MXPA04001253A - Derivados de acidos carboxilicos y agente farmaceutico que comprende los mismos como ingrediente activo. - Google Patents

Derivados de acidos carboxilicos y agente farmaceutico que comprende los mismos como ingrediente activo.

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Publication number
MXPA04001253A
MXPA04001253A MXPA04001253A MXPA04001253A MXPA04001253A MX PA04001253 A MXPA04001253 A MX PA04001253A MX PA04001253 A MXPA04001253 A MX PA04001253A MX PA04001253 A MXPA04001253 A MX PA04001253A MX PA04001253 A MXPA04001253 A MX PA04001253A
Authority
MX
Mexico
Prior art keywords
compounds
alkylene
carboxylic acid
drugs
active ingredient
Prior art date
Application number
MXPA04001253A
Other languages
English (en)
Inventor
Tani Kousuke
Original Assignee
Ono Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co filed Critical Ono Pharmaceutical Co
Publication of MXPA04001253A publication Critical patent/MXPA04001253A/es

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    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/38—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic
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Abstract

Se describe un derivado de acido carboxilico de la formula (I): (ver formula) en donde R1 es -COOH, -COOR6, etc; A es un enlace sencillo, alquileno, etc; R2 es alquilo, alcoxi, etc; B es un anillo carbociclico o un anillo heterociclico; Q es alquileno-Cyc2, etc; D es una cadena de enlace; y R3 es alquilo, un anillo carbociclico o un anillo heterociclico, o una sal no toxica del mismo. El compuesto de la formula (I) (ver formula) que se enlaza al receptor PGE2, especialmente los subtipos EP3 y/o EP4 y muestra la actividad antagonista, son utiles para la prevencion y/o tratamiento de enfermedades que inducen el dolor, comezon, urticaria, alergia, frecuencia urinaria, disturbios de orina, enfermedad de Alzheimer, cancer, dismenorrea, endometriosis, etc.
MXPA04001253A 2001-08-09 2002-08-08 Derivados de acidos carboxilicos y agente farmaceutico que comprende los mismos como ingrediente activo. MXPA04001253A (es)

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PCT/JP2002/008120 WO2003016254A1 (fr) 2001-08-09 2002-08-08 Composes derives d'acide carboxylique et medicaments comprenant ces composes comme principe actif

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Families Citing this family (162)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0102764D0 (sv) * 2001-08-17 2001-08-17 Astrazeneca Ab Compounds
WO2003024484A1 (fr) * 2001-09-14 2003-03-27 Ono Pharmaceutical Co., Ltd. Medicaments pour traiter le prurit
WO2004007472A1 (ja) * 2002-07-10 2004-01-22 Ono Pharmaceutical Co., Ltd. Ｃｃｒ４アンタゴニストおよびその医薬用途
EP2385032A1 (en) * 2002-11-08 2011-11-09 Takeda Pharmaceutical Company Limited GPR40 Receptor function regulator
JP4594611B2 (ja) * 2002-11-08 2010-12-08 武田薬品工業株式会社 受容体機能調節剤
GB0226930D0 (en) 2002-11-19 2002-12-24 Astrazeneca Ab Chemical compounds
JP3988830B2 (ja) 2002-11-22 2007-10-10 日本たばこ産業株式会社 縮合二環式窒素含有複素環
PL377314A1 (pl) 2002-12-20 2006-01-23 Amgen Inc. Modulatory astmy i zapaleń na tle alergicznym
CN1764635A (zh) * 2003-02-07 2006-04-26 小野药品工业株式会社 羧酸化合物
WO2005000356A1 (ja) * 2003-06-27 2005-01-06 Ono Pharmaceutical Co., Ltd. 尿路疾患治療剤
EP2422814A1 (en) * 2003-07-25 2012-02-29 Ono Pharmaceutical Co., Ltd. Remedy for cartilage-related diseases
US7300932B2 (en) 2003-08-07 2007-11-27 Japan Tobacco Inc. Pyrrolo[1,2-b]pyridazine derivatives
JP4720502B2 (ja) * 2003-09-01 2011-07-13 小野薬品工業株式会社 縮環化合物およびその用途
MXPA06002551A (es) * 2003-09-03 2006-06-20 Pfizer Compuestos de aril o heteroaril amida.
TW200526626A (en) 2003-09-13 2005-08-16 Astrazeneca Ab Chemical compounds
JP4667384B2 (ja) 2003-10-07 2011-04-13 レノビス， インコーポレイテッド イオンチャネルリガンドとしてのアミド誘導体および薬学的組成物、ならびにこれらを使用する方法
WO2005051373A1 (ja) * 2003-11-26 2005-06-09 Takeda Pharmaceutical Company Limited 受容体機能調節剤
KR20070007104A (ko) * 2004-02-18 2007-01-12 아스트라제네카 아베 화합물
AU2005214132B9 (en) * 2004-02-18 2009-06-25 Astrazeneca Ab Benzamide derivatives and their use as glucokinae activating agents
SI1725528T1 (sl) 2004-03-11 2013-11-29 4Sc Ag Sulfonilpiroli kot HDAC inhibitorji
WO2005095338A1 (ja) * 2004-03-30 2005-10-13 Takeda Pharmaceutical Company Limited アルコキシフェニルプロパン酸誘導体
CN1950333A (zh) 2004-05-04 2007-04-18 辉瑞大药厂 取代的甲基芳基或杂芳基酰胺化合物
US7618981B2 (en) * 2004-05-06 2009-11-17 Cytokinetics, Inc. Imidazopyridinyl-benzamide anti-cancer agents
GB0412553D0 (en) 2004-06-04 2004-07-07 Univ Aberdeen Therapeutic agents for the treatment of bone conditions
TW200600086A (en) * 2004-06-05 2006-01-01 Astrazeneca Ab Chemical compound
JPWO2006014024A1 (ja) * 2004-08-06 2008-05-01 小野薬品工業株式会社 精神神経系疾患治療剤
JP4888775B2 (ja) * 2004-08-10 2012-02-29 小野薬品工業株式会社 Ｅｐ４アゴニストを含有してなる下部尿路系疾患の予防および／または治療剤
TW200613272A (en) 2004-08-13 2006-05-01 Astrazeneca Ab Isoindolone compounds and their use as metabotropic glutamate receptor potentiators
CN101076529A (zh) * 2004-10-12 2007-11-21 解码遗传学公司 用于阻塞性动脉疾病的芳基磺酰胺迫位取代的双环化合物
JP2008515981A (ja) * 2004-10-12 2008-05-15 デコード ジェネティクス イーエイチエフ 閉塞性動脈疾患のためのカルボン酸ペリ置換二環式化合物
CA2583667A1 (en) * 2004-10-12 2006-04-27 Jasbir Singh Sulfonamide peri-substituted bicyclics for occlusive artery disease
KR20070085371A (ko) * 2004-10-16 2007-08-27 아스트라제네카 아베 페녹시 벤즈아미드 화합물의 제조 방법
GB0423043D0 (en) * 2004-10-16 2004-11-17 Astrazeneca Ab Compounds
FR2880887B1 (fr) * 2005-01-14 2009-01-30 Merck Sante Soc Par Actions Si Derives d'hydroxyphenols, procedes pour leur preparation, compositions pharmaceutiques les contenant et applications en therapeutique
AU2006204724A1 (en) * 2005-01-14 2006-07-20 Millennium Pharmaceuticals, Inc. Cinnamide and hydrocinnamide derivatives with raf-kinase inhibitory activity
EP2522397A1 (en) 2005-02-03 2012-11-14 TopoTarget UK Limited Combination therapies using HDAC inhibitors
MX2007010072A (es) 2005-02-18 2008-01-28 Astrazeneca Ab Derivados de piperidina antibacterianos.
WO2006090850A1 (ja) * 2005-02-25 2006-08-31 Ono Pharmaceutical Co., Ltd. ベンズアミド化合物
US7358370B2 (en) * 2005-02-25 2008-04-15 Serenex, Inc. Benzene, pyridine, and pyridazine derivatives
US7576099B2 (en) 2005-02-28 2009-08-18 Renovis, Inc. Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
CA2599538C (en) 2005-03-15 2013-07-30 Nycomed Gmbh N-sulphonylpyrroles and their use as histone deacetylase inhibitors
GB0508472D0 (en) * 2005-04-26 2005-06-01 Glaxo Group Ltd Compounds
DK1901729T3 (da) 2005-05-13 2012-05-14 Topotarget Uk Ltd Farmaceutiske formuleringer af HDAC-inhibitorer
JP2008542247A (ja) * 2005-05-24 2008-11-27 アストラゼネカ アクチボラグ グルコキナーゼモジュレーターとしての２−フェニル置換イミダゾール［４，５ｂ］ピリジン／ピラジンおよびプリン誘導体
TW200714597A (en) * 2005-05-27 2007-04-16 Astrazeneca Ab Chemical compounds
BRPI0613570B8 (pt) * 2005-07-09 2021-05-25 Astrazeneca Ab composto, composição farmacêutica e uso de um composto ou um sal farmaceuticamente aceitável do mesmo
EP2027113A1 (en) * 2005-07-09 2009-02-25 AstraZeneca AB Heteroaryl benzamide derivatives for use as glk activators in the treatment of diabetes
EP1910350A1 (en) * 2005-07-09 2008-04-16 AstraZeneca AB 2 -heterocyclyloxybenzoyl amino heterocyclyl compounds as modulators of glucokinase for the treatment of type 2 diabetes
AR057455A1 (es) 2005-07-22 2007-12-05 Merck & Co Inc Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica
TW200740435A (en) * 2005-08-10 2007-11-01 Takeda Pharmaceuticals Co Therapeutic agent for diabetes
US9202182B2 (en) * 2005-08-11 2015-12-01 International Business Machines Corporation Method and system for analyzing business architecture
US7807706B2 (en) 2005-08-12 2010-10-05 Astrazeneca Ab Metabotropic glutamate-receptor-potentiating isoindolones
US20070185184A1 (en) * 2005-09-16 2007-08-09 Serenex, Inc. Carbazole derivatives
CA2622673C (en) 2005-09-21 2017-06-27 Thomas Maier Sulphonylpyrroles and use thereof as inhibitors of hdac s
AU2006298881A1 (en) * 2005-09-21 2007-04-12 4Sc Ag Sulphonylpyrrole hydrochloride salts as histone deacetylases inhibitors
CA2627923C (en) * 2005-11-10 2016-01-12 Topotarget Uk Limited Histone deacetylase (hdac) inhibitors (pxdlol) for the treatment of cancer
TW200738621A (en) 2005-11-28 2007-10-16 Astrazeneca Ab Chemical process
WO2007101156A1 (en) * 2006-02-27 2007-09-07 Serenex, Inc. Cyclohexylamino, benzene, pyridine, and pyridazine derivatives
CA2650683A1 (en) * 2006-04-28 2007-11-08 Shionogi & Co., Ltd. Amine derivative having npy y5 receptor antagonist activity
WO2007137042A2 (en) 2006-05-16 2007-11-29 Decode Genetics, Ehf. Process for preparing 7- (acryl0yl) -ind0les
US7705035B2 (en) * 2006-06-12 2010-04-27 Merck Frosst Canada Ltd. Indoline amide derivatives as EP4 receptor ligands
EP2049467B1 (en) * 2006-08-09 2011-03-23 Allergan, Inc. Therapeutic amides and related compounds
JP5207972B2 (ja) * 2006-10-12 2013-06-12 株式会社医薬分子設計研究所 カルボン酸誘導体
TW200825063A (en) * 2006-10-23 2008-06-16 Astrazeneca Ab Chemical compounds
TW200825060A (en) * 2006-10-26 2008-06-16 Astrazeneca Ab Chemical compounds
KR20090090390A (ko) 2006-12-21 2009-08-25 아스트라제네카 아베 Ｇｌｋ 활성제로서 유용한 신규 결정 화합물
KR100850969B1 (ko) * 2007-01-10 2008-08-12 한국화학연구원 신규한 1-[1-(3,4-디알콕시페닐)-알킬]-1ｈ-피라졸 화합물,이의 제조방법 및 이를 포함하는 약제학적 조성물
GB0705400D0 (en) 2007-03-21 2007-05-02 Univ Aberdeen Therapeutic compounds andm their use
US8563594B2 (en) 2007-05-08 2013-10-22 Allergan, Inc. S1P3 receptor inhibitors for treating pain
EP2158183A2 (en) * 2007-05-25 2010-03-03 Vertex Pharmaceuticals Incorporated Ion channel modulators and methods of use
FR2917086B1 (fr) * 2007-06-05 2009-07-17 Galderma Res & Dev Nouveaux derives d'acide 3-phenyl acrylique activateurs des recepteurs de type ppar, leur methode de preparation et leur utilisation dans des compositions cosmetiques ou pharmaceutiques.
FR2917084B1 (fr) * 2007-06-05 2009-07-17 Galderma Res & Dev Nouveaux derives d'acide 3-phenyl propanoique activateurs des recpteurs de type ppar, leur methode de preparation et leur utilisation dans des compositions cosmetiques ou pharmaceutiques.
TWI417100B (zh) 2007-06-07 2013-12-01 Astrazeneca Ab 二唑衍生物及其作為代謝型麩胺酸受體增效劑-８４２之用途
EP2002834A1 (de) * 2007-06-13 2008-12-17 Bayer Schering Pharma Aktiengesellschaft Aryl/Hetarylamide als Modulatoren des EP2-Rezeptors
EP2166841A4 (en) * 2007-06-15 2014-05-07 Mission Pharma Co METHODS AND COMPOSITIONS FOR INHIBITING DOME FACTOR AND ADENYLYLCYCLASE
BRPI0812594A2 (pt) * 2007-08-10 2015-06-23 Lundbeck & Co As H Composto ou sal ou hidrato do mesmo, composição farmacêutica, métodos para modulação da atividade de um receptor p2x7, para tratamento de uma condição responsiva á modulação do receptor p2x7 em um paciente, para inibição de morte de células gangliônicas retinais em um paciente, para determinação da presença ou ausência de receptor p2x7 em uma amostra, preparação farmacêutica acondicionada, e, uso de um composto ou sal ou hidrato do mesmo.
EP2203421B1 (en) * 2007-09-25 2014-05-07 TopoTarget UK Limited Methods of synthesis of certain n-hydroxy-3-(3-phenylsulfamoyl-phenyl)-acrylamide compounds
SA08290668B1 (ar) * 2007-10-25 2012-02-12 شيونوجي آند كو.، ليمتد مشتقات أمين لها نشاط مضاد لمستقبل npy y5 واستخداماتها
WO2009063365A1 (en) * 2007-11-15 2009-05-22 Pfizer Limited Azetidines as ep2 antagonists
AU2008343924B2 (en) 2007-12-19 2013-01-17 Amgen Inc. Phenyl acetic acid derivatives as inflammation modulators
MX2010009642A (es) * 2008-03-07 2010-09-22 Topotarget As Metodos de tratamiento utilizando infusion continua prolongada de belinostat.
US8648097B2 (en) * 2008-03-12 2014-02-11 Ube Industries, Ltd. Pyridylaminoacetic acid compound
PL2280696T3 (pl) 2008-03-18 2015-03-31 Arena Pharm Inc Modulatory receptora prostacykliny (PGI2) użyteczne do leczenia zaburzeń z nim związanych
KR20100132073A (ko) * 2008-04-11 2010-12-16 가부시키가이샤 이야쿠 분지 셋케이 겐쿠쇼 Ｐａｉ―１ 저해제
US8633245B2 (en) * 2008-04-11 2014-01-21 Institute Of Medicinal Molecular Design, Inc. PAI-1 inhibitor
CN102026961B (zh) 2008-05-14 2014-04-09 安斯泰来制药株式会社 酰胺化合物
US7662858B2 (en) 2008-05-23 2010-02-16 Aaipharma, Inc. Method of treating post-surgical acute pain
US7790760B2 (en) 2008-06-06 2010-09-07 Astrazeneca Ab Metabotropic glutamate receptor isoxazole ligands and their use as potentiators 286
WO2009154190A1 (ja) * 2008-06-17 2009-12-23 アステラス製薬株式会社 ピリドン化合物
EP2149554A1 (de) * 2008-07-30 2010-02-03 Bayer Schering Pharma Aktiengesellschaft Indolylamide als Modulatoren des EP2-Rezeptors
EP2149551A1 (de) 2008-07-30 2010-02-03 Bayer Schering Pharma AG N-(Indol-3-ylalkyl)-(hetero)arylamidderivate als Modulatoren des EP2-Rezeptors
EP2149552A1 (de) 2008-07-30 2010-02-03 Bayer Schering Pharma AG 5,6 substituierte Benzamid-Derivate als Modulatoren des EP2-Rezeptors
AR072900A1 (es) 2008-08-04 2010-09-29 Astrazeneca Ab Agentes terapeuticos derivados de pirazolo[3,4-d]pirimidina
EP2320906B1 (en) 2008-08-14 2016-02-24 Beta Pharma Canada Inc. Heterocyclic amide derivatives as ep4 receptor antagonists
GB0815782D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
GB0815781D0 (en) * 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
GB0815784D0 (en) * 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
GB0817208D0 (en) 2008-09-19 2008-10-29 Pimco 2664 Ltd Therapeutic apsap compounds and their use
GB0817207D0 (en) 2008-09-19 2008-10-29 Pimco 2664 Ltd therapeutic apsac compounds and their use
JP5535931B2 (ja) 2008-10-27 2014-07-02 武田薬品工業株式会社 二環性化合物
MX2011005577A (es) * 2008-11-26 2011-08-03 Arena Pharm Inc Derivados de acido carbonico substituidos con pirazolilo como moduladores del receptor de prostaciclina (pgi2) utiles para el tratamiento de trastornos relacionados con estos.
PL2370413T3 (pl) 2008-12-08 2016-01-29 Arena Pharm Inc Modulatory receptora prostacykliny (PGI2) użyteczne w leczeniu zaburzeń z nimi związanych
GB0900555D0 (en) * 2009-01-14 2009-02-11 Topotarget As New methods
WO2010085528A1 (en) 2009-01-23 2010-07-29 Schering Corporation Bridged and fused antidiabetic compounds
JPWO2010087425A1 (ja) 2009-01-30 2012-08-02 国立大学法人京都大学 前立腺癌の進行抑制剤および進行抑制方法
AR075051A1 (es) 2009-02-05 2011-03-02 Schering Corp Compuestos antidiabeticos que contienen ftalazina
GB0902434D0 (en) * 2009-02-13 2009-04-01 Astrazeneca Ab Chemical process
GB0902406D0 (en) * 2009-02-13 2009-04-01 Astrazeneca Ab Crystalline polymorphic form
US8685986B2 (en) 2009-03-30 2014-04-01 Ube Industries, Ltd. Medical composition for treatment or prophylaxis of glaucoma
WO2010116177A1 (en) 2009-04-09 2010-10-14 Astrazeneca Ab A pyrazolo [4,5-e] pyrimidine derivative and its use to treat diabetes and obesity
WO2010116176A1 (en) * 2009-04-09 2010-10-14 Astrazeneca Ab Pyrazolo [4, 5-e] pyrimidine derivative and its use to treat diabetes and obesity
US8227618B2 (en) * 2009-04-23 2012-07-24 Shionogi & Co., Ltd. Amine-derivatives having NPY Y5 receptor antagonistic activity and the uses thereof
DE102009049662A1 (de) 2009-10-13 2011-04-14 Bayer Schering Pharma Aktiengesellschaft 2,5-Disubstituierte 2H-Indazole als EP2-Rezeptor-Antagonisten
DE102009046115A1 (de) 2009-10-28 2011-09-08 Bayer Schering Pharma Aktiengesellschaft Substituierte 3-Phenylpropansäuren und ihre Verwendung
WO2012003145A2 (en) * 2010-07-02 2012-01-05 Allergan, Inc. Therapeutic agents for ocular hypertension
US9714238B2 (en) 2010-07-02 2017-07-25 Allergan, Inc. Therapeutic agents for ocular hypertension
RU2467004C2 (ru) * 2010-10-07 2012-11-20 Учреждение Российской Академии Наук Институт Нефтехимии И Катализа Ран СПОСОБ ПОЛУЧЕНИЯ МЕТИЛОВОГО ЭФИРА 2-БЕНЗО[b]ФУРАНКАРБОНОВОЙ КИСЛОТЫ
DE102011006974A1 (de) 2011-04-07 2012-10-11 Bayer Pharma Aktiengesellschaft Substituierte 1-Benzylcycloalkylcarbonsäuren und ihre Verwendung
EA201300669A1 (ru) 2010-12-07 2013-11-29 Байер Интеллектчуал Проперти Гмбх Замещенные 1-бензилциклоалкилкарбоновые кислоты и их применение
DE102010062544A1 (de) 2010-12-07 2012-06-14 Bayer Schering Pharma Aktiengesellschaft Substituierte 1-Benzylcycloalkylcarbonsäuren und ihre Verwendung
DE102011007272A1 (de) 2011-04-13 2012-10-18 Bayer Pharma Aktiengesellschaft Verzweigte 3-Phenylpropionsäure-Derivate und ihre Verwendung
AU2012289042A1 (en) * 2011-07-22 2014-03-13 Glaxosmithkline Llc Composition
AU2012289961C1 (en) * 2011-08-03 2016-09-01 National Taiwan University Agonists of Src homology-2 containing protein tyrosine phosphatase-1 and treatment methods using the same
TW201326154A (zh) 2011-11-28 2013-07-01 拜耳知識產權公司 作為ｅｐ２受體拮抗劑之新穎２ｈ－吲唑
CN107011229B (zh) 2012-01-06 2019-11-05 诺华股份有限公司 杂环化合物和它们的使用方法
DE102012208530A1 (de) 2012-05-22 2013-11-28 Bayer Pharma AG Substituierte Piperidinoacetamide und ihre Verwendung
NO3009426T3 (es) 2013-06-12 2018-09-29
GB201311361D0 (en) 2013-06-26 2013-08-14 Pimco 2664 Ltd Compounds and their therapeutic use
AU2014324650B2 (en) * 2013-09-27 2018-12-06 Allergan, Inc. Compounds and methods for skin repair
TWI731317B (zh) * 2013-12-10 2021-06-21 美商健臻公司 原肌球蛋白相關之激酶（ｔｒｋ）抑制劑
EA201790905A1 (ru) 2014-10-23 2017-09-29 Арена Фармасьютикалз, Инк. Способ лечения состояний, связанных с рецептором pgi2
EP3224241A4 (en) * 2014-11-27 2018-08-08 Acturum Real Estate AB Bis(sulfonamide) derivatives and their use as mpges inhibitors
WO2016088903A1 (en) * 2014-12-05 2016-06-09 Takeda Pharmaceutical Company Limited Heterocyclic compounds
SI3262028T1 (sl) 2014-12-17 2022-02-28 Pimco 2664 Limited N-(4-hidroksi-4-metil-cikloheksil)-4-fenil-benzensulfonamidne in N-(-4hidroksi-4-metil-cikloheksil)-4-(2-piridil)-benzensulfonamidne spojine in njihova terapevtska uporaba
CN107231803B (zh) 2014-12-18 2019-12-03 建新公司 原肌球蛋白相关激酶(trk)抑制剂的药物制剂
ES2839203T3 (es) * 2015-01-09 2021-07-05 Ono Pharmaceutical Co Compuesto espiro tricíclico
TWI795362B (zh) 2016-07-07 2023-03-11 日商小野藥品工業股份有限公司 拮抗藥與免疫核查點阻礙藥而成之組合
JP6269888B1 (ja) * 2016-07-07 2018-01-31 小野薬品工業株式会社 医薬用途
KR102432505B1 (ko) 2017-03-01 2022-08-12 아레나 파마슈티칼스, 인크. Pgi2-수용체 효능제를 포함하는 조성물 및 그의 제조 방법
WO2018183659A1 (en) * 2017-03-30 2018-10-04 Saint Louis University Compounds and methods targeting gper in calcium disorders
EP3632898B1 (en) 2017-05-22 2023-07-12 ONO Pharmaceutical Co., Ltd. Ep4 antagonist
ES2927851T3 (es) 2017-10-17 2022-11-11 Novartis Ag Sulfonamidas y composiciones de las mismas para tratar afecciones asociadas con la actividad de NLRP
US10905667B2 (en) 2018-07-24 2021-02-02 Bayer Pharma Aktiengesellschaft Orally administrable modified-release pharmaceutical dosage form
US11261154B2 (en) 2018-07-31 2022-03-01 Ono Pharmaceutical Co., Ltd. Benzene derivative
CN111214469B (zh) * 2018-11-26 2022-02-22 绍兴从零医药科技有限公司 预防和治疗慢性疼痛的化合物及其应用
US11690849B2 (en) 2019-04-12 2023-07-04 LA PharmaTech Inc. Method of treating dementia
US10966989B2 (en) 2019-04-12 2021-04-06 LA PharmaTech Inc. Pharmaceutical compositions and methods for treating mental, behavioral, cognitive disorders
US11318144B2 (en) 2019-04-12 2022-05-03 LA PharmaTech Inc. Compositions and methods for treating Alzheimer's disease and Parkinson's disease
US10898493B2 (en) 2019-04-12 2021-01-26 LA PharmaTech Inc. Pharmaceutical compositions and methods for psychiatric symptoms of patients with Alzheimer's disease
US11744833B2 (en) 2019-04-12 2023-09-05 LA PharmaTech Inc. Pharmaceutical compositions and methods for treatment of insomnia
US11938139B2 (en) 2019-04-12 2024-03-26 LA PharmaTech Inc. Pharmaceutical compositions and methods for anxiety, depression and other psychiatric disorders
US11389458B2 (en) 2019-04-12 2022-07-19 LA PharmaTech Inc. Pharmaceutical compositions and methods for treating parkinson's and huntington's disease
US10639314B1 (en) 2019-04-30 2020-05-05 LA PharmaTech Inc. Method of treating Alzheimer's disease
US10639315B1 (en) 2019-05-21 2020-05-05 LA PharmaTech Inc. Pharmaceutical compositions and methods for treating Alzheimer's disease
CA3137393A1 (en) * 2019-04-30 2020-11-05 Jianmin Wang A method of treating mental, behavioral, cognitive disorders
JP2022539944A (ja) * 2019-05-21 2022-09-14 ラ ファーマテック インコーポレイテッド 精神、行動、認知障害を治療するための新規な医薬組成物及び方法
WO2020251957A1 (en) * 2019-06-11 2020-12-17 Teon Therapeutics, Inc. Prostaglandin e2 receptor 4 antagonists and uses thereof
TW202140421A (zh) * 2020-01-29 2021-11-01 日商小野藥品工業股份有限公司 苯衍生物的新穎晶形
JP7384179B2 (ja) * 2020-01-29 2023-11-21 小野薬品工業株式会社 ベンゼン誘導体を含有する医薬組成物
TW202228674A (zh) 2020-11-13 2022-08-01 日商小野藥品工業股份有限公司 藉由併用ｅｐ４拮抗藥與免疫檢查點抑制物質而進行之癌症治療
CN117043140A (zh) 2021-03-22 2023-11-10 拜耳公司 取代的吡咯烷-2-酮、其盐及其作为除草活性物质的用途
US11351179B1 (en) 2021-08-05 2022-06-07 LA PharmaTech Inc. Pharmaceutical compositions and methods for treatment of psychiatric disorders

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4101671A (en) 1973-04-13 1978-07-18 Boehringer Ingelheim Gmbh Aminobenzyl-amines and salts thereof
US3950393A (en) 1973-04-13 1976-04-13 Boehringer Ingelheim Gmbh Aminobenzyl-amides and salts thereof
US4006246A (en) 1973-04-13 1977-02-01 Boehringer Ingelheim Gmbh Pharmaceutical compositions containing an aminobenzyl-amine and method of use
USRE29628E (en) 1973-04-13 1978-05-09 Boehringer Ingelheim Gmbh Aminobenzyl-amines and salts thereof
DE2517229A1 (de) 1975-04-18 1976-10-28 Boehringer Mannheim Gmbh Phenylalkylcarbonsaeure-derivate und verfahren zu ihrer herstellung
DK148576A (da) 1975-04-18 1976-10-19 Boehringer Mannheim Gmbh Fenylalkankarbonsyrederivater og fremgangsmade til deres fremstilling
ZA825413B (en) 1981-08-26 1983-06-29 Pfizer Thromboxane synthetase inhibitors, processes for their production, and pharmaceutical compositions comprising them
FI82680C (fi) 1981-12-11 1991-04-10 Syntex Pharma Int Framstaellning av - arylalkansyror.
US4684020A (en) 1985-09-20 1987-08-04 Conductive Container, Inc. Conductive container
US5268389A (en) 1989-10-16 1993-12-07 Uniroyal Chemical Company, Inc. Thiocarboxylate ester compounds compositions containing the same
IL98319A (en) 1990-07-05 1997-04-15 Roussel Uclaf Sulphurous derivatives of imidazole, their preparation process, and pharmaceutical compositions containing them
DE122010000043I1 (de) 1993-07-02 2011-01-27 Nycomed Gmbh Fluoralkoxy substituierte benzamide und ihre verwendung als zyklisch-nukleotid phosphodiesterase-inhibitoren
US5716993A (en) 1993-12-27 1998-02-10 Eisai Co., Ltd. Anthranilic acid derivatives
FR2716882B1 (fr) 1994-03-04 1996-04-05 Roussel Uclaf Utilisation de dérivés de l'imidazole au traitement d'affections impliquant les récepteurs AT1 et AT2 de l'Angiotensine, certains de ces produits, leur préparation, compositions pharmaceutiques.
DE4430212A1 (de) 1994-08-28 1996-02-29 Merck Patent Gmbh Ortho-substituierte Benzoesäure-Derivate
JPH08208645A (ja) * 1994-09-30 1996-08-13 Nippon Chemiphar Co Ltd キノリン誘導体
AU3578495A (en) 1994-09-30 1996-04-26 Nippon Chemiphar Co. Ltd. Quinoline derivative
JP3909864B2 (ja) 1995-07-26 2007-04-25 小野薬品工業株式会社 ナフチルオキシ酢酸誘導体およびそれらを有効成分として含有する薬剤
WO1997031906A1 (fr) 1996-02-27 1997-09-04 Sankyo Company, Limited Derives d'isoxazole
WO1999047497A2 (en) 1998-03-13 1999-09-23 Merck Frosst Canada & Co. Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment
US6043275A (en) 1998-04-16 2000-03-28 Ono Pharmaceutical Co., Ltd. 3,7-dithiaprostanoic acid derivative
TWI249520B (en) 1998-07-15 2006-02-21 Ono Pharmaceutical Co 5-Thia-omega-substituted phenyl prostaglandin E derivatives, method for producing the same and medicines containing the same as the active ingredient
JP4168488B2 (ja) * 1998-08-28 2008-10-22 ソニー株式会社 液晶表示装置
KR20010074981A (ko) 1998-09-14 2001-08-09 우에노 도시오 ω치환된 페닐프로스타그란딘 Ｅ 유도체 및 그 유도체를유효 성분으로 하는 약제
US6211197B1 (en) 1998-10-07 2001-04-03 Merck Frosst Canada & Co. Prostaglandin receptor ligands
US6639111B2 (en) 2000-01-05 2003-10-28 Ono Pharmaceutical Co., Ltd. 5-thia-ω-(substituted phenyl)-prostaglandin E alcohols, process for preparing the alcohols and pharmaceutical preparations containing the same as the active ingredient
JP4929472B2 (ja) * 2000-08-22 2012-05-09 小野薬品工業株式会社 カルボン酸誘導体、それらの製造方法およびそれらを有効成分として含有する薬剤
BR0210167A (pt) * 2001-06-07 2004-04-06 Lilly Co Eli Composto, composição farmacêutica, métodos para modular um receptor ativado com proliferador de peroxissoma, para tratar ou prevenir uma doença ou condição e para abaixar a glicose no sangue, e, uso de um composto
DE10130374A1 (de) * 2001-06-23 2003-01-02 Boehringer Ingelheim Pharma Substituierte N-Acyl-anilinderivate, deren Herstellung und deren Verwendung als Arzneimittel

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