UY34467A - Procedimiento para la preparación de 5-fluoro-1h-pirazolopiridinas sustituidas - Google Patents

Procedimiento para la preparación de 5-fluoro-1h-pirazolopiridinas sustituidas

Info

Publication number
UY34467A
UY34467A UY0001034467A UY34467A UY34467A UY 34467 A UY34467 A UY 34467A UY 0001034467 A UY0001034467 A UY 0001034467A UY 34467 A UY34467 A UY 34467A UY 34467 A UY34467 A UY 34467A
Authority
UY
Uruguay
Prior art keywords
pirazolopiridinas
fluoro
replaced
procedure
preparation
Prior art date
Application number
UY0001034467A
Other languages
English (en)
Inventor
Fey Dr Peter
Original Assignee
Bayer Ip Gmbh
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ip Gmbh, Bayer Pharma AG filed Critical Bayer Ip Gmbh
Publication of UY34467A publication Critical patent/UY34467A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
    • C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/02—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to acyclic carbon atoms
    • C07C317/04—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/023—Preparation; Separation; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/037—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements with quaternary ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/067—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

La presente solicitud se refiere a un procedimiento nuevo y eficiente para la preparación de nuevas 5-fluoro-1H-pirazolopiridinas sustituidas de la fórmula (VI) que son adecuadas como productos intermedios para la preparación de medicamentos y para la preparación de medicamentos para el tratamiento y/o la profilaxis de enfermedades cardiovasculares. Especialmente son adecuadas las 5-fluoro-1H-pirazolopiridinas de la fórmula (VI) para la preparación del compuesto de la fórmula (I)que sirve para la preparación de medicamentos, para la preparación de medicamentos para el tratamiento y/o la prof ilaxis de enfermedades cardiovasculares
UY0001034467A 2011-11-25 2012-11-23 Procedimiento para la preparación de 5-fluoro-1h-pirazolopiridinas sustituidas UY34467A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11190789 2011-11-25
EP11192301 2011-12-07

Publications (1)

Publication Number Publication Date
UY34467A true UY34467A (es) 2013-06-28

Family

ID=47222101

Family Applications (2)

Application Number Title Priority Date Filing Date
UY0001034467A UY34467A (es) 2011-11-25 2012-11-23 Procedimiento para la preparación de 5-fluoro-1h-pirazolopiridinas sustituidas
UY0001039646A UY39646A (es) 2011-11-25 2022-02-24 Procedimiento para la preparación de 5-fluoro-1h-pirazolopiridinas sustituidas

Family Applications After (1)

Application Number Title Priority Date Filing Date
UY0001039646A UY39646A (es) 2011-11-25 2022-02-24 Procedimiento para la preparación de 5-fluoro-1h-pirazolopiridinas sustituidas

Country Status (42)

Country Link
US (7) US8802847B2 (es)
EP (3) EP2896617B1 (es)
JP (4) JP6189315B2 (es)
KR (3) KR101993022B1 (es)
CN (3) CN105503867B (es)
AP (2) AP3898A (es)
AR (1) AR088983A1 (es)
AU (3) AU2012342547C1 (es)
BR (2) BR122020001312B1 (es)
CA (2) CA3040720C (es)
CL (2) CL2014001339A1 (es)
CO (1) CO6960555A2 (es)
CR (3) CR20190057A (es)
CU (3) CU24354B1 (es)
CY (1) CY1124000T1 (es)
DK (3) DK2896617T3 (es)
DO (3) DOP2014000112A (es)
EA (4) EA033455B1 (es)
EC (1) ECSP14001627A (es)
ES (3) ES2603028T3 (es)
GT (1) GT201400101A (es)
HK (2) HK1203951A1 (es)
HR (3) HRP20161501T1 (es)
HU (3) HUE031029T2 (es)
IL (3) IL232585A0 (es)
JO (3) JOP20120351B1 (es)
LT (3) LT3421470T (es)
MX (1) MX357481B (es)
MY (3) MY197904A (es)
PE (3) PE20190181A1 (es)
PH (2) PH12014501160B1 (es)
PL (3) PL3421470T3 (es)
PT (3) PT2896617T (es)
RS (3) RS55387B1 (es)
SG (3) SG11201402111QA (es)
SI (3) SI3421470T1 (es)
TR (1) TR201816203T4 (es)
TW (5) TWI597280B (es)
UA (3) UA120278C2 (es)
UY (2) UY34467A (es)
WO (1) WO2013076168A1 (es)
ZA (2) ZA201403613B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102010021637A1 (de) 2010-05-26 2011-12-01 Bayer Schering Pharma Aktiengesellschaft Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung
DE102010043380A1 (de) 2010-11-04 2012-05-10 Bayer Schering Pharma Aktiengesellschaft Benzyl-substituierte Carbamate und ihre Verwendung
DE102010043379A1 (de) 2010-11-04 2012-05-10 Bayer Schering Pharma Aktiengesellschaft Substituierte 6-Fluor-1H-Pyrazolo[4,3-b]pyridine und ihre Verwendung
WO2013076168A1 (de) 2011-11-25 2013-05-30 Bayer Pharma Aktiengesellschaft Verfahren zur herstellung von substituierten 5-fluor-1h-pyrazolopyridinen
JP6386478B2 (ja) 2013-02-21 2018-09-05 アドヴェリオ・ファーマ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング メチル｛４，６−ジアミノ−２−［１−（２−フルオロベンジル）−１ｈ−ピラゾロ［３，４−ｂ］ピリジノ−３−イル］ピリミジノ−５−イル｝メチルカルバメートの形態
JO3318B1 (ar) 2013-06-18 2019-03-13 Lilly Co Eli مثبطات bace
CN108463224A (zh) 2015-12-14 2018-08-28 铁木医药有限公司 sGC刺激剂用于胃肠功能障碍治疗的应用
US20190381039A1 (en) 2016-12-13 2019-12-19 Cyclerion Therapeutics, Inc. USE OF sGC STIMULATORS FOR THE TREATMENT OF ESOPHAGEAL MOTILITY DISORDERS
EP3609883B1 (en) 2017-04-11 2022-06-29 Sunshine Lake Pharma Co., Ltd. Fluorine-substituted indazole compounds and uses thereof
US20210177846A1 (en) 2018-07-11 2021-06-17 Cyclerion Therapeutics, Inc. USE OF sGC STIMULATORS FOR THE TREATMENT OF MITOCHONDRIAL DISORDERS
TWI830835B (zh) 2018-12-17 2024-02-01 德商亞德維瑞醫藥有限公司 具改善性質之{4,6-二胺基-2-[5-氟-1-(2-氟芐基)-1H-吡唑並[3,4-b]吡啶-3-基]嘧啶-5-基}胺基甲酸甲酯活性化合物產物、其製造及調配物
CA3127128A1 (en) * 2019-01-22 2020-07-30 Adverio Pharma Gmbh Process for manufacturing 4-(2,2,3,3-tetrafluoropropyl)morpholine
EP4099987A1 (en) 2020-02-03 2022-12-14 Adverio Pharma GmbH Nanoformulations of methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1h-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate
EP3925953A1 (en) 2020-06-16 2021-12-22 Adverio Pharma GmbH Process for preparing methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1h-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate
WO2023034364A1 (en) 2021-08-31 2023-03-09 Teva Pharmaceuticals International Gmbh Solid state forms of vericiguat and process for preparation thereof
ES2956054A1 (es) 2022-05-03 2023-12-12 Moehs Iberica Sl 2-(5-FLUORO-1-(2-FLUOROBENCIL)-1H-PIRAZOLO[3,4-b]PIRIDIN-3-IL)-5-NITROSOPIRIMIDIN-4,6-DIAMINA O UNA SAL DE LA MISMA, PROCEDIMIENTO PARA SU PREPARACION Y SU USO EN LA SINTESIS DE VERICIGUAT
CN115043835B (zh) * 2022-06-17 2023-05-09 常州制药厂有限公司 一种维立西呱的精制纯化方法
WO2024038398A1 (en) * 2022-08-18 2024-02-22 Torrent Pharmaceuticals Limited Novel salt of substituted 5-fluoro-1h-pyrazolopyridines and its uses

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8606936D0 (en) * 1986-03-20 1986-04-23 Ici Plc Organic compounds
GB9013750D0 (en) 1990-06-20 1990-08-08 Pfizer Ltd Therapeutic agents
HUP0001115A3 (en) 1996-10-14 2001-06-28 Bayer Ag Heterocyclylmethyl-substituted pyrazol derivatives, process for their preparation and pharmaceuticals containing the same
DE19642255A1 (de) 1996-10-14 1998-04-16 Bayer Ag Verwendung von 1-Benzyl-3-(substituierten-hetaryl) -kondensierten Pyrazol-Derivaten
US6451805B1 (en) 1997-11-14 2002-09-17 Bayer Aktiengesellschaft Substituted pyrazole derivatives for the treatment of cardiocirculatory diseases
DE19834045A1 (de) 1998-07-29 2000-02-03 Bayer Ag (4-Amino-5-ethylpyrimidin-2-yl)-1-(2-fluorbenzyl)-1H-pyrazolo[3,4-b]pyridin
DE19834047A1 (de) 1998-07-29 2000-02-03 Bayer Ag Substituierte Pyrazolderivate
DE19834044A1 (de) 1998-07-29 2000-02-03 Bayer Ag Neue substituierte Pyrazolderivate
DE19846514A1 (de) 1998-10-09 2000-04-20 Bayer Ag Neue Heterocyclyl-methyl-substituierte Pyrazole
PL348187A1 (en) 1998-11-16 2002-05-06 Basf Ag 3-{benz(ox/thi)azol-7-yl}-1h-pyrimidine-2,4-diones
DE19920352A1 (de) 1999-05-04 2000-11-09 Bayer Ag Substituiertes Pyrazolderivat
DE10057751A1 (de) 2000-11-22 2002-05-23 Bayer Ag Neue Carbamat-substituierte Pyrazolopyridinderivate
DE10057754A1 (de) 2000-11-22 2002-05-23 Bayer Ag Neue Sulfonamid-substituierte Pyrazolopyridinderivate
DE10131987A1 (de) 2000-11-22 2002-05-23 Bayer Ag Neue Pyridin-substituierte Pyrazolopyridinderivate
AR031176A1 (es) 2000-11-22 2003-09-10 Bayer Ag Nuevos derivados de pirazolpiridina sustituidos con piridina
US6903089B1 (en) 2000-11-22 2005-06-07 Bayer Aktiengesellschaft Lactam-substituted pyrazolopyridine derivatives
DE10122894A1 (de) 2001-05-11 2002-11-14 Bayer Ag Neue Sulfonat-substituierte Pyrazolopyridinderivate
SI1401445T1 (sl) 2001-06-22 2007-02-28 Boehringer Ingelheim Pharma Kristalinicen antiholinergik, postopek za njegovo pripravo in njegova uporaba za pripravo zdravila
DE10132416A1 (de) 2001-07-04 2003-01-16 Bayer Ag Neue Morpholin-überbrückte Pyrazolopyridinderivate
DE10153737A1 (de) 2001-10-31 2003-05-28 Boehringer Ingelheim Pharma Kristallines Natriumsalz des Telmisartans, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels
DE10220570A1 (de) * 2002-05-08 2003-11-20 Bayer Ag Carbamat-substituierte Pyrazolopyridine
DE10222550A1 (de) 2002-05-17 2003-11-27 Bayer Ag Substituierte Benzyl-pyrazolopyridine
DE10232572A1 (de) 2002-07-18 2004-02-05 Bayer Ag Neue 2,5-disubstituierte Pyrimidinderivate
DE10232571A1 (de) 2002-07-18 2004-02-05 Bayer Ag 4-Aminosubstituierte Pyrimidinderivate
DE10351903A1 (de) 2003-11-06 2005-06-09 Bayer Healthcare Ag Neue Kombination
DE102006021733A1 (de) * 2006-05-09 2007-11-22 Bayer Healthcare Ag 3-Tetrazolylindazole und 3-Tetrazolylpyrazolopyridine sowie ihre Verwendung
DE102006031175A1 (de) 2006-07-06 2008-01-10 Bayer Healthcare Ag Wässrige Arzneimittelformulierung von 4-[((4-Carboxybutyl)-(2[(4-phenethyl-benzyl)oxy]-phenethyl)amino)methyl]benzoesäur
DE102006043443A1 (de) 2006-09-15 2008-03-27 Bayer Healthcare Ag Neue aza-bicyclische Verbindungen und ihre Verwendung
US20100210644A1 (en) 2007-06-25 2010-08-19 Boehringer Ingelheim International Gmbh Chemical compounds
AR067762A1 (es) * 2007-07-31 2009-10-21 Vertex Pharma Proceso para preparar 5-fluoro-1h-pirazolo (3,4-b) piridin-3-amina y derivados de la misma
EP2262498A2 (en) 2008-03-10 2010-12-22 Vertex Pharmceuticals Incorporated Pyrimidines and pyridines useful as inhibitors of protein kinases
KR100979460B1 (ko) * 2008-05-13 2010-09-02 한국과학기술연구원 함불소알킬그룹이 치환된 이온성 액체의 직접 제조방법
DE102009004245A1 (de) 2009-01-09 2010-07-15 Bayer Schering Pharma Aktiengesellschaft Neue anellierte, Heteroatom-verbrückte Pyrazol- und Imidazol-Derivate und ihre Verwendung
UY33040A (es) * 2009-11-27 2011-06-30 Bayer Schering Pahrma Akitengesellschaft Nuevas formas polimorfas de {4,6diamino-2-[1-(2-fluorobencil-1h-pirazol[3,4-b]piridin-3-il]pirimidin-5-il}carbamato de metilo
DK2504334T3 (en) 2009-11-27 2014-12-08 Bayer Ip Gmbh PROCEDURE FOR PURIFICATION OF METHYL- {4,6-DIAMINO-2- [1- (2-FLUOROBENZYL) -1H-PYRAZOLO [3,4-B] PYRIDIN-3-YL] PYRIMIDIN-5-YL} METHYL CARBAMATE
UY33041A (es) * 2009-11-27 2011-06-30 Bayer Schering Pharma Aktienegesellschaft Procedimiento para la preparaciòn de {4,6-diamino-2-[1-(2-fluorobencil)-1h-pirazolo[3,4-b]piridin-3-il]pirimidin-5-il}carbamato de metilo y su purificaciòn para el uso como principio activo farmacèutico
WO2011115804A1 (en) 2010-03-17 2011-09-22 Ironwood Pharmaceuticals, Inc. Sgc stimulators
DE102010021637A1 (de) * 2010-05-26 2011-12-01 Bayer Schering Pharma Aktiengesellschaft Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung
MX2013000198A (es) 2010-07-09 2013-01-28 Bayer Ip Gmbh Pirimidinadas y triazinas condensadas y su uso.
DE102010040233A1 (de) 2010-09-03 2012-03-08 Bayer Schering Pharma Aktiengesellschaft Bicyclische Aza-Heterocyclen und ihre Verwendung
DE102010040234A1 (de) 2010-09-03 2012-03-08 Bayer Schering Pharma Aktiengesellschaft Verfahren zur Herstellung von 5-Flour-1H-pyrazolo[3,4-b]pyridin-3-carbonitril
DE102010043380A1 (de) 2010-11-04 2012-05-10 Bayer Schering Pharma Aktiengesellschaft Benzyl-substituierte Carbamate und ihre Verwendung
DE102010043379A1 (de) 2010-11-04 2012-05-10 Bayer Schering Pharma Aktiengesellschaft Substituierte 6-Fluor-1H-Pyrazolo[4,3-b]pyridine und ihre Verwendung
DE102011007272A1 (de) 2011-04-13 2012-10-18 Bayer Pharma Aktiengesellschaft Verzweigte 3-Phenylpropionsäure-Derivate und ihre Verwendung
JP6054967B2 (ja) 2011-09-02 2016-12-27 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ 置換アネレート化ピリミジンおよびその使用
WO2013076168A1 (de) 2011-11-25 2013-05-30 Bayer Pharma Aktiengesellschaft Verfahren zur herstellung von substituierten 5-fluor-1h-pyrazolopyridinen

Also Published As

Publication number Publication date
UY39646A (es) 2022-04-29
MX357481B (es) 2018-07-11
RS61609B1 (sr) 2021-04-29
JP6189315B2 (ja) 2017-08-30
DOP2014000112A (es) 2014-07-15
EA033455B1 (ru) 2019-10-31
TW201831447A (zh) 2018-09-01
TW201838993A (zh) 2018-11-01
CA2856706C (en) 2020-06-16
AR088983A1 (es) 2014-07-23
TW201932465A (zh) 2019-08-16
ES2694158T3 (es) 2018-12-18
CR20190057A (es) 2019-04-23
EA201690521A1 (ru) 2016-06-30
US9845300B2 (en) 2017-12-19
BR112014012414B1 (pt) 2022-01-11
CN106905314A (zh) 2017-06-30
CU24257B1 (es) 2017-05-10
CR20140237A (es) 2014-06-19
IL263389B (en) 2022-03-01
AP2015008243A0 (en) 2015-01-31
PT2896617T (pt) 2016-11-18
AU2012342547B2 (en) 2017-08-17
PL3421470T3 (pl) 2021-08-02
IL246265B (en) 2018-12-31
NZ724215A (en) 2018-03-23
EP2896617A1 (de) 2015-07-22
EA201491028A1 (ru) 2014-12-30
ES2603028T3 (es) 2017-02-23
SI2782914T1 (sl) 2018-12-31
AP3898A (en) 2016-11-16
PH12014501160A1 (en) 2014-10-20
EA201491028A8 (ru) 2016-01-29
RS55387B1 (sr) 2017-03-31
AU2012342547C1 (en) 2019-02-21
CU20150124A7 (es) 2016-03-31
ES2603028T8 (es) 2021-12-29
AU2017254916A1 (en) 2017-11-23
US20130143900A1 (en) 2013-06-06
PE20190180A1 (es) 2019-02-01
CN105503867B (zh) 2019-01-11
SG11201402111QA (en) 2014-08-28
SI2896617T1 (sl) 2016-12-30
MY168412A (en) 2018-11-09
PH12015501494B1 (en) 2015-09-07
US20170158652A1 (en) 2017-06-08
CU24354B1 (es) 2018-08-06
KR101993022B1 (ko) 2019-06-25
US20140315926A1 (en) 2014-10-23
JP2018058860A (ja) 2018-04-12
EP2782914A1 (de) 2014-10-01
US20190177288A1 (en) 2019-06-13
TWI659016B (zh) 2019-05-11
AU2012342547A1 (en) 2014-06-05
LT2896617T (lt) 2016-12-12
ZA201403613B (en) 2016-02-24
LT3421470T (lt) 2021-04-26
JP6340391B2 (ja) 2018-06-06
UA116623C2 (uk) 2018-04-25
SG10201604192XA (en) 2016-07-28
DOP2017000013A (es) 2017-02-15
CA3040720A1 (en) 2013-05-30
DK2782914T3 (en) 2018-11-26
EP3421470B8 (de) 2021-08-11
CN104159898B (zh) 2017-01-18
EP3421470B1 (de) 2021-01-20
DOP2021000179A (es) 2021-09-30
US9604948B2 (en) 2017-03-28
DK2896617T3 (en) 2016-12-12
JP2018199698A (ja) 2018-12-20
IL246265A0 (en) 2016-07-31
EA031602B1 (ru) 2019-01-31
US10364229B2 (en) 2019-07-30
CL2014001339A1 (es) 2014-10-17
HRP20181818T1 (hr) 2019-01-11
MY198086A (en) 2023-07-31
TWI665198B (zh) 2019-07-11
CU20140055A7 (es) 2014-10-02
AU2019202123A1 (en) 2019-04-18
HRP20210507T1 (hr) 2021-05-28
CA3040720C (en) 2021-06-15
TW201708219A (zh) 2017-03-01
AP2014007705A0 (en) 2014-06-30
ZA201505970B (en) 2017-08-30
PL2896617T3 (pl) 2017-07-31
CA2856706A1 (en) 2013-05-30
JOP20210065A1 (ar) 2023-01-30
US10633356B2 (en) 2020-04-28
HUE053745T2 (hu) 2021-07-28
TR201816203T4 (tr) 2018-11-21
EP2896617B1 (de) 2016-10-05
US8802847B2 (en) 2014-08-12
TWI597280B (zh) 2017-09-01
US9150573B2 (en) 2015-10-06
KR20140105483A (ko) 2014-09-01
HUE041592T2 (hu) 2019-05-28
US20180065942A1 (en) 2018-03-08
EP2782914B1 (de) 2018-08-01
HK1223613A1 (zh) 2017-08-04
IL232585A0 (en) 2014-06-30
KR101943788B1 (ko) 2019-01-29
ES2864009T3 (es) 2021-10-13
NZ624593A (en) 2016-10-28
PL2782914T3 (pl) 2019-01-31
KR102026059B1 (ko) 2019-09-26
RS57945B1 (sr) 2019-01-31
IL263389A (en) 2018-12-31
WO2013076168A1 (de) 2013-05-30
BR112014012414A2 (pt) 2017-06-06
MY197904A (en) 2023-07-24
JP6392436B2 (ja) 2018-09-19
BR112014012414A8 (pt) 2018-01-23
EP3421470A1 (de) 2019-01-02
DK3421470T3 (da) 2021-04-06
CU20150123A7 (es) 2016-03-31
HRP20161501T1 (hr) 2016-12-16
SI3421470T1 (sl) 2021-07-30
UA119269C2 (uk) 2019-05-27
PT3421470T (pt) 2021-03-31
JP2017031180A (ja) 2017-02-09
PE20190181A1 (es) 2019-02-01
JOP20120351B1 (ar) 2021-08-17
TWI631123B (zh) 2018-08-01
EA201690520A1 (ru) 2016-07-29
US20190177287A1 (en) 2019-06-13
TW201329076A (zh) 2013-07-16
CL2016000344A1 (es) 2017-02-10
PH12015501494A1 (en) 2015-09-07
HUE031029T2 (en) 2017-06-28
CN104159898A (zh) 2014-11-19
BR122020001312B1 (pt) 2022-02-15
ECSP14001627A (es) 2015-11-30
KR20170130612A (ko) 2017-11-28
EA030018B1 (ru) 2018-06-29
JP2015502932A (ja) 2015-01-29
CR20210072A (es) 2021-03-22
JOP20210064A1 (ar) 2023-01-30
AU2017254916B2 (en) 2019-02-28
NZ721592A (en) 2018-02-23
PT2782914T (pt) 2018-11-16
AU2019202123B2 (en) 2020-09-24
EA201892050A1 (ru) 2019-02-28
GT201400101A (es) 2014-11-13
LT2782914T (lt) 2018-10-10
CO6960555A2 (es) 2014-05-30
KR20190018021A (ko) 2019-02-20
CY1124000T1 (el) 2022-05-27
HK1203951A1 (en) 2015-11-06
PH12014501160B1 (en) 2014-10-20
CN105503867A (zh) 2016-04-20
US20160009671A1 (en) 2016-01-14
PE20142359A1 (es) 2015-01-09
UA120278C2 (uk) 2019-11-11
SG10201604196VA (en) 2016-07-28
US10633357B2 (en) 2020-04-28
MX2014006018A (es) 2014-06-04

Similar Documents

Publication Publication Date Title
UY34467A (es) Procedimiento para la preparación de 5-fluoro-1h-pirazolopiridinas sustituidas
UY34472A (es) Derivados modificados de 4-fenil-piridina
UY34550A (es) Bencilpirazoles sustituidos
UY34763A (es) Inhibidores de la agregación plaquetaria
UY34445A (es) Nuevos compuestos inhibidores de la fosfodiesterasa del tipo 10a
UY34820A (es) Compuestos tipo pirrolo-pirrolidinona
UY34374A (es) Benzilindazoles sustituidos
UY34352A (es) 3-pirimidin-4-il-oxazolidin-2-onas como inhibidores de la idh mutante
UY34657A (es) ?derivados macrocíclicos para el tratamiento de enfermedades?.
UY34145A (es) Compuestos inhibidores de metaloenzimas
UY34817A (es) Tienopirimidinas
UY34146A (es) Compuestos inhibidores de metaloenzimas
UY34697A (es) Métodos para preparar análogos de nucleótidos
UY34201A (es) Compuestos de azaindol y métodos para el tratamiento de vih.
UY34523A (es) Derivados de betulina
UY34765A (es) Compuestos novedosos.
UY34302A (es) COMPUESTOS DE HEXAHIDROPIRANO[3,4-d][1,3]TIAZIN-2- AMINA
UY34156A (es) Compuestos inhibidores de metaloenzimas
UY34591A (es) Compuestos de imidazopirrolidinona
UY34177A (es) Nuevos compuestos inhibidores de la fosfodiesterasa tipo 10a
UY34503A (es) ?sal de bromhidrato de pridopidina?
UY34037A (es) Nuevo compuesto útil para el tratamiento de enfermedades degenerativas e inflamatorias.
UY34824A (es) Nucleósidos de espirooxetano de uracilo
UY34792A (es) ?método de uso de profungicidas de uk-2a para control de la roya de soja?.
UY34515A (es) Triazolopiridinas sustituidas