CT & ESD MI200S). Use 5 containers and label them for management. (Iv) Measurement method: About 0.1 g of the adsorbent for internal use is put in a PFA container and covered.
- the string-like molded body was crushed so that the ratio of diameter to length was about 1-2.
- naphthalene in the pitch formed body was extracted and removed with n-hexane, which was about 6 times the weight of the spherical pitch formed body.
- the porous spherical pitch obtained in this way was heated to 235 ° C. through heated air using a fluidized bed, and then oxidized by holding at 235 ° C. for 1 hour, so that it was infusible to heat.
- a porous spherical oxide pitch was obtained.
- the porous spherical oxidized pitch was activated at 900 ° C.
- porous spherical activated carbon for 170 minutes in a nitrogen gas atmosphere containing 50 vol% of water vapor using a fluidized bed to obtain porous spherical activated carbon. Then, oxidation treatment is performed at 470 ° C. for 3 hours and 15 minutes in a mixed gas atmosphere of nitrogen and oxygen having an oxygen concentration of 18.5 vol%, and then reduction treatment is performed at 900 ° C. for 17 minutes in a fluidized bed under a nitrogen gas atmosphere. A porous spherical carbonaceous material was obtained. The main characteristics of the obtained carbonaceous material are as follows.
- a porous spherical carbonaceous material (surface-modified spherical activated carbon) was obtained in the same manner as in the method described in Example 1 of JP-A-2005-314416.
- the specific operation is as follows. 220 g of deionized water and 58 g of methylcellulose were placed in a 1 L separable flask, and 105 g of styrene, 184 g of 57% divinylbenzene (57% divinylbenzene and 43% ethylvinylbenzene), 2,2′-azobis.
- the infusibilizing condition is that a spherical porous oxide resin is obtained by flowing dry air from the lower part of the reaction tube to the upper part at 3 L / min, raising the temperature to 260 ° C. at 5 ° C./h, and holding at 260 ° C. for 4 hours.
- spherical porous oxidized resin After heat treatment of spherical porous oxidized resin at 600 ° C. for 1 hour in a nitrogen atmosphere, activation treatment was performed at 820 ° C.
- the obtained spherical activated carbon was further oxidized in a fluidized bed at 470 ° C. for 3 hours and 15 minutes in a mixed gas atmosphere of nitrogen and oxygen having an oxygen concentration of 18.5 vol%, and then in a fluidized bed under a nitrogen gas atmosphere 900 Reduction treatment was carried out at 17 ° C. for 17 minutes to obtain surface-modified spherical activated carbon.
- the main characteristics of the obtained surface-modified spherical activated carbon are as follows.
- the surface activated characteristics of the spherical activated carbon produced in Production Examples 1 and 2 and the commercially available internal-use adsorbent 1, internal-use adsorbent 2 and internal-use adsorbent 3 were measured according to the above-described method. The results are shown in FIG.
- the charge amount of the spherical activated carbon obtained in Production Example 1 is 0.442 ⁇ C / g and the standard deviation is ⁇ 0.017 ⁇ C / g
- the charge amount of the spherical activated carbon obtained in Production Example 2 is 0.286 ⁇ C / g and the standard deviation.
- the charge amount of the internal use adsorbent 1 is 0.368 ⁇ C / g
- the standard deviation is ⁇ 0.113 ⁇ C / g
- the charge amount of the internal use adsorbent 2 is 0.409 ⁇ C / g
- the charge amount of the adsorbent 3 for internal use is 0.285 ⁇ C / g
- the standard deviation is ⁇ 0.060 ⁇ C / g, both of which are included in 0.028 to 0.707 ⁇ C / g Met.
- Example 1 Adsorbent for internal use consisting of spherical activated carbon obtained in Production Example 1 and polyethylene terephthalate layer (about 16 ⁇ m) / polyethylene layer (about 15 ⁇ m) / aluminum layer (about 9 ⁇ m) / polyethylene layer (about 15 ⁇ m) / antistatic Using a composite film 1 composed of a polyethylene layer (about 30 ⁇ m) containing an agent, a wrapping package was produced. The average value of the inner surface specific resistance of the composite film 1 was measured according to the method described above.
- the packing was performed with a filling rate of 50 shots per minute, a spherical activated carbon (adsorbed charcoal) filling amount of 2 g, a stick packaging shape of 3 cm wide and 9 cm long.
- Spherical activated carbon heated to 60 to 80 ° C. was filled in 2 g into a stick packaging bag, and heat-sealed at about 130 to 150 ° C.
- the manufactured stick package was held in an inverted state and cooled to room temperature to obtain a stick package.
- Example 2 instead of the composite film 1, a composite film 2 comprising a polyethylene terephthalate layer (about 16 ⁇ m) / polyethylene layer (about 15 ⁇ m) / aluminum layer (about 9 ⁇ m) / polyethylene layer (about 15 ⁇ m) / polyvinylidene chloride layer (about 3 ⁇ m) is used. The procedure of Example 1 was repeated except that it was used. The results are shown in Table 2.
- Comparative Example 1 In place of the composite film 1, a composite film 3 composed of a polyethylene terephthalate layer (about 12 ⁇ m) / dry adhesive / aluminum layer (about 9 ⁇ m) / dry adhesive / uncharged polyethylene layer (about 40 ⁇ m) was used. Repeated the operation of Example 1. The results are shown in Table 2.
- Comparative Example 2 a composite film 4 comprising a polyethylene terephthalate layer (about 16 ⁇ m) / polyethylene layer (about 15 ⁇ m) / aluminum layer (about 9 ⁇ m) / polyethylene layer (about 15 ⁇ m) / polyethylene layer (about 30 ⁇ m) was used. Except for this, the operation of Example 1 was repeated. The results are shown in Table 2.
- the inner surface of the packaging material used when it is considered that there is no quality problem in the range of ⁇ to ⁇ in the evaluation results of the number of spherical activated carbon particles in the heat seal part (11), unsealed upper part (12), and unsealed lower part (13) The surface resistivity average value range of was 1.0 ⁇ 10 16 ⁇ or less. Further, as a useful range, the lower limit value of the average surface resistivity of the inner surface of the packaging material in the range of ⁇ which is considered to have no problem in terms of quality is 4 which is the lowest value of the individual measured values of Example 2. .3 ⁇ 10 9 ⁇ , and the highest individual measured value of Comparative Example 1 is 4.4 ⁇ 10 9 ⁇ .
- the limit value is in this vicinity, which is the highest value of Comparative Example 1. 4 ⁇ 10 9 ⁇ was adopted.
- the upper limit value is 1.0 ⁇ 10 16 ⁇ for the highest individual measured value in Example 1, and 1.0 ⁇ 10 16 ⁇ ⁇ for the lowest individual measured value in Comparative Example 2. Therefore, 1.0 ⁇ 10 16 ⁇ , which is the highest individual measured value in Example 1, was adopted.
- the package of the present invention does not bite the internal use adsorbent in the heat seal part, and since there is no internal use adsorbent in the opening part, the internal use adsorbent is very little scattered at the time of opening. That is, it prevents intrusion of outside air into the wrapping package due to biting into the heat seal part, can suppress deterioration of the quality of the internal use adsorbent, and prevents the internal use adsorbent from being scattered during opening. Usability can be improved. As mentioned above, although this invention was demonstrated along the specific aspect, the deformation
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Abstract
Description
従って、本発明の課題は、内服用吸着剤の分包包装体において、ヒートシール部での内服用吸着剤の噛み込みのない分包包装体を提供することである。また、真空状態の開封部近辺において、内服用吸着剤の付着が少なく、開封時に内服用吸着剤が飛散しない分包包装体を提供することである。
本発明者は、前記課題を解決するため、鋭意研究を進めた結果、内面表面固有抵抗平均値が4.4×109Ω以上から1.0×1016Ω以下の範囲の包装材料を用いて、内服用吸着剤を気密包装することにより、前記課題を解決できることを見出した。前記課題の解決は、特に包装材料の内面表面固有抵抗平均値と、内服用吸着剤の表面帯電特性とに関連するものであるが、特に、内服用吸着剤が0.028~0.707μC/gの表面帯電特性を有する球状活性炭である場合に、顕著であった。
本発明は、このような知見に基づくものである。
本発明の分包包装体の好ましい態様においては、前記内服用吸着剤が0.028~0.707μC/gの表面帯電特性を有する球状活性炭からなり、前記表面帯電特性は、フッ素樹脂容器に封入した球状活性炭を、120回転/分で5分間回転した後の帯電量である。
本発明の分包包装体の好ましい態様においては、前記内服用吸着剤が経口投与用吸着剤である。
本発明の分包包装体の別の好ましい態様においては、包装材料が、外層、中間層、及び内層を含む複合フィルムであり、より好ましくは、前記中間層がアルミニウム層を含む。
更に、本発明の分包包装体の好ましい態様においては、前記包装材料が、外側からポリエチレンテレフタレート層及びポリエチレン層からなる外層、アルミニウム層からなる中間層、並びにポリエチレン層及び静電防止剤を含むポリエチレン層からなる内層からなる。
本発明の分包包装体の別の好ましい態様においては、分包形状が幅1cm~6cmであり、且つ長さが6~15cmである。
また、本発明は、内服用吸着剤を、加温状態及び/又は減圧下において、内面表面固有抵抗平均値が4.4×109Ω以上から1.0×1016Ω以下の範囲の包装材料で気密包装することを特徴とする、分包包装体の製造方法に関する。
例えば、特許文献1に記載の経口投与用吸着剤は、直径0.05~1mm、細孔半径80オングストローム以下の空隙量0.2~1.0mL/g、酸性基と塩基性基の両方を有する多孔性の球形炭素質物質である。酸性基と塩基性基の好ましい範囲は、全酸性基(A)0.30~1.20meq/g、全塩基性基(B)0.20~0.70meq/g、A/B 0.40~2.5である。
内面表面固有抵抗平均値は、好ましくは4.5×109Ω~7.5×1015Ωであり、最も好ましくは5.2×109Ω~5.1×1015Ωである。
二重リング電極法による内面表面固有抵抗(表面抵抗率)測定器(例えば、超絶縁計R-503及び測定電極P-616(株)川口電機製作所製)を用いる。図2に測定時の包装材料と電極との模式図を示すが、包装材料を円形の表面電極及び裏面電極で挟み、500Vの電圧を印加し1分後の抵抗値を測定する。表面抵抗値は以下の式で求める。繰り返し3回の個別実測値を求め、その平均値を内面表面固有抵抗平均値とする。
p=(π(D+d)/D-d)×R
R=V/Is
p:表面抵抗率(Ω)
D:リング電極内径(cm)
d:表面電極の内縁の外径(cm)
R:表面抵抗(Ω)
V:印加電圧(500V)
I:電圧印加1分後の電流(A)
(1)弾性率が高く、寸法安定性の良いプラスチックフィルム、セロハン、紙等からなる外層、
(2)ガスバリア性と防湿性に優れるアルミニウム層等からなる中間層、及び
(3)ヒートシール性や超音波シール性のあるシーラント層等からなる内層。
前記において、外層と中間層を兼ね備えたものとしてアルミ蒸着やシリカ蒸着したものなどもある。
帯電防止剤としては、限定されるものではないが、帯電防止樹脂、(例えばカチオン性アクリル樹脂等、又は導電性無機粒子を含む樹脂);アルキル第4級アンモニウム塩;ポリオキシエチレンンエーテル系帯電防止剤、(例えばポリオキシエチレンソルビタン脂肪酸エステル又はポリオキシエチレンソルビタン脂肪酸エステル);アニオン系帯電防止剤;ノニオン系界面活性剤;脂肪酸アミン(例えば、ラウリルアミン、ミリスチルアミン、パルミチルアミン、ステアリルアミン、又はオレイルアミン);脂肪酸グリセリド(例えば、アシル基の炭素数が10~22である脂肪酸モノグリセリド);又は高級アルコール(例えば、炭素数8~36の飽和又は不飽和の脂肪族アルコール)を挙げることができ、特には脂肪酸アミン、脂肪酸グリセリド、又は高級アルコールが好ましい。
(a)外側から約16μmのポリエチレンテレフタレート層及び約15μmのポリエチレン層からなる外層、約9μmのアルミニウム層からなる中間層、並びに約15μmのポリエチレン層及び約30μmの静電防止剤を含むポリエチレン層からなる内層からなる、複合フィルム、及び
(b)外側から約16μmのポリエチレンテレフタレート層及び約15μmのポリエチレン層からなる外層、約9μmのアルミニウム層からなる中間層、並びに約15μmのポリエチレン層及び約3μmのポリ塩化ビニリデン層からなる内層からなる、複合フィルム、を挙げることができる。前記複合フィルム(a)は、5.1×1015Ωの内面表面固有抵抗平均値を有し、前記複合フィルム(b)は5.2×109Ωの内面表面固有抵抗平均値を有している。
なお、本明細書において、「約」の付された数値は、±10%の範囲の数値を意味する。
(A)室温より5℃高い温度乃至300℃の内服用吸着剤を分包包装袋に充填後シールする。又は、内服用吸着剤を分包包装袋に充填後、包装材料と内服用吸着剤とを、室温より5℃高い温度乃至300℃に加温し、シールする。下限の温度は、好ましくは室温より10℃高い温度、より好ましくは室温より15℃高い温度である。上限の温度は、好ましくは200℃、より好ましくは130℃である。
(B)内服用吸着剤を分包包装袋に充填した後、大気圧以下の圧力下でシールする。
以下の実施例において、包装材料の表面固有抵抗平均値及び内服用吸着剤の表面帯電特性は以下の方法で測定した。
(1)内面表面固有抵抗平均値
内面表面固有抵抗平均値は、JIS K 6911に準拠して測定した。内面表面固有抵抗(表面抵抗率)測定器は、超絶縁計R-503及び測定電極P-616((株)川口電機製作所製)を用いる。包装材料(100mm×100mm)を包装材料内層面が表面電極側になるようにして、表面電極及び裏面電極で挟む。表面電極におけるaは80±0.5mm、Dは70±0.5mm、dは50±0.5mmであり、裏面電極におけるAは83±2mmである。表面電極の+極と-極に500Vの電圧を印加し、1分後の抵抗値を測定する。表面抵抗率(Ω)は以下の式で計算した。繰り返し3回の個別実測値(同一ロットについて3回の測定)を求め、その平均値を内面表面固有抵抗平均値とした。
p=(π(D+d)/D-d)×R
R=V/Is
p:表面抵抗率(Ω)
D:リング電極内径(cm)
d:表面電極の内縁の外径(cm)
R:表面抵抗(Ω)
V:印加電圧(500V)
I:電圧印加1分後の電流(A)
以下の条件で帯電量を測定した。繰り返し10回の平均値と標準偏差を求め、平均値を帯電量とした。
(i)測定環境:
20~23℃,45~60%RH。
(ii)使用容器:
60mLの円柱状PFA樹脂容器(アズワン(株)製、PAF樹脂容器、PF-60、蓋部外径:約60mm、胴部外径:約53mm、高さ:約44mm、内径:約48mm、内高さ:約36mm、いずれも蓋をしたときの寸法)であり、容器外面、蓋外面にアルミテープを貼付した容器(PFA容器)。
(iii)使用前の容器内面処置:
測定検体が切り替わる時は、洗剤を用いて入念に洗浄した後、十分に乾燥させる。使用前にイソプロパノールを用いて容器内の汚れ等をふき取り、除電ブロア(MIDORI CT&ESD MI200S)を用いて十分除電を行う。同じ検体を繰り返し測定する場合は、使用前にイソプロパノールを用いて容器内の汚れ等をふき取り、除電ブロア(MIDORI CT&ESD MI200S)を用いて十分除電を行う。使用容器は5個とし、ラベリングして管理する。
(iv)測定方法:
約0.1gの内服用吸着剤を、PFA容器に入れ、蓋をする。これを内面にスポンジ緩衝材を付した容器ホルダー(直径約70mm、高さ約90mm)に入れ、この容器ホルダーを回転攪拌機の回転軸に対して30度傾斜させた状態にセットし、毎分120回転で5分間回転させ、内服用吸着剤を帯電処理する(図4)。帯電処理したPFA容器の蓋を開き、帯電量測定装置EA02(ユーテック製)の検体採取ノズルから、内服用吸着剤を電荷計測部内のフィルタカプセルに吸い込んで電荷量を測定する。なお、フィルタカプセルは、予め重量を測定することによって、風袋処理しておく。電荷量の測定後、フィルタカプセルを取り出し、吸着炭検体質量を秤量して、単位質量あたりの電荷量(帯電量μC/g)を算出する。尚、10回の繰り返し測定値の平均値と標準偏差を求めた。
特許第3522708号(特開2002-308785号公報)の実施例1に記載の方法と同様にして多孔性球状炭素質物質を得た。具体的な操作は、以下の通りである。
石油系ピッチ(軟化点=210℃;キノリン不溶分=1重量%以下;H/C原子比=0.63)68kgと、ナフタレン32kgとを、攪拌翼のついた内容積300Lの耐圧容器に仕込み、180℃で溶融混合を行った後、80~90℃に冷却して押し出し、紐状成形体を得た。次いで、この紐状成形体を直径と長さの比が約1~2になるように破砕した。
0.23重量%のポリビニルアルコール(ケン化度=88%)を溶解して93℃に加熱した水溶液中に、前記の破砕物を投入し、攪拌分散により球状化した後、前記のポリビニルアルコール水溶液を水で置換することにより冷却し、20℃で3時間冷却し、ピッチの固化及びナフタレン結晶の析出を行い、球状ピッチ成形体スラリーを得た。
大部分の水をろ過により除いた後、球状ピッチ成形体の約6倍重量のn-ヘキサンでピッチ成形体中のナフタレンを抽出除去した。このようにして得た多孔性球状ピッチを、流動床を用いて、加熱空気を通じながら、235℃まで昇温した後、235℃にて1時間保持して酸化し、熱に対して不融性の多孔性球状酸化ピッチを得た。
続いて、多孔性球状酸化ピッチを、流動床を用い、50vol%の水蒸気を含む窒素ガス雰囲気中で、900℃で170分間賦活処理して多孔性球状活性炭を得、更にこれを流動床にて、酸素濃度18.5vol%の窒素と酸素との混合ガス雰囲気下で470℃で3時間15分間、酸化処理し、次に流動床にて窒素ガス雰囲気下で900℃で17分間還元処理を行い、多孔性球状炭素質物質を得た。
得られた炭素質材料の主な特性は以下の通りである。
比表面積=1300m2/g(BET法);
細孔容積=0.08mL/g
(水銀圧入法により求めた細孔直径20~15000nmの範囲の細孔容積);
平均粒子径=350μm;
全酸性基=0.67meq/g;及び
全塩基性基=0.54meq/g。
特開2005-314416号公報の実施例1に記載の方法と同様にして多孔性球状炭素質物質(表面改質球状活性炭)を得た。具体的な操作は、以下の通りである。
脱イオン交換水220g、及びメチルセルロース58gを1Lのセパラブルフラスコに入れ、これにスチレン105g、純度57%ジビニルベンゼン(57%のジビニルベンゼンと43%のエチルビニルベンゼン)184g、2,2’-アゾビス(2,4-ジメチルバレロニトリル)1.68g、及びポロゲンとして1-ブタノール63gを適宜加えたのち、窒素ガスで系内を置換し、この二相系を200rpmで攪拌し、55℃に加熱してからそのまま20時間保持した。得られた樹脂を濾過し、ロータリーエバポレーターで乾燥させたのち、減圧乾燥機にて1-ブタノールを樹脂から蒸留により除去してから、90℃において12時間減圧乾燥させ、平均粒子径180μmの球状の多孔性合成樹脂を得た。多孔性合成樹脂の比表面積は約90m2/gであった。
得られた球状の多孔性合成樹脂100gを目皿付き反応管に仕込み、縦型管状炉にて不融化処理を行った。不融化条件は、3L/minで乾燥空気を反応管下部より上部に向かって流し、5℃/hで260℃まで昇温したのち、260℃で4時間保持することにより球状の多孔性酸化樹脂を得た。球状の多孔性酸化樹脂を窒素雰囲気中600℃で1時間熱処理したのち、流動床を用い、64.5vol%の水蒸気を含む窒素ガス雰囲気中、820℃で10時間賦活処理を行い、球状活性炭を得た。得られた球状活性炭を、更に流動床にて、酸素濃度18.5vol%の窒素と酸素の混合ガス雰囲気下470℃で3時間15分間酸化処理し、次に流動床にて窒素ガス雰囲気下900℃で17分間還元処理を行い、表面改質球状活性炭を得た。
得られた表面改質球状活性炭の主な特性は以下の通りである。
比表面積=1763m2/g(BET法);
細孔容積=0.05mL/g
(水銀圧入法により求めた細孔直径20~15000nmの範囲の細孔容積);
平均粒子径=111μm(Dv50);
全酸性基=0.59meq/g;及び
全塩基性基=0.61meq/g。
前記製造例1及び2で製造した球状活性炭、及び市販品の内服用吸着剤1、内服用吸着剤2、内服用吸着剤3の表面帯電特性を、前記の方法に従って測定した。結果を図3に示す。
製造例1で得られた球状活性炭の帯電量は0.442μC/g、標準偏差は±0.017μC/g、製造例2で得られた球状活性炭の帯電量は0.286μC/g、標準偏差は±0.021μC/g、内服用吸着剤1の帯電量は0.368μC/g、標準偏差は±0.113μC/g、内服用吸着剤2の帯電量は0.409μC/g、標準偏差は±0.051μC/g、内服用吸着剤3の帯電量は0.285μC/g、標準偏差は±0.060μC/gであり、いずれも0.028~0.707μC/gに含まれるものであった。
前記製造例1で得られた球状活性炭からなる内服用吸着剤、及びポリエチレンテレフタレート層(約16μm)/ポリエチレン層(約15μm)/アルミニウム層(約9μm)/ポリエチレン層(約15μm)/静電防止剤を含むポリエチレン層(約30μm)からなる複合フィルム1を用いて、分包包装体を製造した。複合フィルム1の内面表面固有抵抗平均値は前記の方法に従って測定した。
岩黒製作所製3列スティック包装機を用いて、充填速度毎分50ショット、球状活性炭(吸着炭)の充填量2g、スティック分包形状を幅3cm、長さ9cmとして、充填包装を行った。60~80℃に加温した球状活性炭を、スティック包装袋に2gずつ充填し、 約130~150℃でヒートシールした。製造したスティック分包品は倒立させた状態で保持して室温まで冷却してスティック分包包装体を得た。
得られたスティック分包包装体について、ヒートシール部における球状活性炭の噛み込み及び開封部付近の球状活性炭の付着を検討した。具体的には、図1におけるヒートシール部(11)、開封上部(12)、及び開封下部(13)における噛み込み、又は付着した球状活性炭の粒子数を100包について肉眼で計数し、平均を求めた。結果は、表1の評価基準に従い、評価した。
複合フィルム1に代えて、ポリエチレンテレフタレート層(約16μm)/ポリエチレン層(約15μm)/アルミニウム層(約9μm)/ポリエチレン層(約15μm)/ポリ塩化ビニリデン層(約3μm)からなる複合フィルム2を用いたことを除いては、実施例1の操作を繰り返した。結果を表2に示す。
複合フィルム1に代えて、ポリエチレンテレフタレート層(約12μm)/ドライ接着剤/アルミニウム層(約9μm)/ドライ接着剤/非電荷ポリエチレン層(約40μm)からなる複合フィルム3を用いたことを除いては、実施例1の操作を繰り返した。結果を表2に示す。
複合フィルム1に代えて、ポリエチレンテレフタレート層(約16μm)/ポリエチレン層(約15μm)/アルミニウム層(約9μm)/ポリエチレン層(約15μm)/ポリエチレン層(約30μm)からなる複合フィルム4を用いたことを除いては、実施例1の操作を繰り返した。結果を表2に示す。
以上、本発明を特定の態様に沿って説明したが、当業者に自明の変形や改良は本発明の範囲に含まれる。
11・・・ヒートシール部;
12・・・開封上部;
13・・・開封下部;
14・・・開封用ミシン目付与部;
21・・・包装材料(内層を表面電極側とする);
22・・・表面電極(+);
23・・・表面電極(-)
24・・・ガード電極;
31・・・容器ホルダー;
32・・・試料容器(PFA容器);
33・・・スポンジ等の緩衝材;
34・・・攪拌機回転軸固定面;
35・・・攪拌機回転軸。
Claims (8)
- 内服用吸着剤を、加温状態及び/又は減圧下において、内面表面固有抵抗平均値が4.4×109Ω以上から1.0×1016Ω以下の範囲の包装材料で気密包装することを特徴とする、分包包装体。
- 内服用吸着剤が0.028~0.707μC/gの表面帯電特性を有する球状活性炭からなり、表面帯電特性は、フッ素樹脂容器に封入した球状活性炭を、120回転/分で5分間回転した後の帯電量である、請求項1に記載の分包包装体。
- 内服用吸着剤が経口投与用吸着剤である、請求項1又は2に記載の分包包装体。
- 包装材料が、外層、中間層、及び内層を含む複合フィルムである、請求項1~3のいずれか一項に記載の分包包装体。
- 包装材料の中間層がアルミニウム層を含む、請求項4に記載の分包包装体。
- 包装材料が、外側からポリエチレンテレフタレート層及びポリエチレン層からなる外層、アルミニウム層からなる中間層、並びにポリエチレン層及び静電防止剤を含むポリエチレン層からなる内層で構成される、請求項4又は5に記載の分包包装体。
- 分包形状が幅1cm~6cmであり、且つ長さが6~15cmであることを特徴とする請求項1の分包包装体。
- 内服用吸着剤を、加温状態及び/又は減圧下において、内面表面固有抵抗平均値が4.4×109Ω以上から1.0×1016Ω以下の範囲の包装材料で気密包装することを特徴とする、分包包装体の製造方法。
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WO2020044453A1 (ja) * | 2018-08-29 | 2020-03-05 | 大日本印刷株式会社 | 包装体用積層体および包装体 |
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CN113879627B (zh) * | 2021-09-24 | 2023-02-14 | 江苏中大包装材料有限公司 | 一种自动分离落料式塑料薄膜热合机构及其热合工艺 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2607422B2 (ja) * | 1992-09-08 | 1997-05-07 | 呉羽化学工業株式会社 | 内服用吸着剤の分包包装体及びその製造方法 |
JP2006175729A (ja) * | 2004-12-22 | 2006-07-06 | Unitika Ltd | 分包袋用積層フィルムおよびそれからなる分包袋 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5673542A (en) * | 1979-11-22 | 1981-06-18 | Kureha Chem Ind Co Ltd | Adsorbent |
JPS6211611A (ja) | 1985-07-10 | 1987-01-20 | ロ−ム株式会社 | 半導体ペレツトの製造方法 |
JP2891439B2 (ja) | 1992-03-02 | 1999-05-17 | シルバー精工株式会社 | 連続噴射型インクジェット記録装置および そのインクジェット飛翔軸自動調整方法 |
CA2105413C (en) * | 1992-09-08 | 2001-04-24 | Saichi Ono | Divided package of adsorbent for internal use and process for producing the same |
CA2170961C (en) * | 1995-03-22 | 2005-08-09 | Walter B. Mueller | Multilayer films for packaging and administering medical solutions |
JPH10180963A (ja) * | 1996-10-29 | 1998-07-07 | Toray Ind Inc | 積層フィルムおよびその製造方法 |
JP2002003623A (ja) * | 2000-06-22 | 2002-01-09 | Mitsubishi Polyester Film Copp | 二軸配向ポリエステルフィルム |
JP2006070047A (ja) * | 2002-11-01 | 2006-03-16 | Kureha Corp | 経口投与用吸着剤、並びに腎疾患治療又は予防剤、及び肝疾患治療又は予防剤 |
JP3835698B2 (ja) | 2002-11-01 | 2006-10-18 | 株式会社クレハ | 経口投与用吸着剤、並びに腎疾患治療又は予防剤、及び肝疾患治療又は予防剤 |
JP3585043B2 (ja) | 2003-01-22 | 2004-11-04 | メルク・ホエイ株式会社 | 医薬用吸着剤及びその製法 |
KR100736290B1 (ko) * | 2003-02-12 | 2007-07-09 | 가부시키가이샤 호소카와 요코 | 의료용 용기 |
JP2005007827A (ja) * | 2003-06-20 | 2005-01-13 | Kureha Chem Ind Co Ltd | 医薬品等の包装材および包装体 |
TWI370012B (en) | 2004-04-02 | 2012-08-11 | Kureha Corp | Adsorbent for oral administration, and agent for treating or preventing renal or liver disease |
TWI370013B (en) | 2004-04-02 | 2012-08-11 | Kureha Corp | Adsorbent for oral administration, and agent for treating or preventing renal or liver disease |
-
2011
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2607422B2 (ja) * | 1992-09-08 | 1997-05-07 | 呉羽化学工業株式会社 | 内服用吸着剤の分包包装体及びその製造方法 |
JP2006175729A (ja) * | 2004-12-22 | 2006-07-06 | Unitika Ltd | 分包袋用積層フィルムおよびそれからなる分包袋 |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016017478A1 (ja) * | 2014-07-29 | 2016-02-04 | 日本合成化学工業株式会社 | エチレン-ビニルエステル系共重合体ケン化物又はその樹脂組成物のペレット群の包装体 |
JPWO2016017478A1 (ja) * | 2014-07-29 | 2017-04-27 | 日本合成化学工業株式会社 | エチレン−ビニルエステル系共重合体ケン化物又はその樹脂組成物のペレット群の包装体 |
WO2020044453A1 (ja) * | 2018-08-29 | 2020-03-05 | 大日本印刷株式会社 | 包装体用積層体および包装体 |
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