UY36771A - Moduladores cot y métodos de uso de los mismos - Google Patents
Moduladores cot y métodos de uso de los mismosInfo
- Publication number
- UY36771A UY36771A UY0001036771A UY36771A UY36771A UY 36771 A UY36771 A UY 36771A UY 0001036771 A UY0001036771 A UY 0001036771A UY 36771 A UY36771 A UY 36771A UY 36771 A UY36771 A UY 36771A
- Authority
- UY
- Uruguay
- Prior art keywords
- methods
- same
- cot
- modulators
- cot modulators
- Prior art date
Links
- 208000024770 Thyroid neoplasm Diseases 0.000 abstract 1
- 201000002510 thyroid cancer Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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- C07B59/002—Heterocyclic compounds
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07—ORGANIC CHEMISTRY
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Abstract
La presente divulgación se refiere en general a moduladores de Cot (cáncer de tiroides Osaka) y métodos de uso y producción de los mismos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562189158P | 2015-07-06 | 2015-07-06 | |
US201562269060P | 2015-12-17 | 2015-12-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY36771A true UY36771A (es) | 2017-01-31 |
Family
ID=56411943
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY0001036771A UY36771A (es) | 2015-07-06 | 2016-07-06 | Moduladores cot y métodos de uso de los mismos |
Country Status (40)
Country | Link |
---|---|
US (6) | US20170008905A1 (es) |
EP (3) | EP3896064A1 (es) |
JP (5) | JP6430060B2 (es) |
KR (5) | KR102073641B1 (es) |
CN (3) | CN109879859B (es) |
AU (4) | AU2016290820B2 (es) |
BR (1) | BR102016015656B1 (es) |
CA (1) | CA2971640C (es) |
CL (1) | CL2017003356A1 (es) |
CO (1) | CO2017013351A2 (es) |
CR (1) | CR20170599A (es) |
CU (1) | CU20170172A7 (es) |
CY (1) | CY1121750T1 (es) |
DK (1) | DK3191470T3 (es) |
DO (1) | DOP2017000311A (es) |
EA (1) | EA036788B1 (es) |
EC (1) | ECSP17084635A (es) |
ES (2) | ES2872076T3 (es) |
HR (1) | HRP20190853T1 (es) |
HU (1) | HUE043310T2 (es) |
IL (4) | IL274568B (es) |
LT (1) | LT3191470T (es) |
MA (1) | MA39422B1 (es) |
ME (1) | ME03425B (es) |
MX (1) | MX370984B (es) |
MY (1) | MY196173A (es) |
NZ (2) | NZ750707A (es) |
PE (1) | PE20180462A1 (es) |
PH (2) | PH12018500031A1 (es) |
PL (2) | PL3191470T3 (es) |
PT (2) | PT3456717T (es) |
RS (1) | RS58639B1 (es) |
SA (1) | SA517381350B1 (es) |
SG (1) | SG11201702041PA (es) |
SI (2) | SI3191470T1 (es) |
SV (1) | SV2017005605A (es) |
TW (3) | TWI634112B (es) |
UA (1) | UA123010C2 (es) |
UY (1) | UY36771A (es) |
WO (1) | WO2017007689A1 (es) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
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US9540343B2 (en) | 2011-07-06 | 2017-01-10 | Gilead Sciences, Inc. | Compounds for the treatment of HIV |
US10118890B2 (en) | 2014-10-10 | 2018-11-06 | The Research Foundation For The State University Of New York | Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration |
EP3319955B1 (en) | 2015-07-06 | 2020-11-25 | Gilead Sciences, Inc. | 6-amino-quinoline-3-carbonitrils as cot modulators |
EP3896064A1 (en) | 2015-07-06 | 2021-10-20 | Gilead Sciences, Inc. | 4,6-diamino-quinoline-3-carbonitrile derivatives as cancer osaka thyroid (cot) modulators for treating crohn's disease and ulcerative colitis |
WO2018005435A1 (en) | 2016-06-30 | 2018-01-04 | Gilead Sciences, Inc. | 4,6-diaminoquinazolines as cot modulators and methods of use thereof |
HUE063811T2 (hu) * | 2016-08-19 | 2024-02-28 | Gilead Sciences Inc | HIV-vírus-fertõzés megelõzõ vagy terápiás kezelésére alkalmas terápiás vegyületek |
EA036921B1 (ru) * | 2017-02-10 | 2021-01-15 | Джилид Сайэнс, Инк. | Терапевтические соединения, которые можно применять для профилактического или терапевтического лечения инфекции вирусом вич |
CN108794516A (zh) * | 2017-04-26 | 2018-11-13 | 上海时莱生物技术有限公司 | 硼酸和硼酸酯类化合物及其制备方法和用途 |
AR112412A1 (es) | 2017-08-17 | 2019-10-23 | Gilead Sciences Inc | Formas de sal de colina de un inhibidor de la cápside del vih |
TW202024061A (zh) | 2017-08-17 | 2020-07-01 | 美商基利科學股份有限公司 | Hiv蛋白質膜抑制劑之固體形式 |
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