UY27982A1 - Nuevos compuestos de imidazol como inhibidores del factor de crecimiento transformante (tgf) - Google Patents

Nuevos compuestos de imidazol como inhibidores del factor de crecimiento transformante (tgf)

Info

Publication number
UY27982A1
UY27982A1 UY27982A UY27982A UY27982A1 UY 27982 A1 UY27982 A1 UY 27982A1 UY 27982 A UY27982 A UY 27982A UY 27982 A UY27982 A UY 27982A UY 27982 A1 UY27982 A1 UY 27982A1
Authority
UY
Uruguay
Prior art keywords
tgf
growth factor
transforming growth
inhibitors
compounds
Prior art date
Application number
UY27982A
Other languages
English (en)
Inventor
Laura Cook Blumberg
Michael John Munchhof
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of UY27982A1 publication Critical patent/UY27982A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Se describen nuevos compuestos de imidazol, incluyendo sus derivados, intermedios para su preparación, composiciones farmacéuticas que los contienen y su uso medicinal. Los compuestos de la presente invención son inhibidores potentes de la ruta se senalización del factor del crecimiento transformante ("TGF)-B. Son de utilidad en el tratamiento de diversos estados de enfermedad relacionados con TGF incluyendo, por ejemplo cáncer y enfermedades fibróticas.
UY27982A 2002-09-18 2003-09-16 Nuevos compuestos de imidazol como inhibidores del factor de crecimiento transformante (tgf) UY27982A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41189402P 2002-09-18 2002-09-18
US48452203P 2003-07-02 2003-07-02

Publications (1)

Publication Number Publication Date
UY27982A1 true UY27982A1 (es) 2004-04-30

Family

ID=32033577

Family Applications (1)

Application Number Title Priority Date Filing Date
UY27982A UY27982A1 (es) 2002-09-18 2003-09-16 Nuevos compuestos de imidazol como inhibidores del factor de crecimiento transformante (tgf)

Country Status (28)

Country Link
US (2) US7153872B2 (es)
EP (1) EP1542990B1 (es)
JP (1) JP4547271B2 (es)
KR (1) KR20050057392A (es)
CN (1) CN1681805A (es)
AP (1) AP2005003264A0 (es)
AR (1) AR041274A1 (es)
AT (1) ATE433968T1 (es)
AU (1) AU2003263404A1 (es)
BR (1) BR0314372A (es)
CA (1) CA2498047C (es)
CO (1) CO5550453A2 (es)
DE (1) DE60328028D1 (es)
EA (1) EA200500378A1 (es)
EC (1) ECSP055680A (es)
ES (1) ES2325687T3 (es)
HR (1) HRP20050252A2 (es)
IS (1) IS7712A (es)
MA (1) MA27441A1 (es)
MX (1) MXPA05002981A (es)
NO (1) NO20051008L (es)
OA (1) OA12928A (es)
PA (1) PA8583301A1 (es)
PE (1) PE20050072A1 (es)
PL (1) PL375980A1 (es)
TW (1) TW200404793A (es)
UY (1) UY27982A1 (es)
WO (1) WO2004026859A1 (es)

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CN1681501A (zh) * 2002-09-18 2005-10-12 辉瑞产品公司 作为转化生长因子(tgf)抑制剂的吡唑衍生物
OA12928A (en) * 2002-09-18 2006-10-13 Pfizer Prod Inc Novel imidazole compounds as transforming growth factor (TGF) inhibitors.
CN1681810A (zh) 2002-09-18 2005-10-12 辉瑞产品公司 作为转化生长因子(tgf)抑制剂的新的噁唑和噻唑化合物
PA8595001A1 (es) * 2003-03-04 2004-09-28 Pfizer Prod Inc Nuevos compuestos heteroaromaticos condensados que son inhibidores del factor de crecimiento transforante (tgf)
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KR101408517B1 (ko) * 2008-03-21 2014-06-17 노파르티스 아게 신규한 헤테로시클릭 화합물 및 그의 용도
WO2009126624A1 (en) 2008-04-11 2009-10-15 Bristol-Myers Squibb Company Triazolo compounds useful as dgat1 inhibitors
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CN102131805A (zh) 2008-06-20 2011-07-20 百时美施贵宝公司 用作激酶抑制剂的咪唑并吡啶和咪唑并吡嗪化合物
CA2765983C (en) 2009-06-26 2017-11-14 Novartis Ag 1,3-disubstituted imidazolidin-2-one derivatives as inhibitors of cyp 17
DE102009043260A1 (de) 2009-09-28 2011-04-28 Merck Patent Gmbh Pyridinyl-imidazolonderivate
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Also Published As

Publication number Publication date
OA12928A (en) 2006-10-13
US7153872B2 (en) 2006-12-26
MA27441A1 (fr) 2005-07-01
AP2005003264A0 (en) 2005-03-31
ECSP055680A (es) 2005-05-30
ATE433968T1 (de) 2009-07-15
WO2004026859A1 (en) 2004-04-01
PL375980A1 (en) 2005-12-12
KR20050057392A (ko) 2005-06-16
NO20051008L (no) 2005-06-07
EA200500378A1 (ru) 2005-08-25
EP1542990B1 (en) 2009-06-17
DE60328028D1 (de) 2009-07-30
AU2003263404A1 (en) 2004-04-08
CA2498047C (en) 2009-05-19
CO5550453A2 (es) 2005-08-31
US20040106608A1 (en) 2004-06-03
CN1681805A (zh) 2005-10-12
PA8583301A1 (es) 2004-09-16
IS7712A (is) 2005-02-24
JP4547271B2 (ja) 2010-09-22
CA2498047A1 (en) 2004-04-01
BR0314372A (pt) 2005-07-19
ES2325687T3 (es) 2009-09-14
JP2006502237A (ja) 2006-01-19
PE20050072A1 (es) 2005-03-01
TW200404793A (en) 2004-04-01
EP1542990A1 (en) 2005-06-22
AR041274A1 (es) 2005-05-11
MXPA05002981A (es) 2005-06-22
HRP20050252A2 (en) 2005-10-31
US20070088037A1 (en) 2007-04-19
US7635702B2 (en) 2009-12-22

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Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20150504