WO2005104648A3 - Nanopartículas pegiladas - Google Patents

Nanopartículas pegiladas Download PDF

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Publication number
WO2005104648A3
WO2005104648A3 PCT/ES2005/000226 ES2005000226W WO2005104648A3 WO 2005104648 A3 WO2005104648 A3 WO 2005104648A3 ES 2005000226 W ES2005000226 W ES 2005000226W WO 2005104648 A3 WO2005104648 A3 WO 2005104648A3
Authority
WO
WIPO (PCT)
Prior art keywords
nanoparticles
polyethylene glycol
type
pegylation
pvm
Prior art date
Application number
PCT/ES2005/000226
Other languages
English (en)
French (fr)
Other versions
WO2005104648A2 (es
Inventor
Garreta Juan Manuel Irache
Krassimira Pavlova Yoncheva
Original Assignee
Inst Cientifico Tecnol Navarra
Garreta Juan Manuel Irache
Krassimira Pavlova Yoncheva
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Cientifico Tecnol Navarra, Garreta Juan Manuel Irache, Krassimira Pavlova Yoncheva filed Critical Inst Cientifico Tecnol Navarra
Priority to AU2005237270A priority Critical patent/AU2005237270B2/en
Priority to EP05745586A priority patent/EP1752142B1/en
Priority to US11/568,454 priority patent/US8628801B2/en
Priority to AT05745586T priority patent/ATE442841T1/de
Priority to DE602005016674T priority patent/DE602005016674D1/de
Priority to JP2007510054A priority patent/JP2007534729A/ja
Priority to CA2564982A priority patent/CA2564982C/en
Priority to BRPI0509827A priority patent/BRPI0509827B8/pt
Priority to MXPA06012583A priority patent/MXPA06012583A/es
Publication of WO2005104648A2 publication Critical patent/WO2005104648A2/es
Publication of WO2005104648A3 publication Critical patent/WO2005104648A3/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
    • A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
    • A61K47/6931—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer
    • A61K47/6933—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer the polymer being obtained by reactions only involving carbon to carbon, e.g. poly(meth)acrylate, polystyrene, polyvinylpyrrolidone or polyvinylalcohol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F222/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides, or nitriles thereof
    • C08F222/04—Anhydrides, e.g. cyclic anhydrides
    • C08F222/06—Maleic anhydride
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less

Abstract

Nanopartículas que comprenden un polímero biodegradable, preferentemente el copolímero de metil vinil éter y anhídrido maleico (PVM/MA) , y un polietilenglicol o derivados de éste. Estas nanopartículas son fáciles de producir, y dan excelentes características de bioadhesion, tamaño y potencial zeta que las hace adecuadas para la administración de moléculas activas. La selección del tipo de polietilenglicol utilizado en su producción permite modular convenientemente las características de estas nanopartículas lo cual puede ser aprovechado ventajosamente según el tipo de fármaco a transportar y/o el modo de administración de la formulación farmacéutica. La pegilación se realiza por incubación simple durante un corto periodo de tiempo de las dos macromoléculas en cuestión, sin necesidad de tener que recurrir al uso de disolventes orgánicos de elevada toxicidad, ni procedimientos de síntesis orgánica largos y penosos. Además, el proceso de pegilación se puede asociar al procedimiento de encapsulación de la molécula biológicamente activa.
PCT/ES2005/000226 2004-04-29 2005-04-28 Nanopartículas pegiladas WO2005104648A2 (es)

Priority Applications (9)

Application Number Priority Date Filing Date Title
AU2005237270A AU2005237270B2 (en) 2004-04-29 2005-04-28 Pegylated nanoparticles
EP05745586A EP1752142B1 (en) 2004-04-29 2005-04-28 Pegylated nanoparticles
US11/568,454 US8628801B2 (en) 2004-04-29 2005-04-28 Pegylated nanoparticles
AT05745586T ATE442841T1 (de) 2004-04-29 2005-04-28 Pegylierte nanoteilchen
DE602005016674T DE602005016674D1 (de) 2004-04-29 2005-04-28 Pegylierte nanoteilchen
JP2007510054A JP2007534729A (ja) 2004-04-29 2005-04-28 ペグ化ナノ粒子
CA2564982A CA2564982C (en) 2004-04-29 2005-04-28 Pegylated nanoparticles
BRPI0509827A BRPI0509827B8 (pt) 2004-04-29 2005-04-28 nanopartículas pegiladas para transporte de moléculas biologicamente ativas, composição farmacêutica, liofilizato constituindo nanopartículas pegiladas e processo de preparação de nanopartículas pegiladas
MXPA06012583A MXPA06012583A (es) 2004-04-29 2005-04-28 Nanoparticulas pegiladas.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200401022A ES2246694B1 (es) 2004-04-29 2004-04-29 Nanoparticulas pegiladas.
ESP200401022 2004-04-29

Publications (2)

Publication Number Publication Date
WO2005104648A2 WO2005104648A2 (es) 2005-11-10
WO2005104648A3 true WO2005104648A3 (es) 2005-12-08

Family

ID=35242088

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/ES2005/000226 WO2005104648A2 (es) 2004-04-29 2005-04-28 Nanopartículas pegiladas

Country Status (13)

Country Link
US (1) US8628801B2 (es)
EP (1) EP1752142B1 (es)
JP (1) JP2007534729A (es)
CN (1) CN1976688A (es)
AT (1) ATE442841T1 (es)
AU (1) AU2005237270B2 (es)
BR (1) BRPI0509827B8 (es)
CA (1) CA2564982C (es)
DE (1) DE602005016674D1 (es)
ES (2) ES2246694B1 (es)
MX (1) MXPA06012583A (es)
RU (1) RU2400215C2 (es)
WO (1) WO2005104648A2 (es)

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CA2564982A1 (en) 2005-11-10
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