WO1994004534A1 - Derive de tetrahydropyrroloindole, procede pour sa fabrication, et intermediaires a cet effet - Google Patents

Derive de tetrahydropyrroloindole, procede pour sa fabrication, et intermediaires a cet effet Download PDF

Info

Publication number
WO1994004534A1
WO1994004534A1 PCT/JP1993/001158 JP9301158W WO9404534A1 WO 1994004534 A1 WO1994004534 A1 WO 1994004534A1 JP 9301158 W JP9301158 W JP 9301158W WO 9404534 A1 WO9404534 A1 WO 9404534A1
Authority
WO
WIPO (PCT)
Prior art keywords
group
methyl
indole
general formula
protecting group
Prior art date
Application number
PCT/JP1993/001158
Other languages
English (en)
Japanese (ja)
Inventor
Shiro Terashima
Yasumichi Fukuda
Original Assignee
Kyorin Pharmaceutical Co., Ltd.
Sagami Chemical Research Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Pharmaceutical Co., Ltd., Sagami Chemical Research Center filed Critical Kyorin Pharmaceutical Co., Ltd.
Priority to AU49811/93A priority Critical patent/AU4981193A/en
Publication of WO1994004534A1 publication Critical patent/WO1994004534A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Definitions

  • the reaction solution was diluted with methylene chloride, washed successively with water, 10% sodium hydrogen carbonate and saturated saline, and dried over anhydrous sodium sulfate.

Abstract

L'invention décrit un intermédiaire pour la production d'un composé qui offre des perspectives comme agent cancérostatique, un procédé pour sa fabrication, et un produit de départ à cet effet. Elle décrit également des dérivés de tétrahydropyrroloindole représentés par la formule générale (1), et leurs isomères optiquement actifs. Dans ladite formule, R1 représente hydrogène ou un groupe hydroxyle protecteur; R2 représente hydrogène ou un groupe amino protecteur; et X représente halogène, hydroxyle, alkylcarbonyloxy, arylcarbonyloxy, alkylsulfonyloxy ou arylsulfonyloxy.
PCT/JP1993/001158 1992-08-21 1993-08-19 Derive de tetrahydropyrroloindole, procede pour sa fabrication, et intermediaires a cet effet WO1994004534A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU49811/93A AU4981193A (en) 1992-08-21 1993-08-19 Tetrahydropyrroloindole derivative, process for producing the same, and intermediates therefor

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP22286192 1992-08-21
JP4/222861 1992-08-21
JP5204254A JPH06116270A (ja) 1992-08-21 1993-08-18 テトラヒドロピロロインドール誘導体及びその製法並びにその中間体
JP5/204254 1993-08-18

Publications (1)

Publication Number Publication Date
WO1994004534A1 true WO1994004534A1 (fr) 1994-03-03

Family

ID=26514367

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1993/001158 WO1994004534A1 (fr) 1992-08-21 1993-08-19 Derive de tetrahydropyrroloindole, procede pour sa fabrication, et intermediaires a cet effet

Country Status (3)

Country Link
JP (1) JPH06116270A (fr)
AU (1) AU4981193A (fr)
WO (1) WO1994004534A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0937726A1 (fr) * 1996-09-18 1999-08-25 Kyorin Pharmaceutical Co., Ltd. Produits intermediaires destines a la preparation de duocarmycine sa et de derives de ce dernier, et procede de production de ces produits intermediaires

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03128379A (ja) * 1989-07-03 1991-05-31 Kyowa Hakko Kogyo Co Ltd Ｄｃ―８８ａ誘導体
JPH0499774A (ja) * 1990-08-14 1992-03-31 Sagami Chem Res Center ２―エピデュオカルマイシンａおよびその製造中間体
JPH04117383A (ja) * 1990-06-20 1992-04-17 Sagami Chem Res Center ２―アルコキシカルボニル―２―メチル―１―オキソ―１，２，３，６，７，８―ヘキサヒドロ―ベンゾ〔１，２―ｂ；４，３―ｂ´〕ジピロール誘導体
JPH05178858A (ja) * 1991-06-28 1993-07-20 Kyowa Hakko Kogyo Co Ltd Ｄｃ−８９誘導体

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03128379A (ja) * 1989-07-03 1991-05-31 Kyowa Hakko Kogyo Co Ltd Ｄｃ―８８ａ誘導体
JPH04117383A (ja) * 1990-06-20 1992-04-17 Sagami Chem Res Center ２―アルコキシカルボニル―２―メチル―１―オキソ―１，２，３，６，７，８―ヘキサヒドロ―ベンゾ〔１，２―ｂ；４，３―ｂ´〕ジピロール誘導体
JPH0499774A (ja) * 1990-08-14 1992-03-31 Sagami Chem Res Center ２―エピデュオカルマイシンａおよびその製造中間体
JPH05178858A (ja) * 1991-06-28 1993-07-20 Kyowa Hakko Kogyo Co Ltd Ｄｃ−８９誘導体

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0937726A1 (fr) * 1996-09-18 1999-08-25 Kyorin Pharmaceutical Co., Ltd. Produits intermediaires destines a la preparation de duocarmycine sa et de derives de ce dernier, et procede de production de ces produits intermediaires
EP0937726A4 (fr) * 1996-09-18 2001-04-11 Kyorin Seiyaku Kk Produits intermediaires destines a la preparation de duocarmycine sa et de derives de ce dernier, et procede de production de ces produits intermediaires

Also Published As

Publication number Publication date
AU4981193A (en) 1994-03-15
JPH06116270A (ja) 1994-04-26

Similar Documents

Publication Publication Date Title
JP3330972B2 (ja) ヌクレオシドのジアステレオ選択的合成法
JP2634775B2 (ja) β−ラクタム系抗生物質中間体の製造方法及びその中間体
KR100309973B1 (ko) 신규β-락탐,탁산의제조방법및측쇄함유탁산
EP0525589A1 (fr) Synthèse asymétrique d'une chaîne latérale du taxol
EP0635488B1 (fr) Procédé pour la préparation des composés d'azétidine et composés précurseurs pour ceci
WO1998012197A1 (fr) Produits intermediaires destines a la preparation de duocarmycine sa et de derives de ce dernier, et procede de production de ces produits intermediaires
JPH07165760A (ja) アゼチジノン化合物及びその製法
JP3450193B2 (ja) ４−置換アゼチジノン誘導体の製造方法
JPH0254350B2 (fr)
WO1994004534A1 (fr) Derive de tetrahydropyrroloindole, procede pour sa fabrication, et intermediaires a cet effet
ES2337013B1 (es) Transposicion de espirolactamas y compuestos asi obtenidos.
JP2510860B2 (ja) 新規なβ−ラクタム誘導体の製造方法
JPS6143357B2 (fr)
US4870169A (en) Intermediates for beta-lactam antibiotics
JPS63284176A (ja) （１ｒ，５ｒ，６ｓ）−６−〔（１ｒ）−１−ヒドロキシエチル〕−１−メチルカルバペネム−３−カルボン酸誘導体の高立体選択的製造方法
JP3140155B2 (ja) Ｎ，ｎ’−ジ置換アミド誘導体
US4675396A (en) 7-Oxo-4-thia-1-azabicyclo(3,2,0)heptane derivatives
JPH075590B2 (ja) ４−置換β−ラクタム化合物
JP3037965B2 (ja) ２―アルコキシカルボニル―２―メチル―１―オキソ―１，２，３，６，７，８―ヘキサヒドロ―ベンゾ〔１，２―ｂ；４，３―ｂ´〕ジピロール誘導体
US5359077A (en) Process for preparation of 2-oxo-1 piperidinyl derivatives
JP3118143B2 (ja) アゼチジノン化合物の新規な製法およびその新規原料化合物
JPH06279409A (ja) 光学活性１，４−ジヒドロピリジン誘導体およびその製造方法
US4734495A (en) Process and intermediates for beta-lactam antibiotics
JPH06166672A (ja) ６−メトキシインドール誘導体の新規製造法
JP2735840B2 (ja) ピラゾリジン誘導体およびピラゾリジノン誘導体

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AU BB BG BR CA CZ FI HU KR LK MG MN MW NO NZ PL RO RU SD SK UA US

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: CA