SI1401445T1 - Kristalinicen antiholinergik, postopek za njegovo pripravo in njegova uporaba za pripravo zdravila - Google Patents

Kristalinicen antiholinergik, postopek za njegovo pripravo in njegova uporaba za pripravo zdravila

Info

Publication number
SI1401445T1
SI1401445T1 SI200230431T SI200230431T SI1401445T1 SI 1401445 T1 SI1401445 T1 SI 1401445T1 SI 200230431 T SI200230431 T SI 200230431T SI 200230431 T SI200230431 T SI 200230431T SI 1401445 T1 SI1401445 T1 SI 1401445T1
Authority
SI
Slovenia
Prior art keywords
production
drug
anticholinergic
crystalline
crystalline anticholinergic
Prior art date
Application number
SI200230431T
Other languages
English (en)
Inventor
Peter Sieger
Ulrike Werthmann
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of SI1401445T1 publication Critical patent/SI1401445T1/sl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D451/00Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06Oxygen atoms
    • C07D451/10Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/468-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, ***e
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
SI200230431T 2001-06-22 2002-06-08 Kristalinicen antiholinergik, postopek za njegovo pripravo in njegova uporaba za pripravo zdravila SI1401445T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10129710 2001-06-22
DE10215436 2002-04-08
PCT/EP2002/006291 WO2003000265A1 (de) 2001-06-22 2002-06-08 Kristallines anticholinergikum, verfahren zu dessen herstellung und dessen verwendung zur herstellung eines arzneimittels

Publications (1)

Publication Number Publication Date
SI1401445T1 true SI1401445T1 (sl) 2007-02-28

Family

ID=26009556

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200230431T SI1401445T1 (sl) 2001-06-22 2002-06-08 Kristalinicen antiholinergik, postopek za njegovo pripravo in njegova uporaba za pripravo zdravila

Country Status (38)

Country Link
EP (1) EP1401445B1 (sl)
JP (1) JP2005504015A (sl)
KR (2) KR101011353B1 (sl)
CN (1) CN100586948C (sl)
AR (1) AR037491A1 (sl)
AT (1) ATE337006T1 (sl)
AU (1) AU2002345016B2 (sl)
BG (1) BG66303B1 (sl)
BR (1) BR0210537A (sl)
CA (1) CA2450961C (sl)
CO (1) CO5550423A2 (sl)
CY (1) CY1105223T1 (sl)
CZ (1) CZ302786B6 (sl)
DE (1) DE50207943D1 (sl)
DK (1) DK1401445T3 (sl)
EA (1) EA005813B1 (sl)
EE (1) EE05316B1 (sl)
EG (1) EG24851A (sl)
ES (1) ES2271280T3 (sl)
HK (1) HK1068540A1 (sl)
HR (1) HRP20031066B1 (sl)
HU (1) HUP0400333A3 (sl)
IL (2) IL159238A0 (sl)
ME (1) ME00412B (sl)
MX (1) MXPA03011718A (sl)
MY (1) MY122779A (sl)
NO (1) NO334301B1 (sl)
NZ (1) NZ530690A (sl)
PE (2) PE20081305A1 (sl)
PL (1) PL208137B1 (sl)
PT (1) PT1401445E (sl)
RS (1) RS50441B (sl)
SA (1) SA02230255B1 (sl)
SI (1) SI1401445T1 (sl)
SK (1) SK287262B6 (sl)
TW (2) TW200617007A (sl)
UY (1) UY27342A1 (sl)
WO (1) WO2003000265A1 (sl)

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ATE539754T1 (de) 2004-04-22 2012-01-15 Boehringer Ingelheim Int Arzneinmittelkombinationen enthaltend benzoxazine zur behandlung von atemwegserkrankungen
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DE102004024454A1 (de) 2004-05-14 2005-12-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Enantiomerenreine Betaagonisten, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
ES2322148T3 (es) 2004-08-11 2009-06-17 BOEHRINGER INGELHEIM PHARMA GMBH &amp; CO. KG Medicamentos que contienen anticolinergicos para el tratamiento en las vias urinarias.
US20060079544A1 (en) * 2004-08-13 2006-04-13 Boehringer Ingelheim International Gmbh Medicaments for the prevention or treatment of alveolar pneumonia comprising an anticholinergic
DE102004048389A1 (de) 2004-10-01 2006-04-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Modifizierung von Oberflächen von Laktose als Hilfsstoff zur Verwendung für Pulverinhalativa
JP5053997B2 (ja) 2005-04-28 2012-10-24 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 炎症性疾患の治療用の新規化合物
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DE102005030733A1 (de) 2005-07-01 2007-01-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Arzneimittelkombinationen zur Behandlung von Atemwegserkrankungen enthaltend langwirksame Beta-2-Agonisten und wenigstens einen weiteren Wirkstoff
ES2530991T3 (es) 2005-08-15 2015-03-09 Boehringer Ingelheim Int Procedimiento para la obtención de betamiméticos
TWI396541B (zh) 2005-10-10 2013-05-21 Boehringer Ingelheim Int 用於治療呼吸疾病之新穎藥物組合
US7423146B2 (en) 2005-11-09 2008-09-09 Boehringer Ingelheim International Gmbh Process for the manufacturing of pharmaceutically active 3,1-benzoxazine-2-ones
US9108962B2 (en) 2005-12-19 2015-08-18 Sicor, Inc. Forms of tiotropium bromide and processes for preparation thereof
PL2123650T3 (pl) * 2005-12-19 2012-09-28 Sicor Inc Nowa postać bromku tiotropium i sposób jej wytwarzania
CN100999521B (zh) * 2006-01-13 2010-12-08 江苏正大天晴药业股份有限公司 结晶性抗胆碱药噻托溴铵
EP1847543A1 (de) 2006-04-19 2007-10-24 Boehringer Ingelheim Pharma GmbH & Co. KG Dihydrothienopyrimidine zur Behandlung von entzündlichen Erkrankungen
EP1874781B9 (de) 2006-04-19 2010-09-08 Boehringer Ingelheim International GmbH Dihydrothienopyrimidine zur behandlung von entzündlichen erkrankungen
ATE505193T1 (de) 2006-08-07 2011-04-15 Boehringer Ingelheim Int Arzneimittelkombinationen zur behandlung von atemwegserkrankungen
PE20080610A1 (es) 2006-08-22 2008-07-15 Boehringer Ingelheim Int Nuevos beta-agonistas enantiomericamente puros, procedimientos para su preparacion y uso como medicamentos
GB0716026D0 (en) 2007-08-16 2007-09-26 Norton Healthcare Ltd An inhalable medicament
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EP2093219A1 (de) 2008-02-22 2009-08-26 Boehringer Ingelheim International Gmbh Kristalline, enantiomerenreine Salzform eines Betamimetikums und dessen Verwendung als Arzneimittel
EP2379525B1 (en) 2008-12-19 2015-07-29 Boehringer Ingelheim International GmbH Cyclic pyrimidin-4-carboxamides as ccr2 receptor antagonists for treatment of inflammation, asthma and copd
EP2403851B1 (en) 2009-03-06 2015-06-17 Mahmut Bilgic New crystalline forms of tiotropium bromide
ES2524829T3 (es) 2009-12-17 2014-12-12 Boehringer Ingelheim International Gmbh Nuevos antagonistas del receptor CCR2 y usos de los mismos
JP5658272B2 (ja) 2009-12-17 2015-01-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ccr2の新規アンタゴニスト及びこれらの使用
EP2528915B1 (en) 2010-01-29 2015-10-28 Boehringer Ingelheim International GmbH Substituted naphthyridines and their use as syk kinase inhibitors
WO2011141477A1 (en) 2010-05-12 2011-11-17 Boehringer Ingelheim International Gmbh New ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments
JP2013526507A (ja) 2010-05-12 2013-06-24 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規ccr2受容体アンタゴニスト、その製造方法及び薬物としてのその使用
EP2571870B1 (en) 2010-05-17 2015-01-21 Boehringer Ingelheim International GmbH Ccr2 antagonists and uses thereof
US9018212B2 (en) 2010-05-25 2015-04-28 Boehringer Ingelheim International Gmbh Pyridazine carboxamides as CCR2 receptor antagonists
US8962656B2 (en) 2010-06-01 2015-02-24 Boehringer Ingelheim International Gmbh CCR2 antagonists
TR201007108A2 (tr) * 2010-08-25 2012-03-21 B�Lg�� Mahmut Yeni tiotropyum bromür kristali ve üretim yöntemi.@
EP2668177B1 (en) 2011-01-28 2014-10-22 Boehringer Ingelheim International GmbH Substituted pyridinyl-pyrimidines and their use as medicaments
TR201101897A2 (tr) 2011-02-28 2012-09-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür içeren kristal madde
TR201111589A2 (tr) * 2011-03-03 2012-09-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür susuz kristal formu.
TR201102068A2 (tr) 2011-03-03 2012-09-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür içeren kristal maddeler
JP5786257B2 (ja) 2011-06-16 2015-09-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規の選択的ccr2拮抗薬
EP2731941B1 (en) 2011-07-15 2019-05-08 Boehringer Ingelheim International GmbH Novel and selective ccr2 antagonists
AU2012288969B2 (en) 2011-07-26 2017-02-23 Boehringer Ingelheim International Gmbh Substituted quinolines and their use as medicaments
US20130059866A1 (en) 2011-08-24 2013-03-07 Boehringer Ingelheim International Gmbh Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma
DK2782914T3 (en) 2011-11-25 2018-11-26 Adverio Pharma Gmbh PROCEDURE FOR PREPARING SUBSTITUTED 5-FLUOR-1H-PYRAZOLOPYRIDINES
CZ304368B6 (cs) 2011-11-28 2014-04-02 Zentiva, K.S. Směsný solvát tiotropium bromidu a způsob jeho přípravy
GB201200525D0 (en) 2011-12-19 2012-02-29 Teva Branded Pharmaceutical Prod R & D Inc An inhalable medicament
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CN104797579A (zh) 2012-11-05 2015-07-22 赞蒂瓦有限合伙公司 噻托溴铵溶剂化物的稳定化
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DE10064816A1 (de) * 2000-12-22 2002-06-27 Boehringer Ingelheim Pharma Verfahren zur Herstellung eines Anticholinergikums

Also Published As

Publication number Publication date
HRP20031066A2 (en) 2004-04-30
ME00412B (me) 2011-10-10
WO2003000265A1 (de) 2003-01-03
KR100971616B1 (ko) 2010-07-22
IL159238A (en) 2010-04-15
CA2450961C (en) 2010-03-30
CY1105223T1 (el) 2010-03-03
SK522004A3 (en) 2004-06-08
EA200301293A1 (ru) 2004-08-26
NO334301B1 (no) 2014-02-03
CZ302786B6 (cs) 2011-11-09
CZ2004120A3 (cs) 2004-05-12
HUP0400333A2 (hu) 2004-12-28
EG24851A (en) 2010-10-27
YU99703A (sh) 2006-05-25
SK287262B6 (sk) 2010-04-07
TW200617007A (en) 2006-06-01
NO20035696D0 (no) 2003-12-19
BG108440A (en) 2004-08-31
CA2450961A1 (en) 2003-01-03
PE20081305A1 (es) 2008-10-01
HRP20031066B1 (en) 2011-10-31
AR037491A1 (es) 2004-11-17
EE05316B1 (et) 2010-08-16
HK1068540A1 (en) 2005-04-29
RS50441B (sr) 2010-03-02
EA005813B1 (ru) 2005-06-30
EP1401445B1 (de) 2006-08-23
EE200400029A (et) 2004-04-15
JP2005504015A (ja) 2005-02-10
ATE337006T1 (de) 2006-09-15
BR0210537A (pt) 2004-06-22
PE20030130A1 (es) 2003-04-02
MEP62008A (en) 2011-05-10
IL159238A0 (en) 2004-06-01
MXPA03011718A (es) 2004-12-06
CN1520294A (zh) 2004-08-11
CN100586948C (zh) 2010-02-03
NZ530690A (en) 2005-05-27
PT1401445E (pt) 2006-10-31
DE50207943D1 (de) 2006-10-05
PL364489A1 (en) 2004-12-13
PL208137B1 (pl) 2011-03-31
EP1401445A1 (de) 2004-03-31
KR20040018285A (ko) 2004-03-02
SA02230255B1 (ar) 2006-10-31
DK1401445T3 (da) 2006-11-27
HUP0400333A3 (en) 2012-10-29
CO5550423A2 (es) 2005-08-31
KR101011353B1 (ko) 2011-01-28
AU2002345016B2 (en) 2008-04-17
BG66303B1 (bg) 2013-03-29
TWI261589B (en) 2006-09-11
UY27342A1 (es) 2003-02-28
MY122779A (en) 2006-05-31
ES2271280T3 (es) 2007-04-16
KR20090031638A (ko) 2009-03-26

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