WO2006117046A1 - Mehrstufige coatingvorrichtung für formkörper - Google Patents
Mehrstufige coatingvorrichtung für formkörper Download PDFInfo
- Publication number
- WO2006117046A1 WO2006117046A1 PCT/EP2006/002993 EP2006002993W WO2006117046A1 WO 2006117046 A1 WO2006117046 A1 WO 2006117046A1 EP 2006002993 W EP2006002993 W EP 2006002993W WO 2006117046 A1 WO2006117046 A1 WO 2006117046A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- drum
- moldings
- segment
- coating
- coating device
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D1/00—Processes for applying liquids or other fluent materials
- B05D1/02—Processes for applying liquids or other fluent materials performed by spraying
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/0002—Processes of manufacture not relating to composition and compounding ingredients
- A23G3/0063—Coating or filling sweetmeats or confectionery
- A23G3/0089—Coating with atomised liquid, droplet bed, liquid spray
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/005—Coating of tablets or the like
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B13/00—Machines or plants for applying liquids or other fluent materials to surfaces of objects or other work by spraying, not covered by groups B05B1/00 - B05B11/00
- B05B13/02—Means for supporting work; Arrangement or mounting of spray heads; Adaptation or arrangement of means for feeding work
- B05B13/0221—Means for supporting work; Arrangement or mounting of spray heads; Adaptation or arrangement of means for feeding work characterised by the means for moving or conveying the objects or other work, e.g. conveyor belts
- B05B13/025—Means for supporting work; Arrangement or mounting of spray heads; Adaptation or arrangement of means for feeding work characterised by the means for moving or conveying the objects or other work, e.g. conveyor belts the objects or work being present in bulk
- B05B13/0257—Means for supporting work; Arrangement or mounting of spray heads; Adaptation or arrangement of means for feeding work characterised by the means for moving or conveying the objects or other work, e.g. conveyor belts the objects or work being present in bulk in a moving container, e.g. a rotatable foraminous drum
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05C—APPARATUS FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05C3/00—Apparatus in which the work is brought into contact with a bulk quantity of liquid or other fluent material
- B05C3/02—Apparatus in which the work is brought into contact with a bulk quantity of liquid or other fluent material the work being immersed in the liquid or other fluent material
- B05C3/04—Apparatus in which the work is brought into contact with a bulk quantity of liquid or other fluent material the work being immersed in the liquid or other fluent material with special provision for agitating the work or the liquid or other fluent material
- B05C3/08—Apparatus in which the work is brought into contact with a bulk quantity of liquid or other fluent material the work being immersed in the liquid or other fluent material with special provision for agitating the work or the liquid or other fluent material the work and the liquid or other fluent material being agitated together in a container, e.g. tumbled
Definitions
- the invention relates to a device according to the preamble of claim 1. It is a quasi-continuous coating device for coating moldings, especially for pharmaceutical products, such as tablets, dragees, pellets and granules.
- the coating device comprises a rotating coating drum, which is subdivided by a transport element into several segments, wherein the supply of process media for all segments can be done individually and depending on the stage of the coating process and the molded body by means of this transport element in the axial direction through the Drum be transported.
- this transport element is shaped as a spindle.
- the invention also relates to an associated method or the use of the device.
- the coating layer is thus adjusted very precisely in pharmaceuticals, often not several different coating layers are required to meet all the above requirements. Furthermore, due to regulatory requirements, the concentrations and masses of all substances per single tablet must be kept within very narrow tolerances, so that previously continuous processes were hardly realized. Essentially, two systems are described in the prior art, both of which work batchwise.
- the first system is a kind of rotating pan or kettle with a generally central opening through which the moldings are filled.
- the heap of moldings is formed by the rotation of the pan in a continuous flow and roll held and over nozzles with a coating medium, usually a liquid, evenly sprayed.
- a coating medium usually a liquid, evenly sprayed.
- the axis of rotation of the boiler is oriented at an angle of approx. 30-50 ° to the horizontal, so that the boiler opening points diagonally upwards.
- volatile constituents are filtered off with suction and then the coated and moist shaped bodies are dried.
- EP 0 088 317 A1 discloses such a system in which the shaped bodies are sprayed with coating medium via nozzles which are attached to a fixed pipe, the pipe projecting through the free opening into the interior of the boiler.
- the suction and drying is realized by a grating, which is mounted inside the boiler and is covered as far as possible by the debris in the filled state even during the rotation.
- the suction line of the device according to EP 0 088 317 A1 is also guided by the aforementioned boiler opening to the outside.
- a comparable device is also disclosed in DE 27 31 351 A1, FR 2 222 957 A1 or in DE 24 23 933 A1. In this first system, the fully coated charge is discharged from the supply lines through the one boiler opening after decoupling.
- the uncoated molded bodies are filled on one side or through a wall opening of a coating drum or container.
- the coating drum rotates during the coating process about a substantially horizontal axis.
- EP 0 198 929 A1, DE 44 45 618 A1 or FR 2,053,554 A5 disclose such coating devices for shaped bodies.
- Another prior art coating apparatus provides multiple directions of movement of the drum and drum internals to hold the moldings in suspension.
- DE 31 49 421 A1 in conjunction with DE-2218729 A discloses such a device.
- the built in the drum mixing, stirring and conveying devices improve the mixing throughout the drum interior, but do not allow continuous production operation.
- a disadvantage of the known in the prior art devices for coating of pharmaceutical moldings is that these are all devices for batch processes that do not allow continuous or quasi-continuous operation and sometimes required multiple Um colllvorêtn are consuming, delay the Process and require expensive suction or encapsulation devices.
- Coating apparatus for coating moldings comprising a perforated drum accommodated in a housing, a mold body conduit for guiding the moldings into the interior of the drum, at least one fluid conduit and nozzles for spraying fluids inside the drum, wherein, in operation, the drum rotates about its horizontal axis to move the body heap.
- the coating device comprises at least one gas suction line to remove moisture and dust from the housing and drum interior of the coating device.
- the drum has several so-called. Segments (drum longitudinal sections), wherein the segments are formed by a transport element, and leads to at least one segment at least one fluid line, are arranged at which nozzles to spray the moldings within the segment. The number of segments is arbitrary and limited only by the mechanical requirements of the drum or the transport element and the other internals.
- the coating device comprises as a transport element, a cylindrical spiral or helix.
- the cylindrical spiral is rotatably mounted and the segments and the pitch of the cylindrical spiral are dimensioned such that by the rotation of the cylindrical spiral by a maximum of one revolution, the molded body of a segment completely moved into the respective subsequent segment or from the coating device be transported out.
- the radius of the cylindrical spiral is ideally chosen such that a small gap remains between the inner side of the drum and the outer edge of the cylindrical spiral, which gap is less than or equal to half the smallest diameter of the shaped bodies to be coated. way smaller than one-fifth of this diameter is.
- the separating element is arranged in a grinding manner in the drum.
- the rotation of the drum and the cylindrical spiral with respect to rotational direction and speed of each other completely independent.
- the segments in the interior of the drum in the region of the axis of rotation are connected to each other by a through opening.
- each individual segment can be supplied with one or more process media independently of the adjacent segment.
- An improved embodiment of the invention is that in at least one segment, one or more mixer elements are arranged, which are mounted so movable that they can be immersed in the bed of the moldings and lifted out of this bed. In the immersed position, these mixing elements produce a transverse mixing in the heap of shaped bodies moved by the rotation of the drum.
- the mixing element is fastened to the transport element, wherein it is shaped such that during the movement of the transport element and the associated transport of the shaped body in the axial direction, no shaped body is lifted out of the total drive ,
- a particular advantage of the invention is the fact that not a single molding can leave the respective segment via a short circuit flow before the end of a coating stage, which is very essential for pharmaceutical products.
- the individual stages within the coating process are just as sharply demarcated as in a known in the art batch device.
- the transition of the moldings in the next treatment stage or the discharge can be done with moving or stationary drum, wherein the cylindrical spiral is rotated by half a maximum or a full rotation, depending on the dimensioning of the segments.
- the invention further includes a process for coating spherical particles, in which the coating device according to the invention and described above is used.
- From the invention is further included to use the coating device according to the invention or the coating process for coating moldings, for manufacturing processes of pharmaceutical products or food.
- the coating device according to the invention can thus be directly connected to the tablet press and the subsequent primary packaging plant, such as a blister machine. This avoids intermediate storage with all the disadvantages of the break and the additional residence times. In particular, for highly effective substances such a closed process from granules to finished packaging can be realized.
- Fig. 1 shows the coating device 1 according to the invention, consisting of an outer housing 2 in which a rotatably mounted perforated drum 3 is arranged.
- an open cylindrical spiral 4 is further provided, which divides the drum interior into three segments A to C.
- the molded bodies 6 to be coated are introduced into the segment A via the molded body conduit 7 and, after complete treatment, leave the coating apparatus via the conduit 8 in all segments.
- FIG. 1 also shows an exhaust element 5 in the form of a shell, which faces a partial surface of the drum 3 with a very small gap width.
- This exhaust air element 5 is connected via the Gasabsaug réelle 9 with a vacuum pump, not shown, and sucks the moisture and dust from the interior of the housing 2 and especially the bed of moldings 6 on the perforated wall of the drum 3 to the outside.
- the moldings 6 are raised by the rotation of the drum 3 at the foot of the bed and rolls due to gravity, especially on the Haufwerksober Structure down, the lowest point of the drum 3 from.
- the exhaust air element 5 is shaped in such a way that it mainly covers completely the drum surface covered by the molded bodies 6 in operation from the rear side.
- nozzles 10 are arranged, which are supplied via a line 11 with fluid, wherein the line 11 in the example shown as an attachment for the nozzles 10 acts.
- the nozzles are arranged in the segments A and B, in which the coating liquid is applied to the moldings 6.
- the segment C the drying and cooling of the coated moldings 6, wherein in the example shown via a gas pressure line 14 and a gas outlet 13 targeted a suitable gas is passed into the segment C in order to optimize the drying and cooling process.
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Polymers & Plastics (AREA)
- Veterinary Medicine (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Medicinal Preparation (AREA)
- Application Of Or Painting With Fluid Materials (AREA)
- Spray Control Apparatus (AREA)
- Coating Apparatus (AREA)
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/919,725 US20090220676A1 (en) | 2005-05-03 | 2006-04-01 | Multi-stage coating device for moulded bodies |
MX2007013820A MX2007013820A (es) | 2005-05-03 | 2006-04-01 | Dispositivo de revestimiento de etapas multiples para formas solidas. |
EP06742531A EP1877195A1 (de) | 2005-05-03 | 2006-04-01 | Mehrstufige coatingvorrichtung für formkörper |
JP2008509314A JP2008540072A (ja) | 2005-05-03 | 2006-04-01 | 固体部材の多段塗布装置 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102005020992.0 | 2005-05-03 | ||
DE102005020992A DE102005020992B3 (de) | 2005-05-03 | 2005-05-03 | Mehrstufige Coatingvorrichtung für Formkörper |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2006117046A1 true WO2006117046A1 (de) | 2006-11-09 |
Family
ID=36649603
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2006/002993 WO2006117046A1 (de) | 2005-05-03 | 2006-04-01 | Mehrstufige coatingvorrichtung für formkörper |
Country Status (7)
Country | Link |
---|---|
US (1) | US20090220676A1 (de) |
EP (1) | EP1877195A1 (de) |
JP (1) | JP2008540072A (de) |
CN (1) | CN101193710A (de) |
DE (1) | DE102005020992B3 (de) |
MX (1) | MX2007013820A (de) |
WO (1) | WO2006117046A1 (de) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2346496A1 (de) * | 2008-10-14 | 2011-07-27 | Bayer Healthcare Llc | Verfahren zur beschichtung von objekten |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102005010005A1 (de) * | 2005-03-04 | 2006-12-28 | Nunner, Dieter | Vorrichtung und Verfahren zur Beschichtung von Kleinteilen |
US7908992B2 (en) * | 2007-01-09 | 2011-03-22 | R.P. Scherer Technologies, Llc | System and method for dusting soft capsules |
DE102008001104A1 (de) * | 2008-04-10 | 2009-10-15 | Gebrüder Lödige Maschinenbau GmbH | Geschlossen vollperforierte Coating Trommel |
IT1392568B1 (it) * | 2008-12-24 | 2012-03-09 | Soremartec Sa | Metodo e macchina per il rivestimento in continuo di anime di prodotti, in particolare, prodotti dolciari |
IT1401362B1 (it) * | 2010-06-10 | 2013-07-18 | Soremartec Sa | Metodo per il rivestimento di anime di prodotti dolciari |
CN103044134B (zh) * | 2012-12-10 | 2014-08-20 | 金正大生态工程集团股份有限公司 | 一种对包膜控释肥进行防漂浮处理、添加微量元素的装置及其工作方法 |
CN108405223B (zh) * | 2016-06-21 | 2020-08-07 | 台州市路桥欧铂喷塑电泳有限公司 | 一种自动上漆装置及其上漆方法 |
CN106694312A (zh) * | 2017-02-28 | 2017-05-24 | 贾建胜 | 一种家用***生产用密封圈润滑装置 |
CN107242600A (zh) * | 2017-08-09 | 2017-10-13 | 李占福 | 一种饲料添加剂包衣装置 |
CN107625649B (zh) * | 2017-10-10 | 2020-04-14 | 吉林农业科技学院 | 一种中药制丸丸体包衣装置 |
CN108654925B (zh) * | 2018-05-11 | 2021-09-17 | 江苏武专科技有限公司 | 螺栓类小工件用浸漆装置 |
CN111374890A (zh) * | 2018-12-29 | 2020-07-07 | 甘肃康华制药机械设备有限公司 | 一种中药炒药机 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1115517A (en) * | 1966-04-13 | 1968-05-29 | Plastic Coatings Ltd | Improvements in or relating to methods of and means for coating, cleaning or otherwise treating articles |
US3911860A (en) * | 1973-05-08 | 1975-10-14 | Driam Metallprodukt Gmbh & Co | Device for the continuous production of dragees |
US3946996A (en) * | 1972-04-18 | 1976-03-30 | Barmag Barmer Maschinenfabrik Aktiengesellschaft | Mixing and granulating apparatus |
US5010838A (en) * | 1985-07-10 | 1991-04-30 | Nabisco Brands, Inc. | Apparatus for continuous pan coating |
US5401534A (en) * | 1992-03-17 | 1995-03-28 | Rhone-Poulenc Agrochimie | Process and apparatus for continuous treatment of particles |
WO2005011398A1 (de) * | 2003-08-01 | 2005-02-10 | Driam Anlagenbau Gmbh | Verfahren und vorrichtung zum kontinuierlichen beschichten von kernen mit einer dragiervorrichtung |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH428094A (de) * | 1963-09-19 | 1967-01-15 | Wander Ag Dr A | Vorrichtung zum Überziehen von Formlingen mit einem Deckbelag |
FR2053554A5 (en) * | 1969-07-08 | 1971-04-16 | Dumoulin Et Cie Ets | Variable tilt coating drum |
DE2315882C3 (de) * | 1973-03-30 | 1975-10-23 | Glatt, Werner, 7859 Haltingen | Trocknungsvorrichtung für eine Dragiertrommel |
JPS5621466Y2 (de) * | 1976-10-05 | 1981-05-21 | ||
AT375279B (de) * | 1980-12-15 | 1984-07-25 | Gergely Gerhard | Verfahren und vorrichtung zur oberflaechenbehandlung von granulaten oder presskoerpern |
DE3207869A1 (de) * | 1982-03-05 | 1983-09-15 | Boehringer Mannheim Gmbh, 6800 Mannheim | Vorrichtung zum ueberziehen eines dragiergutes |
EP0198929A1 (de) * | 1983-12-21 | 1986-10-29 | Takeda Chemical Industries, Ltd. | Einrichtung zum Beschichten |
JPS60133838A (ja) * | 1983-12-21 | 1985-07-17 | Takeda Chem Ind Ltd | パンコ−チング装置 |
DE4445618C2 (de) * | 1994-12-21 | 1997-09-04 | Loedige Maschbau Gmbh Geb | Vorrichtung für die Filmlackierung und/oder Zuckerdragierung |
-
2005
- 2005-05-03 DE DE102005020992A patent/DE102005020992B3/de not_active Expired - Fee Related
-
2006
- 2006-04-01 EP EP06742531A patent/EP1877195A1/de not_active Withdrawn
- 2006-04-01 MX MX2007013820A patent/MX2007013820A/es unknown
- 2006-04-01 WO PCT/EP2006/002993 patent/WO2006117046A1/de active Application Filing
- 2006-04-01 JP JP2008509314A patent/JP2008540072A/ja not_active Withdrawn
- 2006-04-01 US US11/919,725 patent/US20090220676A1/en not_active Abandoned
- 2006-04-01 CN CNA2006800200853A patent/CN101193710A/zh active Pending
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1115517A (en) * | 1966-04-13 | 1968-05-29 | Plastic Coatings Ltd | Improvements in or relating to methods of and means for coating, cleaning or otherwise treating articles |
US3946996A (en) * | 1972-04-18 | 1976-03-30 | Barmag Barmer Maschinenfabrik Aktiengesellschaft | Mixing and granulating apparatus |
US3911860A (en) * | 1973-05-08 | 1975-10-14 | Driam Metallprodukt Gmbh & Co | Device for the continuous production of dragees |
US5010838A (en) * | 1985-07-10 | 1991-04-30 | Nabisco Brands, Inc. | Apparatus for continuous pan coating |
US5401534A (en) * | 1992-03-17 | 1995-03-28 | Rhone-Poulenc Agrochimie | Process and apparatus for continuous treatment of particles |
WO2005011398A1 (de) * | 2003-08-01 | 2005-02-10 | Driam Anlagenbau Gmbh | Verfahren und vorrichtung zum kontinuierlichen beschichten von kernen mit einer dragiervorrichtung |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2346496A1 (de) * | 2008-10-14 | 2011-07-27 | Bayer Healthcare Llc | Verfahren zur beschichtung von objekten |
EP2346496A4 (de) * | 2008-10-14 | 2012-10-17 | Bayer Healthcare Llc | Verfahren zur beschichtung von objekten |
Also Published As
Publication number | Publication date |
---|---|
EP1877195A1 (de) | 2008-01-16 |
JP2008540072A (ja) | 2008-11-20 |
MX2007013820A (es) | 2008-02-05 |
CN101193710A (zh) | 2008-06-04 |
DE102005020992B3 (de) | 2006-12-14 |
US20090220676A1 (en) | 2009-09-03 |
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