UA80394C2 - Method of treating of demyelinating diseases - Google Patents

Method of treating of demyelinating diseases Download PDF

Info

Publication number: UA80394C2
Authority: UA; Ukraine
Prior art keywords: alkyl; hydrogen; halogen; represents hydrogen; compound
Prior art date: 2001-02-15

Application number

UA2003098376A

Other languages

English (en)

Ukrainian (uk)

Original Assignee

Aventis Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-02-15

Filing date

2002-02-14

Publication date

2007-09-25

2002-02-14 Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc

2007-09-25 Publication of UA80394C2 publication Critical patent/UA80394C2/uk

Links

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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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UA2003098376A 2001-02-15 2002-02-14 Method of treating of demyelinating diseases UA80394C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US26884601P	2001-02-15	2001-02-15
PCT/US2002/005501 WO2002064126A2 (en)	2001-02-15	2002-02-14	Method of treating of demyelinating diseases or conditions

Publications (1)

Publication Number	Publication Date
UA80394C2 true UA80394C2 (en)	2007-09-25

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ID=23024747

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
UA2003098376A UA80394C2 (en)	2001-02-15	2002-02-14	Method of treating of demyelinating diseases
UAA200603708A UA88773C2 (ru)	2001-02-15	2006-04-04	Способ лечения раздражения мочевого пузыря и чрезмерно активного мочевого пузыря

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Application Number	Title	Priority Date	Filing Date
UAA200603708A UA88773C2 (ru)	2001-02-15	2006-04-04	Способ лечения раздражения мочевого пузыря и чрезмерно активного мочевого пузыря

Country Status (39)

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US (10)	US6967210B2 (ru)
EP (1)	EP1368031A2 (ru)
JP (3)	JP2004518711A (ru)
KR (3)	KR100951540B1 (ru)
CN (2)	CN1529598A (ru)
AP (1)	AP1749A (ru)
AR (1)	AR035750A1 (ru)
AU (3)	AU2002247200B9 (ru)
BR (1)	BR0207272A (ru)
CA (1)	CA2438712A1 (ru)
CO (1)	CO5390085A1 (ru)
CR (1)	CR7023A (ru)
CZ (1)	CZ20032172A3 (ru)
EA (2)	EA012409B1 (ru)
EC (1)	ECSP024218A (ru)
EE (1)	EE200300363A (ru)
GB (1)	GB0119435D0 (ru)
HK (1)	HK1080361B (ru)
HR (1)	HRP20030652A2 (ru)
HU (1)	HUP0303203A3 (ru)
IL (2)	IL157341A0 (ru)
MA (1)	MA26152A1 (ru)
ME (1)	MEP21208A (ru)
MX (1)	MXPA03006110A (ru)
MY (1)	MY157745A (ru)
NO (1)	NO20033622L (ru)
NZ (4)	NZ539159A (ru)
OA (1)	OA12549A (ru)
PA (1)	PA8540101A1 (ru)
PE (1)	PE20040175A1 (ru)
PL (1)	PL363638A1 (ru)
SG (1)	SG134170A1 (ru)
SK (1)	SK10392003A3 (ru)
TR (4)	TR200800691T2 (ru)
TW (1)	TWI325319B (ru)
UA (2)	UA80394C2 (ru)
WO (1)	WO2002064126A2 (ru)
YU (1)	YU62903A (ru)
ZA (1)	ZA200306124B (ru)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0119435D0 (en) *	2001-02-15	2001-10-03	Aventis Pharm Prod Inc	Method of treating of demyelinating diseases or conditions
WO2004058168A2 (en) *	2002-12-20	2004-07-15	Dynogen Pharmaceuticals, Inc.	METHODS OF TREATING NON-PAINFUL BLADDER DISORDERS USING α2δ SUBUNIT CALCIUM CHANNEL MODULATORS
US20040209960A1 (en) *	2003-01-30	2004-10-21	Dynogen Pharmaceuticals, Inc.	Methods of treating lower urinary tract disorders using sodium channell modulators
BRPI0408608A (pt) *	2003-03-21	2006-03-07	Dynogen Pharmaceuticals Inc	uso de moduladores da subunidade (alfa)2(delta) de canal de cálcio e moduladores de músculo liso para tratamento de sintoma de um distúrbio do trato urinário inferior
GT200500063A (es) *	2004-04-01	2005-10-14		Metodo para tratar la esquizofrenia y/o anormalidades glucoregulatorias
GB0510164D0 (en) *	2005-04-28	2005-06-22	Paradigm Therapeutics Ltd	Ion channel
FR2892021B1 (fr) *	2005-10-19	2008-01-04	Urogene	Traitement de l'incontinence urinaire d'effort et mixte
FR2892022B1 (fr) *	2005-10-19	2008-01-04	Urogene Sa	Traitement des symptomes de l'irritation de la vessie
US8420593B1 (en) *	2006-06-16	2013-04-16	Landon C. G. Miller	Compositions and methods for regulating membrane potential
DE102008044844B4 (de) *	2008-08-28	2018-08-30	Siemens Healthcare Gmbh	Verfahren zur Ermittlung einer Schwächungskarte zur Verwendung in der Positronenemissionstomographie und von Homogenitätsinformationen des Magnetresonanzmagnetfeldes
CN102822979B (zh) *	2010-03-26	2015-08-26	株式会社半导体能源研究所	半导体器件
WO2012009204A1 (en) *	2010-07-15	2012-01-19	The Trustees Of Columbia University In The City Of New York	Methods for diagnosing and treating concussive disorders
US20130030025A1 (en) *	2011-01-28	2013-01-31	Wessel Thomas C	Use of potassium channel blockers to treat cerebral palsy
TWI592156B (zh) *	2011-10-04	2017-07-21	艾可達醫療公司	使用胺基吡啶以治療與中風有關之感覺動作損傷之方法
US20190060286A1 (en)	2016-02-29	2019-02-28	University Of Florida Research Foundation, Incorpo	Chemotherapeutic Methods
WO2019126643A1 (en) *	2017-12-22	2019-06-27	Massachusetts Institute Of Technology	Compositions and methods for williams syndrome (ws) therapy
CA3207205A1 (en) *	2021-01-20	2022-07-28	Rush University Medical Center	Improved treatment for globoid cell leukodsytrophy or krabbe disease

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4880822A (en) *	1987-04-24	1989-11-14	Hoechst-Roussel Pharmaceuticals, Inc.	N-(pyridinyl)-1H-indol-1-amines
DE3852335T2 (de) *	1987-04-24	1995-05-11	Hoechst Roussel Pharma	N-(Pyridinyl)-1H-indol-1-amine, Verfahren zu deren Herstellung und ihre Verwendung als Arzneimittel.
US4970218A (en)	1987-04-24	1990-11-13	Hoechst-Roussel Pharmaceuticals Inc.	N-(pyridinyl)-1H-indol-1-amines
ES2068294T3 (es) *	1989-08-02	1995-04-16	Hoechst Roussel Pharma	2,3-dihidro-1-(piridinilamino)-indoles, un procedimiento para su preparacion y su uso como medicamentos.
US5214038A (en) *	1991-04-15	1993-05-25	Hoechst-Roussel Pharmaceuticals Inc.	1-(pyrido[3,4-b]-1,4-oxazinyl-4-yl)-1H-indoles and intermediates for the preparation thereof
DE4325491A1 (de) *	1993-07-29	1995-02-02	Boehringer Ingelheim Kg	Verwendung von zentral wirksamen alpha-2-Agonisten zur Hemmung des Postaggressionsstoffwechsels
US5459274A (en) *	1994-05-13	1995-10-17	Hoechst-Roussel Pharmaceuticals Inc.	Preparation of N-alkyl-N-pyridinyl-1H-indol-1-amines
US5565475A (en) *	1994-11-08	1996-10-15	Muhlhauser; Mark A.	Method of treating urinary bladder dysfunctions with 3-tetrahydropyridine derivatives
EP0731108A1 (en) *	1995-03-10	1996-09-11	Boehringer Mannheim Gmbh	Method of manufacturing a therapeutic agent for the regeneration of oligodendrocytes
FR2754147B1 (fr)	1996-10-03	2000-02-04	Mbh Technologies Sa	Installation et procede pour le traitement de carcasses
US5939405A (en) *	1998-01-29	1999-08-17	Bristol-Myers Squibb Company	Phosphate derivatives of diaryl 1,3,4-oxadiazolone
AU5483500A (en) *	1999-07-09	2001-01-30	Ortho-Mcneil Pharmaceutical, Inc.	Neurotrophic 2-azetidinecarboxylic acid derivatives, and related compositions and methods
GB0119435D0 (en) *	2001-02-15	2001-10-03	Aventis Pharm Prod Inc	Method of treating of demyelinating diseases or conditions

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Also Published As

Publication number	Publication date
US20060025452A1 (en)	2006-02-02
YU62903A (sh)	2006-05-25
EA200300882A1 (ru)	2003-12-25
KR20090005254A (ko)	2009-01-12
HRP20030652A2 (en)	2005-06-30
PA8540101A1 (es)	2003-09-05
WO2002064126A2 (en)	2002-08-22
HUP0303203A3 (en)	2007-11-28
WO2002064126A3 (en)	2003-02-20
US7230015B2 (en)	2007-06-12
SG134170A1 (en)	2007-08-29
UA88773C2 (ru)	2009-11-25
SK10392003A3 (sk)	2004-01-08
TWI325319B (en)	2010-06-01
MXPA03006110A (es)	2005-07-01
US20090270458A1 (en)	2009-10-29
EA200600896A1 (ru)	2006-08-25
HUP0303203A2 (hu)	2003-12-29
KR100951542B1 (ko)	2010-04-09
CN100522164C (zh)	2009-08-05
AU2009238332A1 (en)	2009-12-10
TR200800693T2 (tr)	2008-07-21
CZ20032172A3 (cs)	2004-01-14
EE200300363A (et)	2003-10-15
KR100951540B1 (ko)	2010-04-09
US20090209595A1 (en)	2009-08-20
IL157341A0 (en)	2004-02-19
AU2002247200B2 (en)	2007-12-13
BR0207272A (pt)	2004-02-10
CN1679564A (zh)	2005-10-12
EP1368031A2 (en)	2003-12-10
AP2003002834A0 (en)	2003-09-30
CO5390085A1 (es)	2004-04-30
ECSP024218A (es)	2003-09-24
CA2438712A1 (en)	2002-08-22
US20040157888A1 (en)	2004-08-12
MEP21208A (en)	2010-06-10
CN1529598A (zh)	2004-09-15
KR20090005255A (ko)	2009-01-12
TR200301330T2 (tr)	2004-12-21
US20050159456A1 (en)	2005-07-21
MA26152A1 (fr)	2004-07-01
NZ556697A (en)	2009-01-31
US20040157889A1 (en)	2004-08-12
US20090281147A1 (en)	2009-11-12
AU2008201179A1 (en)	2008-04-03
NZ527011A (en)	2005-07-29
US20090209594A1 (en)	2009-08-20
PE20040175A1 (es)	2004-03-29
JP2010120958A (ja)	2010-06-03
US20030105150A1 (en)	2003-06-05
NO20033622D0 (no)	2003-08-14
ZA200306124B (en)	2004-11-08
HK1080361B (zh)	2009-10-30
NZ539159A (en)	2006-11-30
JP2009185045A (ja)	2009-08-20
US7534803B2 (en)	2009-05-19
AU2002247200B9 (en)	2008-07-10
US6967210B2 (en)	2005-11-22
AU2008201179B2 (en)	2009-08-20
OA12549A (en)	2006-06-05
KR20040014459A (ko)	2004-02-14
PL363638A1 (en)	2004-11-29
EA012409B1 (ru)	2009-10-30
JP2004518711A (ja)	2004-06-24
NO20033622L (no)	2003-10-06
HK1080361A1 (en)	2006-04-28
AR035750A1 (es)	2004-07-07
GB0119435D0 (en)	2001-10-03
MY157745A (en)	2016-07-15
TR200800692T2 (tr)	2008-03-21
CR7023A (es)	2003-11-17
US20050234105A1 (en)	2005-10-20
AP1749A (en)	2007-06-13
EA011319B1 (ru)	2009-02-27
TR200800691T2 (tr)	2008-03-21
NZ544720A (en)	2007-08-31
US7179821B2 (en)	2007-02-20
IL157341A (en)	2010-11-30

Publication	Publication Date	Title
UA80394C2 (en)	2007-09-25	Method of treating of demyelinating diseases
US20070197643A1 (en)	2007-08-23	Use of (z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluoromethylphenyl)-amide for treating inflammatory bowel disease
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