UA76256C2 - Composition containing acid-unstable physiologically active compound and process for its preparation - Google Patents

Composition containing acid-unstable physiologically active compound and process for its preparation Download PDF

Info

Publication number: UA76256C2
Authority: UA; Ukraine
Prior art keywords: coating; composition; drug; water; enteric
Prior art date: 2001-11-21

Application number

UA20040604883A

Other languages

English (en)

Ukrainian (uk)

Original Assignee

Eisai Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-11-21

Filing date

2002-11-20

Publication date

2006-07-17

2002-11-20 Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd

2006-07-17 Publication of UA76256C2 publication Critical patent/UA76256C2/uk

Links

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229920000642 polymer Polymers 0.000 claims abstract description 44
229920003176 water-insoluble polymer Polymers 0.000 claims abstract description 39
238000000576 coating method Methods 0.000 claims description 98
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HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 claims description 34
239000000126 substance Substances 0.000 claims description 24
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KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 18
-1 aminoalkyl methacrylate Chemical compound 0.000 claims description 18
BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims description 18
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 15
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AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 1
229910052782 aluminium Inorganic materials 0.000 description 1
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
239000005557 antagonist Substances 0.000 description 1
125000003289 ascorbyl group Chemical class [H]O[C@@]([H])(C([H])([H])O*)[C@@]1([H])OC(=O)C(O*)=C1O* 0.000 description 1
230000009286 beneficial effect Effects 0.000 description 1
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230000033228 biological regulation Effects 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
DKPFZGUDAPQIHT-UHFFFAOYSA-N butyl acetate Chemical group CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 description 1
239000002775 capsule Substances 0.000 description 1
235000013736 caramel Nutrition 0.000 description 1
DGQLVPJVXFOQEV-NGOCYOHBSA-N carminic acid Chemical compound OC1=C2C(=O)C=3C(C)=C(C(O)=O)C(O)=CC=3C(=O)C2=C(O)C(O)=C1[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O DGQLVPJVXFOQEV-NGOCYOHBSA-N 0.000 description 1
229940114118 carminic acid Drugs 0.000 description 1
150000001746 carotenes Chemical class 0.000 description 1
235000005473 carotenes Nutrition 0.000 description 1
230000008859 change Effects 0.000 description 1
AGOYDEPGAOXOCK-KCBOHYOISA-N clarithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@](C)([C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)OC)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 AGOYDEPGAOXOCK-KCBOHYOISA-N 0.000 description 1
229960002626 clarithromycin Drugs 0.000 description 1
239000008199 coating composition Substances 0.000 description 1
239000011247 coating layer Substances 0.000 description 1
229940080423 cochineal Drugs 0.000 description 1
230000007423 decrease Effects 0.000 description 1
238000011161 development Methods 0.000 description 1
238000007908 dry granulation Methods 0.000 description 1
238000001035 drying Methods 0.000 description 1
229960003276 erythromycin Drugs 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
150000002170 ethers Chemical class 0.000 description 1
239000003925 fat Substances 0.000 description 1
239000000945 filler Substances 0.000 description 1
239000000576 food coloring agent Substances 0.000 description 1
239000001530 fumaric acid Substances 0.000 description 1
235000011087 fumaric acid Nutrition 0.000 description 1
WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
150000008282 halocarbons Chemical class 0.000 description 1
229960001340 histamine Drugs 0.000 description 1
229930195733 hydrocarbon Natural products 0.000 description 1
150000002430 hydrocarbons Chemical class 0.000 description 1
238000007654 immersion Methods 0.000 description 1
230000006872 improvement Effects 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
210000000936 intestine Anatomy 0.000 description 1
150000002576 ketones Chemical class 0.000 description 1
XCOBTUNSZUJCDH-UHFFFAOYSA-B lithium magnesium sodium silicate Chemical compound [Li+].[Li+].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Na+].[Na+].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3 XCOBTUNSZUJCDH-UHFFFAOYSA-B 0.000 description 1
230000007774 longterm Effects 0.000 description 1
159000000003 magnesium salts Chemical class 0.000 description 1
239000000845 maltitol Substances 0.000 description 1
235000010449 maltitol Nutrition 0.000 description 1
VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 1
229940035436 maltitol Drugs 0.000 description 1
239000000463 material Substances 0.000 description 1
239000011159 matrix material Substances 0.000 description 1
125000005395 methacrylic acid group Chemical group 0.000 description 1
238000002156 mixing Methods 0.000 description 1
PJUIMOJAAPLTRJ-UHFFFAOYSA-N monothioglycerol Chemical compound OCC(O)CS PJUIMOJAAPLTRJ-UHFFFAOYSA-N 0.000 description 1
238000000465 moulding Methods 0.000 description 1
239000003921 oil Substances 0.000 description 1
235000019198 oils Nutrition 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
230000035515 penetration Effects 0.000 description 1
235000019371 penicillin G benzathine Nutrition 0.000 description 1
229940056360 penicillin g Drugs 0.000 description 1
208000011906 peptic ulcer disease Diseases 0.000 description 1
150000002978 peroxides Chemical class 0.000 description 1
230000002085 persistent effect Effects 0.000 description 1
229920002689 polyvinyl acetate Polymers 0.000 description 1
239000011118 polyvinyl acetate Substances 0.000 description 1
229920002451 polyvinyl alcohol Polymers 0.000 description 1
XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
238000003825 pressing Methods 0.000 description 1
238000003672 processing method Methods 0.000 description 1
239000011253 protective coating Substances 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
238000011160 research Methods 0.000 description 1
230000000979 retarding effect Effects 0.000 description 1
XWGJFPHUCFXLBL-UHFFFAOYSA-M rongalite Chemical compound [Na+].OCS([O-])=O XWGJFPHUCFXLBL-UHFFFAOYSA-M 0.000 description 1
239000012488 sample solution Substances 0.000 description 1
239000000377 silicon dioxide Substances 0.000 description 1
235000012239 silicon dioxide Nutrition 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011734 sodium Substances 0.000 description 1
HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
235000010262 sodium metabisulphite Nutrition 0.000 description 1
235000010265 sodium sulphite Nutrition 0.000 description 1
AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
235000019345 sodium thiosulphate Nutrition 0.000 description 1
239000007787 solid Substances 0.000 description 1
230000006641 stabilisation Effects 0.000 description 1
238000011105 stabilization Methods 0.000 description 1
230000000087 stabilizing effect Effects 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
229940071138 stearyl fumarate Drugs 0.000 description 1
238000003756 stirring Methods 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
230000008961 swelling Effects 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 description 1
235000019165 vitamin E Nutrition 0.000 description 1
229940046009 vitamin E Drugs 0.000 description 1
239000011709 vitamin E Substances 0.000 description 1
229920003169 water-soluble polymer Polymers 0.000 description 1
238000005550 wet granulation Methods 0.000 description 1
238000009736 wetting Methods 0.000 description 1
239000008096 xylene Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Inorganic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

UA20040604883A 2001-11-21 2002-11-20 Composition containing acid-unstable physiologically active compound and process for its preparation UA76256C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2001356018		2001-11-21
PCT/JP2002/012132 WO2003043661A1 (fr)	2001-11-21	2002-11-20	Compositions de preparation contenant des composes actifs au plan physiologiques et instables aux acides et leur procede de production

Publications (1)

Publication Number	Publication Date
UA76256C2 true UA76256C2 (en)	2006-07-17

Family

ID=19167613

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UA20040604883A UA76256C2 (en)	2001-11-21	2002-11-20	Composition containing acid-unstable physiologically active compound and process for its preparation

Country Status (25)

Country	Link
EP (1)	EP1454634A4 (fr)
JP (1)	JP4540092B2 (fr)
KR (1)	KR20050044545A (fr)
CN (2)	CN1589156A (fr)
AP (1)	AP1919A (fr)
AU (1)	AU2002366029B2 (fr)
BR (1)	BR0214372A (fr)
CA (1)	CA2466726C (fr)
CO (1)	CO5580800A2 (fr)
CR (1)	CR7351A (fr)
EC (1)	ECSP045110A (fr)
HU (1)	HUP0402323A3 (fr)
IL (2)	IL161983A0 (fr)
IS (1)	IS7266A (fr)
MA (1)	MA26346A1 (fr)
MX (1)	MXPA04004775A (fr)
NO (1)	NO20042563L (fr)
NZ (1)	NZ532907A (fr)
RO (1)	RO122395B1 (fr)
RU (1)	RU2311906C2 (fr)
SI (1)	SI21447A (fr)
TW (1)	TWI302461B (fr)
UA (1)	UA76256C2 (fr)
WO (1)	WO2003043661A1 (fr)
ZA (1)	ZA200403551B (fr)

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US8071128B2 (en)	1996-06-14	2011-12-06	Kyowa Hakko Kirin Co., Ltd.	Intrabuccally rapidly disintegrating tablet and a production method of the tablets
WO2005092336A1 (fr) *	2004-03-26	2005-10-06	Eisai R&D Management Co., Ltd.	Préparation de lessivage maîtrisé et procédé de fabrication de ladite préparation
US8747895B2 (en)	2004-09-13	2014-06-10	Aptalis Pharmatech, Inc.	Orally disintegrating tablets of atomoxetine
US9884014B2 (en)	2004-10-12	2018-02-06	Adare Pharmaceuticals, Inc.	Taste-masked pharmaceutical compositions
MX2007004741A (es)	2004-10-21	2007-09-07	Eurand Pharmaceuticals Ltd	Composiciones farmaceuticas con sabor enmascarado con formadores de poro gastrosolubles.
EP1830886B1 (fr)	2004-12-27	2016-04-13	Eisai R&D Management Co., Ltd.	Methode de stabilisation d'un medicament contre la demence
CN101146521A (zh) *	2005-03-14	2008-03-19	太阳医药高级研究有限公司	提供包含纤维素和甲基丙烯酸衍生物包衣的口服药物输送***
WO2006111853A2 (fr) *	2005-04-18	2006-10-26	Aurobindo Pharma Limited	Formes posologiques solides stables d'un medicament labile en milieu acide
US9161918B2 (en)	2005-05-02	2015-10-20	Adare Pharmaceuticals, Inc.	Timed, pulsatile release systems
US20100105738A1 (en) *	2006-10-06	2010-04-29	Mitsuru Mizuno	Extended release formulations of a proton pump inhibitor
KR20100097145A (ko) *	2007-11-27	2010-09-02	오하라 야꾸힝 고교 가부시키가이샤	조립물의 제조 방법
CN101822671A (zh) *	2009-03-06	2010-09-08	信谊药厂	雷贝拉唑组合物及其制备方法
EP2506836B1 (fr)	2009-12-02	2018-02-14	Adare Pharmaceuticals S.R.L.	Microcapsules de fexofénadine et compositions les contenant
NZ605562A (en) *	2010-07-09	2013-11-29	Teijin Pharma Ltd	Deuterated benzylbenzene derivatives and methods of use
JP2018184360A (ja) *	2017-04-25	2018-11-22	ニプロ株式会社	経口投与用の腸溶性徐放性製剤
KR102227486B1 (ko) *	2017-06-30	2021-03-12	롯데정밀화학 주식회사	프로톤 펌프 저해제를 포함하는 경구용 고형제제 조성물, 이를 포함하는 경구용 고형제제 및 그 제조방법

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DE2336218C3 (de) *	1973-07-17	1985-11-14	Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz	Orale Arzneiform
JPS5944311A (ja) *	1982-09-07	1984-03-12	Santen Pharmaceut Co Ltd	徐放性顆粒およびその製造法
ATE124864T1 (de) *	1989-03-10	1995-07-15	Yamanouchi Pharma Co Ltd	Die wirkstoffabgabe steuerndes überzugsmaterial für lang wirksame formulierungen.
EP0447168A3 (en) *	1990-03-16	1993-01-07	Yamanouchi Pharmaceutical Co. Ltd.	Long acting granular pharmaceutical composition
JPH0826977A (ja) *	1994-07-19	1996-01-30	Tanabe Seiyaku Co Ltd	溶出制御型経口製剤
JPH09323926A (ja) *	1996-03-15	1997-12-16	Nikken Chem Co Ltd	バルプロ酸ナトリウムの徐放性錠剤
ES2137862B1 (es) *	1997-07-31	2000-09-16	Intexim S A	Preparacion farmaceutica oral que comprende un compuesto de actividad antiulcerosa y procedimiento para su obtencion.
US20020039597A1 (en) *	1998-04-20	2002-04-04	Koji Ukai	Stabilized compositions containing benzimidazole-type compounds
KR101032289B1 (ko) *	1998-05-18	2011-05-06	다케다 야쿠힌 고교 가부시키가이샤	미세과립
JP2001055322A (ja) *	1999-08-18	2001-02-27	Tanabe Seiyaku Co Ltd	パルス放出型製剤
KR20020038759A (ko) *	1999-10-20	2002-05-23	다니구치 미즈오	벤즈이미다졸계 화합물 안정화 방법
US6627223B2 (en) *	2000-02-11	2003-09-30	Eurand Pharmaceuticals Ltd.	Timed pulsatile drug delivery systems

2002
- 2002-11-20 RU RU2004118495/15A patent/RU2311906C2/ru not_active IP Right Cessation
- 2002-11-20 MX MXPA04004775A patent/MXPA04004775A/es active IP Right Grant
- 2002-11-20 IL IL16198302A patent/IL161983A0/xx unknown
- 2002-11-20 BR BR0214372-0A patent/BR0214372A/pt not_active IP Right Cessation
- 2002-11-20 JP JP2003545339A patent/JP4540092B2/ja not_active Expired - Fee Related
- 2002-11-20 RO ROA200400455A patent/RO122395B1/ro unknown
- 2002-11-20 SI SI200220036A patent/SI21447A/sl not_active IP Right Cessation
- 2002-11-20 CN CNA02823233XA patent/CN1589156A/zh active Pending
- 2002-11-20 CA CA2466726A patent/CA2466726C/fr not_active Expired - Fee Related
- 2002-11-20 NZ NZ532907A patent/NZ532907A/en not_active IP Right Cessation
- 2002-11-20 WO PCT/JP2002/012132 patent/WO2003043661A1/fr active Application Filing
- 2002-11-20 HU HU0402323A patent/HUP0402323A3/hu unknown
- 2002-11-20 AU AU2002366029A patent/AU2002366029B2/en not_active Ceased
- 2002-11-20 AP APAP/P/2004/003045A patent/AP1919A/en active
- 2002-11-20 KR KR1020047007672A patent/KR20050044545A/ko active Search and Examination
- 2002-11-20 EP EP02803548A patent/EP1454634A4/fr not_active Withdrawn
- 2002-11-20 CN CN2010105157913A patent/CN101982199A/zh active Pending
- 2002-11-20 UA UA20040604883A patent/UA76256C2/uk unknown
- 2002-11-21 TW TW091133989A patent/TWI302461B/zh not_active IP Right Cessation
2004
- 2004-05-10 ZA ZA200403551A patent/ZA200403551B/en unknown
- 2004-05-13 IL IL161983A patent/IL161983A/en active IP Right Review Request
- 2004-05-14 IS IS7266A patent/IS7266A/is unknown
- 2004-05-17 EC EC2004005110A patent/ECSP045110A/es unknown
- 2004-05-18 CO CO04045751A patent/CO5580800A2/es not_active Application Discontinuation
- 2004-05-18 MA MA27683A patent/MA26346A1/fr unknown
- 2004-05-20 CR CR7351A patent/CR7351A/es unknown
- 2004-06-18 NO NO20042563A patent/NO20042563L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
NO20042563L (no)	2004-06-18
CA2466726A1 (fr)	2003-05-30
AU2002366029B2 (en)	2008-01-31
CR7351A (es)	2005-05-12
RU2311906C2 (ru)	2007-12-10
AP1919A (en)	2008-11-13
AP2004003045A0 (en)	2004-06-30
MA26346A1 (fr)	2004-10-01
CN101982199A (zh)	2011-03-02
TW200300353A (en)	2003-06-01
KR20050044545A (ko)	2005-05-12
EP1454634A1 (fr)	2004-09-08
BR0214372A (pt)	2004-10-26
RU2004118495A (ru)	2005-03-20
JPWO2003043661A1 (ja)	2005-03-10
AU2002366029A1 (en)	2003-06-10
IL161983A0 (en)	2005-11-20
NZ532907A (en)	2007-05-31
HUP0402323A3 (en)	2008-04-28
MXPA04004775A (es)	2005-02-17
CN1589156A (zh)	2005-03-02
IS7266A (is)	2004-05-14
WO2003043661A1 (fr)	2003-05-30
HUP0402323A2 (hu)	2005-02-28
IL161983A (en)	2009-11-18
EP1454634A4 (fr)	2007-05-30
CO5580800A2 (es)	2005-11-30
JP4540092B2 (ja)	2010-09-08
SI21447A (sl)	2004-10-31
ZA200403551B (en)	2005-07-07
RO122395B1 (ro)	2009-05-29
TWI302461B (en)	2008-11-01
CA2466726C (fr)	2011-02-22
ECSP045110A (es)	2004-08-27

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