WO2002011744A1 - Capsule renfermant des antioxydants de type opc (oligomeres procyanidoliques ) a base d'extrait de pepins de raisin et son procede de preparation - Google Patents

Capsule renfermant des antioxydants de type opc (oligomeres procyanidoliques ) a base d'extrait de pepins de raisin et son procede de preparation Download PDF

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Publication number
WO2002011744A1
WO2002011744A1 PCT/CN2001/001203 CN0101203W WO0211744A1 WO 2002011744 A1 WO2002011744 A1 WO 2002011744A1 CN 0101203 W CN0101203 W CN 0101203W WO 0211744 A1 WO0211744 A1 WO 0211744A1
Authority
WO
WIPO (PCT)
Prior art keywords
grape seed
seed extract
opc
vitamin
strong antioxidant
Prior art date
Application number
PCT/CN2001/001203
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English (en)
Chinese (zh)
Inventor
Changling Li
Enrong Wu
Original Assignee
Shanghai Beijing Medical University Biology Science And Technology Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai Beijing Medical University Biology Science And Technology Co., Ltd. filed Critical Shanghai Beijing Medical University Biology Science And Technology Co., Ltd.
Priority to AU2002214921A priority Critical patent/AU2002214921A1/en
Publication of WO2002011744A1 publication Critical patent/WO2002011744A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/074—Ganoderma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants

Definitions

  • the present invention relates to a medical formulation containing a raw material or a reaction product thereof with an unknown structure, and particularly to a medicine formulated from plants and vitamins.
  • oligomeric anthocyanin (OPC) extracted from grape seeds has antioxidant effects, can eliminate free radicals, and protect blood vessels; total gypenosides can scavenge hydroxyl free radicals and oxygen free radicals.
  • Positive inotropic effect and significant inhibitory effect of the central nervous system have been widely used to improve heart function, treat insomnia, headache, stress and other symptoms.
  • Ganoderma contains a large number of enzymes and a variety of trace elements, and is an effective anti-aging drug. They are all plant-derived drugs with special active ingredients. Different preparations made from their single or complex or complex flavors are widely used in the fields of medicine, health food and cosmetics.
  • grape seed oil can reduce the total cholesterol and glyceride content of high-fat serum, reduce the deposition of liver fat and heart fat, extend the clotting time, reduce blood reducing viscosity and platelet aggregation rate, and Aortic plaque Block formation has an inhibitory effect (PLA Journal of Preventive Medicine 1995, 13 (2) 126-128); Facinu et al. Reported that proanthocyanidin in grape seeds can be used for the treatment of microvascular diseases, and studies have shown that it is cleared from ischemia The implementation of oxygen free radicals in vascular endothelial cells.
  • the purpose of the present invention is to develop a high antioxidant, enhance immune function, lower blood pressure, lower blood lipids, improve heart function, delay aging, promote human metabolism, inhibit tumors,
  • the manufacturing method of grape seed extract OPC strong antioxidant compound capsules of the present invention is as follows: the grape seed extract OPC, Glycoside total glycosides, ganoderma spore powder and vitamin C are sampled for inspection. Product quality standards set by the Ministry of Health
  • the present invention is refined by using grape seed extract (anthocyanidin OPC) extracted from modern science, gum blue total saponin, ganoderma spore powder, and vitamin C as raw materials. Rich in OPC polyphenols, saponins, polysaccharides, etc., with a variety of effective antioxidants, a variety of biologically active ingredients, functional tests (tested by multiple animal and mouse tests) have been shown to delay aging and regulate body immunity Function and other health effects, no toxic side effects.
  • the healing mechanism of these raw materials is as follows:
  • the flavonoids in grape seeds have been proved by medicine to be powerful oxidants. Their antioxidant capacity is 50 times that of V E and 20 times that of V c .
  • the oxidation effect is also reflected in the protection of biochemical components inside and outside the cell from free radical attack, which prolongs Cell life, which can play an anti-aging and soften blood vessels to improve microcirculation, achieve cosmetic functions, can also reduce the role of red blood cell aggregation, and reduce capillary permeability.
  • Grape seed extract has also been confirmed by some major medical institutions in France, the United States, Canada, and Europe. It has unique features in the prevention of cancerous cell structure, suppresses the growth of cancer cells, and avoids various cancer complications.
  • Glycoside is a well-known medicine for treating chronic bronchitis in the elderly. Contains a variety of chemical ingredients with a wide range of pharmacological activities, its anti-cancer, anti-aging, anti-fatigue, anti-ulcer, analgesia, lowering blood lipids, increasing the body's resistance to hypoxia, high temperature and prevention of diabetes, corticosteroid side effects, etc. The curative effect has been confirmed by pharmacological tests and clinical studies. The positive effect on the myocardium and the significant inhibition of the central nervous system have been widely used in clinical improvement of cardiac function, treatment of insomnia, headache, nervousness and other symptoms.
  • Ganoderma spore powder Modern scientific research has found that mycelium can secrete a large number of enzymes on the fiber substrate of ganoderma, mainly including lipase, maltase, laccase, invertase, amylase, saccharifying enzyme, rennet, and cellulase. , Hemicellulase, milky enzyme, tanninase, urease, trypsin, lipopeptidase, etc., these enzymes are widely involved in the body's material metabolism and energy metabolism. The full absorption and conversion of matter provides the material basis for energy metabolism, the energy released by the redox effect, and the energy required for matter metabolism, so that the entire metabolism can reach a new balance.
  • Ganoderma contains a variety of trace elements, such as silver, boron, calcium, iron, potassium, phosphorus, sodium, manganese, zinc, germanium, and bismuth. These trace elements are effective in enhancing the body's immunity and disease resistance. makes an important impact. At the same time, these trace elements are the main elements of human body's endocrine hormone synthesis. These endocrine hormones play an important role in regulating the body's metabolism.
  • Vitamin C powder plays an important role in cellular respiration. Vitamin C participates in amino acid metabolism, neurotransmitter synthesis, collagen and tissue cell interstitial synthesis, which can reduce capillary permeability, strengthen blood coagulation, and stimulate blood clotting. Function, promote the absorption of iron in the intestine, promote the reduction of blood lipids, increase the resistance to infection, participate in the detoxification function, have an antihistamine effect and prevent the production of carcinogens (nitrosamines), clinical use-scurvy Prevention and treatment; appropriate supplementation of acute and chronic infectious diseases to enhance body resistance Strength, promote recovery and wound healing; patients with Keshan disease can be treated with large doses when cardiogenic shock occurs; used for liver cirrhosis, acute skin diseases, aphthous ulcers, and promote wound healing, etc. In recent years, reports on colds , Certain cancers, hyperlipidemia, etc. have a certain effect.
  • Vitamin C is one of the vitamins necessary to maintain the body's metabolism. Prevention of scurvy and treatment of gingivitis, anemia, loss of appetite, malnutrition, loss of resistance, developmental cessation and recovery from illness caused by insufficient vitamin c, and is used for bleeding in the mouth, nose, kidney, uterus and other organs, each An acute infectious disease.
  • Grape seed extract OPC has the functions of high anti-oxidation and increasing immune function, and the function of blood pressure lowering, blood lipid lowering, heart function improving, and aging delaying of G. japonicum; Ganoderma spore powder promotes human metabolism, increases immune function, inhibits Tumor; Vitamin C's appetite and resistance-enhancing effects are integrated into one according to the needs of humans. Proportionedly, the cost of the invention is a strong antioxidant compound capsule containing light brown powder medicine. The recommended daily dose for adults (60kg weight) is 800mg.
  • the capsule of the present invention contains grape seed polyphenols 150 to 170 mg / g, total saponins 200 to 230 mg / g, crude polysaccharides 25 to 30 mg / g, vitamin C 280 to 300 mg / g, iron 100 to 110 mg / 100 g, zinc 2.0 to 2.5 mg / 100g, of which OPC has 50 times the antioxidant effect of V E and 20 times of V c . It can also reduce the proportion of natural mutagenesis of cells by 65%. It has anti-cancer and anti-cancer effects. Through the test of the capsule's immunomodulatory effect, it was proved that the capsule of the present invention has a significant enhancement effect on mouse humoral immune function (IGN-PFC number) and cellular immune function (DTH).
  • IGN-PFC number mouse humoral immune function
  • DTH cellular immune function
  • the invention's capsule has 30% more antioxidant capacity than the OPC single preparation, and has significant effects in preventing and treating heart and cerebrovascular diseases and enhancing immune function.
  • the capsule of the present invention has no toxic side effect, LD 5 . > 10.0g / kg body weight. Therefore, the capsules of the present invention have stronger health-care effects than foreign products, and have significant effects in terms of antioxidant effects, anti-aging, enhancing immune function, reducing cholesterol, lowering blood pressure, and lowering blood lipids.
  • Vitamin C powder is a white powder, a medicinal raw material.
  • Raw material processing Sampling and testing the four raw materials of grape seed extract OPC, Gum blue saponin, Ganoderma spore powder and Vitamin C, which should comply with the product quality standards set by the country and the Ministry of Health, and then take Co-60 dose 5GY Remove the outer packaging by radiation sterilization, and then ultraviolet sterilize for 6-10 hours, then take out the sieve (80-100 mesh sieve) to sieve out any solid impurities that may exist. If the water content exceeds the standard, dry in an oven at a temperature of 60-80 ° C, The time is 20-30 minutes, and the moisture content after drying is ⁇ 7% by weight.
  • Example 1 Example 2
  • Example 3 Example 4 Grape Seed Extract 16kg 10 kg 20 kg 20 kg
  • the drug is a light brown powder.
  • Capsule packing 300mg of medicine is packed into each capsule. Capsules are packed with capsules. After the ultraviolet light is irradiated, it enters the inner packaging process. Inspection and packing are performed before the inner packaging is sealed. One capsule, capped and capped after dispensing.
  • Table 1 Effect of the capsule of the present invention on the number of IgM-PFCs in mice / 5 X 10 6 spleen cells (s) Number of animals in the group IgM-PFC number / 5 X 10 6 spleens Cell control group 10 1555.0 ⁇ 248.0
  • mice after oral administration of the capsules of the present invention to mice for 30 days, the capsules have significantly enhanced humoral immune function (IgM-PFC number) and cellular immune function (DTH) of mice effect.
  • IgM-PFC number humoral immune function
  • DTH cellular immune function
  • Example 6 Experimental test animals of the capsules of the present invention for anti-oxidation and anti-aging function: Kunming mice, 10 months old, weighing 45 to 55 grams, female, provided by the Experimental Animal Center of the Academy of Military Medical Sciences. Test method: 48 healthy female 10-month-old mice were selected and randomly divided into four groups of 12 animals each, including three test groups and one control group.
  • the dose design is based on 1, 10, and 30 times the daily dosage (800 mg) of a 60 kg body weight adult, ⁇ P 13.3, 130.0, 400 mg / kg body weight, and is formulated with distilled water as a solvent.
  • Each test group and control group are at 0.1ml / 10g body weight
  • the test substance was administered by oral gavage once a day for 30 days. 30 minutes after the last gavage, the iliac vein blood and liver were collected, and the superoxide dismutase (SOD) activity, whole blood glutathione peroxidase activity (GSH-px), and liver peroxidation in animal red blood cells were measured. Lipid (LPO) content. Results were calculated using "Microsoft Excel" software. test results:
  • Test animals 800 Drosophila melanogaster were selected, and the female and male halves were provided by the Department of Biology of Peking University.
  • the test substance was divided into three dose groups, each of which had a concentration of 0.2%, 1%, and 5% of the culture medium, and a negative control group (basal medium group) was set up, and the culture medium thickness of each culture tube was 0.5. ⁇ L0cm. Collect 800 adult adults that have just emerged for 10 hours, and divide them into four groups. Each group contains 100 female and male fruit flies. Each group is filled with culture tube. Each tube contains 25 fruit flies. ° C ⁇ 1. C 65% relative humidity in a biochemical incubator. The culture medium of each group was changed every 4 days, and the pH value of each group was kept the same.
  • the number of fly survivals and deaths until all deaths, and the average number of survival days of the last 10 dead fruit flies in each group is the highest average lifespan of the group. After the test, the average life expectancy, the highest average life expectancy, and half of the death time were calculated. The results were analyzed by analysis of variance for data statistics, and statistics were made according to the sex of the animals.
  • Drosophila average life expectancy Compared with the control group, the female and male Drosophila in the 5% dose group had significant differences (P ⁇ 0.05). There was no significant difference between the other dose groups and the control group (P> 0.05).
  • the capsule fruit fly survival test result of the present invention is a positive result.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Botany (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

L'invention concerne une capsule renfermant des antioxydants de type OPC (oligomères procyanidoliques ) à base d'extrait de pépins de raisin et son procédé de préparation. Ce genre de capsule à base d'extrait de pépins de raison est constituée d'OPC, de gypénosides, de spores de Ganoderma Lucidum et de vitamine C. Elle contient également en abondance des polyphénols OPC, des saponines et des polysaccharides entre autres. Par ailleurs l'invention fait preuve d'une action anti-oxydante et immunorégulatrice tout en protégeant des effets du vieillissement.
PCT/CN2001/001203 2000-07-27 2001-07-25 Capsule renfermant des antioxydants de type opc (oligomeres procyanidoliques ) a base d'extrait de pepins de raisin et son procede de preparation WO2002011744A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002214921A AU2002214921A1 (en) 2000-07-27 2001-07-25 A strong antioxidant composite capsule containing grape seed extract opc and process for producing the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN00121388A CN1111068C (zh) 2000-07-27 2000-07-27 一种葡萄籽提取物opc强抗氧化复合胶囊及其制造方法
CN00121388.1 2000-07-27

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Publication Number Publication Date
WO2002011744A1 true WO2002011744A1 (fr) 2002-02-14

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PCT/CN2001/001203 WO2002011744A1 (fr) 2000-07-27 2001-07-25 Capsule renfermant des antioxydants de type opc (oligomeres procyanidoliques ) a base d'extrait de pepins de raisin et son procede de preparation

Country Status (3)

Country Link
CN (1) CN1111068C (fr)
AU (1) AU2002214921A1 (fr)
WO (1) WO2002011744A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1396271A1 (fr) * 2002-08-21 2004-03-10 Chee-Keung Chung Spores de ganoderma lucidum qui sont activées pour germination comme agent anti-vieillissement et contre symptomes de la menopause
EP1398036A1 (fr) * 2002-09-05 2004-03-17 Chee-Keung Chung Spores de ganoderma lucidum pour le traitement de maladies autoimmunes
CN115444894A (zh) * 2022-09-24 2022-12-09 北京东方红航天生物技术股份有限公司 早期干预肝纤维化的组合物及其制备方法、制剂
CN117618527A (zh) * 2023-12-04 2024-03-01 山东益衡元健康科技有限公司 一种改善雄性激素水平和雄性性能力的组合物、制备方法及应用

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US7585518B2 (en) 2002-11-19 2009-09-08 Kimberly-Clark Worldwide, Inc. Products and methods for maintaining or increasing ceramide levels in skin
US7037535B2 (en) 2002-11-19 2006-05-02 Kimberly-Clark Worldwide, Inc. Method and composition for neutralizing house dust mite feces
US20050019379A1 (en) 2003-07-22 2005-01-27 Kimberly-Clark Worldwide, Inc. Wipe and methods for improving skin health
CN100420391C (zh) * 2006-12-18 2008-09-24 东北虎药业股份有限公司 一种具有减肥及抗氧化功能的保健食品
CN102511826A (zh) * 2011-12-29 2012-06-27 苏州爱斯欧蒂生物科技有限公司 降脂保健品及其制备方法
CN103156878A (zh) * 2013-04-11 2013-06-19 天津市园艺工程研究所 一种桑黃多糖opc缓释微囊
CN105475999A (zh) * 2015-11-27 2016-04-13 杭州海王生物工程有限公司 具有抗氧化、改善肝损伤和增强免疫力功效的组合物
CN109007833A (zh) * 2018-08-22 2018-12-18 广州市顺芝堂生物科技有限公司 一种调节人体免疫功能的组合物、胶囊及其制备方法

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CN1255357A (zh) * 1998-11-27 2000-06-07 海太制果株式会社 具有强力的抵抗酪氨酸酶活性的葡萄种子提取物及其应用
EP1047392A1 (fr) * 1997-12-24 2000-11-02 Shaklee Corporation Composition hautement efficace pour proteger la peau contre les effets nuisibles du rayonnement ultraviolet

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CN1083387A (zh) * 1993-05-31 1994-03-09 季永高 灵芝绞股蓝口服液
US5895652A (en) * 1996-07-29 1999-04-20 Longevity Institute International Method of metabolic adjuvanation and cellular repair
EP1047392A1 (fr) * 1997-12-24 2000-11-02 Shaklee Corporation Composition hautement efficace pour proteger la peau contre les effets nuisibles du rayonnement ultraviolet
CN1255357A (zh) * 1998-11-27 2000-06-07 海太制果株式会社 具有强力的抵抗酪氨酸酶活性的葡萄种子提取物及其应用

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6893641B2 (en) 1999-10-12 2005-05-17 Chee-Keung Chung Ganoderma lucidum spores for treatment of autoimmune diseases
US6908614B2 (en) 1999-10-12 2005-06-21 Chee-Keung Chung Anti-aging/menopause symptoms relief using ganoderma lucidum spores
EP1396271A1 (fr) * 2002-08-21 2004-03-10 Chee-Keung Chung Spores de ganoderma lucidum qui sont activées pour germination comme agent anti-vieillissement et contre symptomes de la menopause
JP2004131482A (ja) * 2002-08-21 2004-04-30 Chee Keung Chung ガノデルマルシダム胞子を用いた抗老化／更年期症状緩和
EP1398036A1 (fr) * 2002-09-05 2004-03-17 Chee-Keung Chung Spores de ganoderma lucidum pour le traitement de maladies autoimmunes
CN115444894A (zh) * 2022-09-24 2022-12-09 北京东方红航天生物技术股份有限公司 早期干预肝纤维化的组合物及其制备方法、制剂
CN115444894B (zh) * 2022-09-24 2024-06-04 北京东方红航天生物技术股份有限公司 早期干预肝纤维化的组合物及其制备方法、制剂
CN117618527A (zh) * 2023-12-04 2024-03-01 山东益衡元健康科技有限公司 一种改善雄性激素水平和雄性性能力的组合物、制备方法及应用

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AU2002214921A1 (en) 2002-02-18
CN1111068C (zh) 2003-06-11

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