WO1998056787A1 - Composes 4-phenylpiperidine - Google Patents
Composes 4-phenylpiperidine Download PDFInfo
- Publication number
- WO1998056787A1 WO1998056787A1 PCT/NL1997/000328 NL9700328W WO9856787A1 WO 1998056787 A1 WO1998056787 A1 WO 1998056787A1 NL 9700328 W NL9700328 W NL 9700328W WO 9856787 A1 WO9856787 A1 WO 9856787A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- group
- alkyl
- compound according
- acid
- paroxetine
- Prior art date
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- 0 *C=C([C@](CCNC1)C1NO[C@@](CC1)*C2=C1OCO2)C=CCF Chemical compound *C=C([C@](CCNC1)C1NO[C@@](CC1)*C2=C1OCO2)C=CCF 0.000 description 2
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
Definitions
- the present invention relates to a group of tri-substituted, 4-phenylpiperidines, to a process for preparing such compounds, to a medicament comprising such compounds, and to the use of such compounds for the manufacture of a medicament .
- Paroxetine has been used as a therapeutic agent in the form of a salt with pharmaceutically acceptable acids.
- the first clinical trials were conducted with the acetate salt.
- paroxetine hydrochloride A known useful salt of paroxetine is the hydrochloride . This salt is considered to be the active substance in several marketed pharmaceutical products, e.g. Paxil or Seroxat . A number of forms of paroxetine hydrochloride have been described:
- EP 223403 discloses paroxetine hydrochloride hemihydrate and pharmaceutical compositions based thereon. Most of these known salts of paroxetine have unsuitable physico-chemical characteristics for ensuring safe and efficient handling during production thereof and formulation into final forms, since they are unstable (acetate, maleate) and possess undesirable hygroscopi- city.
- crystalline paroxetine hydrochloride hemihydrate approaches these problems, but as stated in WO 95/16448, its limited photostability causes undesired colouration during classical wet tabletting procedure. Moreover, crystalline paroxetine hydrochloride hemihydrate exhibits only limited solubility in water.
- the aqueous solubility is low, for example less than 3 g/ml , the dissolution rate at in vivo administration could be rate-limiting in the absorption process.
- the aqueous solubility of the paroxetine hemihydrate at room temperature exceeds this threshold by a relatively small margin.
- an object of the present invention is to provide a compound with improved characteristics.
- the present invention comprises a compound, and pharmaceutically acceptable salts, having the formula I:
- - R represents an alkyl or alkynyl group having 1-4 carbon atoms, or a phenyl group optionally substituted by C alkyl, alkylthio, alkoxy, halogen, nitro, acylamino, methylsulfonyl or methylenedioxy, or represents tetrahydronaphthyl
- - R 1 represents hydrogen, trifluoro (C ) alkyl, alkyl or alkynyl ,
- - X represents hydrogen, alkyl having 1-4 carbon atoms, alkoxy, trifluoroalkyl, hydroxy, halogen, methylthio or aralkoxy, - R 2 represents:
- phenyl group optionally substituted by one or more of the following groups :
- the inventors have found that these compounds exhibit good stability and very high solubility. This yields the advantage that high concentrations of the compound are obtainable in small volumes.
- the R group is preferably the 3,4 methylenedioxyphenyl group of the formula:
- the X group is preferably a fluorine group attached to position 4 in the phenyl ring.
- the R 2 group preferably represents a C1-C4 alkyl group, and most preferably represents a C1-C2 alkyl group in order to provide an optimum solubility.
- the compounds can have a solubility at about 20 °C of at least about 10 mg/ml water, preferably having a solubility in water of at least 100, for example 500 and most preferably of at least 1000 mg/ml water.
- a process for preparing a compound as above comprising the steps of mixing together a 4 phenylpiperidine compound, a salt and/or a base thereof having the formula II:
- - R represents an alkyl or alkynyl group having 1-4 carbon atoms, or a phenyl group optionally substituted by C alkyl, alkylthio, alkoxy, halogen, nitro, acylamino, methylsulfonyl or methylenedioxy, or represents tetrahydronaphthyl ,
- - R represents hydrogen, trifluoro (C ⁇ _. ) alkyl, alkyl or alkynyl
- - X represents hydrogen, alkyl having 1-4 carbon atoms, alkoxy, trifluoroalkyl, hydroxy, halogen, methylthio or aralkoxy, . with a sulfonic acid of the general formula R_-S0 3 H, wherein R 2 represents: - a C1-C10 alkyl group,
- phenyl group optionally substituted by one or more of the following groups:
- the compounds of the invention can be prepared from the free base of the 4 phenylpiperidine, having the formula II, this preferably being paroxetine, by treatment with a sulfonic acid as defined above in a suitable solvent to form a solution of the desired acid addition salt, whereafter this is precipitated out of the solution.
- the forming of a solution may preferably ' proceed at temperatures from about 0 °C to the boiling point of the solvent .
- the solution may be purif ied by treatment of activated charcoal , silica gel , kieselguhr or other suitable materials .
- the solution of a salt of the invention can be formed by dissolution of a salt of 4 phenyl piperidine having the formula II with an organic sulfonic acid .
- the compounds of the invention may be prepared from a paroxetine C1 -C5 carboxylate , such as the acetate , by addition of corresponding organic sulfonic acid to the solution of the said carboxylate , as follows :
- a medicament for use as a medicament and, according to a fifth aspect, a medicament comprising this compound, and to the use thereof for treating depressions, obsessive compulsive disorders, panic disorders, bulimia, anorexia, pain, obesity, senile demential, migraine, anorexia, social phobia, depressions arising from pre-menstrual tension.
- a compound of the invention as a reagent in further syntheses. More specifically, the compounds of the present invention can be used as a start reagent for forming further acid addition salts, for example for providing further paroxetine acid addition salts, by reacting with a suitable reagent, i.e. with a corresponding acid.
- a suitable reagent i.e. with a corresponding acid.
- paroxetine acetate proceeds as follows :
- the preparation of a further salt, as above, results in this further salt having a high purity.
- the inventors have shown that such salts have a surprisingly high purity.
- the compounds of the present invention can react with a base, such as an inorganic and/or an organic base, to form (liberate) free bases of the corresponding compounds.
- a base such as an inorganic and/or an organic base
- the free bases liberated from the compounds of the present invention have surprisingly higher purity than if prepared by known methods which is especially important in case of their use for production of pharmaceuticals .
- the new compounds of the first aspect of the invention can also form hydrates and/or solvates by a contact with a corresponding reaction partner, i ⁇ e. with water and/or with a solvent.
- a corresponding reaction partner i ⁇ e. with water and/or with a solvent.
- further salts, hydrates and solvates for example these of paroxetine, are the: hydrochloride oxalate dihydrate hydrobromide succinate trihydrate hydroiodide tartrate hexahydrate acetate citrate methanolate propionate embonate ethanolate maleate hemihydrate fumarate hydrate
- the inventors have shown that such salts have a surprisingly high purity.
- bases which can be employed in the preparation of the free bases are: sodium hydroxide, potassium hydroxide, calcium hydroxide, ammonium hydroxide, sodium carbonate, methylamine, dimethylamine, triethylamine, pyridine and such like.
- the compounds according to the present invention exhibit high solubility, they can be dosed, for example injected, in a high concentration, low volume solution, this method of dosing being particularly advantageous with certain patients, such as manic depressives and such like, i.e. patients who are unable or unwilling to swallow medicine.
- compositions according to the present invention comprise a compound of the invention alone or together with a pharmaceutically acceptable carrier or diluent.
- the preferred formulations are those for oral administration (tablets, capsules) but formulations for parenteral or topical administration are also within the scope of the invention.
- the high water solubility of the compounds of the invention enables high dissolution rates in solid dosage forms based on the compounds of the invention to be obtained, during the in vitro release as well as good bioavailability after peroral application jLn vivo.
- the tablets containing compounds of the present invention can be prepared both by tabletting procedure in which water is present (e.g. aqueous granulation) as well as by tabletting processing it which water is absent (direct compression, dry granulation) and may be coated by any suitable means of coating.
- a seeding crystal of paroxetine methane sulfonate was made as follows:
- Paroxetine p-toluene sulfonate from paroxetine 5.0 g (15 mmol) of paroxetine was dissolved in 25 ml of hot ethylacetate.
- Paroxetine p-chlorobenzene sulfonate from paroxetine 1.1 g (3.3 mmol) of paroxetine was dissolved in 3 ml of hot ethylacetate.
- Paroxetine acetate from paroxetine methane sulfonate 1.0 g (2.4 mmol) of paroxetine methane sulfonate in 5 ml of hot iso-propanol. To this solution was added 0.2 g (3.2 mmol) of acetic acid. The mixture was 0 placed at 4 °C overnight after which a solid was precipitated. The solid was filtered off and washed 3 times with 10 ml of ether and dried in a vacuumoven. 0.5 g (1.3 mmol) off white crystals were obtained 5 Yield 54%
- the purity of the compound obtained was 99.5% (HPLC) .
- the compounds of the invention are crystalline, with defined melting points, DSC curves and IR spectra. It cannot be excluded that, under different conditions of their formation and under specific conditions, they could exist also in other crystalline or polymorph modifications which may differ from those as described herein.
- the compounds of the invention are also generally very stable and non-hygroscopic.
- the present invention comprising acid addition salts with organic sulfonic acids are substantially free of the bound organic solvent.
- the amount of bound organic solvent should be less than 2.0% (w/w) as calculated on the anhydrous basis. They nevertheless may contain crystallization water and also unbound water, that is to say water which is other than water of crystallization.
- Table 2 and 3 examples of results of . hygroscopicity tests and stability tests ( in comparison with known salts of paroxetine) are presented.
- paroxetine maleate m.p.: 128-130°C.
- paroxetine acetate m.p.: 123-125°C.
- H 3 , IH 2.50-3.00 (m, H 4 , H 2a ⁇ , H 6a ⁇ , 3H); 3.05-3.75 (m, H 2 H 6 H 7 , 3H);
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Priority Applications (37)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EEP200200633A EE200200633A (et) | 1997-06-10 | 1997-06-10 | Meetod triasendatud 4-fenüülpiperidiinühendi soola ja aluse vormide saamiseks, saadud soola ja aluse vormid |
DE69704679T DE69704679T2 (de) | 1997-06-10 | 1997-06-10 | 4-phenylpiperidin-derivate |
DE29724281U DE29724281U1 (de) | 1997-06-10 | 1997-06-10 | 4-Phenylpiperidin-Verbindungen |
AT97926276T ATE200781T1 (de) | 1997-06-10 | 1997-06-10 | 4-phenylpiperidin-derivate |
PCT/NL1997/000328 WO1998056787A1 (fr) | 1997-06-10 | 1997-06-10 | Composes 4-phenylpiperidine |
EP97926276A EP0994872B9 (fr) | 1997-06-10 | 1997-06-10 | Composes 4-phenylpiperidine |
PT97926276T PT994872E (pt) | 1997-06-10 | 1997-06-10 | Composto de 4-fenilpiperidina |
SI9730138T SI0994872T1 (fr) | 1997-06-10 | 1997-06-10 | |
CZ19994295A CZ295301B6 (cs) | 1997-06-10 | 1997-06-10 | Deriváty 4-fenylpiperidinu, způsob jejich přípravy, jejich použití a lék je obsahující |
TR1999/03025T TR199903025T2 (xx) | 1997-06-10 | 1997-06-10 | 4-Fenilpiperidin bile�imleri. |
PL97336895A PL188450B1 (pl) | 1997-06-10 | 1997-06-10 | Pochodne 4-fenylopiperydyny, sposób wytwarzania pochodnych 4-fenylopiperydyny, zastosowanie pochodnej 4-fenylopiperydyny oraz środek farmaceutyczny |
TR2002/01156T TR200201156T2 (tr) | 1997-06-10 | 1997-06-10 | 4-Fenilpiperidin bileşimleri. |
EP00203910A EP1078925A1 (fr) | 1997-06-10 | 1997-06-10 | Composés 4-phenylpiperidine |
DK97926276T DK0994872T3 (da) | 1997-06-10 | 1997-06-10 | 4-phenylpiperidin-forbindelser |
BR9714787-7A BR9714787A (pt) | 1997-06-10 | 1997-06-10 | Compostos de 4- fenilpiperidina e processo para sua preparação |
JP50212699A JP2002503248A (ja) | 1997-06-10 | 1997-06-10 | 4−フェニルピペリジン化合物 |
IL13336697A IL133366A (en) | 1997-06-10 | 1997-06-10 | 4-Phenylpiperidine compounds, process for their preparation and uses thereof |
US08/872,023 US5874447A (en) | 1997-06-10 | 1997-06-10 | 4-Phenylpiperidine compounds for treating depression |
CA002293247A CA2293247C (fr) | 1997-06-10 | 1997-06-10 | Composes 4-phenylpiperidine |
SK1619-99A SK283394B6 (sk) | 1997-06-10 | 1997-06-10 | Zlúčeniny 4-fenylpiperidínu a jej farmaceuticky prijateľné soli, spôsob ich prípravy, liečivo s ich obsahom a ich použitie |
KR1019997011625A KR100543614B1 (ko) | 1997-06-10 | 1997-06-10 | 4-페닐피페리딘 화합물 |
HU0003141A HUP0003141A3 (en) | 1997-06-10 | 1997-06-10 | 4-phenylpiperidine derivatives, process for producing them and pharmaceutical compositions containing them |
EEP199900570A EE03970B1 (et) | 1997-06-10 | 1997-06-10 | 4-fenüülpiperidiinühend, selle valmistamine ja kasutamine ning seda sisaldav ravim |
ES97926276T ES2155995T3 (es) | 1997-06-10 | 1997-06-10 | Compuestos de 4-fenilpiperidina. |
AU31080/97A AU3108097A (en) | 1997-06-10 | 1997-06-10 | 4-phenylpiperidine compounds |
UA99126690A UA53707C2 (uk) | 1997-06-10 | 1997-10-06 | Похідні 4-фенілпіперидину, спосіб їх отримання (варіанти) і фармацевтична композиція |
US09/200,743 US7598271B1 (en) | 1997-06-10 | 1998-11-30 | Crystalline paroxetine methane sulfonate |
NO19995455A NO317371B1 (no) | 1997-06-10 | 1999-11-08 | 4-Fenylpiperidinforbindelser |
IS5249A IS1927B (is) | 1997-06-10 | 1999-11-16 | 4-fenýlpíperidín efnasambönd |
BG103980A BG64315B1 (bg) | 1997-06-10 | 1999-12-10 | 4-фенилпиперидинови соли, метод за получаването им и използването им като лекарствено средство |
HK00106418A HK1027352A1 (en) | 1997-06-10 | 2000-10-10 | 4-phenylpiperidine compounds |
GR20010400220T GR3035784T3 (en) | 1997-06-10 | 2001-04-26 | 4-phenylpiperidine compounds |
US09/855,710 US6900327B2 (en) | 1997-06-10 | 2001-05-16 | 4-phenylpiperidine compounds |
NO20033765A NO20033765D0 (no) | 1997-06-10 | 2003-08-25 | 4-Fenylpiperidinforbindelser |
NO20033766A NO20033766D0 (no) | 1997-06-10 | 2003-08-25 | 4-Fenylpiperidinforbindelser |
IS7098A IS7098A (is) | 1997-06-10 | 2004-01-08 | 4-fenýlpíperidín efnasambönd |
US12/358,997 US20090326233A1 (en) | 1997-06-10 | 2009-01-23 | 4-phenylpiperidine compounds |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/872,023 US5874447A (en) | 1997-06-10 | 1997-06-10 | 4-Phenylpiperidine compounds for treating depression |
PCT/NL1997/000328 WO1998056787A1 (fr) | 1997-06-10 | 1997-06-10 | Composes 4-phenylpiperidine |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1998056787A1 true WO1998056787A1 (fr) | 1998-12-17 |
Family
ID=26647319
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/NL1997/000328 WO1998056787A1 (fr) | 1997-06-10 | 1997-06-10 | Composes 4-phenylpiperidine |
Country Status (26)
Country | Link |
---|---|
US (4) | US5874447A (fr) |
EP (2) | EP1078925A1 (fr) |
JP (1) | JP2002503248A (fr) |
KR (1) | KR100543614B1 (fr) |
AT (1) | ATE200781T1 (fr) |
AU (1) | AU3108097A (fr) |
BG (1) | BG64315B1 (fr) |
BR (1) | BR9714787A (fr) |
CA (1) | CA2293247C (fr) |
CZ (1) | CZ295301B6 (fr) |
DE (2) | DE29724281U1 (fr) |
DK (1) | DK0994872T3 (fr) |
EE (2) | EE03970B1 (fr) |
ES (1) | ES2155995T3 (fr) |
GR (1) | GR3035784T3 (fr) |
HK (1) | HK1027352A1 (fr) |
HU (1) | HUP0003141A3 (fr) |
IL (1) | IL133366A (fr) |
IS (2) | IS1927B (fr) |
NO (3) | NO317371B1 (fr) |
PL (1) | PL188450B1 (fr) |
PT (1) | PT994872E (fr) |
SI (1) | SI0994872T1 (fr) |
SK (1) | SK283394B6 (fr) |
TR (2) | TR200201156T2 (fr) |
WO (1) | WO1998056787A1 (fr) |
Cited By (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2336364A (en) * | 1998-07-02 | 1999-10-20 | Smithkline Beecham Plc | Paroxetine methanesulfonate |
WO1999052901A1 (fr) * | 1998-04-09 | 1999-10-21 | Smithkline Beecham Plc | Maleate de paroxetine |
WO2000001692A1 (fr) * | 1998-07-02 | 2000-01-13 | Smithkline Beecham Plc | Sels de paroxetine |
WO2000008016A1 (fr) * | 1998-08-08 | 2000-02-17 | Smithkline Beecham Plc | Sels de paroxetine |
WO2000035910A1 (fr) * | 1998-12-11 | 2000-06-22 | Smithkline Beecham Plc | Derive paroxetinique |
WO2000039121A1 (fr) * | 1998-12-29 | 2000-07-06 | Smithkline Beecham P.L.C. | Procede de preparation d'un acetate de paroxetine ou d'analogues de paroxetine |
WO2000039122A1 (fr) * | 1998-12-29 | 2000-07-06 | Smithkline Beecham Plc | Procede de preparation d'un acetate de paroxetine et de ses analogues |
WO2000039123A1 (fr) * | 1998-12-29 | 2000-07-06 | Smithkline Beecham Plc | Procede de preparation d'un sel d'acetate de paroxetine ou d'analogues de paroxetine |
GR1003490B (el) * | 1999-06-22 | 2000-11-30 | Smithkline Beecham P.L.C. | Νεες φαρμακευτικες συνθεσεις που περιεχουν αλας παροξετινης |
WO2000078752A1 (fr) * | 1999-06-22 | 2000-12-28 | Smithkline Beecham P.L.C. | Procede de production de chlorhydrate de paroxetine |
WO2000078290A2 (fr) * | 1999-06-22 | 2000-12-28 | Smithkline Beecham P.L.C. | Nouvelle preparation |
WO2001012624A1 (fr) * | 1999-08-12 | 2001-02-22 | Smithkline Beecham P.L.C. | Paroxetine |
WO2002017921A2 (fr) * | 2000-08-28 | 2002-03-07 | Synthon B.V. | Compositions a base de paroxetine et leurs procedes de fabrication |
WO2002022609A1 (fr) * | 2000-09-14 | 2002-03-21 | Asahi Glass Company, Limited | Procede de production de sel de paroxetine sensiblement exempt de solvant organique |
WO2003020717A1 (fr) * | 2001-08-02 | 2003-03-13 | Spurcourt Limited | Sel d'isethionate de paroxetine, procede de preparation et utilisation dans le traitement de la depression |
WO2003082804A1 (fr) * | 2002-03-28 | 2003-10-09 | Synthon B.V. | Besylate de venlafaxine |
US8501777B2 (en) | 2005-10-13 | 2013-08-06 | Nsab, Filial Af Neurosearch Sweden Ab, Sverige | 3,5-disubstituted phenyl-piperidines as modulators of dopamine neurotransmission |
WO2013115163A1 (fr) * | 2012-01-31 | 2013-08-08 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Dérivé de paroxétine |
USRE46117E1 (en) | 1999-12-22 | 2016-08-23 | Teva Pharmaceuticals International Gmbh | Modulators of dopamine neurotransmission |
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CN104039777A (zh) * | 2012-01-31 | 2014-09-10 | 卫材R&D管理有限公司 | 帕罗西汀衍生物 |
WO2013115163A1 (fr) * | 2012-01-31 | 2013-08-08 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Dérivé de paroxétine |
US11207308B2 (en) | 2012-04-04 | 2021-12-28 | Prilenia Neurotherapeutics Ltd. | Pharmaceutical compositions for combination therapy |
US10259791B2 (en) | 2014-08-28 | 2019-04-16 | Eisai R&D Management Co., Ltd. | High-purity quinoline derivative and method for manufacturing same |
US11090386B2 (en) | 2015-02-25 | 2021-08-17 | Eisai R&D Management Co., Ltd. | Method for suppressing bitterness of quinoline derivative |
US11369623B2 (en) | 2015-06-16 | 2022-06-28 | Prism Pharma Co., Ltd. | Anticancer combination of a CBP/catenin inhibitor and an immune checkpoint inhibitor |
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