UY33776A - Ácidos 1-bencilcicloalquilcarboxílicos sustituidos y su uso - Google Patents
Ácidos 1-bencilcicloalquilcarboxílicos sustituidos y su usoInfo
- Publication number
- UY33776A UY33776A UY33776A UY33776A UY33776A UY 33776 A UY33776 A UY 33776A UY 33776 A UY33776 A UY 33776A UY 33776 A UY33776 A UY 33776A UY 33776 A UY33776 A UY 33776A
- Authority
- UY
- Uruguay
- Prior art keywords
- bencilcicloalquilcarboxílicos
- acids substituted
- prevention
- treatment
- diseases
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/53—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/55—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a carbon atom of an unsaturated carbon skeleton
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente solicitud se refiere a nuevos derivados de ácido 1-bencilcicloalquilcarboxílico sustituidos, procedimientos para su preparación, su uso para el tratamiento y/o la prevención de enfermedades así como su uso para la preparación de medicamentos para el tratamiento y/o la prevención de enfermedades, especialmente para el tratamiento y/o la prevención enfermedades cardiovasculares.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102010062544A DE102010062544A1 (de) | 2010-12-07 | 2010-12-07 | Substituierte 1-Benzylcycloalkylcarbonsäuren und ihre Verwendung |
DE102011006974A DE102011006974A1 (de) | 2011-04-07 | 2011-04-07 | Substituierte 1-Benzylcycloalkylcarbonsäuren und ihre Verwendung |
Publications (1)
Publication Number | Publication Date |
---|---|
UY33776A true UY33776A (es) | 2012-06-29 |
Family
ID=45463539
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY33776A UY33776A (es) | 2010-12-07 | 2011-12-07 | Ácidos 1-bencilcicloalquilcarboxílicos sustituidos y su uso |
Country Status (26)
Country | Link |
---|---|
US (1) | US9018258B2 (es) |
EP (1) | EP2649045B1 (es) |
JP (1) | JP5989660B2 (es) |
KR (1) | KR20130136504A (es) |
CN (1) | CN103492361B (es) |
AP (1) | AP2013006953A0 (es) |
AR (1) | AR084220A1 (es) |
AU (1) | AU2011340721A1 (es) |
BR (1) | BR112013013663A2 (es) |
CA (1) | CA2819880C (es) |
CL (1) | CL2013001600A1 (es) |
CO (1) | CO6771409A2 (es) |
CR (1) | CR20130259A (es) |
DO (1) | DOP2013000125A (es) |
EA (1) | EA201300669A1 (es) |
EC (1) | ECSP13012668A (es) |
ES (1) | ES2544532T3 (es) |
HK (1) | HK1192879A1 (es) |
IL (1) | IL226422A0 (es) |
MA (1) | MA34721B1 (es) |
MX (1) | MX2013006053A (es) |
SG (1) | SG190296A1 (es) |
TW (1) | TW201249782A (es) |
UY (1) | UY33776A (es) |
WO (1) | WO2012076466A2 (es) |
ZA (1) | ZA201305076B (es) |
Families Citing this family (32)
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DE102009012314A1 (de) * | 2009-03-09 | 2010-09-16 | Bayer Schering Pharma Aktiengesellschaft | Oxo-heterocyclisch substituierte Alkylcarbonsäuren und ihre Verwendung |
DE102009046115A1 (de) | 2009-10-28 | 2011-09-08 | Bayer Schering Pharma Aktiengesellschaft | Substituierte 3-Phenylpropansäuren und ihre Verwendung |
DE102011007272A1 (de) | 2011-04-13 | 2012-10-18 | Bayer Pharma Aktiengesellschaft | Verzweigte 3-Phenylpropionsäure-Derivate und ihre Verwendung |
DE102012208530A1 (de) | 2012-05-22 | 2013-11-28 | Bayer Pharma AG | Substituierte Piperidinoacetamide und ihre Verwendung |
EP2900639B1 (en) | 2012-09-27 | 2017-08-16 | Portola Pharmaceuticals, Inc. | Bicyclic dihydropyridone kinase inhibitors |
CN104058990B (zh) * | 2013-03-21 | 2017-03-15 | 博瑞生物医药(苏州)股份有限公司 | 一种阿利克仑或其盐的分离分析方法 |
TW201625601A (zh) | 2014-07-02 | 2016-07-16 | 諾華公司 | 噻吩-2-基-吡啶-2-基-1h-吡唑-4-羧酸衍生物及其作為可溶性鳥苷酸環化酶活化劑之用途 |
TW201625584A (zh) | 2014-07-02 | 2016-07-16 | 諾華公司 | 茚滿及吲哚啉衍生物及其作為可溶性鳥苷酸環化酶活化劑之用途 |
TW201625586A (zh) | 2014-07-02 | 2016-07-16 | 諾華公司 | 環己烯-1-基-吡啶-2-基-1h-吡唑-4-羧酸衍生物及其作為可溶性鳥苷酸環化酶活化劑之用途 |
JPWO2016052353A1 (ja) * | 2014-09-29 | 2017-07-13 | 日産化学工業株式会社 | ジェミナルジフルオロ化合物の製造方法 |
CA2970987A1 (en) | 2014-12-18 | 2016-06-23 | Bayer Pharma Aktiengesellschaft | Substituted pyridyl-cycloalkyl-carboxylic acids, compositions containing them and medical uses thereof |
JP6748113B2 (ja) | 2015-05-06 | 2020-08-26 | バイエル・ファルマ・アクティエンゲゼルシャフト | 全身性硬化症(SSc)に付随する指潰瘍(DU)を治療するための単独のまたはPDE5阻害剤と組み合わせたsGC刺激剤、sGC活性化剤の使用 |
SI3325013T2 (sl) | 2015-07-23 | 2023-11-30 | Bayer Pharma Aktiengesellschaft | Stimulatorji/aktivatorji topne gvanilat ciklaze v kombinaciji z zaviralcem NEP in/ali antagonistom angiotenzina II in njihova uporaba |
CA3039735A1 (en) | 2016-10-11 | 2018-04-19 | Bayer Pharma Aktiengesellschaft | Combination containing sgc activators and mineralocorticoid receptor antagonists |
WO2019081456A1 (en) | 2017-10-24 | 2019-05-02 | Bayer Aktiengesellschaft | USE OF SGC ACTIVATORS AND STIMULATORS COMPRISING A BETA2 SUBUNIT |
BR112020010837A2 (pt) * | 2017-12-01 | 2020-11-10 | Bayer Pharma Aktiengesellschaft | processo para preparar ácido (3s)-3-(4-cloro-3-{[(2s,3r)- 2-(4-clorofenil)-4,4,4-trifluoro-3- metilbutanoil]amino}fenil)-3-ciclopropilpropanoico e sua forma cristalina para uso como composto farmaceuticamente ativo |
EP3498298A1 (en) | 2017-12-15 | 2019-06-19 | Bayer AG | The use of sgc stimulators and sgc activators alone or in combination with pde5 inhibitors for the treatment of bone disorders including osteogenesis imperfecta (oi) |
CA3089159A1 (en) | 2018-02-06 | 2019-08-15 | Jiangsu Hengrui Medicine Co., Ltd. | Pyrazolo[1,5-a][1,3,5]triazine-2-amine derivative, preparation method therefor and medical use thereof |
WO2019211081A1 (en) | 2018-04-30 | 2019-11-07 | Bayer Aktiengesellschaft | The use of sgc activators and sgc stimulators for the treatment of cognitive impairment |
WO2019219672A1 (en) | 2018-05-15 | 2019-11-21 | Bayer Aktiengesellschaft | 1,3-thiazol-2-yl substituted benzamides for the treatment of diseases associated with nerve fiber sensitization |
EP3574905A1 (en) | 2018-05-30 | 2019-12-04 | Adverio Pharma GmbH | Method of identifying a subgroup of patients suffering from dcssc which benefits from a treatment with sgc stimulators and sgc activators in a higher degree than a control group |
US10905667B2 (en) | 2018-07-24 | 2021-02-02 | Bayer Pharma Aktiengesellschaft | Orally administrable modified-release pharmaceutical dosage form |
US20220128561A1 (en) | 2019-01-17 | 2022-04-28 | Bayer Aktiengesellschaft | Methods to determine whether a subject is suitable of being treated with an agonist of soluble gyanylyl cyclase (sgc) |
WO2020164008A1 (en) | 2019-02-13 | 2020-08-20 | Bayer Aktiengesellschaft | Process for the preparation of porous microparticles |
TW202112359A (zh) | 2019-06-07 | 2021-04-01 | 德商拜耳廠股份有限公司 | sGC活化劑於治療眼科疾病之用途 |
WO2021209269A1 (en) * | 2020-04-17 | 2021-10-21 | Dsm Ip Assets B.V. | A process for preparation of substituted enamine compounds |
CN115175681A (zh) | 2020-12-10 | 2022-10-11 | 拜耳公司 | sGC活化剂用于治疗眼科疾病的用途 |
CN117460713A (zh) * | 2021-07-15 | 2024-01-26 | 江苏恒瑞医药股份有限公司 | 3-苯基丙酸类化合物、其制备方法及其在医药上的应用 |
CN114478326B (zh) * | 2022-01-21 | 2023-10-03 | 安徽宁亿泰科技有限公司 | 一种苯嘧磺草胺关键中间体的合成方法 |
TW202342420A (zh) * | 2022-02-18 | 2023-11-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 羧酸類化合物、其製備方法及其在醫藥上的應用 |
WO2023237577A1 (en) | 2022-06-09 | 2023-12-14 | Bayer Aktiengesellschaft | Soluble guanylate cyclase activators for use in the treatment of heart failure with preserved ejection fraction in women |
CN115838338A (zh) * | 2022-11-29 | 2023-03-24 | 浙江工业大学 | 一种制备酰胺的方法 |
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DE102009012314A1 (de) * | 2009-03-09 | 2010-09-16 | Bayer Schering Pharma Aktiengesellschaft | Oxo-heterocyclisch substituierte Alkylcarbonsäuren und ihre Verwendung |
DE102009046115A1 (de) | 2009-10-28 | 2011-09-08 | Bayer Schering Pharma Aktiengesellschaft | Substituierte 3-Phenylpropansäuren und ihre Verwendung |
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2011
- 2011-12-05 JP JP2013542493A patent/JP5989660B2/ja not_active Expired - Fee Related
- 2011-12-05 CA CA2819880A patent/CA2819880C/en not_active Expired - Fee Related
- 2011-12-05 ES ES11805433.7T patent/ES2544532T3/es active Active
- 2011-12-05 AP AP2013006953A patent/AP2013006953A0/xx unknown
- 2011-12-05 EA EA201300669A patent/EA201300669A1/ru unknown
- 2011-12-05 KR KR1020137017749A patent/KR20130136504A/ko not_active Application Discontinuation
- 2011-12-05 MX MX2013006053A patent/MX2013006053A/es not_active Application Discontinuation
- 2011-12-05 EP EP11805433.7A patent/EP2649045B1/de not_active Not-in-force
- 2011-12-05 BR BR112013013663A patent/BR112013013663A2/pt not_active IP Right Cessation
- 2011-12-05 SG SG2013037502A patent/SG190296A1/en unknown
- 2011-12-05 WO PCT/EP2011/071747 patent/WO2012076466A2/de active Application Filing
- 2011-12-05 CN CN201180066977.8A patent/CN103492361B/zh not_active Expired - Fee Related
- 2011-12-05 AU AU2011340721A patent/AU2011340721A1/en not_active Abandoned
- 2011-12-06 TW TW100144758A patent/TW201249782A/zh unknown
- 2011-12-06 US US13/312,320 patent/US9018258B2/en active Active
- 2011-12-07 AR ARP110104601 patent/AR084220A1/es not_active Application Discontinuation
- 2011-12-07 UY UY33776A patent/UY33776A/es not_active Application Discontinuation
-
2013
- 2013-05-19 IL IL226422A patent/IL226422A0/en unknown
- 2013-05-30 CO CO13132647A patent/CO6771409A2/es not_active Application Discontinuation
- 2013-06-04 CR CR20130259A patent/CR20130259A/es unknown
- 2013-06-04 DO DO2013000125A patent/DOP2013000125A/es unknown
- 2013-06-05 MA MA35974A patent/MA34721B1/fr unknown
- 2013-06-05 CL CL2013001600A patent/CL2013001600A1/es unknown
- 2013-06-07 EC ECSP13012668 patent/ECSP13012668A/es unknown
- 2013-07-05 ZA ZA2013/05076A patent/ZA201305076B/en unknown
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2014
- 2014-06-27 HK HK14106471.9A patent/HK1192879A1/zh not_active IP Right Cessation
Also Published As
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SG190296A1 (en) | 2013-06-28 |
KR20130136504A (ko) | 2013-12-12 |
WO2012076466A3 (de) | 2012-08-30 |
AP2013006953A0 (en) | 2013-06-30 |
AU2011340721A1 (en) | 2013-06-20 |
CO6771409A2 (es) | 2013-10-15 |
EP2649045A2 (de) | 2013-10-16 |
MX2013006053A (es) | 2013-06-18 |
DOP2013000125A (es) | 2013-11-15 |
IL226422A0 (en) | 2013-07-31 |
JP2014510017A (ja) | 2014-04-24 |
CN103492361A (zh) | 2014-01-01 |
BR112013013663A2 (pt) | 2016-09-06 |
ZA201305076B (en) | 2014-12-23 |
EA201300669A1 (ru) | 2013-11-29 |
TW201249782A (en) | 2012-12-16 |
MA34721B1 (fr) | 2013-12-03 |
CA2819880A1 (en) | 2012-06-14 |
JP5989660B2 (ja) | 2016-09-07 |
ES2544532T3 (es) | 2015-09-01 |
US20120172448A1 (en) | 2012-07-05 |
CN103492361B (zh) | 2015-07-15 |
CR20130259A (es) | 2013-06-28 |
CA2819880C (en) | 2019-01-22 |
ECSP13012668A (es) | 2013-08-30 |
AR084220A1 (es) | 2013-05-02 |
CL2013001600A1 (es) | 2013-10-25 |
WO2012076466A2 (de) | 2012-06-14 |
HK1192879A1 (zh) | 2014-09-05 |
US9018258B2 (en) | 2015-04-28 |
EP2649045B1 (de) | 2015-05-27 |
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