WO2002083175A1 - Agents ameliorant la fonction visuelle - Google Patents

Agents ameliorant la fonction visuelle Download PDF

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Publication number
WO2002083175A1
WO2002083175A1 PCT/JP2002/003590 JP0203590W WO02083175A1 WO 2002083175 A1 WO2002083175 A1 WO 2002083175A1 JP 0203590 W JP0203590 W JP 0203590W WO 02083175 A1 WO02083175 A1 WO 02083175A1
Authority
WO
WIPO (PCT)
Prior art keywords
visual function
improving agents
function improving
optic nerve
promoting
Prior art date
Application number
PCT/JP2002/003590
Other languages
English (en)
French (fr)
Inventor
Yoshiko Takayama
Yukuo Yoshida
Masayoshi Uehata
Original Assignee
Senju Pharmaceutical Co., Ltd.
Mitsubishi Pharma Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senju Pharmaceutical Co., Ltd., Mitsubishi Pharma Corporation filed Critical Senju Pharmaceutical Co., Ltd.
Priority to CA2443918A priority Critical patent/CA2443918C/en
Priority to US10/474,369 priority patent/US7109208B2/en
Priority to EP02717107.3A priority patent/EP1378247B1/en
Priority to JP2002580976A priority patent/JP4204326B2/ja
Priority to KR1020037013344A priority patent/KR100865262B1/ko
Publication of WO2002083175A1 publication Critical patent/WO2002083175A1/ja
Priority to HK04109315.5A priority patent/HK1066462A1/xx
Priority to US11/366,460 priority patent/US7696194B2/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PCT/JP2002/003590 2001-04-11 2002-04-11 Agents ameliorant la fonction visuelle WO2002083175A1 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CA2443918A CA2443918C (en) 2001-04-11 2002-04-11 Visual function disorder improving agents containing rho kinase inhibitors
US10/474,369 US7109208B2 (en) 2001-04-11 2002-04-11 Visual function disorder improving agents
EP02717107.3A EP1378247B1 (en) 2001-04-11 2002-04-11 Visual function disorder improving agents
JP2002580976A JP4204326B2 (ja) 2001-04-11 2002-04-11 視覚機能障害改善剤
KR1020037013344A KR100865262B1 (ko) 2001-04-11 2002-04-11 시각 기능 장애 개선제
HK04109315.5A HK1066462A1 (en) 2001-04-11 2004-11-25 Visual function improving agents
US11/366,460 US7696194B2 (en) 2001-04-11 2006-03-03 Visual function disorder improving agents

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2001113329 2001-04-11
JP2001-113329 2001-04-11
JP2001-308010 2001-10-03
JP2001308010 2001-10-03

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/366,460 Division US7696194B2 (en) 2001-04-11 2006-03-03 Visual function disorder improving agents

Publications (1)

Publication Number Publication Date
WO2002083175A1 true WO2002083175A1 (fr) 2002-10-24

Family

ID=26613462

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/003590 WO2002083175A1 (fr) 2001-04-11 2002-04-11 Agents ameliorant la fonction visuelle

Country Status (8)

Country Link
US (2) US7109208B2 (ja)
EP (1) EP1378247B1 (ja)
JP (2) JP4204326B2 (ja)
KR (2) KR100883077B1 (ja)
CN (2) CN101310771B (ja)
CA (2) CA2707827A1 (ja)
HK (1) HK1066462A1 (ja)
WO (1) WO2002083175A1 (ja)

Cited By (33)

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WO2003037308A2 (de) * 2001-11-02 2003-05-08 Morphochem Aktiengesellschaft für kombinatorische Chemie Verwendung von inhibitoren der rho-kinasen zur stimulation des nervenwachstums
WO2004091662A1 (ja) * 2003-04-18 2004-10-28 Senju Pharmaceutical Co. Ltd. 角膜知覚回復剤
WO2005118582A1 (ja) 2004-06-03 2005-12-15 Senju Pharmaceutical Co., Ltd. アミド化合物を含有する角膜知覚回復剤
WO2006112313A1 (ja) * 2005-04-13 2006-10-26 Ube Industries, Ltd. インダゾール誘導体を有効成分として含む網膜神経細胞保護剤
WO2008016016A1 (en) 2006-07-31 2008-02-07 Senju Pharmaceutical Co., Ltd. Aqueous liquid preparation containing amide compound
WO2008105442A1 (ja) 2007-02-28 2008-09-04 Asahi Kasei Pharma Corporation スルホンアミド誘導体
US7498342B2 (en) 2004-06-17 2009-03-03 Plexxikon, Inc. Compounds modulating c-kit activity
WO2009028631A1 (ja) 2007-08-29 2009-03-05 Senju Pharmaceutical Co., Ltd. 角膜内皮細胞接着促進剤
WO2010010702A1 (ja) * 2008-07-24 2010-01-28 国立大学法人大阪大学 軸性近視の予防または治療剤
US7846941B2 (en) 2005-05-17 2010-12-07 Plexxikon, Inc. Compounds modulating c-kit and c-fms activity and uses therefor
US7863288B2 (en) 2005-06-22 2011-01-04 Plexxikon, Inc. Compounds and methods for kinase modulation, and indications therefor
US7893075B2 (en) 2006-11-22 2011-02-22 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
WO2011081221A1 (en) 2009-12-29 2011-07-07 Senju Pharmaceutical Co., Ltd. Therapeutic agent (y - 39983 ) for corneal endothelial dysfunction
US8067434B2 (en) 2003-12-19 2011-11-29 Plexxikon Inc. Compounds and methods for development of Ret modulators
WO2013100208A1 (ja) 2011-12-28 2013-07-04 京都府公立大学法人 角膜内皮細胞の培養正常化
US8865735B2 (en) 2011-02-21 2014-10-21 Hoffman-La Roche Inc. Solid forms of a pharmaceutically active substance
WO2014174747A1 (ja) 2013-04-24 2014-10-30 国立大学法人九州大学 眼底疾患治療剤
WO2015016371A1 (ja) 2013-07-30 2015-02-05 京都府公立大学法人 角膜内皮細胞マーカー
WO2015029923A1 (ja) * 2013-08-26 2015-03-05 ロート製薬株式会社 眼科用製剤
WO2015064768A1 (ja) 2013-10-31 2015-05-07 京都府公立大学法人 角膜内皮の小胞体細胞死関連疾患治療薬
WO2015080297A1 (en) 2013-11-27 2015-06-04 Kyoto Prefectural Public University Corporation Application of laminin to corneal endothelial cell culture
US9096593B2 (en) 2009-11-06 2015-08-04 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
US9138438B2 (en) 2005-03-31 2015-09-22 Asahi Glass Company, Limited Method for protecting a retinal neuronal cell
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
JP2015229671A (ja) * 2014-06-06 2015-12-21 株式会社デ・ウエスタン・セラピテクス研究所 網膜色素上皮細胞保護剤
US9447089B2 (en) 2009-04-03 2016-09-20 Plexxikon Inc. Compositions and uses thereof
US9469640B2 (en) 2007-07-17 2016-10-18 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
US9624213B2 (en) 2011-02-07 2017-04-18 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
WO2017141926A1 (en) 2016-02-15 2017-08-24 Kyoto Prefectural Public University Corporation Human functional corneal endothelial cell and application thereof
WO2020045642A1 (ja) 2018-08-31 2020-03-05 学校法人同志社 眼細胞を保存または培養するための組成物および方法
WO2020071438A1 (ja) 2018-10-02 2020-04-09 学校法人同志社 角膜内皮細胞を保存するための方法および容器
WO2021172554A1 (ja) 2020-02-27 2021-09-02 京都府公立大学法人 ヒト機能性角膜内皮細胞およびその応用
WO2023085369A1 (ja) 2021-11-11 2023-05-19 学校法人同志社 角膜内皮細胞の凍結保存製剤およびその製造法

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WO2005034765A2 (en) * 2003-10-03 2005-04-21 Scimed Life Systems, Inc. Systems for a delivering a medical implant to an anatomical location in a patient
US20070014833A1 (en) * 2005-03-30 2007-01-18 Sirtris Pharmaceuticals, Inc. Treatment of eye disorders with sirtuin modulators
US20100022517A1 (en) * 2006-12-18 2010-01-28 Richards Lori A Ophthalmic formulation of rho kinase inhibitor compound
US8071779B2 (en) 2006-12-18 2011-12-06 Inspire Pharmaceuticals, Inc. Cytoskeletal active rho kinase inhibitor compounds, composition and use
US8895507B2 (en) * 2007-04-16 2014-11-25 The Board Of Trustees Of The Leland Stanford Junior University Modulation of synaptogenesis
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JP2012006918A (ja) * 2010-05-27 2012-01-12 Santen Pharmaceut Co Ltd イソキノリンスルホニル誘導体を有効成分として含有する網脈絡膜変性疾患の予防または治療剤
TW201202214A (en) * 2010-05-27 2012-01-16 Santen Pharmaceutical Co Ltd Novel indazole derivative or salt thereof, production intermediate thereof, and prophylactic or therapeutic agent for chorioretinal degeneratire disease using the same
RU2452436C1 (ru) * 2011-01-31 2012-06-10 Федеральное государственное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова Федерального агентства по высокотехнологичной медицинской помощи" Способ лечения атрофии зрительного нерва сосудистого генеза
CA2859832C (en) * 2011-12-20 2015-07-14 Research Foundation Of The City University Of New York Method for screening a drug in retinal tissue
CA2965770C (en) 2014-10-31 2024-02-13 Kyoto Prefectural Public University Corporation Treatment of cornea using laminin
US11918630B2 (en) 2014-10-31 2024-03-05 Kyoto Prefectural Public University Corporation Treatment of retina and nerve using laminin
EP4088719A1 (en) * 2015-10-13 2022-11-16 Institut National de la Santé et de la Recherche Médicale (INSERM) Methods and pharmaceutical compositions for the treatment of retinal capillary non-perfusion
WO2017064119A1 (en) * 2015-10-13 2017-04-20 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of retinal capillary non-perfusion
WO2018041824A1 (en) * 2016-08-29 2018-03-08 Amneal Pharmaceuticals Company Gmbh Stable pharmaceutical composition of ethacrynic acid
MA52813A (fr) * 2018-06-07 2021-04-14 Disarm Therapeutics Inc Inhibiteurs de sarm1
EP3801503A4 (en) * 2018-06-07 2021-12-08 Disarm Therapeutics, Inc. INHIBITORS OF SARM1
EP3801499B1 (en) * 2018-06-07 2024-02-28 Disarm Therapeutics, Inc. Inhibitors of sarm1
US20220242859A1 (en) * 2019-06-06 2022-08-04 Disarm Therapeutics, Inc. Inhibitors of sarm1
KR20230027186A (ko) * 2020-06-19 2023-02-27 엔도제나 테라퓨틱스, 인코포레이티드 새로운 화합물 및 망막 색소 상피와 관련된 질병의 치료 및/또는 예방에서 치료적 활성 물질로서의 이들의 용도

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EP1378247A1 (en) 2004-01-07
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EP1378247B1 (en) 2016-08-24
JP2008247923A (ja) 2008-10-16
US20060148852A1 (en) 2006-07-06
KR20080047633A (ko) 2008-05-29
EP1378247A4 (en) 2007-07-25
CN1501813A (zh) 2004-06-02
JP4802211B2 (ja) 2011-10-26
US7696194B2 (en) 2010-04-13
CA2443918A1 (en) 2002-10-24
US7109208B2 (en) 2006-09-19
US20040106646A1 (en) 2004-06-03
CA2707827A1 (en) 2002-10-24
KR20040007495A (ko) 2004-01-24
KR100883077B1 (ko) 2009-02-10
CN100411686C (zh) 2008-08-20
HK1066462A1 (en) 2005-03-24
JPWO2002083175A1 (ja) 2004-08-05
JP4204326B2 (ja) 2009-01-07
KR100865262B1 (ko) 2008-10-24

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