WO2005085860B1 - Nouveaux marqueurs de proliferation en pratique clinique et leur utilisation pour le pronostic ou diagnostic du cancer - Google Patents
Nouveaux marqueurs de proliferation en pratique clinique et leur utilisation pour le pronostic ou diagnostic du cancerInfo
- Publication number
- WO2005085860B1 WO2005085860B1 PCT/EP2005/002578 EP2005002578W WO2005085860B1 WO 2005085860 B1 WO2005085860 B1 WO 2005085860B1 EP 2005002578 W EP2005002578 W EP 2005002578W WO 2005085860 B1 WO2005085860 B1 WO 2005085860B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- caf
- subunits
- antibodies
- diagnosis
- detecting
- Prior art date
Links
- 230000035755 proliferation Effects 0.000 title claims abstract 4
- 201000011510 cancer Diseases 0.000 title claims abstract 3
- 238000003745 diagnosis Methods 0.000 title claims abstract 3
- 238000004393 prognosis Methods 0.000 title claims abstract 3
- 206010028980 Neoplasm Diseases 0.000 claims abstract 3
- 102000008868 Chromatin Assembly Factor-1 Human genes 0.000 claims abstract 2
- 108010088529 Chromatin Assembly Factor-1 Proteins 0.000 claims abstract 2
- 239000012472 biological sample Substances 0.000 claims abstract 2
- 210000004027 cells Anatomy 0.000 claims abstract 2
- 230000002062 proliferating Effects 0.000 claims abstract 2
- 238000002560 therapeutic procedure Methods 0.000 claims abstract 2
- 108090001123 antibodies Proteins 0.000 claims 3
- 102000004965 antibodies Human genes 0.000 claims 3
- 238000001514 detection method Methods 0.000 claims 3
- 230000001413 cellular Effects 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 229920000160 (ribonucleotides)n+m Polymers 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 210000003855 Cell Nucleus Anatomy 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 210000003483 Chromatin Anatomy 0.000 claims 1
- 108010077544 Chromatin Proteins 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 206010017758 Gastric cancer Diseases 0.000 claims 1
- 102000009339 Proliferating Cell Nuclear Antigen Human genes 0.000 claims 1
- 108010009063 Proliferating Cell Nuclear Antigen Proteins 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 102000002067 Protein Subunits Human genes 0.000 claims 1
- 108010001267 Protein Subunits Proteins 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 229960000070 antineoplastic Monoclonal antibodies Drugs 0.000 claims 1
- 239000000090 biomarker Substances 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 238000003365 immunocytochemistry Methods 0.000 claims 1
- 238000010166 immunofluorescence Methods 0.000 claims 1
- 238000003364 immunohistochemistry Methods 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 108010045030 monoclonal antibodies Proteins 0.000 claims 1
- 229960000060 monoclonal antibodies Drugs 0.000 claims 1
- 102000005614 monoclonal antibodies Human genes 0.000 claims 1
- 108091008117 polyclonal antibodies Proteins 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 238000001262 western blot Methods 0.000 claims 1
- 102100001522 CHAF1A Human genes 0.000 abstract 1
- 108060001350 CHAF1A Proteins 0.000 abstract 1
Abstract
La présente invention a trait à un procédé permettant l'évaluation de l'état de prolifération cellulaire dans un échantillon biologique humain ou non humain, comprenant des sous-unités de facteur d'assemblage en chromatine (CAF-1) comme marqueurs de la prolifération. L'invention est utile pour le pronostic ou le diagnostic du cancer et le suivi de la réponse tumorale en thérapie.
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2555656A CA2555656C (fr) | 2004-02-27 | 2005-02-28 | Nouveaux marqueurs de proliferation en pratique clinique et leur utilisation pour le pronostic ou diagnostic du cancer |
| DE602005019694T DE602005019694D1 (de) | 2004-02-27 | 2005-02-28 | Neue proliferationsmarker in der klinischen praxis und deren verwendung zur krebsprognose oder -diagnose |
| JP2007500191A JP4848355B2 (ja) | 2004-02-27 | 2005-02-28 | 臨床診療における新規増殖マーカーおよび癌の予後または診断のためのそれらの用途 |
| EP05715950A EP1721165B1 (fr) | 2004-02-27 | 2005-02-28 | Nouveaux marqueurs de proliferation en pratique clinique et leur utilisation pour le pronostic ou diagnostic du cancer |
| AT05715950T ATE459883T1 (de) | 2004-02-27 | 2005-02-28 | Neue proliferationsmarker in der klinischen praxis und deren verwendung zur krebsprognose oder -diagnose |
| US11/510,612 US7781174B2 (en) | 2004-02-27 | 2006-08-28 | Proliferation markers in clinical practice and their use for cancer prognosis or diagnosis |
| US12/792,855 US20110003706A1 (en) | 2004-02-27 | 2010-06-03 | Proliferation markers in clinical practice and their use for breast cancer prognosis or diagnosis |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54811104P | 2004-02-27 | 2004-02-27 | |
| US60/548,111 | 2004-02-27 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US11/510,612 Continuation-In-Part US7781174B2 (en) | 2004-02-27 | 2006-08-28 | Proliferation markers in clinical practice and their use for cancer prognosis or diagnosis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| WO2005085860A2 WO2005085860A2 (fr) | 2005-09-15 |
| WO2005085860A3 WO2005085860A3 (fr) | 2005-11-10 |
| WO2005085860B1 true WO2005085860B1 (fr) | 2006-01-05 |
Family
ID=34919336
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/EP2005/002578 WO2005085860A2 (fr) | 2004-02-27 | 2005-02-28 | Nouveaux marqueurs de proliferation en pratique clinique et leur utilisation pour le pronostic ou diagnostic du cancer |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7781174B2 (fr) |
| EP (1) | EP1721165B1 (fr) |
| JP (1) | JP4848355B2 (fr) |
| AT (1) | ATE459883T1 (fr) |
| CA (1) | CA2555656C (fr) |
| DE (1) | DE602005019694D1 (fr) |
| WO (1) | WO2005085860A2 (fr) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11254916B2 (en) | 2006-03-02 | 2022-02-22 | Viacyte, Inc. | Methods of making and using PDX1-positive pancreatic endoderm cells |
| AU2007224116B2 (en) | 2006-03-02 | 2013-11-07 | Viacyte, Inc. | Endocrine precursor cells, pancreatic hormone-expressing cells and methods of production |
| US20100144830A1 (en) * | 2006-09-19 | 2010-06-10 | Masahiko Kuroda | Cancer cell identification marker and cancer cell proliferation inhibitor |
| EA016386B1 (ru) | 2007-05-30 | 2012-04-30 | Ф. Хоффманн-Ля Рош Аг | Ненуклеозидные ингибиторы обратной транскриптазы |
| WO2009126543A1 (fr) | 2008-04-08 | 2009-10-15 | Nuclea Biomarkers, Llc | Panel de biomarqueurs pour la prédiction d'un cancer colorectal récurrent |
| EP2243843A1 (fr) * | 2009-04-24 | 2010-10-27 | Institut Curie | HP1ALPHA en tant que marqueur de pronostic dans le cancer humain |
| WO2011151321A1 (fr) | 2010-05-31 | 2011-12-08 | Institut Curie | Asf1b, marqueur pronostic et cible thérapeutique du cancer chez l'être humain |
| JP2014519813A (ja) | 2011-04-25 | 2014-08-21 | オーエスアイ・ファーマシューティカルズ，エルエルシー | 癌薬剤発見、診断、および治療におけるｅｍｔ遺伝子シグネチャーの使用 |
| EP4060344A1 (fr) | 2015-06-08 | 2022-09-21 | Arquer Diagnostics Limited | Procédés et kits |
| CN107771285A (zh) | 2015-06-08 | 2018-03-06 | 阿奎尔诊断有限公司 | 方法 |
| US10839509B2 (en) | 2015-07-10 | 2020-11-17 | 3Scan Inc. | Spatial multiplexing of histological stains |
| CA3058406A1 (fr) * | 2017-03-30 | 2018-10-04 | The Board Of Trustees Of The University Of Illinois | Methode et kit permettant diagnostiquer un cancer du pancreas de stade precoce |
| JP7025730B2 (ja) | 2018-02-28 | 2022-02-25 | 日東紡績株式会社 | 固定化細胞又はｆｆｐｅ組織切片から抗原性を増強した細胞核を脱離する方法並びにそのための抗原賦活剤及びキット |
| CN111766385B (zh) * | 2020-07-06 | 2023-09-26 | 河南赛诺特生物技术有限公司 | 术中快速鉴别肺癌和硬化性肺细胞瘤的免疫组化试剂盒 |
| CN113984483B (zh) * | 2021-09-28 | 2023-10-20 | 福建医科大学 | 一种冰冻切片盖玻片贴片染色方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6071715A (en) * | 1993-08-12 | 2000-06-06 | Board Of Regents, The University Of Texas System | Nucleic acids encoding novel proteins which bind to retinoblastoma protein |
| CN100342030C (zh) * | 2000-11-24 | 2007-10-10 | 卫材R&D管理有限公司 | 试验肿瘤细胞对于抗癌药剂敏感性的方法 |
| WO2003025138A2 (fr) * | 2001-09-17 | 2003-03-27 | Protein Design Labs, Inc. | Procedes de diagnostic du cancer, compositions et procedes de criblage de modulateurs du cancer |
| AU2003217774A1 (en) * | 2002-02-28 | 2003-09-16 | Georgetown University | Method and composition for detection and treatment of breast cancer |
-
2005
- 2005-02-28 WO PCT/EP2005/002578 patent/WO2005085860A2/fr active Application Filing
- 2005-02-28 JP JP2007500191A patent/JP4848355B2/ja not_active Expired - Fee Related
- 2005-02-28 AT AT05715950T patent/ATE459883T1/de not_active IP Right Cessation
- 2005-02-28 DE DE602005019694T patent/DE602005019694D1/de active Active
- 2005-02-28 EP EP05715950A patent/EP1721165B1/fr not_active Not-in-force
- 2005-02-28 CA CA2555656A patent/CA2555656C/fr not_active Expired - Fee Related
-
2006
- 2006-08-28 US US11/510,612 patent/US7781174B2/en not_active Expired - Fee Related
-
2010
- 2010-06-03 US US12/792,855 patent/US20110003706A1/en not_active Abandoned
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