ES2177592T3 - Nanoparticulas biocompatibles y biodegradables para la absorcion y administracion de medicamentos proteinicos. - Google Patents
Nanoparticulas biocompatibles y biodegradables para la absorcion y administracion de medicamentos proteinicos.Info
- Publication number
- ES2177592T3 ES2177592T3 ES95110445T ES95110445T ES2177592T3 ES 2177592 T3 ES2177592 T3 ES 2177592T3 ES 95110445 T ES95110445 T ES 95110445T ES 95110445 T ES95110445 T ES 95110445T ES 2177592 T3 ES2177592 T3 ES 2177592T3
- Authority
- ES
- Spain
- Prior art keywords
- biocompatible
- proteinic
- medicines
- administration
- absorption
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002105 nanoparticle Substances 0.000 title abstract 2
- 238000010521 absorption reaction Methods 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 abstract 2
- 229920000249 biocompatible polymer Polymers 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
- A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5192—Processes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/788—Of specified organic or carbon-based composition
- Y10S977/797—Lipid particle
- Y10S977/798—Lipid particle having internalized material
- Y10S977/799—Containing biological material
- Y10S977/801—Drug
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Nanotechnology (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
COMBINACION DE POLIMEROS OBTENIBLE MEDIANTE UN PROCESO QUE INCLUYE LAS SIGUIENTES FASES DE MEZCLA: - UN POLIMERO BIOCOMPATIBLE CAPAZ DE FORMAR NANOPARTICULAS Y - UN AGENTE DE INTERACCION BIOCOMPATIBLE PARA CONSEGUIR LA COMBINACION POLIMERICA SUCEPTIBLE DE SER ADMINISTRADA CON EL MEDICAMENTO CUYO AGENTE INTERACTUANTE ES CAPAZ DE PRESERVAR LA ACTIVIDAD DEL MEDICAMENTO A ADMINISTRAR Y EN LA CUAL EL AGENTE INTERACTUANTE ES CAPAZ DE CONTROLAR LA DISTRIBUCION DEL MEDICAMENTO A ADMINISTRAR.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP95110445A EP0752245B1 (en) | 1995-07-05 | 1995-07-05 | Biocompatible and biodegradable nanoparticles designed for proteinaceous drugs absorption and delivery |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2177592T3 true ES2177592T3 (es) | 2002-12-16 |
Family
ID=8219415
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95110445T Expired - Lifetime ES2177592T3 (es) | 1995-07-05 | 1995-07-05 | Nanoparticulas biocompatibles y biodegradables para la absorcion y administracion de medicamentos proteinicos. |
Country Status (10)
Country | Link |
---|---|
US (1) | US5962566A (es) |
EP (1) | EP0752245B1 (es) |
JP (1) | JP3486417B2 (es) |
AT (1) | ATE217792T1 (es) |
CA (1) | CA2226166C (es) |
DE (1) | DE69526787T2 (es) |
DK (1) | DK0752245T3 (es) |
ES (1) | ES2177592T3 (es) |
PT (1) | PT752245E (es) |
WO (1) | WO1997002022A1 (es) |
Families Citing this family (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU752802C (en) | 1997-11-14 | 2006-04-13 | Pacira Pharmaceuticals, Inc. | Production of multivesicular liposomes |
US7651875B2 (en) * | 1998-06-08 | 2010-01-26 | Borealis Technical Limited | Catalysts |
US6264991B1 (en) * | 1998-08-18 | 2001-07-24 | Southern Research Institute | Compositions and methods for treating intracellular infections |
CN1406140A (zh) | 2000-02-28 | 2003-03-26 | 吉倪塞思公司 | 纳米胶囊包封***与方法 |
US20050048126A1 (en) | 2000-12-22 | 2005-03-03 | Barrett Rabinow | Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug |
US8067032B2 (en) | 2000-12-22 | 2011-11-29 | Baxter International Inc. | Method for preparing submicron particles of antineoplastic agents |
US9700866B2 (en) | 2000-12-22 | 2017-07-11 | Baxter International Inc. | Surfactant systems for delivery of organic compounds |
US20040126900A1 (en) * | 2001-04-13 | 2004-07-01 | Barry Stephen E | High affinity peptide- containing nanoparticles |
US20060003012A9 (en) | 2001-09-26 | 2006-01-05 | Sean Brynjelsen | Preparation of submicron solid particle suspensions by sonication of multiphase systems |
CA2461349C (en) | 2001-09-26 | 2011-11-29 | Baxter International Inc. | Preparation of submicron sized nanoparticles via dispersion and solvent or liquid phase removal |
EP1306127B2 (en) * | 2001-10-26 | 2011-09-07 | OctoPlus PolyActive Sciences B.V. | Method for the preparation of purified microparticles |
WO2003043586A2 (en) * | 2001-11-20 | 2003-05-30 | Advanced Inhalation Research, Inc. | Compositions for sustained action product delivery |
US20040038303A1 (en) * | 2002-04-08 | 2004-02-26 | Unger Gretchen M. | Biologic modulations with nanoparticles |
ATE466281T1 (de) * | 2002-05-07 | 2010-05-15 | Univ New York State Res Found | ßHIGH THROUGPUTß METHODE, UM BIOMOLEKÜLANLIEFERUNG FORMULIERUNGEN ZU KENNZEICHNEN |
US7160551B2 (en) * | 2002-07-09 | 2007-01-09 | The Board Of Trustees Of The University Of Illinois | Injectable system for controlled drug delivery |
EP1537846A1 (en) * | 2002-09-11 | 2005-06-08 | Tanabe Seiyaku Co., Ltd. | Process for the production of microspheres and unit therefor |
US8409618B2 (en) | 2002-12-20 | 2013-04-02 | Kimberly-Clark Worldwide, Inc. | Odor-reducing quinone compounds |
US7666410B2 (en) | 2002-12-20 | 2010-02-23 | Kimberly-Clark Worldwide, Inc. | Delivery system for functional compounds |
US6780896B2 (en) * | 2002-12-20 | 2004-08-24 | Kimberly-Clark Worldwide, Inc. | Stabilized photoinitiators and applications thereof |
ES2226567B1 (es) * | 2003-06-20 | 2006-07-01 | Universidad De Santiago De Compostela | Nanoparticulas de acido hialuronico. |
ES2232287B1 (es) * | 2003-07-04 | 2006-11-01 | Advanced In Vitro Cell Technologies, S.L. | Nanoparticulas de derivados polioxietilenados. |
WO2005035606A1 (en) * | 2003-10-10 | 2005-04-21 | Samyang Corporation | Amphiphilic block copolymer and polymeric composition comprising the same for drug delivery |
US7837663B2 (en) | 2003-10-16 | 2010-11-23 | Kimberly-Clark Worldwide, Inc. | Odor controlling article including a visual indicating device for monitoring odor absorption |
US7754197B2 (en) | 2003-10-16 | 2010-07-13 | Kimberly-Clark Worldwide, Inc. | Method for reducing odor using coordinated polydentate compounds |
US7879350B2 (en) | 2003-10-16 | 2011-02-01 | Kimberly-Clark Worldwide, Inc. | Method for reducing odor using colloidal nanoparticles |
US7678367B2 (en) | 2003-10-16 | 2010-03-16 | Kimberly-Clark Worldwide, Inc. | Method for reducing odor using metal-modified particles |
US7488520B2 (en) | 2003-10-16 | 2009-02-10 | Kimberly-Clark Worldwide, Inc. | High surface area material blends for odor reduction, articles utilizing such blends and methods of using same |
US7794737B2 (en) | 2003-10-16 | 2010-09-14 | Kimberly-Clark Worldwide, Inc. | Odor absorbing extrudates |
US7413550B2 (en) | 2003-10-16 | 2008-08-19 | Kimberly-Clark Worldwide, Inc. | Visual indicating device for bad breath |
ES2246694B1 (es) * | 2004-04-29 | 2007-05-01 | Instituto Cientifico Y Tecnologico De Navarra, S.A. | Nanoparticulas pegiladas. |
ES2246695B1 (es) * | 2004-04-29 | 2007-05-01 | Instituto Cientifico Y Tecnologico De Navarra, S.A. | Composicion estimuladora de la respuesta inmunitaria que comprende nanoparticulas a base de un copolimero de metil vinil eter y anhidrido maleico. |
CA2571899A1 (en) * | 2004-07-01 | 2006-08-03 | Yale University | Targeted and high density drug loaded polymeric materials |
US7332159B2 (en) * | 2004-09-30 | 2008-02-19 | Board Of Regents Of The University Of Nebraska | Method and composition for inhibiting reperfusion injury in the brain |
US8846607B2 (en) * | 2004-10-29 | 2014-09-30 | President And Fellows Of Harvard College | Particles for treatment of pulmonary infection |
US8263105B2 (en) | 2004-12-01 | 2012-09-11 | Tyco Healthcare Group Lp | Biomaterial drug delivery and surface modification compositions |
CA2526541C (en) | 2004-12-01 | 2013-09-03 | Tyco Healthcare Group Lp | Novel biomaterial drug delivery and surface modification compositions |
WO2006112477A1 (ja) * | 2005-04-20 | 2006-10-26 | Taiho Pharmaceutical Co., Ltd. | アジュバントとしてのポリアミノ酸 |
KR100718329B1 (ko) * | 2005-09-08 | 2007-05-14 | 광주과학기술원 | 다당류로 기능화된 수화젤막을 가지는 나노입자와 이를포함하는 서방형 약물전달시스템 및 그 제조방법 |
US20070248675A1 (en) * | 2005-09-08 | 2007-10-25 | Gwangju Institute Of Science And Technology | Composite comprising polysaccharide-functionalized nanoparticle and hydrogel matrix, a drug delivery system and a bone defect replacement matrix for sustained release comprising the same, and the preparation method thereof |
US7977103B2 (en) | 2006-04-20 | 2011-07-12 | Kimberly-Clark Worldwide, Inc. | Method for detecting the onset of ovulation |
US8124598B2 (en) | 2006-09-14 | 2012-02-28 | Sharon Sageman | 7-keto DHEA for psychiatric use |
US20080102127A1 (en) * | 2006-10-26 | 2008-05-01 | Gao Hai Y | Hybrid lipid-polymer nanoparticulate delivery composition |
EP2078052B1 (en) * | 2006-10-31 | 2010-07-28 | Surmodics Pharmaceuticals, Inc. | Spheronized polymer particles |
US10265407B2 (en) | 2007-02-15 | 2019-04-23 | Yale University | Modular nanodevices for smart adaptable vaccines |
WO2008109347A2 (en) * | 2007-03-02 | 2008-09-12 | Yale University | Methods for ex vivo administration of drugs to grafts using polymeric nanoparticles |
US8722736B2 (en) | 2007-05-22 | 2014-05-13 | Baxter International Inc. | Multi-dose concentrate esmolol with benzyl alcohol |
US8426467B2 (en) | 2007-05-22 | 2013-04-23 | Baxter International Inc. | Colored esmolol concentrate |
US20090061009A1 (en) * | 2007-08-29 | 2009-03-05 | Joseph Schwarz | Composition and Method of Treatment of Bacterial Infections |
US20100160274A1 (en) * | 2007-09-07 | 2010-06-24 | Sharon Sageman | 7-KETO DHEA for Psychiatric Use |
WO2009073215A1 (en) * | 2007-12-06 | 2009-06-11 | Bend Research, Inc. | Pharmaceutical compositions comprising nanoparticles and a resuspending material |
US8986253B2 (en) | 2008-01-25 | 2015-03-24 | Tandem Diabetes Care, Inc. | Two chamber pumps and related methods |
KR101005562B1 (ko) | 2008-05-01 | 2011-01-05 | 한국생명공학연구원 | 난용성 약물을 함유하는 균일한 크기의 고분자 나노입자제조방법 |
US8408421B2 (en) | 2008-09-16 | 2013-04-02 | Tandem Diabetes Care, Inc. | Flow regulating stopcocks and related methods |
WO2010033878A2 (en) | 2008-09-19 | 2010-03-25 | David Brown | Solute concentration measurement device and related methods |
WO2010114768A1 (en) * | 2009-03-30 | 2010-10-07 | Cerulean Pharma Inc. | Polymer-epothilone conjugates, particles, compositions, and related methods of use |
WO2010114770A1 (en) * | 2009-03-30 | 2010-10-07 | Cerulean Pharma Inc. | Polymer-agent conjugates, particles, compositions, and related methods of use |
CA2756072A1 (en) * | 2009-03-30 | 2010-10-14 | Cerulean Pharma Inc. | Polymer-agent conjugates, particles, compositions, and related methods of use |
US8758323B2 (en) | 2009-07-30 | 2014-06-24 | Tandem Diabetes Care, Inc. | Infusion pump system with disposable cartridge having pressure venting and pressure feedback |
JP5796275B2 (ja) * | 2010-06-02 | 2015-10-21 | セイコーエプソン株式会社 | 分光測定器 |
CN103221070B (zh) | 2010-08-30 | 2019-07-12 | 哈佛大学校长及研究员协会 | 用于狭窄病变和溶解血栓疗法的切变控制释放 |
EP2841098A4 (en) | 2012-04-23 | 2016-03-02 | Allertein Therapeutics Llc | NANOPARTICLES FOR THE TREATMENT OF ALLERGIES |
US9180242B2 (en) | 2012-05-17 | 2015-11-10 | Tandem Diabetes Care, Inc. | Methods and devices for multiple fluid transfer |
US9173998B2 (en) | 2013-03-14 | 2015-11-03 | Tandem Diabetes Care, Inc. | System and method for detecting occlusions in an infusion pump |
CA2907915C (en) | 2013-04-03 | 2023-03-07 | Allertein Therapeutics, Llc | Immunomodulatory nanoparticle compositions comprising a plurality of nanoparticles comprising biodegradable or biocompatible polymers and hydrophilic and hydrophobic cellular components |
ES2640648T3 (es) | 2013-09-16 | 2017-11-03 | Astrazeneca Ab | Nanopartículas poliméricas terapéuticas y métodos para su fabricación y uso |
WO2015160794A1 (en) * | 2014-04-14 | 2015-10-22 | Ecosynthetix Ltd. | Bio-based nanoparticle and composite materials derived therefrom |
CA2959660A1 (en) | 2014-09-03 | 2016-03-10 | Genesegues, Inc. | Therapeutic nanoparticles and related compositions, methods, and systems |
US10548881B2 (en) | 2016-02-23 | 2020-02-04 | Tarveda Therapeutics, Inc. | HSP90 targeted conjugates and particles and formulations thereof |
US11654117B2 (en) * | 2016-11-03 | 2023-05-23 | Case Western Reserve University | Melt processed viral nanoparticle constructs |
US20230355540A1 (en) | 2020-09-29 | 2023-11-09 | Oxford University Innovation Limited | Stroke treatment |
US11033495B1 (en) | 2021-01-22 | 2021-06-15 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
US11357727B1 (en) | 2021-01-22 | 2022-06-14 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
US11278494B1 (en) | 2021-01-22 | 2022-03-22 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4548922A (en) * | 1983-06-06 | 1985-10-22 | Beth Israel Hospital | Drug administration |
FR2608988B1 (fr) * | 1986-12-31 | 1991-01-11 | Centre Nat Rech Scient | Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanoparticules |
AU610594B2 (en) * | 1987-04-16 | 1991-05-23 | Christian Bindschaedler | Process for preparing a powder of water-insoluble polymer which can be redispersed in a liquid phase, the resulting powder and utilization thereof |
FR2660556B1 (fr) * | 1990-04-06 | 1994-09-16 | Rhone Poulenc Sante | Microspheres, leur procede de preparation et leur utilisation. |
US5145684A (en) * | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
FR2678168B1 (fr) * | 1991-06-28 | 1993-09-03 | Rhone Poulenc Rorer Sa | Nanoparticules ayant un temps de capture par le dysteme reticulo endothelial allonge. |
US5330768A (en) * | 1991-07-05 | 1994-07-19 | Massachusetts Institute Of Technology | Controlled drug delivery using polymer/pluronic blends |
ES2034891B1 (es) * | 1991-08-08 | 1993-12-16 | Cusi Lab | Procedimiento de elaboracion en continuo de sistemas coloidales dispersos, en forma de nanocapsulas o nanoparticulas. |
ES2078175B1 (es) * | 1993-12-31 | 1996-10-16 | Cusi Lab | Formulacion farmaceutica conteniendo clobetasona y tobramicina y sus aplicaciones. |
-
1995
- 1995-07-05 AT AT95110445T patent/ATE217792T1/de not_active IP Right Cessation
- 1995-07-05 EP EP95110445A patent/EP0752245B1/en not_active Expired - Lifetime
- 1995-07-05 ES ES95110445T patent/ES2177592T3/es not_active Expired - Lifetime
- 1995-07-05 DK DK95110445T patent/DK0752245T3/da active
- 1995-07-05 DE DE69526787T patent/DE69526787T2/de not_active Expired - Fee Related
- 1995-07-05 PT PT95110445T patent/PT752245E/pt unknown
-
1996
- 1996-07-02 US US08/973,863 patent/US5962566A/en not_active Expired - Fee Related
- 1996-07-02 JP JP50480797A patent/JP3486417B2/ja not_active Expired - Fee Related
- 1996-07-02 CA CA002226166A patent/CA2226166C/en not_active Expired - Fee Related
- 1996-07-02 WO PCT/EP1996/002878 patent/WO1997002022A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
DE69526787D1 (de) | 2002-06-27 |
EP0752245B1 (en) | 2002-05-22 |
JP3486417B2 (ja) | 2004-01-13 |
PT752245E (pt) | 2002-09-30 |
JPH11504655A (ja) | 1999-04-27 |
CA2226166A1 (en) | 1997-01-23 |
WO1997002022A1 (en) | 1997-01-23 |
US5962566A (en) | 1999-10-05 |
EP0752245A1 (en) | 1997-01-08 |
CA2226166C (en) | 2001-05-08 |
ATE217792T1 (de) | 2002-06-15 |
DK0752245T3 (da) | 2002-09-09 |
DE69526787T2 (de) | 2002-12-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2177592T3 (es) | Nanoparticulas biocompatibles y biodegradables para la absorcion y administracion de medicamentos proteinicos. | |
GT199900151A (es) | Sistema de entrega controlado de droga administrado oralmente, que provee control temporal y espacial. | |
FR2771004B1 (fr) | Utilisation de derives de benzhydryl sulfinyle pour la fabrication de medicaments ayant un effet eveillant dans des situations de troubles de la vigilance d'origine medicamenteuse | |
MX9301823A (es) | Composicion para el suministro de liberacion controlado de un agente biologicamente activo. | |
AU6764390A (en) | Pharmaceutical granules and drug dosage units made therefrom | |
NO923769L (no) | System for iontoforetisk tilfoersel av et medikament | |
GEP20043216B (en) | Orally Administered Controlled Drug Delivery System | |
BRPI0410956A (pt) | pelìculas com base em óxido de polietileno e sistemas de liberação de droga feitos delas | |
DE69229566D1 (de) | Zusammensetzung und verfahren zur freisetzung von arzneistoffen | |
ES2094781T3 (es) | Composicion farmaceutica de microparticulas con liberacion controlada y su proceso de preparacion. | |
ES2177637T3 (es) | Medicamentos para el tratamiento de la restenosis, que comprenden polimeros liberadores de oxido nitrico. | |
ATE321529T1 (de) | Dosierungsform für eine verzögerte und zunehmende wirkstoffsfreisetzung | |
MX9301821A (es) | Sistema de matriz polimerica biodegradable regulador de degradacion y metodo de tratamiento del mismo. | |
UA29563C2 (uk) | Мікрокапсула для тривалого вивільнення фізіологічно активного пептиду | |
IS1858B (is) | Aðferð til að framleiða lyfjablöndu á formi smápilla til að meðhöndla þarmabólgur | |
BG95911A (bg) | Лекарствена парентерална форма с депо действие | |
GR3022033T3 (en) | Transdermal system with stepwise drug release, and its use in local or systemic cosmetic administration | |
UA39884C2 (uk) | Таблетка на основі клодронової кислоти, спосіб її одержання та спосіб лікування остеопорозу | |
KR910005858A (ko) | 지방산 요법 | |
ATE206911T1 (de) | Feste arzneimittelform mit polymerem material verteiltem wirkstoff | |
KR890007728A (ko) | 진통제 제조방법 | |
Mendels et al. | Antidepressant effects of desipramine administered in two dosage schedules. | |
HU9600670D0 (en) | Dextrane esters, process for producing them and their use for encasing and encapsulating medicaments | |
Valentine et al. | Low-Molecular-Weight Heparin in the Initial Treatment of Proximal Deep Vein Thrombosis | |
Paprocki | Workshop B |