UY36903A - Derivados de indol mono- o disustituidos como inhibidores de la replicación viral del dengue - Google Patents

Derivados de indol mono- o disustituidos como inhibidores de la replicación viral del dengue

Info

Publication number
UY36903A
UY36903A UY0001036903A UY36903A UY36903A UY 36903 A UY36903 A UY 36903A UY 0001036903 A UY0001036903 A UY 0001036903A UY 36903 A UY36903 A UY 36903A UY 36903 A UY36903 A UY 36903A
Authority
UY
Uruguay
Prior art keywords
mono
dengue
indol
disabled
inhibitors
Prior art date
Application number
UY0001036903A
Other languages
English (en)
Inventor
Dorothée Alice Marie-Eve Bardiot
Arnaud Didier M Marchand
Pierre Jean-Marie Bernard Raboisson
Bart Rudolf Romanie Kesteleyn
Jean François BONFANTI
Tim Hugo Maria Jonckers
Original Assignee
Janssen Pharmaceuticals Inc
Univ Leuven Kath
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceuticals Inc, Univ Leuven Kath filed Critical Janssen Pharmaceuticals Inc
Publication of UY36903A publication Critical patent/UY36903A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se divulgan compuestos indólicos mono- o disustituidos, métodos para prevenir o tratar infecciones virales por dengue utilizando dichos compuestos y para su uso para tratar o prevenir infecciones virales por dengue. Se divulgan también a composiciones farmacéuticas o preparados combinados de los compuestos, a las composiciones o preparados para su uso como una medicina para la prevención o el tratamiento de infecciones virales por dengue. Se divulgan también los procesos para la preparación de los compuestos.
UY0001036903A 2015-09-16 2016-09-16 Derivados de indol mono- o disustituidos como inhibidores de la replicación viral del dengue UY36903A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15185523 2015-09-16
EP16163472 2016-04-01

Publications (1)

Publication Number Publication Date
UY36903A true UY36903A (es) 2017-03-31

Family

ID=56926217

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001036903A UY36903A (es) 2015-09-16 2016-09-16 Derivados de indol mono- o disustituidos como inhibidores de la replicación viral del dengue

Country Status (30)

Country Link
US (1) US10765662B2 (es)
EP (1) EP3350162B1 (es)
JP (2) JP7050666B2 (es)
KR (1) KR102646174B1 (es)
CN (1) CN108473422B (es)
AU (1) AU2016324982B2 (es)
CA (1) CA2996979C (es)
CL (1) CL2018000696A1 (es)
CO (1) CO2018003471A2 (es)
CR (1) CR20180213A (es)
DK (1) DK3350162T3 (es)
EA (1) EA035663B1 (es)
EC (1) ECSP18020055A (es)
ES (1) ES2893298T3 (es)
HK (1) HK1257842A1 (es)
HR (1) HRP20211352T1 (es)
HU (1) HUE055870T2 (es)
IL (1) IL258043B (es)
JO (1) JOP20160198B1 (es)
LT (1) LT3350162T (es)
MA (1) MA42810A (es)
MX (1) MX2018003255A (es)
NI (1) NI201800039A (es)
PE (1) PE20181165A1 (es)
PH (1) PH12018500576A1 (es)
SI (1) SI3350162T1 (es)
TW (1) TWI758255B (es)
UA (1) UA122973C2 (es)
UY (1) UY36903A (es)
WO (1) WO2017046255A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201116559D0 (en) 2011-09-26 2011-11-09 Univ Leuven Kath Novel viral replication inhibitors
GB201305376D0 (en) 2013-03-25 2013-05-08 Univ Leuven Kath Novel viral replication inhibitors
JOP20160086B1 (ar) 2015-05-08 2021-08-17 2 Katholieke Univ Leuven Ku Leuven Research And Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JO3633B1 (ar) 2015-09-16 2020-08-27 Katholieke Univ Leuven Ku Leuven Research & Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
CO2018006164A2 (es) 2015-12-16 2018-09-20 Loxo Oncology Inc Compuestos útiles como inhibidores de cinasa
AU2017242893A1 (en) 2016-03-31 2018-08-09 Janssen Pharmaceuticals, Inc. Substituted indole derivatives as dengue viral replication inhibitors
CR20180496A (es) 2016-03-31 2018-12-06 Univ Leuven Kath Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue
JOP20170069B1 (ar) 2016-04-01 2021-08-17 1 Janssen Pharmaceuticals Inc مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
KR102359766B1 (ko) * 2016-04-01 2022-02-07 얀센 파마슈티칼즈, 인코포레이티드 뎅기 바이러스 복제 억제제로서 치환된 인돌 화합물 유도체
JOP20180025B1 (ar) * 2017-03-31 2021-08-17 Janssen Pharmaceuticals Inc مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20180026A1 (ar) * 2017-03-31 2019-01-30 Univ Leuven Kath مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
CN110753682B (zh) 2017-05-22 2023-06-30 杨森制药公司 作为登革热病毒复制抑制剂的经取代的吲哚啉衍生物
UA125407C2 (uk) 2017-05-22 2022-03-02 Янссен Фармасьютікалз, Інк. Заміщені похідні індоліну як інгібітори реплікації вірусів денге

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE296286T1 (de) 1997-10-27 2005-06-15 Lilly Co Eli Morpholino-n-ethyl ester prodrogen von indol spla 2 hemmer
GB0110832D0 (en) 2001-05-03 2001-06-27 Virogen Ltd Antiviral compounds
CA2468202A1 (en) 2001-12-12 2003-06-19 Conforma Therapeutics Corporation Assays and implements for determining and modulating hsp90 binding activity
GB0215293D0 (en) 2002-07-03 2002-08-14 Rega Foundation Viral inhibitors
US20060211698A1 (en) 2005-01-14 2006-09-21 Genelabs, Inc. Bicyclic heteroaryl derivatives for treating viruses
MX2007009561A (es) 2005-02-09 2008-01-14 Migenix Inc Composiciones y metodos para tratar o evitar infecciones de flaviviridae.
EP2142535A2 (en) 2007-03-29 2010-01-13 Novartis Ag 3-imidazolyl-indoles for the treatment of proliferative diseases
FR2928645A1 (fr) * 2008-03-14 2009-09-18 Sanofi Aventis Sa Nouveaux derives de carbazole inhibiteurs d'hsp90, compositions les contenant et utilisation
BRPI0909985A2 (pt) 2008-06-03 2015-08-25 Siga Technologies Inc Composição farmacêutica e método para o tratamento ou profilaxia de uma infecção viral ou doença associada à mesma
MX2011001872A (es) * 2008-08-18 2011-05-23 Univ Yale Moduladores de mif.
ES2612731T3 (es) 2008-08-19 2017-05-18 Janssen Pharmaceutica Nv Antagonistas de receptores al frío de mentol
TWI453207B (zh) 2008-09-08 2014-09-21 Signal Pharm Llc 胺基***并吡啶，其組合物及使用其之治療方法
GB0910003D0 (en) 2009-06-11 2009-07-22 Univ Leuven Kath Novel compounds for the treatment of neurodegenerative diseases
US8993604B2 (en) 2009-06-30 2015-03-31 Siga Technologies, Inc. Treatment and prevention of dengue virus infections
JP5777223B2 (ja) 2010-01-15 2015-09-09 ギリアード サイエンシーズ， インコーポレイテッド フラビウイルス科ウイルスのインヒビター
JP2013523657A (ja) 2010-03-26 2013-06-17 グラクソ グループ リミテッド キナーゼ阻害剤としてのインダゾリル‐ピリミジン
GB201116559D0 (en) 2011-09-26 2011-11-09 Univ Leuven Kath Novel viral replication inhibitors
GB201305376D0 (en) 2013-03-25 2013-05-08 Univ Leuven Kath Novel viral replication inhibitors
US9567299B2 (en) 2013-10-23 2017-02-14 Janssen Sciences Ireland Uc Carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
WO2015116886A1 (en) 2014-01-31 2015-08-06 Bristol-Myers Squibb Company Macrocycles with hetrocyclic p2' groups as factor xia inhibitors
EA032546B1 (ru) 2014-10-01 2019-06-28 Янссен Фармасьютикалз, Инк. Производные моно- или дизамещенных индолов в качестве ингибиторов репликации вирусов денге
WO2016050831A1 (en) * 2014-10-01 2016-04-07 Janssen Pharmaceuticals, Inc. Mono- or di-substituted indoles as dengue viral replication inhibitors
NO2721243T3 (es) 2014-10-01 2018-10-20
JOP20150335B1 (ar) 2015-01-16 2022-03-14 Janssen Pharmaceuticals Inc مشتقات اندول بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
AR103680A1 (es) 2015-02-23 2017-05-24 Lilly Co Eli Inhibidores selectivos de bace1
JOP20160086B1 (ar) 2015-05-08 2021-08-17 2 Katholieke Univ Leuven Ku Leuven Research And Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JO3633B1 (ar) 2015-09-16 2020-08-27 Katholieke Univ Leuven Ku Leuven Research & Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
ES2907686T3 (es) 2015-11-03 2022-04-26 Zoetis Services Llc Compuestos poliméricos sol-gel y sus usos
AU2017242893A1 (en) 2016-03-31 2018-08-09 Janssen Pharmaceuticals, Inc. Substituted indole derivatives as dengue viral replication inhibitors
CR20180496A (es) 2016-03-31 2018-12-06 Univ Leuven Kath Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue
AR108012A1 (es) 2016-03-31 2018-07-04 Takeda Pharmaceuticals Co Derivados de azaespiro[3,4]octan-6-ona como inhibidores de magl
KR102359766B1 (ko) 2016-04-01 2022-02-07 얀센 파마슈티칼즈, 인코포레이티드 뎅기 바이러스 복제 억제제로서 치환된 인돌 화합물 유도체
NZ746554A (en) 2016-04-01 2023-03-31 Signal Pharm Llc Substituted aminopurine compounds, compositions thereof, and methods of treatment therewith
MX2018012016A (es) 2016-04-01 2019-01-24 Basf Se Compuestos biciclicos.
WO2017173410A1 (en) 2016-04-01 2017-10-05 Amgen Inc. Chimeric receptors to flt3 and methods of use thereof
JOP20170069B1 (ar) 2016-04-01 2021-08-17 1 Janssen Pharmaceuticals Inc مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
KR20200068750A (ko) 2016-04-01 2020-06-15 카이트 파마 인코포레이티드 키메라 수용체 및 그의 사용 방법
AU2017240667C1 (en) 2016-04-01 2022-11-24 Kite Pharma, Inc. Chimeric antigen and T cell receptors and methods of use
JOP20180025B1 (ar) 2017-03-31 2021-08-17 Janssen Pharmaceuticals Inc مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20180026A1 (ar) 2017-03-31 2019-01-30 Univ Leuven Kath مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
CN110753682B (zh) 2017-05-22 2023-06-30 杨森制药公司 作为登革热病毒复制抑制剂的经取代的吲哚啉衍生物
UA125407C2 (uk) 2017-05-22 2022-03-02 Янссен Фармасьютікалз, Інк. Заміщені похідні індоліну як інгібітори реплікації вірусів денге

Also Published As

Publication number Publication date
CR20180213A (es) 2018-06-27
HUE055870T2 (hu) 2021-12-28
US10765662B2 (en) 2020-09-08
HK1257842A1 (zh) 2019-11-01
CA2996979A1 (en) 2017-03-23
MA42810A (fr) 2018-07-25
EA035663B1 (ru) 2020-07-23
KR20180052672A (ko) 2018-05-18
CA2996979C (en) 2024-01-30
IL258043A (en) 2018-05-31
PH12018500576A1 (en) 2018-10-15
TWI758255B (zh) 2022-03-21
LT3350162T (lt) 2021-09-27
KR102646174B1 (ko) 2024-03-08
EA201890722A1 (ru) 2018-09-28
PE20181165A1 (es) 2018-07-19
AU2016324982B2 (en) 2021-04-15
CN108473422B (zh) 2021-06-15
CO2018003471A2 (es) 2018-07-10
WO2017046255A1 (en) 2017-03-23
DK3350162T3 (da) 2021-10-04
IL258043B (en) 2021-08-31
JOP20160198B1 (ar) 2022-03-14
AU2016324982A1 (en) 2018-03-15
EP3350162A1 (en) 2018-07-25
CL2018000696A1 (es) 2018-07-06
EP3350162B1 (en) 2021-07-14
HRP20211352T1 (hr) 2022-02-04
JP7050666B2 (ja) 2022-04-08
MX2018003255A (es) 2018-11-09
ES2893298T3 (es) 2022-02-08
UA122973C2 (uk) 2021-01-27
JP2018528220A (ja) 2018-09-27
ECSP18020055A (es) 2018-04-30
NI201800039A (es) 2018-07-24
US20180256545A1 (en) 2018-09-13
CN108473422A (zh) 2018-08-31
SI3350162T1 (sl) 2021-11-30
TW201722913A (zh) 2017-07-01
JP2021181485A (ja) 2021-11-25

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