WO2010122872A1 - 医療用容器およびシリンジ - Google Patents
医療用容器およびシリンジ Download PDFInfo
- Publication number
- WO2010122872A1 WO2010122872A1 PCT/JP2010/055315 JP2010055315W WO2010122872A1 WO 2010122872 A1 WO2010122872 A1 WO 2010122872A1 JP 2010055315 W JP2010055315 W JP 2010055315W WO 2010122872 A1 WO2010122872 A1 WO 2010122872A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- bag body
- liquid
- mouth
- syringe
- gasket
- Prior art date
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/202—Separating means
- A61J1/2037—Separating means having valve means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31596—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/10—Bag-type containers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
- A61M2005/31516—Piston or piston-rod constructions, e.g. connection of piston with piston-rod reducing dead-space in the syringe barrel after delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31596—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
- A61M2005/31598—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing having multiple telescopically sliding coaxial pistons encompassing volumes for components to be mixed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
- A61M5/281—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule
- A61M5/282—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule by compression of deformable ampoule or carpule wall
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3148—Means for causing or aiding aspiration or plunger retraction
Definitions
- the present invention relates to a medical container and a syringe.
- a vial container drug storage container
- a vial container drug storage container
- a cylindrical container main body in which one opening functions as a mouth part, and the container main body is divided into two spaces, a first space and a second space.
- a member having a partition member that slides on and a medicine stored in a first space see, for example, Patent Document 1.
- the mouth of the syringe that has separated the dissolving liquid is connected to the mouth of the vial container, and the dissolving liquid is added. inject. Thereafter, in a state where the syringe and the vial container are connected, a pumping operation is performed with a pusher of the syringe, whereby the dissolution liquid is taken in and out of the vial container, and the drug is uniformly dissolved in the dissolution liquid. Then, the dissolution liquid in which the drug is dissolved is sucked into the syringe and taken out.
- An object of the present invention is to provide a medical container and a syringe excellent in operability when injecting and discharging a liquid.
- the present invention provides a cylindrical body having a mouth part through which liquid can enter and exit at the tip part, A bag body that is installed inside the cylinder body, has flexibility, and inverts;
- the medical device is configured such that when the liquid enters and exits through the mouth portion, the bag body is reversed, and the volume of the space surrounded by the cylindrical body and the bag body changes.
- the bag body is inverted with an intermediate portion in the axial direction in the cylindrical body as a fulcrum.
- the bag body has a bottom portion and a side portion formed integrally with an edge portion of the bottom portion, It is preferable that the side portion is in close contact with a portion of the cylindrical body on the tip side when the bag body is inverted.
- the thickness of the side portion is thinner than the thickness of the bottom portion and / or the material of the bottom portion is harder than the material of the side portion.
- a flexible thin portion is formed at the boundary between the bottom and the side.
- the bag body has a raised portion that reversely enters the mouth portion when the liquid flows out through the mouth portion.
- a gasket attached to the tip of the cylindrical body, A syringe outer cylinder in which the cylindrical body is inserted so as to be movable in the axial direction together with the gasket; It is preferable that the space can communicate with the distal end side space surrounded by the syringe outer cylinder and the gasket via the mouth portion.
- the present invention comprises a syringe outer cylinder, A gasket inserted into the syringe outer cylinder so as to be movable in its axial direction; A pusher connected to the gasket and moving the gasket;
- the pusher has a cylindrical body having a mouth part through which liquid can enter and exit at the tip part,
- a bag body that is installed inside the cylinder body, has flexibility, and inverts;
- the syringe is configured such that when the liquid enters and exits through the mouth portion, the bag body is reversed, and the volume of the space surrounded by the cylindrical body and the bag body changes. It is.
- the opening of the bag body is fixed to the inner peripheral portion of the cylindrical body along the circumferential direction.
- the cylindrical body has a stepped portion having an inner diameter changed on an inner peripheral portion thereof, It is preferable that an opening of the bag is fixed to the stepped portion.
- the bag body has different colors on the front surface and the back surface.
- the medical container of the present invention preferably includes an opening / closing means for opening and closing the mouth.
- the opening / closing means is constituted by a valve body that is attached to the mouth portion and is made of an elastic material and has a slit that opens and closes when necessary.
- the medical container of the present invention preferably includes an opening / closing means that opens and closes the mouth to switch communication / blocking between the space and the distal end side space.
- the opening / closing means is formed by a break communication portion provided at the mouth portion and communicating by breakage.
- the present invention also includes a medical container of the present invention, A gasket attached to the tip of the cylindrical body; It is preferable that it is a syringe provided with the said syringe and the syringe outer cylinder inserted so that the movement to the axial direction was possible with the said gasket.
- FIG. 1 is a longitudinal sectional view showing an embodiment when the medical container of the present invention is applied to a vial container.
- FIG. 2 is a longitudinal sectional view showing an embodiment when the medical container of the present invention is applied to a vial container.
- FIG. 3 is a longitudinal sectional view showing an embodiment when the medical container of the present invention is applied to a vial container.
- FIG. 4 is a longitudinal sectional view showing an embodiment (syringe of the present invention) when the medical container of the present invention is applied to a syringe.
- FIG. 5 is a longitudinal sectional view showing an embodiment (syringe of the present invention) when the medical container of the present invention is applied to a syringe.
- FIG. 6 is a longitudinal sectional view showing an embodiment (syringe of the present invention) when the medical container of the present invention is applied to a syringe.
- 7 is a cross-sectional view taken along line AA in FIG.
- FIG. 8 is an enlarged view of a region [B] surrounded by a one-dot chain line in FIG.
- FIGS. 1 to 3 are longitudinal sectional views each showing an embodiment in which the medical container of the present invention is applied to a vial container.
- the lower side in FIGS. 1 to 3 is referred to as a “base end” and the upper side is referred to as a “tip”.
- a vial container (medical container) 1A shown in FIGS. 1 to 3 includes a container body (tubular body) 2A having a mouth portion 7 at a tip portion, a valve body 5 as an opening / closing means for opening and closing the mouth portion 7, and a container.
- a liquid Q such as a dissolving liquid, a diluting liquid, or a chemical liquid is injected into the container body 2 through the mouth portion 7, and an operation for mixing the drug P and the liquid Q is performed. Is called. Below, what mixed the chemical
- medicine P it is necessary to dissolve when using a medicine, an antibiotic, a hemostatic agent, or the like that is dangerous if a medical worker accidentally touches it, such as an anticancer agent or an immunosuppressant. Drugs, drugs that require dilution such as drugs for children, vaccines, heparin, drugs that can be used multiple times such as drugs for children, and the like.
- the liquid Q is not particularly limited, and examples thereof include physiological saline.
- the injection of the liquid Q can be performed using, for example, a prefilled syringe 90.
- the prefilled syringe 90 is disposed concentrically with the mouth portion 901 on the outer periphery of the syringe outer cylinder having the mouth portion 901 that protrudes from the end portion and the mouth portion 901. It has a cylindrical lock portion 902, a gasket (not shown) that slides along the longitudinal direction in the syringe outer cylinder, and a pusher (not shown) that moves the gasket.
- a liquid Q is filled in a space surrounded by the syringe outer cylinder and the gasket. The liquid Q flows out from the mouth portion 901 of the syringe outer cylinder by pressing the pusher.
- the configuration of the vial container 1A will be described.
- the container body 2 ⁇ / b> A has a bottomed cylindrical shape, and is formed with the mouth portion 7 protruding from the bottom portion 22.
- a stepped portion 231 having an abrupt change in inner diameter is formed in the middle of the inner peripheral portion 23 thereof.
- the step portion 231 serves as a fixing portion to which the bag body 3A is fixed and also serves as a fulcrum when the bag body 3A is reversed.
- the container body 2A can be divided into a small-diameter portion 24 on the distal end side and a large-diameter portion 25 on the proximal end side through the step portion 231.
- the mouth portion 7 is a portion where the liquid Q enters and exits, that is, a portion constituting a flow path through which the liquid Q passes.
- the mouth portion 7 has an overall outer diameter that is further reduced than the outer diameter of the small diameter portion 24, and a cylindrical portion 72 that protrudes from the bottom portion 22 toward the distal end, and a cylindrical portion 72. And a lid 73 to be mounted.
- the cylindrical portion 72 has a valve body installation portion 721 formed therein.
- the valve body setting portion 721 is divided into a second lumen portion 723 and a third lumen portion 724 that is located on the proximal end side and is smaller in diameter than the inner diameter of the second lumen portion 723. be able to.
- bore part 724 is a little larger than the largest outer diameter of the trunk
- an inner protrusion 725 made of a tubular body is provided at the center of the bottom surface 722 of the cylindrical portion 72. As shown in FIGS. 2 and 3, when the valve body 5 starts to be pressed, the internal protrusion 725 supports the inside of the valve body 5 and can prevent the valve body 5 from buckling. . Further, it is possible to prevent the liquid Q from staying when the liquid Q passes through the mouth portion 7.
- the lid portion 73 has a lumen portion for accommodating the valve body 5 therein, and is connected to the cylindrical portion 72 (valve body installation portion 721).
- a first lumen portion 731 into which a later-described head portion 50 of the valve body 5 can be inserted, and the first lumen portion 731 are communicated with and expanded from the first lumen portion 731.
- a diameter fitting portion 733 is formed.
- the first lumen portion 731 is formed so that its shape corresponds to the outer shape of the head 50 of the valve body 5.
- the fitting part 733 is a part that fits to the outer peripheral part of the cylindrical part 72.
- the lid part 73 and the cylindrical part 72 are connected in a liquid-tight manner, and thus the liquid Q inside the mouth part 7 can be prevented from leaking between the lid part 73 and the cylindrical part 72.
- the first lumen portion 731 and the second lumen portion 723 communicate with each other, and the first lumen portion 731 and the second lumen portion are connected.
- the valve body 5 can be installed in the space formed by the 723 and the third lumen portion 724.
- a male screw portion 738 is formed on the outer periphery of the lid portion 73.
- the male screw portion 738 is a portion that is screwed with a female screw portion 903 formed on the inner peripheral portion of the lock portion 902 of the prefilled syringe 90 (see FIGS. 2 and 3).
- the constituent material of the container body 2A is not particularly limited.
- polyolefins such as polyethylene, polypropylene and cyclic polyethylene, polyesters such as polyethylene terephthalate, vinyl resins such as vinyl chloride resin and polyvinyl alcohol, and other heat Examples thereof include resin materials such as plastic resins, and one or more of these can be used in combination.
- 2 A of container main bodies have transparency in order to ensure internal visibility.
- the valve body 5 is attached (installed) to the mouth portion 7.
- the valve body 5 is made of an elastic material.
- the elastic material include various rubber materials such as silicone rubber and various thermoplastic elastomers. By using such an elastic material, moderate elasticity can be obtained on the tip surface 511 of the valve body 5. Thereby, when the prefilled syringe 90 is connected to the opening
- the valve body 5 includes a tubular body portion 55 and a head portion 50 provided integrally with one end portion of the body portion 55.
- the head portion 50 has a bottomed cylindrical shape, and includes a lumen portion 515 through which the liquid Q and the chemical solution R can pass, and a slit (opening / closing portion) that reaches the lumen portion 515 from the flat distal end surface 511. ) 512 is formed.
- the slit 512 has a substantially single character shape. Since the shape of the slit 512 is simple as described above, the front end surface 511 is deformed when the front end surface 511 (near the slit 512) is pressed, so that the slit 512 is reliably opened. Further, when the pressing is released, the front end surface 511 is restored, so that the slit 512 is reliably closed. Thus, the valve body 5 has a self-occlusion property.
- the mouth portion 7 can be easily and reliably sealed (see FIG. 1) / unsealed (see FIGS. 2 and 3).
- the tip surface 511 is flat, when the prefilled syringe 90 is connected, the tip surface 511 (slit 512) can be easily sterilized in advance.
- the head portion 50 is inserted into the first lumen portion 731 of the lid portion 73, and the slit 512 is closed.
- the trunk portion 55 is formed of a cylindrical body having a bellows shape. That is, the body 55 has a bellows shape in which the large-diameter ring portion 552 and the small-diameter ring portion 553 are alternately arranged in the axial direction in the outer shape. Such a body portion 55 functions as a deforming portion that urges the head portion 50 in a direction in which the head portion 50 is inserted into the first lumen portion 731 of the lid portion 73.
- drum 55 functions as a deformation
- a proximal end cap 8A is attached to the proximal end opening 26 of the container body 2A.
- the base end cap 8 ⁇ / b> A includes a plate-like portion 81 that covers the base-end opening 26, and a fitting portion 82 that is formed at the edge of the plate-like portion 81 along the circumferential direction.
- the plate-like portion 81 has a plurality of through-holes 811 penetrating in the thickness direction.
- the fitting portion 82 has a ring shape, and its inner diameter is set slightly smaller than the outer diameter of the large diameter portion 25 of the container body 2A. As a result, the fitting portion 82 is fitted to the large diameter portion 25, so that the base end cap 8 ⁇ / b> A is securely attached to the base end opening 26 of the container main body 2 ⁇ / b> A and detached from the base end opening 26. Is prevented.
- the constituent material of the base end cap 8A is not particularly limited, but for example, the constituent materials mentioned in the description of the container body 2A can be used.
- a flexible bag 3A is installed inside the container body 2A.
- the bag body 3 ⁇ / b> A can be turned upside down when the liquid Q (chemical solution R) enters and exits through the mouth 7.
- most of the bag body 3A is located in the small diameter portion 24 of the container main body 2A in the initial state (see FIG. 1), and when the liquid Q is injected, the bag body 3A is inverted. 25 (see FIG. 2).
- the liquid Q (chemical solution R) is discharged, the liquid Q is reversed again and is positioned in the small diameter portion 24 of the container body 2A (see FIG. 3).
- the bag body 3A that can be reversed in this way is, for example, a polyolefin resin such as polyethylene or polypropylene, a blend resin or copolymer resin containing these polyolefin resins, a polyester resin such as polyethylene terephthalate, a polyamide resin such as nylon, or a polychlorinated resin.
- a polyolefin resin such as polyethylene or polypropylene
- a blend resin or copolymer resin containing these polyolefin resins a polyester resin such as polyethylene terephthalate
- a polyamide resin such as nylon
- a polychlorinated resin a polychlorinated resin.
- Single-layer films such as vinylidene, vinyl chloride-polyvinylidene chloride copolymer, single-layer films obtained by vapor-depositing aluminum, silica, etc., and these single-layer films and other films and metal foils such as aluminum foil Examples include laminated multilayer films, and those having particularly
- the bag 3 ⁇ / b> A has a bag shape including a bottom portion 31 and side portions 32 formed integrally with the bottom portion 31 at the edge of the bottom portion 31. Note that the bag 3A is manufactured by vacuum forming, pressure forming, or the like.
- the edge part 331 of the opening part 33 folded back toward the outer side.
- the folded edge portion 331 is fixed along a circumferential direction to a step portion 231 (inner peripheral portion 23) provided near the middle in the axial direction of the container body 2A. Since the bag body 3A is fixed to the container body 2A in this way, when the bag body 3A is reversed, the edge portion 331 serves as a fulcrum, and the reversal is easily and reliably performed.
- the method for fixing the bag body 3A is not particularly limited. For example, a method using adhesion (adhesion with an adhesive or a solvent), a method using fusion (thermal fusion, high-frequency fusion, ultrasonic fusion, etc.), etc. Is mentioned.
- the bag body 3A may be one in which the edge portion 331 is directly fixed to the surface in the vicinity of the middle in the axial direction of the container main body 2A from which the step portion 231 is omitted. Further, the bag body 3A includes the step portion 231. May extend from the inner front end to the base end of the container main body 2A, and a middle portion thereof serves as a fulcrum and may be reversed.
- the thickness t2 of the side portion 32 is thinner than the thickness t1 of the bottom portion 31.
- the side 32 is sequentially reversed from the vicinity of the edge of the bottom 31 toward the proximal end side, and the bag body 3A is reliably reversed.
- the side portion 32 is similarly reversed from the vicinity of the edge portion of the bottom portion 31 toward the distal end side, and the bag body 3A can be reliably reversed.
- the thickness t ⁇ b> 1 of the bottom portion 31 and the thickness t ⁇ b> 2 of the side portion 32 may be equal to each other.
- the boundary part 34 between the bottom part 31 and the side part 32 is preferably a thin part whose thickness is thinner than the thicknesses t1 and t2.
- the boundary part 34 becomes a part which has a softness
- the same reversal can also be performed by using a material that is harder than the material of the side portion 32 as the material of the bottom portion 31.
- a raised portion 311 is formed at the center of the bottom 31 of the bag body 3A.
- the raised portion 311 is raised toward the proximal direction in the initial state.
- the storage space 21 having a size necessary for storing the medicine P in the initial state can be secured, and the medicine solution R can be reconstituted after being inverted, that is, when the medicine R is returned to the original state.
- the protruding portion 311 is directed in the tip direction with the protruding direction reversed (see FIG. 3). Then, the raised portion 311 that is raised in the distal direction enters the root portion 726 of the mouth portion 7.
- the root portion 726 of the mouth portion 7 has a tapered portion whose inner diameter gradually decreases in the distal direction.
- the shape of the inner portion of the root portion 726 matches the outer shape of the raised portion 311.
- the bag body 3A since the shape of the bag body 3A is easily held due to the thickness t1 of the bottom portion 31 and the like being reversed, when the bag body 3A is reversed, the bag body 3A is reversed while retaining the shape, and is uniformly deformed in appearance.
- the bag body 3A preferably has different colors on the front surface and the back surface. Thereby, it can be visually confirmed whether 3 A of bag bodies are reversed.
- the usage state (usage method) of the vial container 1A will be described.
- most of the bag body 3 ⁇ / b> A portion other than the edge portion 331) is located in the small diameter portion 24 of the container body 2 ⁇ / b> A.
- the bottom 3A of the bag 3A in the initial state is separated from the bottom 22 of the container main body 2A, and the side 32 is in close contact with the inner peripheral portion 23 of the container main body 2A.
- the storage space 21 at this time is surrounded by the bottom 31 (including the raised portion 311) and the bottom 22 (including the mouth portion 7).
- the mouth part 7 of the vial container 1A and the lock part 902 of the prefilled syringe 90 are screwed together, and the vial container 1A and the prefilled syringe 90 are connected.
- the mouth 901 of the prefilled syringe 90 presses the valve body 5 of the mouth 7 of the vial container 1A in the proximal direction.
- the slit 512 of the valve body 5 is opened, and the inside of the vial container 1A and the inside of the prefilled syringe 90 communicate with each other.
- the pusher of the prefilled syringe 90 is pressed.
- the liquid Q in the prefilled syringe 90 is inject
- the volume of the storage space 21 is increased, and the bottom 31 of the bag body 3A is pressed toward the proximal direction, so that the bag body 3A is inverted.
- the storage space 21 at this time is surrounded by the bottom portion 31 and the side portion 32 of the bag body 3A, the bottom portion 22 (including the mouth portion 7), and the small diameter portion 24 of the container main body 2A.
- the pumping operation is performed by reciprocating the pusher of the prefilled syringe 90. Also at this time, since the bag 3A repeats reversal, frictional resistance is not substantially generated between the bag 3A and the container body 2A. Thereby, the pumping operation can be performed without feeling resistance, and the operability is excellent. Moreover, the chemical
- the vial container 1A is excellent in operability when the liquid Q is discharged.
- the suction amount of the chemical solution R can be appropriately adjusted according to the pull amount of the pusher of the prefilled syringe 90. In the state shown in FIG. 3, almost all of the chemical solution R in the storage space 21 is sucked.
- Second Embodiment 4 to 6 are longitudinal sectional views showing an embodiment (syringe of the present invention) when the medical container of the present invention is applied to a syringe
- FIG. 7 is a sectional view taken along line AA in FIG.
- FIG. 8 is an enlarged view of a region [B] surrounded by a one-dot chain line in FIG.
- the upper side in FIGS. 4 to 6 is referred to as a “base end” and the lower side is referred to as a “tip”.
- This embodiment is the same as the first embodiment except that the application form of the medical container is different.
- a syringe (medical container) 1B shown in FIGS. 4 to 6 is a two-chamber prefilled syringe in which a medicine P and a liquid Q for dissolving the medicine P are separated into two chambers and stored in advance in the syringe.
- the syringe 1B includes an outer cylinder (syringe outer cylinder) 4, a gasket 6 that can slide in the outer cylinder 4, an inner cylinder 2B that is attached to the gasket 6, and a bag body 3B that is installed in the inner cylinder 2B.
- the distal end cap 9 is detachably attached to the mouth portion 41 of the outer cylinder 4, and the proximal end cap 8B is attached to the proximal end opening 26 of the inner cylinder 2B.
- the outer cylinder 4 is composed of a bottomed cylindrical member having a bottom 42 on the tip side. As shown in FIG. 7, in the middle of the outer cylinder 4, the cross-sectional shape of the inner periphery thereof is an ellipse. At this position, the gasket 6 is also regulated so that its outer peripheral portion is elliptical. As a result, as will be described later, when the inner cylinder 2B is rotated around its axis with respect to the outer cylinder 4 (see FIG. 4), the gasket 6 is prevented from rotating together with the inner cylinder 2B, and only the inner cylinder 2B is Can be rotated.
- a mouth part 41 having a reduced diameter with respect to the body part of the outer cylinder 4 is integrally formed.
- a hub of a needle tube, connectors, a tube or the like (not shown) is fitted and attached to the mouth portion 41 and used.
- a cap mounting portion 43 that is disposed concentrically with the mouth portion 41 is formed to project.
- the cap mounting portion 43 has a ring shape, and the tip cap 9 is detachably mounted on the outer peripheral portion thereof.
- a flange 44 is formed on the outer periphery of the base end of the outer cylinder 4.
- the operation can be performed by placing a finger on the flange 44.
- the outer cylinder 4 is provided with a scale for measurement.
- polystyrene resin such as polyethylene, a polypropylene, cyclic polyethylene, Polyester, such as a polyethylene terephthalate, Vinyl-type resins, such as a vinyl chloride resin and polyvinyl alcohol, Other thermoplastic resins Such a resin material can be used, and one or more of these can be used in combination.
- 2 A of container main bodies have transparency in order to ensure internal visibility.
- the front end cap 9 is attached to the cap attaching portion 43 of the outer cylinder 4 by fitting.
- the tip cap 9 is a sealing member that seals the mouth portion 41.
- the tip cap 9 has a cup shape, and its inner diameter is set slightly smaller than the outer diameter of the cap mounting portion 43. Thereby, the tip cap 9 is securely fitted and attached to the cap attaching portion 43, and when the tip cap 9 is pulled in the distal direction, the fitting is released and is removed from the cap attaching portion 43.
- tip cap 9 Although it does not specifically limit as a constituent material of the front-end
- tip cap 9 the constituent material which was mentioned by description about the outer cylinder 4 can be used.
- the sealing method of the mouth part 41 is not limited to the one using the tip cap 9, and may be sealed by, for example, an elastic stopper, film sticking, or the like.
- a gasket 6 made of an elastic material is inserted in the outer cylinder 4.
- a plurality of ring-shaped convex portions 61 and 62 projecting toward the outer peripheral side are formed on the outer peripheral portion of the gasket 6 over the entire periphery.
- two convex portions 61 and 62 are formed along the axial direction of the gasket 6. That is, the convex portions 61 and 62 are formed in the middle of the axial direction of the gasket 6 (center portion) and the tip portion, respectively.
- the front end side of the convex part 62 has a tapered surface whose outer diameter gradually decreases toward the front end.
- the formation position and number of the convex portions 61 and 62, the cross-sectional shape, and the like are not limited thereto.
- the gasket 6 is formed with a recess 63 that opens to the base end face thereof.
- the tip of the inner cylinder 2B is inserted into the recess 63.
- rotation support portions 631 and 632 for rotatably supporting the inner cylinder 2B are formed at two locations in the axial direction on the inner peripheral portion of the recess 63.
- Each rotation support part 631 and 632 is comprised by the enlarged diameter part which the internal diameter of the recessed part 63 expanded, and each rib 271 and 272 of the inner cylinder 2B mentioned later are inserted.
- the elastic material constituting the gasket 6 is not particularly limited, and examples thereof include various rubber materials such as natural rubber, isoprene rubber, butadiene rubber and styrene-butadiene rubber, and various thermoplastic elastomers such as styrene and polyolefin. 1 type or 2 types or more of these can be mixed and used.
- an inner cylinder 2B fitted with a gasket 6 is inserted in the outer cylinder 4.
- the inner cylinder 2B has both a function as a pusher for moving and operating the gasket 6 and a function as a container for storing the liquid Q.
- the inner cylinder 2B has a bottomed cylindrical shape, and a mouth part 221 is formed at the bottom part 22 (tip part).
- the mouth portion 221 is configured by a through hole that penetrates the bottom portion 22 in the thickness direction.
- the inside of the inner cylinder 2B (the storage space 21) and the front end side space 46 communicate with each other through the mouth portion 221, and the liquid Q can flow out (in and out) toward the front end side space 46 (see FIG. 5). ).
- the mouth portion 221 of the inner cylinder 2 ⁇ / b> B is sealed with the breaking communication portion 28.
- the fracture communication portion 28 is formed so as to protrude integrally with the bottom portion 22 of the inner cylinder 2B.
- rupture communication part 28 is comprised so that it may fracture
- the opening 221 is opened by this breakage, and the inside of the inner cylinder 2 ⁇ / b> B and the front end side space 46 communicate with each other through the opened opening 221.
- the breaking communication portion 28 is a portion that functions as an opening / closing means that opens and closes the mouth portion 221 and switches between communication / blocking between the inner cylinder 2B and the distal end side space 46.
- rupture communication part 28 is inserted is dented and formed in the gasket 6 at the bottom part of the recessed part 63.
- FIG. 5 By inserting the breaking communication portion 28 into the insertion portion 633, when the inner cylinder 2B is rotated, a shear stress acts on the breaking communication portion 28, and the breaking communication portion 28 breaks when the breaking limit is exceeded. To do. And this fracture
- a through hole 634 is formed in the gasket 6 at a position different from the insertion portion 633 at the bottom of the recess 63.
- the through-hole 634 is a part that communicates the inside of the inner cylinder 2 ⁇ / b> B and the distal end side space 46 together with the opened mouth 221 (see FIG. 5).
- the inner cylinder 2B is formed with a step portion 231 having a sharply changed inner diameter in the middle of the inner peripheral portion 23 thereof.
- the step portion 231 becomes a fixing portion to which the bag body 3B is fixed.
- the inner cylinder 2B can be divided into a small-diameter portion 24 on the distal end side and a large-diameter portion 25 on the proximal end side through the step portion 231.
- the constituent material of the inner cylinder 2B is not particularly limited, but for example, the constituent materials mentioned in the description of the outer cylinder 4 can be used. Moreover, the inner cylinder 2B has transparency in order to ensure internal visibility.
- a proximal end cap 8B is attached to the proximal end opening 26 of the inner cylinder 2B.
- the proximal end cap 8B includes a disc-shaped plate-like portion 81 that covers the proximal-end opening 26, and a fitting portion 82 that is disposed concentrically with the plate-like portion 81 and is formed along the circumferential direction thereof. is doing.
- the fitting portion 82 has a ring shape, and its outer diameter is set to be slightly larger than the inner diameter of the large diameter portion 25 of the inner cylinder 2B. As a result, the fitting portion 82 is fitted to the large diameter portion 25, so that the base end cap 8 ⁇ / b> B is securely attached to the base end opening 26 of the inner cylinder 2 ⁇ / b> B and detached from the base end opening 26. Is prevented.
- constituent material of the base end cap 8B is not particularly limited, and for example, the constituent materials described in the description of the outer cylinder 4 can be used.
- a flexible bag 3B is installed inside the inner cylinder 2B.
- the storage space 21 surrounded by the bag 3B and the inner cylinder 2B is filled with the liquid Q.
- the bag body 3B can be reversed by the liquid Q flowing out through the mouth portion 221.
- the bag body 3B is positioned in the large diameter portion 25 of the inner cylinder 2B in an initial state (see FIG. 4), and is reversed when the liquid Q is sucked into the distal end side space 46. 24 (see FIG. 5).
- the bag 3B that can be reversed in this way can use the constituent materials described in the first embodiment.
- the bag body 3 ⁇ / b> B has a bag shape including a bottom portion 31 and side portions 32 formed integrally with the bottom portion 31 at the edge of the bottom portion 31.
- the bag body 3B has an edge portion 331 of the opening 33 folded back outward.
- the folded edge portion 331 is fixed to the step portion 231 (inner peripheral portion 23) of the inner cylinder 2B along the circumferential direction. Since the bag body 3B is fixed to the inner cylinder 2B as described above, when the bag body 3B is reversed, the edge portion 331 serves as a fulcrum, and the reversal is easily and reliably performed.
- the method for fixing the bag 3B is not particularly limited. For example, a method using adhesion (adhesion with an adhesive or a solvent), a method using fusion (thermal fusion, high-frequency fusion, ultrasonic fusion, etc.), etc. Is mentioned.
- the thickness t1 of the bottom portion 31 and the thickness t2 of the side portion 32 are equivalent. Further, the boundary portion 34 between the bottom portion 31 and the side portion 32 is a thin portion whose thickness t3 is thinner than the thicknesses t1 and t2. Thus, as described in the first embodiment, when the bag body 3B is reversed, the reversal is smoothly and reliably performed.
- the inverted bag body 3B has a bottom portion 31 that is in close contact with the bottom portion 22 of the inner cylinder 2B, and a side portion 32 that is in close contact with the small-diameter portion 24 (inner peripheral portion 23) of the inner cylinder 2B. .
- a raised portion similar to the raised portion 311 formed on the bag body 3A of the first embodiment may be formed on the bottom portion 31 of the bag body 3B. Thereby, the residue of the chemical solution R in the storage space 21 can be prevented more reliably.
- the bag body 3B may have different colors on the front surface and the back surface. Thereby, it can be visually confirmed whether the bag 3B is reversed.
- the usage state (usage method) of the syringe 1B will be described.
- the bag 3 ⁇ / b> B is located in the large diameter portion 25 of the inner cylinder 2 ⁇ / b> B.
- the storage space 21 at this time is surrounded by the bottom part 31 and the side part 32 of the bag body 3B, and the bottom part 22 and the small diameter part 24 of the inner cylinder 2B.
- the storage space 21 is filled with the liquid Q.
- the side portion 32 of the bag body 3B is separated from the large diameter portion 25 (inner peripheral portion 23) of the inner cylinder 2B.
- the side portion 32 is easily deformed, so that the pulling operation of the inner cylinder 2B described later can be easily performed.
- the mouth portion 221 of the inner cylinder 2B is sealed by the fracture communication portion 28.
- the inner cylinder 2B is rotated around its axis with respect to the outer cylinder 4.
- the breaking communication portion 28 is broken, and thus the mouth portion 221 is opened.
- This rotation operation is performed until the mouth 221 is displaced to a position that coincides with the through hole 634 of the gasket 6 (see FIG. 5).
- a marker or a positioning mechanism is preferably provided so that the mouth 221 and the through hole 634 can coincide with each other.
- the rotation angle of the rotation operation is not particularly limited, and is preferably 60 to 180 degrees, for example, and more preferably 60 to 90 degrees.
- the inner cylinder 2 ⁇ / b> B is pulled in the proximal direction with respect to the outer cylinder 4.
- the front end side space 46 is decompressed, and a suction force for sucking the liquid Q from the storage space 21 is generated.
- the liquid Q in the storage space 21 sequentially passes through the opening 221 of the inner cylinder 2B and the through hole 634 of the gasket 6 and flows into the distal end side space 46, and the bag body 3B is inverted. Further, this pulling operation is performed until the storage space 21 substantially disappears, that is, until the liquid Q completely flows out of the storage space 21.
- the syringe 1B has excellent operability when the liquid Q is discharged.
- a pumping operation for reciprocating the inner cylinder 2B in the axial direction with respect to the outer cylinder 4 may be performed. Even in this pumping operation, since the bag body 3B repeats reversal, a frictional resistance is not substantially generated between the bag body 3B and the inner cylinder 2B. Thereby, it is excellent in the operativity of pumping operation.
- the inner cylinder 2B is pressed against the outer cylinder 4 toward the distal end.
- the gasket 6 slides in the distal direction within the outer cylinder 4, and the chemical solution R in the distal end side space 46 is sent (discharged) to the connectors, tubes, hub of the needle tube, or the like.
- the inner cylinder 2B When the inner cylinder 2B is pressed, the inner cylinder 2B can be rotated to seal the mouth 221 again at an arbitrary position on the bottom of the recess 63 of the gasket 6.
- the arbitrary position may be any location as long as the mouth portion 221 can be sealed, such as a portion where the breaking communication portion 28 is located or a portion different from the portion.
- the medical container and the syringe of the present invention have been described with respect to the illustrated embodiment.
- the present invention is not limited to this, and each part constituting the medical container and the syringe exhibits the same function. It can be replaced with any configuration obtained. Moreover, arbitrary components may be added.
- the medical container of the present invention may be a combination of any two or more configurations (features) of the above embodiments.
- the bag body when the liquid is injected into the space through the mouth portion of the cylindrical body, the bag body is pressed toward the proximal end by the liquid, and thus the bag body is inverted. At this time, the volume of the space increases, and accordingly, the liquid flows into (fills in) the storage space.
- the present invention is excellent in operability during liquid injection.
- the bag body When the liquid in the space is sucked, the bag body is reversed in the direction in which the volume of the space decreases.
- the present invention is excellent in operability when discharging the liquid. Further, when the raised portion is provided, the space is substantially lost when the liquid is discharged, so that the liquid is prevented or suppressed from remaining in the space, so that the liquid can be used up without waste. Can do. Therefore, it has industrial applicability.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Fluid Mechanics (AREA)
- Physics & Mathematics (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
Description
上記目的を達成するために、本発明は、先端部に液体が出入り可能な口部を有する筒体と、
前記筒体の内側に設置され、可撓性を有し、反転する袋体とを備え、
前記口部を介して液体が出入りすることにより、前記袋体が反転して、前記筒体と前記袋体とで囲まれた空間の容積が変化するよう構成されていることを特徴とする医療用容器である。
前記側部は、前記袋体が反転した際、前記筒体の前記支点より先端側の部分に密着するのが好ましい。
前記ガスケットとともに前記筒体がその軸方向に移動可能に挿入されたシリンジ外筒とをさらに備え、
前記空間は、前記口部を介して、前記シリンジ外筒と前記ガスケットとで囲まれた先端側空間と連通可能であるのが好ましい。
前記シリンジ外筒にその軸方向に移動可能に挿入されたガスケットと、
前記ガスケットに接続され、該ガスケットを移動操作する押し子を備え、
前記押し子は、先端部に液体が出入り可能な口部を有する筒体と、
前記筒体の内側に設置され、可撓性を有し、反転する袋体とを備え、
前記口部を介して液体が出入りすることにより、前記袋体が反転して、前記筒体と前記袋体とで囲まれた空間の容積が変化するよう構成されていることを特徴とするシリンジである。
前記段差部に前記袋体の開口部が固定されているのが好ましい。
前記筒体の先端部に装着されたガスケットと、
前記ガスケットとともに前記筒体がその軸方向に移動可能に挿入されたシリンジ外筒とを備えるシリンジであるのが好ましい。
図1~図3は、それぞれ、本発明の医療用容器をバイアル容器に適用した場合の実施形態を示す縦断面図である。なお、以下では、説明の都合上、図1~図3中の下側を「基端」、上側を「先端」と言う。
容器本体2Aは、有底筒状をなし、その底部22に口部7が突出して形成されたものである。この容器本体2Aには、その内周部23の途中に、内径が急峻に変化した段差部231が形成されている。段差部231は、袋体3Aが固定される固定部となるとともに、袋体3Aが反転する際の支点にもなる。また、容器本体2Aは、段差部231を介して、先端側の小径部24と、基端側の大径部25とに分けることができる。
嵌合部82は、リング状をなし、その内径が容器本体2Aの大径部25の外径よりも若干小さく設定されている。これにより、嵌合部82が大径部25に嵌合することとなり、よって、基端キャップ8Aが容器本体2Aの基端開口部26に確実に装着され、当該基端開口部26から離脱するのが防止される。
[1] 図1に示す初期状態では、袋体3Aは、そのほとんどの部分(縁部331以外の部分)が容器本体2Aの小径部24に位置している。初期状態の袋体3Aは、その底部31が容器本体2Aの底部22と離間しており、側部32が容器本体2Aの内周部23に密着している。このときの収納空間21は、底部31(***部311を含む)と底部22(口部7を含む)とで囲まれたものとなっている。
図4~図6は、それぞれ、本発明の医療用容器をシリンジに適用した場合の実施形態(本発明のシリンジ)を示す縦断面図、図7は、図4中のA-A線断面図、図8は、図4中の一点鎖線で囲まれた領域[B]の拡大図である。なお、以下では、説明の都合上、図4~図6中の上側を「基端」、下側を「先端」と言う。
[1] 図4に示す初期状態では、袋体3Bは、内筒2Bの大径部25に位置している。このときの収納空間21は、袋体3Bの底部31および側部32と、内筒2Bの底部22および小径部24とで囲まれたものとなっている。そして、収納空間21内に液体Qが充填されている。
また、空間内の液体が吸引されると、それとともに、空間の容積が減少する方向に袋体が反転する。このように袋体が反転して空間の容積が減少するときにも、袋体と筒体との間に摩擦抵抗が実質的に発生せず、よって、その抵抗力を感じることなく液体を排出することができる。従って、本発明は、液体の排出時の操作性にも優れたものとなっている。
また、***部を有する場合には、液体が排出された際に、空間が実質的に消失するため、当該空間内に液体が残留するのが防止または抑制され、よって、液体を無駄なく使い切ることができる。
従って、産業上の利用可能性を有する。
Claims (8)
- 先端部に液体が出入り可能な口部を有する筒体と、
前記筒体の内側に設置され、可撓性を有し、反転する袋体とを備え、
前記口部を介して液体が出入りすることにより、前記袋体が反転して、前記筒体と前記袋体とで囲まれた空間の容積が変化するよう構成されていることを特徴とする医療用容器。 - 前記袋体は、前記筒体内の軸方向の中間付近を支点として反転する請求項1に記載の医療用容器。
- 前記袋体は、底部と該底部の縁部に一体的に形成された側部とを有し、
前記側部は、前記袋体が反転した際、前記筒体の前記支点より先端側の部分に密着する請求項2に記載の医療用容器。 - 前記側部の厚さが前記底部の厚さよりも薄いおよび/または底部の材質が側部の材質よりも硬質である請求項3に記載の医療用容器。
- 前記底部と前記側部との境界部には、柔軟な薄肉部が形成されている請求項3に記載の医療用容器。
- 前記袋体は、液体が前記口部を介して流出した際、逆転して前記口部に入り込む***部を有する請求項1に記載の医療用容器。
- 前記筒体の先端部に装着されたガスケットと、
前記ガスケットとともに前記筒体がその軸方向に移動可能に挿入されたシリンジ外筒とをさらに備え、
前記空間は、前記口部を介して、前記シリンジ外筒と前記ガスケットとで囲まれた先端側空間と連通可能である請求項1に記載の医療用容器。 - シリンジ外筒と、
前記シリンジ外筒にその軸方向に移動可能に挿入されたガスケットと、
前記ガスケットに接続され、該ガスケットを移動操作する押し子を備え、
前記押し子は、先端部に液体が出入り可能な口部を有する筒体と、
前記筒体の内側に設置され、可撓性を有し、反転する袋体とを備え、
前記口部を介して液体が出入りすることにより、前記袋体が反転して、前記筒体と前記袋体とで囲まれた空間の容積が変化するよう構成されていることを特徴とするシリンジ。
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/265,522 US9155679B2 (en) | 2009-04-21 | 2010-03-26 | Medical container and syringe |
EP10766931.9A EP2422761B1 (en) | 2009-04-21 | 2010-03-26 | Medical container and syringe |
JP2011510268A JP5550638B2 (ja) | 2009-04-21 | 2010-03-26 | 医療用容器 |
CN201080017172.XA CN102395346B (zh) | 2009-04-21 | 2010-03-26 | 医疗用容器 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2009-103182 | 2009-04-21 | ||
JP2009103182 | 2009-04-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2010122872A1 true WO2010122872A1 (ja) | 2010-10-28 |
Family
ID=43010995
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2010/055315 WO2010122872A1 (ja) | 2009-04-21 | 2010-03-26 | 医療用容器およびシリンジ |
Country Status (5)
Country | Link |
---|---|
US (1) | US9155679B2 (ja) |
EP (1) | EP2422761B1 (ja) |
JP (1) | JP5550638B2 (ja) |
CN (1) | CN102395346B (ja) |
WO (1) | WO2010122872A1 (ja) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013035543A1 (ja) | 2011-09-07 | 2013-03-14 | テルモ株式会社 | 医療用容器および医療用容器の製造方法 |
CN103458852A (zh) * | 2011-03-28 | 2013-12-18 | 泰尔茂株式会社 | 药剂收纳容器 |
CN104023770A (zh) * | 2011-12-22 | 2014-09-03 | B.布劳恩梅尔松根公司 | 多腔混合容器 |
JPWO2013047029A1 (ja) * | 2011-09-27 | 2015-03-26 | テルモ株式会社 | 医療用容器 |
US20160367438A1 (en) * | 2012-10-22 | 2016-12-22 | Parenteral Technologies, Llc | Methods and apparatuses for delivering medicaments to intravenous fluid |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6695817B1 (en) | 2000-07-11 | 2004-02-24 | Icu Medical, Inc. | Medical valve with positive flow characteristics |
US20060161115A1 (en) | 2004-11-05 | 2006-07-20 | Fangrow Thomas F | Soft-grip medical connector |
US8454579B2 (en) | 2009-03-25 | 2013-06-04 | Icu Medical, Inc. | Medical connector with automatic valves and volume regulator |
USD644731S1 (en) | 2010-03-23 | 2011-09-06 | Icu Medical, Inc. | Medical connector |
US8758306B2 (en) | 2010-05-17 | 2014-06-24 | Icu Medical, Inc. | Medical connectors and methods of use |
DE102010044141A1 (de) * | 2010-11-18 | 2012-05-24 | Raumedic Ag | Dosiervorrichtung |
WO2014028452A1 (en) * | 2012-08-15 | 2014-02-20 | Coeur, Inc. | Syringe |
CA2932124C (en) | 2013-12-11 | 2023-05-09 | Icu Medical, Inc. | Check valve |
USD786427S1 (en) | 2014-12-03 | 2017-05-09 | Icu Medical, Inc. | Fluid manifold |
USD793551S1 (en) | 2014-12-03 | 2017-08-01 | Icu Medical, Inc. | Fluid manifold |
WO2018085318A2 (en) * | 2016-11-01 | 2018-05-11 | Hanss Basil G | Self-contained syringe for dissolution and administration of drugs |
GB2556088A (en) | 2016-11-18 | 2018-05-23 | Owen Mumford Ltd | Packaging and devices for mixing medicament substances |
US10968031B2 (en) | 2017-12-27 | 2021-04-06 | Sulzer Mixpac Ag | Piston for a collapsible cartridge |
EP4382746A2 (de) * | 2020-11-27 | 2024-06-12 | Erbe Elektromedizin GmbH | Pumpeneinheit für medizinische zwecke |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4861335A (en) * | 1985-07-26 | 1989-08-29 | Duoject Medical Systems Inc. | Syringe |
EP0505611A2 (de) * | 1991-03-05 | 1992-09-30 | Kautex Werke Reinold Hagen Ag | Quetschflasche mit Innenbehälter |
JP2006055452A (ja) | 2004-08-20 | 2006-03-02 | Terumo Corp | 薬剤収納容器 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2514575A (en) * | 1945-02-17 | 1950-07-11 | Howard T Hein | Introversion syringe |
GB1583157A (en) * | 1976-05-07 | 1981-01-21 | Kenova Ab | Syringes |
US4131217A (en) * | 1977-05-19 | 1978-12-26 | Landstingens Inkopscentral, L I C | Device for emptying a container |
US4312344A (en) * | 1980-04-03 | 1982-01-26 | Kenova Ab | Syringe |
US4581016A (en) * | 1984-02-29 | 1986-04-08 | Gettig Pharmaceutical Instrument Co. | Dual cartridge wet/dry syringe |
CN1143693C (zh) * | 1996-03-15 | 2004-03-31 | 武田药品工业株式会社 | 注射器 |
JP3147347B2 (ja) * | 1996-04-23 | 2001-03-19 | 株式会社ニッショー | 薬液自己注入用具 |
JP3928248B2 (ja) * | 1998-02-27 | 2007-06-13 | ニプロ株式会社 | 薬液自己注入用具 |
US6083204A (en) * | 1998-09-29 | 2000-07-04 | Malerba; Richard | Method and apparatus for gravity-fed intravenous infusion |
CA2441026A1 (en) * | 2001-03-15 | 2002-10-03 | Naoya Tani | Check valve and liquid container with check valve |
US7083323B2 (en) * | 2003-05-19 | 2006-08-01 | Advanced Technology Materials, Inc. | Flexible mixing bag for mixing solids, liquids and gases |
ES2377000T3 (es) * | 2005-09-07 | 2012-03-21 | Thomas Steffen | Dispositivo para la inyección de material de alta viscosidad |
CN101244297B (zh) * | 2007-02-14 | 2010-09-08 | 丁玉英 | 粉针剂自动混药装置 |
CN201101760Y (zh) * | 2007-11-16 | 2008-08-20 | 张秀媛 | 一种专用配药注射针 |
CN100594951C (zh) * | 2008-01-21 | 2010-03-24 | 陈庆强 | 一种防污染加药器 |
JP5517029B2 (ja) * | 2009-03-25 | 2014-06-11 | ニプロ株式会社 | 薬液自己注入装置 |
-
2010
- 2010-03-26 CN CN201080017172.XA patent/CN102395346B/zh active Active
- 2010-03-26 EP EP10766931.9A patent/EP2422761B1/en not_active Not-in-force
- 2010-03-26 JP JP2011510268A patent/JP5550638B2/ja active Active
- 2010-03-26 WO PCT/JP2010/055315 patent/WO2010122872A1/ja active Application Filing
- 2010-03-26 US US13/265,522 patent/US9155679B2/en active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4861335A (en) * | 1985-07-26 | 1989-08-29 | Duoject Medical Systems Inc. | Syringe |
EP0505611A2 (de) * | 1991-03-05 | 1992-09-30 | Kautex Werke Reinold Hagen Ag | Quetschflasche mit Innenbehälter |
JP2006055452A (ja) | 2004-08-20 | 2006-03-02 | Terumo Corp | 薬剤収納容器 |
Non-Patent Citations (1)
Title |
---|
See also references of EP2422761A4 * |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103458852A (zh) * | 2011-03-28 | 2013-12-18 | 泰尔茂株式会社 | 药剂收纳容器 |
WO2013035543A1 (ja) | 2011-09-07 | 2013-03-14 | テルモ株式会社 | 医療用容器および医療用容器の製造方法 |
JPWO2013035543A1 (ja) * | 2011-09-07 | 2015-03-23 | テルモ株式会社 | 医療用容器および医療用容器の製造方法 |
US9700487B2 (en) | 2011-09-07 | 2017-07-11 | Terumo Kabushiki Kaisha | Medical container and method of manufacturing the same |
JPWO2013047029A1 (ja) * | 2011-09-27 | 2015-03-26 | テルモ株式会社 | 医療用容器 |
US9668938B2 (en) | 2011-09-27 | 2017-06-06 | Terumo Kabushiki Kaisha | Medical container |
CN104023770A (zh) * | 2011-12-22 | 2014-09-03 | B.布劳恩梅尔松根公司 | 多腔混合容器 |
US20160367438A1 (en) * | 2012-10-22 | 2016-12-22 | Parenteral Technologies, Llc | Methods and apparatuses for delivering medicaments to intravenous fluid |
US10143622B2 (en) * | 2012-10-22 | 2018-12-04 | Parenteral Technologies, Llc | Methods and apparatuses for delivering medicaments to intravenous fluid |
US11058606B2 (en) * | 2012-10-22 | 2021-07-13 | Parenteral Technologies, Llc | Methods and apparatuses for delivering medicaments to intravenous fluid |
Also Published As
Publication number | Publication date |
---|---|
JP5550638B2 (ja) | 2014-07-16 |
CN102395346A (zh) | 2012-03-28 |
US9155679B2 (en) | 2015-10-13 |
CN102395346B (zh) | 2014-01-29 |
EP2422761A1 (en) | 2012-02-29 |
EP2422761A4 (en) | 2014-02-26 |
JPWO2010122872A1 (ja) | 2012-10-25 |
US20120053529A1 (en) | 2012-03-01 |
EP2422761B1 (en) | 2016-11-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP5550638B2 (ja) | 医療用容器 | |
JP4112851B2 (ja) | 2室型プレフィルドシリンジ | |
JP5361875B2 (ja) | コネクタ組立体 | |
WO2013035543A1 (ja) | 医療用容器および医療用容器の製造方法 | |
JP6096676B2 (ja) | 医療用器具 | |
JP2010179063A (ja) | 薬剤収納容器 | |
JP3811005B2 (ja) | 医療用容器 | |
WO2011093389A1 (ja) | 薬剤収納容器 | |
JP5426550B2 (ja) | 薬剤収納容器 | |
JP4598359B2 (ja) | 液体注入器具 | |
JP4144027B2 (ja) | 2成分混合タイプのプレフィルドシリンジ | |
JP2004129867A (ja) | 口部材およびそれを備える薬液容器 | |
US9668938B2 (en) | Medical container | |
JP6633956B2 (ja) | 液体注入器具 | |
JP3748664B2 (ja) | 薬液注入器具 | |
WO2013047030A1 (ja) | 医療用容器 | |
JP6718724B2 (ja) | 液体注入器具 | |
JP4152103B2 (ja) | プレフィルドシリンジ | |
JP5963741B2 (ja) | 薬剤収納容器 | |
JP2003199825A (ja) | プレフィルドシリンジ | |
JP2017148228A (ja) | 薬剤収納済み軟質医療用容器および薬剤投与具 | |
WO2012117622A1 (ja) | プレフィルドシリンジ及びプレフィルドシリンジの製造方法 | |
JP2005034637A (ja) | 変位栓体付き注排口及び該注排口を備えてなる医療用容器 | |
JP4426162B2 (ja) | 口部材およびそれを備える薬液容器 | |
JP2006081686A (ja) | バイアルポートおよびこれを備えた薬液キット |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WWE | Wipo information: entry into national phase |
Ref document number: 201080017172.X Country of ref document: CN |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 10766931 Country of ref document: EP Kind code of ref document: A1 |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2011510268 Country of ref document: JP |
|
REEP | Request for entry into the european phase |
Ref document number: 2010766931 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 13265522 Country of ref document: US Ref document number: 2010766931 Country of ref document: EP |
|
NENP | Non-entry into the national phase |
Ref country code: DE |