UA116772C2 - Виділене моноклональне антитіло або його імунологічно-активний фрагмент, що зв'язується з cd47 - Google Patents

Виділене моноклональне антитіло або його імунологічно-активний фрагмент, що зв'язується з cd47

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Publication number
UA116772C2
UA116772C2 UAA201409709A UAA201409709A UA116772C2 UA 116772 C2 UA116772 C2 UA 116772C2 UA A201409709 A UAA201409709 A UA A201409709A UA A201409709 A UAA201409709 A UA A201409709A UA 116772 C2 UA116772 C2 UA 116772C2
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antibody
relates
antibodies
methods
active fragment
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UAA201409709A
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English (en)
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Брендан Еккельман
Джон Тіммер
Амір Разаі
Куінн Деверо
Кайл Джоунз
Пітер Л. Нгуі
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ІНХІБРКС ЕлПі
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48947976&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA116772(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by ІНХІБРКС ЕлПі filed Critical ІНХІБРКС ЕлПі
Publication of UA116772C2 publication Critical patent/UA116772C2/uk

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Винахід стосується виділеного моноклонального антитіла або його імунологічно-активного фрагмента, що зв’язується з CD47, де антитіло або його імунологічно-активний фрагмент не викликає значного рівня гемаглютинації червоних кров’яних тілець після введення. Винахід також стосується фармацевтичної композиції , яка містить дане антитіло, для застосування в полегшенні симптомів раку.
UAA201409709A 2012-02-06 2013-06-02 Виділене моноклональне антитіло або його імунологічно-активний фрагмент, що зв'язується з cd47 UA116772C2 (uk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261595216P 2012-02-06 2012-02-06
US201261659752P 2012-06-14 2012-06-14
PCT/US2013/024995 WO2013119714A1 (en) 2012-02-06 2013-02-06 Cd47 antibodies and methods of use thereof

Publications (1)

Publication Number Publication Date
UA116772C2 true UA116772C2 (uk) 2018-05-10

Family

ID=48947976

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Application Number Title Priority Date Filing Date
UAA201409709A UA116772C2 (uk) 2012-02-06 2013-06-02 Виділене моноклональне антитіло або його імунологічно-активний фрагмент, що зв'язується з cd47

Country Status (35)

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US (4) US9045541B2 (uk)
EP (2) EP3578569A1 (uk)
JP (1) JP6273212B2 (uk)
KR (2) KR102338833B1 (uk)
CN (2) CN104271757B (uk)
AU (1) AU2013217114B2 (uk)
BR (1) BR112014019331A2 (uk)
CA (1) CA2863834A1 (uk)
CL (1) CL2014002086A1 (uk)
CO (1) CO7111273A2 (uk)
CR (1) CR20140406A (uk)
CY (1) CY1121911T1 (uk)
DK (1) DK2812443T3 (uk)
EA (1) EA034778B1 (uk)
EC (1) ECSP14016994A (uk)
ES (1) ES2743203T3 (uk)
HK (1) HK1205195A1 (uk)
HR (1) HRP20191500T1 (uk)
HU (1) HUE13746964T2 (uk)
IL (1) IL233934B (uk)
LT (1) LT2812443T (uk)
ME (1) ME03512B (uk)
MX (1) MX360772B (uk)
MY (1) MY169341A (uk)
NZ (1) NZ628314A (uk)
PE (1) PE20141908A1 (uk)
PH (1) PH12014501758B1 (uk)
PL (1) PL2812443T3 (uk)
PT (1) PT2812443T (uk)
RS (1) RS59159B1 (uk)
SG (2) SG10201700160RA (uk)
SI (1) SI2812443T1 (uk)
UA (1) UA116772C2 (uk)
WO (1) WO2013119714A1 (uk)
ZA (1) ZA201405864B (uk)

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BR112014019331A8 (pt) 2018-01-16
JP6273212B2 (ja) 2018-01-31
SI2812443T1 (sl) 2019-10-30
HK1205195A1 (en) 2015-12-11
MX2014009427A (es) 2015-05-11
ME03512B (me) 2020-04-20
EP3578569A1 (en) 2019-12-11
PH12014501758B1 (en) 2014-11-10
PL2812443T3 (pl) 2020-01-31
KR20200040897A (ko) 2020-04-20
CN104271757A (zh) 2015-01-07
PE20141908A1 (es) 2014-12-21
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