WO2009069558A1 - 医療用インプラント用ラクチド／ε－カプロラクトン共重合体、医療用インプラント用ラクチド／ε－カプロラクトン共重合体の製造方法、医療用インプラント及び人工硬膜 - Google Patents

医療用インプラント用ラクチド／ε－カプロラクトン共重合体、医療用インプラント用ラクチド／ε－カプロラクトン共重合体の製造方法、医療用インプラント及び人工硬膜 Download PDF

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Publication number
WO2009069558A1
WO2009069558A1 PCT/JP2008/071249 JP2008071249W WO2009069558A1 WO 2009069558 A1 WO2009069558 A1 WO 2009069558A1 JP 2008071249 W JP2008071249 W JP 2008071249W WO 2009069558 A1 WO2009069558 A1 WO 2009069558A1
Authority
WO
WIPO (PCT)
Prior art keywords
medical implant
lactide
copolymer
caprolactone copolymer
caprolactone
Prior art date
Application number
PCT/JP2008/071249
Other languages
English (en)
French (fr)
Inventor
Hidetoshi Arimura
Tsuguyoshi Taira
Yoshitake Takahashi
Original Assignee
Gunze Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2007308547A external-priority patent/JP2009131358A/ja
Priority claimed from JP2007308548A external-priority patent/JP2009132769A/ja
Application filed by Gunze Limited filed Critical Gunze Limited
Priority to EP08854298A priority Critical patent/EP2218466A4/en
Priority to AU2008330777A priority patent/AU2008330777A1/en
Priority to CN2008801183661A priority patent/CN101878048A/zh
Priority to BRPI0819859-4A priority patent/BRPI0819859A2/pt
Publication of WO2009069558A1 publication Critical patent/WO2009069558A1/ja

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials For Medical Uses (AREA)
  • Polyesters Or Polycarbonates (AREA)

Abstract

　本発明は、高級アルコールを含まずに極めて安全性が高く、かつ、人工硬膜や人工血管等の柔軟性が求められる医療用インプラントを作製するのに有用である柔軟な医療用インプラント用ラクチド／ε−カプロラクトン共重合体を提供することを目的とする。また、該共重合体の製造方法や、該共重合体を用いてなる医療用インプラント、人工硬膜を提供することを目的とする。 本発明は、医療用インプラント用途に用いるためのラクチドとε‐カプロラクトンとの共重合体であって、ラクチドとε‐カプロラクトンとのモル比（ラクチド／ε‐カプロラクトン）が４０／６０～６０／４０、重量平均分子量が１００，０００～５００，０００以下であり、かつ、高級アルコール成分を含有せず、加熱溶融して成形体としたときの結晶に由来する融解エンタルピーが１０Ｊ／ｇ以下であるラクチド／ε−カプロラクトン共重合体である。
PCT/JP2008/071249 2007-11-29 2008-11-21 医療用インプラント用ラクチド／ε－カプロラクトン共重合体、医療用インプラント用ラクチド／ε－カプロラクトン共重合体の製造方法、医療用インプラント及び人工硬膜 WO2009069558A1 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP08854298A EP2218466A4 (en) 2007-11-29 2008-11-21 COPOLYMER OF LACTIDE / EPSILON-CAPROLACTONE FOR MEDICAL IMPLANT, PROCESS FOR PRODUCTION OF LACTIDE / EPSILON-CAPROLACTONE COPOLYMER FOR MEDICAL IMPLANT, MEDICAL IMPLANT AND ARTIFICIAL HORSE-MOTHER
AU2008330777A AU2008330777A1 (en) 2007-11-29 2008-11-21 Lactide/E-caprolactone copolymer for medical implant, method for producing lactide/epsilon-caprolactone copolymer for medical implant, medical implant and artificial dura mater
CN2008801183661A CN101878048A (zh) 2007-11-29 2008-11-21 医用植入体用丙交酯/ε-己内酯共聚物及其制造方法、医用植入体以及人工硬脑膜
BRPI0819859-4A BRPI0819859A2 (pt) 2007-11-29 2008-11-21 Copolímero de lactida/épisilon-caprolactona para implante médico, método para a produção de copolímero de lactida/épisilon-caprolactona para implante médico, implante médico e dura-máter artificial

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2007-308547 2007-11-29
JP2007308547A JP2009131358A (ja) 2007-11-29 2007-11-29 人工硬膜
JP2007-308548 2007-11-29
JP2007308548A JP2009132769A (ja) 2007-11-29 2007-11-29 医療用インプラント用ラクチド／ε−カプロラクトン共重合体

Publications (1)

Publication Number Publication Date
WO2009069558A1 true WO2009069558A1 (ja) 2009-06-04

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/071249 WO2009069558A1 (ja) 2007-11-29 2008-11-21 医療用インプラント用ラクチド／ε－カプロラクトン共重合体、医療用インプラント用ラクチド／ε－カプロラクトン共重合体の製造方法、医療用インプラント及び人工硬膜

Country Status (8)

Country Link
EP (1) EP2218466A4 (ja)
KR (1) KR20100111664A (ja)
CN (1) CN101878048A (ja)
AU (1) AU2008330777A1 (ja)
BR (1) BRPI0819859A2 (ja)
RU (1) RU2010126481A (ja)
TW (1) TW200922533A (ja)
WO (1) WO2009069558A1 (ja)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101316069B1 (ko) * 2011-08-25 2013-10-11 한국과학기술연구원 유연한 폴리락티드 입체이성질 복합체의 제조방법 및 이의 방법에 의해 제조된 화합물
JP2019526305A (ja) * 2016-11-07 2019-09-19 グンゼ株式会社 生体組織補強材料及び人工硬膜
CN111372969A (zh) * 2017-11-20 2020-07-03 瑞比奥科技公司 组合物

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US20130236499A1 (en) * 2012-03-12 2013-09-12 Sasa Andjelic Segmented, Semicrystalline Poly(Lactide-co-epsilon-Caprolactone) Absorbable Copolymers
CN103418031A (zh) * 2012-05-17 2013-12-04 天津市康尔医疗器械有限公司 一种可吸收硬脑膜修复补片及其制备方法
CN104640904B (zh) * 2012-10-18 2017-05-24 郡是株式会社 生物分解性高分子化合物
JP6242382B2 (ja) 2013-04-12 2017-12-06 国立大学法人京都工芸繊維大学 ラクチド−ラクトン共重合体の製造方法
CN104558542B (zh) * 2013-10-25 2016-05-25 中国石油化工股份有限公司 一种透明弹性聚乳酸共聚物及制备方法
ES2897898T3 (es) 2013-12-17 2022-03-03 Nurami Medical Ltd Una matriz multicapa sustituta de tejidos y usos de la misma
CN106390204B (zh) * 2016-11-16 2019-08-02 浙江省人民医院 一种复合型人工硬脑膜的制备方法
SE542824C2 (en) * 2017-09-22 2020-07-14 Ingevity Uk Ltd Process for producing a lactone copolymer
EP3461857A1 (en) * 2017-09-28 2019-04-03 Helmholtz-Zentrum Geesthacht Zentrum für Material- und Küstenforschung GmbH Surface-functionalised polymeric object and method of its production
CN109364294B (zh) * 2018-11-27 2019-12-17 普丽妍（南京）医疗科技有限公司 一种可吸收人工硬脑膜及其制备方法
WO2020241624A1 (ja) * 2019-05-30 2020-12-03 東レ株式会社 ポリマー組成物、成形体および神経再生誘導チューブ
CN115298243B (zh) * 2020-04-06 2023-12-12 帝人株式会社 脂肪族聚酯的制造方法、脂肪族聚酯树脂和脂肪族聚酯树脂组合物

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JPS60501217A (ja) * 1983-05-05 1985-08-01 ヘクセル　コ−ポレ−シヨン ラクチド―カプロラクトン重合体及びその製造方法
JPH06501045A (ja) 1990-09-10 1994-01-27 リュークスニベルシテイト　テ　グロニンゲン ラクチドとε−カプロラクトンとの共重合体から医療に応用できる物品を製造する方法
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TAKASAWA H.: "Seitai Kyushusei Zairyo o Mochiita Iryo Yogu Kaihatsu", JOURNAL OF JAPANESE SOCIETY FOR BIOMATERIALS, vol. 16, no. 4, 1998, pages 213 - 221, XP008135993 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101316069B1 (ko) * 2011-08-25 2013-10-11 한국과학기술연구원 유연한 폴리락티드 입체이성질 복합체의 제조방법 및 이의 방법에 의해 제조된 화합물
JP2019526305A (ja) * 2016-11-07 2019-09-19 グンゼ株式会社 生体組織補強材料及び人工硬膜
CN111372969A (zh) * 2017-11-20 2020-07-03 瑞比奥科技公司 组合物

Also Published As

Publication number Publication date
CN101878048A (zh) 2010-11-03
AU2008330777A1 (en) 2009-06-04
BRPI0819859A2 (pt) 2015-06-16
RU2010126481A (ru) 2012-01-10
EP2218466A4 (en) 2013-01-16
EP2218466A1 (en) 2010-08-18
KR20100111664A (ko) 2010-10-15
TW200922533A (en) 2009-06-01

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