UA97673C2 - КОМПОЗИЦИЯ НА ОСНОВЕ ГИБРИДНОГО БЕЛКА GLP-1Fc - Google Patents

КОМПОЗИЦИЯ НА ОСНОВЕ ГИБРИДНОГО БЕЛКА GLP-1Fc

Info

Publication number
UA97673C2
UA97673C2 UAA201000210A UAA201000210A UA97673C2 UA 97673 C2 UA97673 C2 UA 97673C2 UA A201000210 A UAA201000210 A UA A201000210A UA A201000210 A UAA201000210 A UA A201000210A UA 97673 C2 UA97673 C2 UA 97673C2
Authority
UA
Ukraine
Prior art keywords
glp
fusion protein
protein formulation
formulation
polysorbate
Prior art date
Application number
UAA201000210A
Other languages
English (en)
Ukrainian (uk)
Inventor
Кингман НГ
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39870243&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA97673(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of UA97673C2 publication Critical patent/UA97673C2/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Изобретение касается композиции, пригодной для лечения диабета и ожирения, а также ряда других состояний или расстройств, которая находится в виде стабильного раствора, содержащего терапевтически эффективное количество гибридного белка Glp-1-Fc в цитратном буфере с полисорбатом-80 и маннитом, причем рН упомянутого раствора равняется от приблизительно 6 до 7.
UAA201000210A 2007-07-10 2008-07-09 КОМПОЗИЦИЯ НА ОСНОВЕ ГИБРИДНОГО БЕЛКА GLP-1Fc UA97673C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94885507P 2007-07-10 2007-07-10
PCT/US2008/069473 WO2009009562A2 (en) 2007-07-10 2008-07-09 Glp-1-fc fusion protein formulation

Publications (1)

Publication Number Publication Date
UA97673C2 true UA97673C2 (ru) 2012-03-12

Family

ID=39870243

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201000210A UA97673C2 (ru) 2007-07-10 2008-07-09 КОМПОЗИЦИЯ НА ОСНОВЕ ГИБРИДНОГО БЕЛКА GLP-1Fc

Country Status (19)

Country Link
US (1) US20100196405A1 (ru)
EP (1) EP2175834B8 (ru)
JP (1) JP2010533197A (ru)
KR (1) KR20100020516A (ru)
CN (1) CN101730523A (ru)
AT (1) ATE499088T1 (ru)
AU (1) AU2008275180A1 (ru)
BR (1) BRPI0813699B1 (ru)
CA (1) CA2691695C (ru)
DE (1) DE602008005155D1 (ru)
EA (1) EA201070121A1 (ru)
HK (1) HK1141237A1 (ru)
HR (1) HRP20110242T1 (ru)
MX (1) MX2010000380A (ru)
NZ (1) NZ582480A (ru)
RS (1) RS52378B (ru)
UA (1) UA97673C2 (ru)
WO (1) WO2009009562A2 (ru)
ZA (1) ZA201000149B (ru)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107661288A (zh) * 2016-07-29 2018-02-06 江苏泰康生物医药有限公司 含有glp‑1 类似物融合蛋白的稳定液体制剂及其制备

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2519031C1 (ru) * 2010-01-19 2014-06-10 Ханми Сайенс Ко., Лтд. Жидкие препаративные формы для длительно действующего конъюгата g-csf
JP5800527B2 (ja) * 2010-03-30 2015-10-28 日東電工株式会社 安定化医薬組成物、安定化医薬組成物溶液製剤、フィルム状製剤及びフィルム状製剤の製造方法
CN102533655A (zh) * 2010-12-21 2012-07-04 青岛黄海制药有限责任公司 高效表达人源重组蛋白GLP1/Fc的CHO-S细胞株及其建立方法
SG195258A1 (en) 2011-06-10 2013-12-30 Hanmi Science Co Ltd Novel oxyntomodulin derivatives and pharmaceutical composition for treating obesity comprising the same
PE20181268A1 (es) 2011-06-17 2018-08-03 Hanmi Science Co Ltd Un conjugado que comprende oxintomodulina y un fragmento de inmunoglobulina, y el uso del mismo
WO2014014206A1 (en) * 2012-07-20 2014-01-23 University-Industry Cooperation Group Of Kyung Hee University Novel peptide tag and uses thereof
US10441665B2 (en) 2012-07-25 2019-10-15 Hanmi Pharm. Co., Ltd. Liquid formulation of long acting insulinotropic peptide conjugate
KR101968344B1 (ko) 2012-07-25 2019-04-12 한미약품 주식회사 옥신토모듈린 유도체를 포함하는 고지혈증 치료용 조성물
AR094821A1 (es) * 2012-07-25 2015-09-02 Hanmi Pharm Ind Co Ltd Formulación líquida de un conjugado de péptido insulinotrópico de acción prolongada
AR091902A1 (es) * 2012-07-25 2015-03-11 Hanmi Pharm Ind Co Ltd Formulacion liquida de un conjugado de insulina de accion prolongada
AR092862A1 (es) * 2012-07-25 2015-05-06 Hanmi Pharm Ind Co Ltd Formulacion liquida de insulina de accion prolongada y un peptido insulinotropico y metodo de preparacion
UA116217C2 (uk) 2012-10-09 2018-02-26 Санофі Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону
AR093387A1 (es) 2012-11-06 2015-06-03 Hanmi Pharm Ind Co Ltd Formulacion liquida de un conjugado de proteina que comprende oxintomodulina y un fragmento de inmunoglobulina
KR101993393B1 (ko) 2012-11-06 2019-10-01 한미약품 주식회사 옥신토모듈린 유도체를 포함하는 당뇨병 또는 비만성 당뇨병 치료용 조성물
JP2016503771A (ja) 2012-12-21 2016-02-08 サノフイ エキセンジン−４誘導体
CN104173275A (zh) * 2013-05-21 2014-12-03 深圳翰宇药业股份有限公司 度拉鲁肽注射剂及其制备方法
TW201609796A (zh) 2013-12-13 2016-03-16 賽諾菲公司 非醯化之艾塞那肽－４（ｅｘｅｎｄｉｎ－４）胜肽類似物
EP3080150B1 (en) 2013-12-13 2018-08-01 Sanofi Exendin-4 peptide analogues as dual glp-1/gip receptor agonists
EP3080149A1 (en) 2013-12-13 2016-10-19 Sanofi Dual glp-1/glucagon receptor agonists
WO2015086729A1 (en) 2013-12-13 2015-06-18 Sanofi Dual glp-1/gip receptor agonists
TW201625668A (zh) 2014-04-07 2016-07-16 賽諾菲公司 作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物
TW201625669A (zh) 2014-04-07 2016-07-16 賽諾菲公司 衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑
TW201625670A (zh) 2014-04-07 2016-07-16 賽諾菲公司 衍生自ｅｘｅｎｄｉｎ－４之雙重ｇｌｐ－１／升糖素受體促效劑
US9932381B2 (en) 2014-06-18 2018-04-03 Sanofi Exendin-4 derivatives as selective glucagon receptor agonists
TWI802396B (zh) 2014-09-16 2023-05-11 南韓商韓美藥品股份有限公司 長效glp-1/高血糖素受體雙促效劑治療非酒精性脂肝疾病之用途
CN104293834B (zh) * 2014-10-11 2018-03-23 上海兴迪金生物技术有限公司 GLP‑1或其类似物与抗体Fc片段融合蛋白的制备方法
KR102418477B1 (ko) 2014-12-30 2022-07-08 한미약품 주식회사 글루카곤 유도체
DK3257524T3 (da) * 2015-02-11 2020-11-23 Gmax Biopharm Llc Stabiliseret opløsningspræparat af farmaceutisk glp-1r-antistoffusionsprotein
AR105616A1 (es) 2015-05-07 2017-10-25 Lilly Co Eli Proteínas de fusión
AR105319A1 (es) 2015-06-05 2017-09-27 Sanofi Sa Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico
AR105284A1 (es) 2015-07-10 2017-09-20 Sanofi Sa Derivados de exendina-4 como agonistas peptídicos duales específicos de los receptores de glp-1 / glucagón
WO2018024162A1 (en) * 2016-08-03 2018-02-08 Sunshine Lake Pharma Co., Ltd. Glp-1 fusion protein comprising mutated immunoglobulin fc portion
CN108210890A (zh) * 2016-12-09 2018-06-29 江苏泰康生物医药有限公司 重组人胰高血糖素样肽-1类似物融合蛋白的新型稳定制剂
GB201621987D0 (en) * 2016-12-22 2017-02-08 Archer Virgil L See Archer Sheri A Arecor Ltd Novel composition
HUE063776T2 (hu) 2017-06-01 2024-01-28 Lilly Co Eli Dulaglutid krónikus vesebetegség kezelésére
BR112020002871A2 (pt) * 2017-08-15 2020-07-28 Kindred Biosciences, Inc. variantes fc de igg para uso veterinário
CN111356472A (zh) * 2017-11-21 2020-06-30 伊莱利利公司 使用杜拉鲁肽的方法和含有杜拉鲁肽的组合物
CN109836503B (zh) * 2017-11-24 2022-09-16 浙江道尔生物科技有限公司 一种治疗代谢疾病的多重活性蛋白
TWI705820B (zh) 2018-06-22 2020-10-01 美商美國禮來大藥廠 Gip/glp1促效劑組合物
WO2020190591A1 (en) 2019-03-15 2020-09-24 Eli Lilly And Company Preserved formulations
CA3056663C (en) 2019-04-05 2022-10-18 Jeffrey S. RIESMEYER Use of dulaglutide in reducing risk of cardiovascular events in patients with type 2 diabetes mellitus
GB201917723D0 (en) * 2019-12-04 2020-01-15 Nv Rose Llc Stable liquid formulations of glucagon-like peptide 1 or analogues thereof
KR102349717B1 (ko) * 2020-03-12 2022-01-11 주식회사 에스엘메타젠 신규 대사증후군 및 그와 관련된 질환 치료용 약학 조성물
CN114053217B (zh) * 2020-08-03 2023-04-18 华兰生物工程股份有限公司 一种Exendin-4-Fc融合蛋白注射制剂及其制备方法
CN112494658A (zh) * 2020-12-04 2021-03-16 苏桥生物(苏州)有限公司 一种稳定的Fc融合蛋白制剂
CN114685644A (zh) 2020-12-29 2022-07-01 苏州康宁杰瑞生物科技有限公司 一种人glp-1多肽变体及其应用
CN117616037A (zh) 2021-07-06 2024-02-27 苏州康宁杰瑞生物科技有限公司 融合蛋白及其应用
CN117143242B (zh) * 2023-10-30 2024-03-29 南京佰抗生物科技有限公司 抗Galectin-3蛋白的单克隆抗体组合物及应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101044162B (zh) * 2004-12-22 2010-10-27 伊莱利利公司 Glp-1类似物融合蛋白质制剂

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107661288A (zh) * 2016-07-29 2018-02-06 江苏泰康生物医药有限公司 含有glp‑1 类似物融合蛋白的稳定液体制剂及其制备

Also Published As

Publication number Publication date
DE602008005155D1 (de) 2011-04-07
HRP20110242T1 (hr) 2011-05-31
EP2175834A2 (en) 2010-04-21
ATE499088T1 (de) 2011-03-15
EP2175834B1 (en) 2011-02-23
RS52378B (en) 2012-12-31
MX2010000380A (es) 2010-03-29
BRPI0813699B1 (pt) 2021-06-22
ZA201000149B (en) 2011-04-28
AU2008275180A1 (en) 2009-01-15
CN101730523A (zh) 2010-06-09
EP2175834B8 (en) 2012-08-22
JP2010533197A (ja) 2010-10-21
NZ582480A (en) 2011-03-31
WO2009009562A2 (en) 2009-01-15
US20100196405A1 (en) 2010-08-05
WO2009009562A3 (en) 2009-07-09
HK1141237A1 (en) 2010-11-05
CA2691695A1 (en) 2009-01-15
KR20100020516A (ko) 2010-02-22
EA201070121A1 (ru) 2010-06-30
BRPI0813699A2 (pt) 2014-12-30
CA2691695C (en) 2014-03-18

Similar Documents

Publication Publication Date Title
HK1141237A1 (en) Glp-1-fc fusion protein formulation glp-1-fc
TW200833357A (en) Stable polypeptide formulations
ZA200500966B (en) Biphasic composition induced by polydextrose and sucrose
WO2006119958A3 (en) Use of flibanserin in the treatment of chronic pain
MY147643A (en) Use of benzo-fused heterocycle sulfamide derivatives for the treatment of mania and bipolar disorder
ZA200501128B (en) Biphasic composition induced by polydextrose
SG151327A1 (en) Deazapurines useful as inhibitors of janus kinases
MX2009009624A (es) Droxidopa y composicion farmaceutica de la misma para el tratamiento de la fibromialgia.
MX2007010560A (es) Roflumilast para el tratamiento de diabetes mellitus.
WO2007125501A3 (en) Liquid compositions comprising phenylephrine and acetaminophen and their use for the treatment of respiratory illness
NZ623123A (en) A process for concentration of a polypeptide
EP1907014A4 (en) CHONDROGENIC COMPOSITIONS AND METHODS OF USE
ATE464045T1 (de) Zusammensetzung aus milchsäure und lactoferrin
WO2008034796A3 (en) Estratriene derivatives and their uses as 17beta-hydr0xyster0id dehydrogenase inhibitors
WO2006114105A3 (en) Use of modified factor vii for treating bleeding
NZ601592A (en) Recombinant elastase proteins and methods of manufacturing and use thereof
MX2010005205A (es) Isoformas de neurregulina solubles activas modificadas postraduccionalmente.
EA200800537A1 (ru) Маррубиин и композиция для уменьшения храпа, упаковка и методика
WO2007138382A3 (en) Cyclic peptides for modulating growth of neo-vessels and their use in therapeutic angiogenesis
WO2007095609A3 (en) Use of benzo-heteroaryl sulfamide derivatives for the treatment of mania and bipolar disorder
WO2007021933A3 (en) Methods and compositions for use in treating vascular diseases and conditions
MX2007012991A (es) Formas solidas cristalinas y amorfas de halofenato (-) y metodoss relacionados a las mismas.
WO2009019433A3 (en) Fertilisation protein