UY25693A1 - Procedimiento para preparar forma polimorfa del hidrogenosulfato de clopidogrel - Google Patents
Procedimiento para preparar forma polimorfa del hidrogenosulfato de clopidogrelInfo
- Publication number
- UY25693A1 UY25693A1 UY25693A UY25693A UY25693A1 UY 25693 A1 UY25693 A1 UY 25693A1 UY 25693 A UY25693 A UY 25693A UY 25693 A UY25693 A UY 25693A UY 25693 A1 UY25693 A1 UY 25693A1
- Authority
- UY
- Uruguay
- Prior art keywords
- clopidogrel
- clopidogrel hydrogensulfate
- hydrogensulfate form
- procedure
- hydrogensulfate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C30—CRYSTAL GROWTH
- C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
- C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Metallurgy (AREA)
- Materials Engineering (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Steroid Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Procedimiento para la preparación de (+)-(S) hidrogenosulfato de clopidogrel forma 2 representado en la figura 1, según: a- polimorfo cristalino (+)-(S) del hidrogenosulfato de clopidogrel forma 2 caracterizado porque su difractograma de polvo de rayos X muestra los siguientes picos característicos expresados en distancias interplanares de aproximadamente 4,11; 6,86; 5,01; 3,74; 6,49; 5,66 Amstrong; b- polimorfo cristalino (+)-(S) del hidrogenosulfato de clopidogrel forma 2 caracterizado porque su espectro infrarrojo presenta absorciones características expresadas en 1/cm en: 2551, 1497, 1189 y 1029, con porcentajes de transmitancia respectivos de aproximadamente: 43; 63,7; 18; 33,2; c- polimorfo cristalino (+)-(S) del hidrogenosulfato de clopidogrel forma 2 caracterizado porque tiene un punto de fusión de 176 sC; caracterizado porque se vuelven a daar las aguas madre hidroacetónicas resultantes de la cristalización de la forma 1 del (+)-(S) hidrogenosulfato de clopidogrel para obtener al cabo de 3 a 6 meses cristales de hidrogenosulfato de clopidogrel forma 2. Se incluye aquel procedimiento donde: se pone en solución el camfosulfonato de (+)-(s)-alfa-(2-clorofenil)-4,5,6,7-tetrahidrotieno[3,2-c]piridinil-5-acetato de metilo en un solvente orgánico; se extrae el ácido camfosulfónico mediante una solución acuosa alcalina de carbonato de potasio y se lava en agua; se encuentra la fase orgánica bajo presión reducida y se retoma el residuo de concentración en la acetona; y se caracteriza porque se agrega H2SO4 y se ceba con el hidrogenosulfato de clopidogrel forma 2, se cristaliza el producto, se enfría, se filtra y se lavan los cristales que luego se secan bajo presión reducida para suministrar el hidrogenosulfato de clopidogrel forma 2.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9807464A FR2779726B1 (fr) | 1998-06-15 | 1998-06-15 | Forme polymorphe de l'hydrogenosulfate de clopidogrel |
Publications (1)
Publication Number | Publication Date |
---|---|
UY25693A1 true UY25693A1 (es) | 2000-03-31 |
Family
ID=9527349
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY25693A UY25693A1 (es) | 1998-06-15 | 1999-09-06 | Procedimiento para preparar forma polimorfa del hidrogenosulfato de clopidogrel |
Country Status (44)
Families Citing this family (85)
Publication number | Priority date | Publication date | Assignee | Title |
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FR2792836B3 (fr) | 1999-04-30 | 2001-07-27 | Sanofi Sa | Composition pharmaceutique sous forme unitaire contenant de l'aspirine et de l'hydrogenosulfate de clopidogrel |
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US7074928B2 (en) | 2002-01-11 | 2006-07-11 | Teva Pharmaceutical Industries, Ltd. | Polymorphs of clopidogrel hydrogensulfate |
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CA2544443C (en) * | 2003-11-03 | 2010-08-17 | Cadila Healthcare Limited | Processes for preparing different forms of (s)-(+)-clopidogrel bisulfate |
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ES2592280T3 (es) | 2010-04-19 | 2016-11-29 | Cadila Healthcare Limited | Una composición farmacéutica que comprende agentes antiplaquetarios y un agente estimulante de eritropoyesis |
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CN107698620A (zh) | 2015-06-23 | 2018-02-16 | 江苏天士力帝益药业有限公司 | 一种氘代噻吩并哌啶衍生物、制备方法及其应用 |
CN110198705A (zh) | 2017-01-23 | 2019-09-03 | 同和药品株式会社 | 包含hmg-coa还原酶抑制剂和氯吡格雷的复合制剂 |
CN107163060B (zh) * | 2017-05-24 | 2021-03-02 | 常州制药厂有限公司 | 一种硫酸氢氯吡格雷晶型ii制备方法 |
CN107337683B (zh) * | 2017-08-16 | 2019-08-16 | 中荣凯特(北京)生物科技有限公司 | 一种噻吩并吡啶类衍生物硫酸氢盐的晶型ⅱ及其制备方法和应用 |
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1998
- 1998-06-15 FR FR9807464A patent/FR2779726B1/fr not_active Expired - Lifetime
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1999
- 1999-06-10 AT AT99923711T patent/ATE222256T1/de active
- 1999-06-10 EE EEP200000745A patent/EE03972B1/xx unknown
- 1999-06-10 PT PT99923711T patent/PT1087976E/pt unknown
- 1999-06-10 AU AU40483/99A patent/AU752170B2/en not_active Expired
- 1999-06-10 EP EP99923711A patent/EP1087976B1/fr not_active Expired - Lifetime
- 1999-06-10 RS YUP-777/00A patent/RS49870B/sr unknown
- 1999-06-10 PL PL344998A patent/PL201894B1/pl unknown
- 1999-06-10 NZ NZ507914A patent/NZ507914A/xx not_active IP Right Cessation
- 1999-06-10 JP JP2000554740A patent/JP3641584B2/ja not_active Expired - Lifetime
- 1999-06-10 CZ CZ20004637A patent/CZ299654B6/cs not_active IP Right Cessation
- 1999-06-10 CN CN99807458A patent/CN1128805C/zh not_active Expired - Lifetime
- 1999-06-10 EA EA200001187A patent/EA002386B1/ru not_active IP Right Cessation
- 1999-06-10 AP APAP/P/2000/001979A patent/AP1344A/en active
- 1999-06-10 KR KR10-2000-7014164A patent/KR100511238B1/ko not_active IP Right Cessation
- 1999-06-10 DE DE69902536T patent/DE69902536T2/de not_active Expired - Lifetime
- 1999-06-10 WO PCT/FR1999/001371 patent/WO1999065915A1/fr active IP Right Grant
- 1999-06-10 ES ES99923711T patent/ES2181439T3/es not_active Expired - Lifetime
- 1999-06-10 SK SK1909-2000A patent/SK286340B6/sk not_active IP Right Cessation
- 1999-06-10 HU HU0104343A patent/HU225871B1/hu unknown
- 1999-06-10 DK DK99923711T patent/DK1087976T3/da active
- 1999-06-10 BR BR9911219-1A patent/BR9911219A/pt not_active Application Discontinuation
- 1999-06-10 ID IDW20002434A patent/ID28264A/id unknown
- 1999-06-10 IL IL13979099A patent/IL139790A0/xx unknown
- 1999-06-10 CA CA002334870A patent/CA2334870C/en not_active Expired - Fee Related
- 1999-06-10 TR TR2000/03417T patent/TR200003417T2/xx unknown
- 1999-06-10 ME MEP-2000-777A patent/ME00686B/me unknown
- 1999-06-10 OA OA1200000343A patent/OA11567A/en unknown
- 1999-06-10 US US09/623,333 patent/US6429210B1/en not_active Expired - Lifetime
- 1999-06-12 DZ DZ990117A patent/DZ2817A1/xx active
- 1999-06-14 MY MYPI99002428A patent/MY129439A/en unknown
- 1999-06-14 EG EG71099A patent/EG24015A/xx active
- 1999-06-15 CO CO99037210A patent/CO5040084A1/es unknown
- 1999-06-15 TW TW088110001A patent/TW562805B/zh not_active IP Right Cessation
- 1999-06-16 AR ARP990102869A patent/AR014854A1/es not_active Application Discontinuation
- 1999-07-04 SA SA99200321A patent/SA99200321B1/ar unknown
- 1999-09-06 UY UY25693A patent/UY25693A1/es not_active Application Discontinuation
- 1999-10-06 UA UA2000116344A patent/UA70323C2/uk unknown
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2000
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- 2000-11-17 IS IS5716A patent/IS2469B/is unknown
- 2000-11-20 IL IL139790A patent/IL139790A/en unknown
- 2000-11-27 BG BG104987A patent/BG64508B1/bg unknown
- 2000-12-14 NO NO20006395A patent/NO327161B1/no not_active IP Right Cessation
- 2000-12-14 HR HR970350A patent/HRP20000863B1/xx not_active IP Right Cessation
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2001
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2002
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