WO2004089415A3 - Therapie combinatoire utilisant un inhibiteur de 11$g(b)-hydroxysteroide deshydrogenase de type 1 et agoniste du recepteur de glucocorticoides pour minimiser les effets secondaires associes a la therapie a base d'agoniste du recepteur de glucocorticoides - Google Patents
Therapie combinatoire utilisant un inhibiteur de 11$g(b)-hydroxysteroide deshydrogenase de type 1 et agoniste du recepteur de glucocorticoides pour minimiser les effets secondaires associes a la therapie a base d'agoniste du recepteur de glucocorticoides Download PDFInfo
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- WO2004089415A3 WO2004089415A3 PCT/DK2004/000248 DK2004000248W WO2004089415A3 WO 2004089415 A3 WO2004089415 A3 WO 2004089415A3 DK 2004000248 W DK2004000248 W DK 2004000248W WO 2004089415 A3 WO2004089415 A3 WO 2004089415A3
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- receptor agonist
- inhibitor
- hydroxysteroid dehydrogenase
- glucocorticoid receptor
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- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- Animal Behavior & Ethology (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04725890A EP1615667A2 (fr) | 2003-04-11 | 2004-04-06 | Therapie combinatoire utilisant un inhibiteur de 11beta-hydroxysteroide deshydrogenase de type 1 et agoniste du recepteur de glucocorticoides |
JP2006504351A JP2006522744A (ja) | 2003-04-11 | 2004-04-06 | グルココルチコイド受容体アゴニスト療法に伴う副作用を最小化するための、11β−ヒドロキシステロイドデヒドロゲナーゼ1型阻害剤およびグルココルチコイド受容体アゴニストを使用する併用療法 |
US11/246,814 US20060094699A1 (en) | 2003-04-11 | 2005-10-07 | Combination therapy using an 11beta-hydroxysteroid dehydrogenase type 1 inhibitor and a glucocorticoid receptor agonist to minimize the side effects associated with glucocorticoid receptor agonist therapy |
US12/491,659 US20090264412A1 (en) | 2003-04-11 | 2009-06-25 | Combination Therapy Using An 11beta-Hydroxysteroid Dehydrogenase Type 1 Inhibitor And A Glucocorticoid Receptor Agonist To Minimize The Side Effects Associated With Glucocorticoid Receptor Agonist Therapy |
Applications Claiming Priority (58)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200300998 | 2003-02-07 | ||
DKPA200300571 | 2003-04-11 | ||
DKPA200300571 | 2003-04-11 | ||
DKPA200300566 | 2003-04-11 | ||
DKPA200300566 | 2003-04-11 | ||
DKPA200300565 | 2003-04-11 | ||
DKPA200300568 | 2003-04-11 | ||
DKPA200300568 | 2003-04-11 | ||
DKPA200300570 | 2003-04-11 | ||
DKPA200300570 | 2003-04-11 | ||
DKPA200300565 | 2003-04-11 | ||
DKPA200300569 | 2003-04-11 | ||
DKPA200300569 | 2003-04-11 | ||
US46780003P | 2003-05-02 | 2003-05-02 | |
US46745303P | 2003-05-02 | 2003-05-02 | |
US46736303P | 2003-05-02 | 2003-05-02 | |
US46728403P | 2003-05-02 | 2003-05-02 | |
US46736203P | 2003-05-02 | 2003-05-02 | |
US46744303P | 2003-05-02 | 2003-05-02 | |
US60/467,443 | 2003-05-02 | ||
US60/467,800 | 2003-05-02 | ||
US60/467,362 | 2003-05-02 | ||
US60/467,453 | 2003-05-02 | ||
US60/467,284 | 2003-05-02 | ||
US60/467,363 | 2003-05-02 | ||
DKPA20030778 | 2003-05-22 | ||
DKPA200300776 | 2003-05-22 | ||
DKPA200300776 | 2003-05-22 | ||
DKPA200300778 | 2003-05-22 | ||
US47515703P | 2003-06-02 | 2003-06-02 | |
US47519503P | 2003-06-02 | 2003-06-02 | |
US60/475,157 | 2003-06-02 | ||
US60/475,195 | 2003-06-02 | ||
DKPA200300972 | 2003-06-27 | ||
DKPA200300972 | 2003-06-27 | ||
DKPA200300989 | 2003-06-30 | ||
DKPA200300989 | 2003-06-30 | ||
DKPA200300990 | 2003-06-30 | ||
DKPA200300988 | 2003-06-30 | ||
DKPA200300990 | 2003-06-30 | ||
DKPA200300988 | 2003-06-30 | ||
DKPA200300998 | 2003-07-02 | ||
US48609803P | 2003-07-10 | 2003-07-10 | |
US48609503P | 2003-07-10 | 2003-07-10 | |
US48607803P | 2003-07-10 | 2003-07-10 | |
US48609403P | 2003-07-10 | 2003-07-10 | |
US48609703P | 2003-07-10 | 2003-07-10 | |
US60/486,078 | 2003-07-10 | ||
US60/486,095 | 2003-07-10 | ||
US60/486,097 | 2003-07-10 | ||
US60/486,094 | 2003-07-10 | ||
US60/486,098 | 2003-07-10 | ||
DKPA200301910 | 2003-12-22 | ||
DKPA200301910 | 2003-12-22 | ||
DKPA200400009 | 2004-01-06 | ||
DKPA200400009 | 2004-01-06 | ||
US53709904P | 2004-01-16 | 2004-01-16 | |
US60/537,099 | 2004-01-16 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/246,814 Continuation US20060094699A1 (en) | 2003-04-11 | 2005-10-07 | Combination therapy using an 11beta-hydroxysteroid dehydrogenase type 1 inhibitor and a glucocorticoid receptor agonist to minimize the side effects associated with glucocorticoid receptor agonist therapy |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2004089415A2 WO2004089415A2 (fr) | 2004-10-21 |
WO2004089415A3 true WO2004089415A3 (fr) | 2005-03-10 |
Family
ID=33163367
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/DK2004/000248 WO2004089415A2 (fr) | 2003-04-11 | 2004-04-06 | Therapie combinatoire utilisant un inhibiteur de 11$g(b)-hydroxysteroide deshydrogenase de type 1 et agoniste du recepteur de glucocorticoides pour minimiser les effets secondaires associes a la therapie a base d'agoniste du recepteur de glucocorticoides |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP1615667A2 (fr) |
JP (1) | JP2006522744A (fr) |
WO (1) | WO2004089415A2 (fr) |
Cited By (4)
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US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
US8927549B2 (en) | 2008-11-21 | 2015-01-06 | High Point Pharmaceuticals, Llc | Adamantyl benzamide derivatives |
US9394285B2 (en) | 2013-03-15 | 2016-07-19 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
US9402831B2 (en) | 2011-11-14 | 2016-08-02 | Synta Pharmaceutical Corp. | Combination therapy of HSP90 inhibitors with BRAF inhibitors |
Families Citing this family (98)
Publication number | Priority date | Publication date | Assignee | Title |
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NZ535889A (en) | 2002-03-26 | 2006-03-31 | Boehringer Ingelheim Pharma | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
ATE482747T1 (de) * | 2003-04-11 | 2010-10-15 | High Point Pharmaceuticals Llc | Neue amide derivate und deren pharmazeutische verwendungen |
SE0301232D0 (sv) * | 2003-04-25 | 2003-04-25 | Astrazeneca Ab | Novel use |
UY28526A1 (es) | 2003-09-24 | 2005-04-29 | Boehringer Ingelheim Pharma | Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos |
WO2005090320A2 (fr) * | 2004-03-12 | 2005-09-29 | Wyeth | Derives de triazole et leur methode d'utilisation pour traiter les infections par le vih |
US7795272B2 (en) | 2004-03-13 | 2010-09-14 | Boehringer Ingelheim Pharmaceutical, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof |
JP5014983B2 (ja) | 2004-05-07 | 2012-08-29 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 11−ベータヒドロキシステロイドデヒドロゲナーゼ阻害剤としてのピロリジン−2−オン及びピペリジン−2−オン誘導体 |
US20060063930A1 (en) * | 2004-08-20 | 2006-03-23 | Agoston Gregory E | Compositions and methods comprising proteinase activated receptor antagonists |
DE602005017159D1 (de) | 2004-08-30 | 2009-11-26 | Janssen Pharmaceutica Nv | Oxysteroid-dehydrogenase-inhibitoren |
JP5208505B2 (ja) * | 2004-08-30 | 2013-06-12 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 11−ベータヒドロキシステロイドデヒドロゲナーゼ阻害剤としてのn−2アダマンタニル−2−フェノキシ−アセトアミド誘導体 |
JP5137574B2 (ja) | 2004-08-30 | 2013-02-06 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 11−ベータヒドロキシステロイドヒドロゲナーゼ阻害剤としての三環式ラクタム誘導体 |
WO2006046915A1 (fr) * | 2004-10-29 | 2006-05-04 | Astrazeneca Ab | Utilisation de derives insatures de quinoline ou de naphtalene comme medicaments |
EP1817295B1 (fr) | 2004-11-18 | 2012-11-07 | Synta Pharmaceuticals Corp. | Composes triazole modulant l'activite de hsp90 |
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JP4880671B2 (ja) | 2005-04-05 | 2012-02-22 | エフ.ホフマン−ラ ロシュ アーゲー | 1H−ピラゾール4−カルボキシルアミドその製造方法および11β−ヒドロキシステロイドデヒドロゲナーゼとしてのその使用 |
KR100970294B1 (ko) * | 2005-06-08 | 2010-07-15 | 니뽄 다바코 산교 가부시키가이샤 | 복소환 화합물 |
JP5368789B2 (ja) * | 2005-06-17 | 2013-12-18 | アポジー・バイオテクノロジー・コーポレイション | スフィンゴシンキナーゼ阻害剤 |
AU2006338265B2 (en) | 2005-08-18 | 2011-04-14 | Synta Pharmaceuticals Corp. | Triazole compounds that modulate HSP90 activity |
US7622492B2 (en) | 2005-08-31 | 2009-11-24 | Hoffmann-La Roche Inc. | Pyrazolones as inhibitors of 11β-hydroxysteroid dehydrogenase |
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AU2007207055B2 (en) | 2006-01-18 | 2011-06-02 | F. Hoffmann-La Roche Ag | Thiazoles as 11 beta-HSD1 inhibitors |
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EP1998760A2 (fr) * | 2006-03-30 | 2008-12-10 | James E. Summerton | Compositions outils oncologiques et procédés d'utilisation pour détecter et traiter des tumeurs |
US8034834B2 (en) | 2006-05-25 | 2011-10-11 | Synta Pharmaceuticals Corp. | Method for treating proliferative disorders with HSP90 inhibitors |
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US8115005B2 (en) | 2006-08-04 | 2012-02-14 | Decode Genetics Ehf. | Pyrazolylphenyl and pyrrolylphenyl inhibitors of LTA4H for treating inflammation |
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KR20090040478A (ko) | 2006-08-24 | 2009-04-24 | 노파르티스 아게 | 2-(피라진-2-일)-티아졸 및 2-(1H-피라졸-3-일)-티아졸 유도체, 및 대사, 심혈관 및 기타 장애의 치료를 위한 스테아로일-CoA 데새투라제(SCD) 억제제로서의 관련 화합물 |
US7727978B2 (en) | 2006-08-24 | 2010-06-01 | Bristol-Myers Squibb Company | Cyclic 11-beta hydroxysteroid dehydrogenase type I inhibitors |
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CN101516877B (zh) | 2006-09-22 | 2013-09-11 | 诺瓦提斯公司 | 杂环有机化合物 |
RU2470040C2 (ru) * | 2006-10-17 | 2012-12-20 | Ратджерс, Те Стейт Юниверсити Оф Нью Джерси | N-замещенные мономеры и полимеры |
JP2010512331A (ja) | 2006-12-06 | 2010-04-22 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | グルココルチコイド模倣薬、それらの製造方法、医薬組成物、及びこれらの使用 |
AU2007336238A1 (en) | 2006-12-20 | 2008-06-26 | Novartis Ag | 2-substituted 5-membered heterocycles as SCD inhibitors |
US20110003852A1 (en) | 2007-02-23 | 2011-01-06 | Soren Ebdrup | N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase |
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- 2004-04-06 EP EP04725890A patent/EP1615667A2/fr not_active Withdrawn
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WO2002072084A2 (fr) * | 2001-03-08 | 2002-09-19 | Sterix Limited | Utilisation |
WO2002076435A2 (fr) * | 2001-03-23 | 2002-10-03 | The University Of Edinburgh | Modulation d'un profile lipidique |
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US8927549B2 (en) | 2008-11-21 | 2015-01-06 | High Point Pharmaceuticals, Llc | Adamantyl benzamide derivatives |
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US9394285B2 (en) | 2013-03-15 | 2016-07-19 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
Also Published As
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EP1615667A2 (fr) | 2006-01-18 |
WO2004089415A2 (fr) | 2004-10-21 |
JP2006522744A (ja) | 2006-10-05 |
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