UA109131C2 - 5,7-ЗАМЕЩЕННЫЕ ИМИДАЗО[1,2-c]ПИРИМИДИНЫ КАК ИНГИБИТОРЫ JAK-КИНАЗ - Google Patents
5,7-ЗАМЕЩЕННЫЕ ИМИДАЗО[1,2-c]ПИРИМИДИНЫ КАК ИНГИБИТОРЫ JAK-КИНАЗInfo
- Publication number
- UA109131C2 UA109131C2 UAA201212901A UAA201212901A UA109131C2 UA 109131 C2 UA109131 C2 UA 109131C2 UA A201212901 A UAA201212901 A UA A201212901A UA A201212901 A UAA201212901 A UA A201212901A UA 109131 C2 UA109131 C2 UA 109131C2
- Authority
- UA
- Ukraine
- Prior art keywords
- inhibitors
- jak kinases
- pyrimidines
- imidazo
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Abstract
Соединения Формулы I: EMBED ISISServer , I и их стереоизомеры и фармацевтически приемлемые соли, и сольваты, где R1, R2, R3, R4, R5, R6, R7, X1 и X2 имеют значения, приведенные в описании, является ингибиторами одной или больше JAK-киназ и пригодные для лечения аутоиммунных заболеваний, воспалительных заболеваний, отторжения пересаженных органов, тканей и клеток, а также гематологических расстройств и злокачественных новообразований, и сопутствующих заболеваний.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32418610P | 2010-04-14 | 2010-04-14 | |
PCT/US2011/031896 WO2011130146A1 (en) | 2010-04-14 | 2011-04-11 | 5, 7-substituted-imidazo [1, 2-c] pyrimidines as inhibitors of jak kinases |
Publications (1)
Publication Number | Publication Date |
---|---|
UA109131C2 true UA109131C2 (ru) | 2015-07-27 |
Family
ID=43984073
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA201212901A UA109131C2 (ru) | 2010-04-14 | 2011-04-11 | 5,7-ЗАМЕЩЕННЫЕ ИМИДАЗО[1,2-c]ПИРИМИДИНЫ КАК ИНГИБИТОРЫ JAK-КИНАЗ |
Country Status (20)
Country | Link |
---|---|
US (1) | US8962596B2 (ru) |
EP (1) | EP2558468B1 (ru) |
JP (2) | JP2013523884A (ru) |
KR (1) | KR20130094710A (ru) |
CN (1) | CN102985424B (ru) |
AR (1) | AR081075A1 (ru) |
AU (1) | AU2011240808B2 (ru) |
CA (1) | CA2796388A1 (ru) |
CL (1) | CL2012002882A1 (ru) |
CO (1) | CO6630187A2 (ru) |
CR (1) | CR20120572A (ru) |
MX (1) | MX2012011941A (ru) |
NZ (1) | NZ603446A (ru) |
RU (1) | RU2012148246A (ru) |
SG (1) | SG184870A1 (ru) |
TW (1) | TWI494314B (ru) |
UA (1) | UA109131C2 (ru) |
UY (1) | UY33328A (ru) |
WO (1) | WO2011130146A1 (ru) |
ZA (1) | ZA201208544B (ru) |
Families Citing this family (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MY162590A (en) | 2005-12-13 | 2017-06-30 | Incyte Holdings Corp | Heteroaryl substituted pyrrolo[2,3-b] pyridines and pyrrolo[2,3-b] pyrimidines as janus kinase inhibitors |
EP3495369B1 (en) | 2007-06-13 | 2021-10-27 | Incyte Holdings Corporation | Use of salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h- pyrazol-1-yl)-3- cyclopentylpropanenitrile |
MX2011012262A (es) | 2009-05-22 | 2012-01-25 | Incyte Corp | 3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il] octano-o heptano-nitrilo como inhibidores de cinasas janus (jak). |
EA025520B1 (ru) | 2009-05-22 | 2017-01-30 | Инсайт Холдингс Корпорейшн | N-(ГЕТЕРО)АРИЛПИРРОЛИДИНОВЫЕ ПРОИЗВОДНЫЕ ПИРАЗОЛ-4-ИЛ-ПИРРОЛО[2,3-d]ПИРИМИДИНОВ И ПИРРОЛ-3-ИЛ-ПИРРОЛО[2,3-d]ПИРИМИДИНОВ В КАЧЕСТВЕ ИНГИБИТОРОВ ЯНУС-КИНАЗЫ |
RS57869B1 (sr) | 2009-06-17 | 2018-12-31 | Vertex Pharma | Inhibitori replikacije virusa gripa |
TW201113285A (en) | 2009-09-01 | 2011-04-16 | Incyte Corp | Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
SI3354652T1 (sl) | 2010-03-10 | 2020-08-31 | Incyte Holdings Corporation | Derivati piperidin-4-il azetidina kot inhibitorji JAK1 |
SG10201910912TA (en) | 2010-05-21 | 2020-01-30 | Incyte Corp | Topical Formulation for a JAK Inhibitor |
US9034884B2 (en) | 2010-11-19 | 2015-05-19 | Incyte Corporation | Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as JAK inhibitors |
BR112013012502A2 (pt) | 2010-11-19 | 2019-03-06 | Incyte Corporation | pirrolopiridina ciclobutil substituída e derivados de pirrolopirimidina derivativos como inibidores de jak |
KR20140014110A (ko) | 2010-12-16 | 2014-02-05 | 버텍스 파마슈티칼스 인코포레이티드 | 인플루엔자 바이러스 복제의 억제제 |
MY165963A (en) | 2011-06-20 | 2018-05-18 | Incyte Holdings Corp | Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as jak inhibitors |
UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
TW201313721A (zh) | 2011-08-18 | 2013-04-01 | Incyte Corp | 作為jak抑制劑之環己基氮雜環丁烷衍生物 |
UA111854C2 (uk) * | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки для отримання інгібіторів jak |
KR20140076619A (ko) * | 2011-10-12 | 2014-06-20 | 어레이 바이오파마 인크. | 5,7-치환된-이미다조[1,2-c]피리미딘 |
CA2854879A1 (en) * | 2011-11-07 | 2013-05-16 | Vertex Pharmaceuticals Incorporated | Methods for treating inflammatory diseases and pharmaceutical combinations useful therefor |
US9193733B2 (en) | 2012-05-18 | 2015-11-24 | Incyte Holdings Corporation | Piperidinylcyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors |
JP6196678B2 (ja) | 2012-10-24 | 2017-09-13 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | C型肝炎ウイルス阻害剤 |
SG11201503695XA (en) | 2012-11-15 | 2015-06-29 | Incyte Corp | Sustained-release dosage forms of ruxolitinib |
US20160123982A1 (en) | 2013-02-04 | 2016-05-05 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for assaying jak2 activity in red blood cells and uses thereof |
EA030705B1 (ru) * | 2013-03-06 | 2018-09-28 | Инсайт Холдингс Корпорейшн | Способы и промежуточные соединения при получении ингибитора jak |
WO2014146249A1 (en) * | 2013-03-19 | 2014-09-25 | Merck Sharp & Dohme Corp. | Geminally substituted cyanoethylpyrazolo pyridones as janus kinase inhibitors |
ES2661012T3 (es) * | 2013-03-28 | 2018-03-27 | Takeda Pharmaceutical Company Limited | Compuesto heterocíclico |
WO2014172639A1 (en) * | 2013-04-19 | 2014-10-23 | Ruga Corporation | Raf kinase inhibitors |
PE20160126A1 (es) | 2013-05-17 | 2016-02-24 | Incyte Corp | Derivados del bipirazol como inhibidores jak |
ES2792549T3 (es) | 2013-08-07 | 2020-11-11 | Incyte Corp | Formas de dosificación de liberación sostenida para un inhibidor de JAK1 |
JP6615755B2 (ja) | 2013-11-13 | 2019-12-04 | バーテックス ファーマシューティカルズ インコーポレイテッド | インフルエンザウイルスの複製の阻害剤 |
SI3068782T1 (sl) | 2013-11-13 | 2018-10-30 | Vertex Pharmaceuticals Incorporated | Postopki za pripravo inhibitorjev v replikacije virusov gripe |
WO2015184305A1 (en) | 2014-05-30 | 2015-12-03 | Incyte Corporation | TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1 |
WO2016025918A1 (en) | 2014-08-15 | 2016-02-18 | Janssen Pharmaceuticals, Inc. | Pyrazoles |
CR20170309A (es) | 2014-12-05 | 2018-02-02 | Celgene Corp | Pirazolo [1,5-a] pirazinas 4,6-sustituidas como inhibidores de janus cinasas |
CN105777754B (zh) * | 2014-12-16 | 2019-07-26 | 北京赛林泰医药技术有限公司 | 吡咯并嘧啶化合物 |
MX2017009449A (es) | 2015-01-20 | 2018-05-28 | Wuxy Fortune Pharmaceutical Co Ltd | Inhibidor jak. |
JP6600365B2 (ja) * | 2015-04-29 | 2019-10-30 | 无▲錫▼福祈制▲薬▼有限公司 | Jak阻害剤 |
EP3294717B1 (en) | 2015-05-13 | 2020-07-29 | Vertex Pharmaceuticals Inc. | Methods of preparing inhibitors of influenza viruses replication |
JP6857617B2 (ja) | 2015-05-13 | 2021-04-14 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | インフルエンザウイルスの複製の阻害剤 |
DK3305788T3 (da) | 2015-05-29 | 2020-09-28 | Wuxi Fortune Pharmaceutical Co Ltd | Janus-kinase-hæmmer |
AR104918A1 (es) * | 2015-06-19 | 2017-08-23 | Lilly Co Eli | Procesos e intermediarios para la preparación de {1-(etilsulfonil)-3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il]azetidin-3-il}acetonitrilo |
CN105294699B (zh) * | 2015-12-04 | 2019-06-11 | 上海勋和医药科技有限公司 | 巴瑞替尼的制备方法 |
JP6770580B2 (ja) * | 2016-01-26 | 2020-10-14 | 杭州華東医薬集団生物医薬有限公司Hangzhou Huadong Medicine Group Biopharmaceutical Co., Ltd. | ピロロピリミジン5員環アザ環状誘導体およびその利用 |
CO2018008799A2 (es) * | 2016-02-24 | 2018-09-20 | Pfizer | Derivados de pirazolo[1,5-a]pirazin-4-ilo como inhibidores de jak |
US11524961B2 (en) | 2017-01-23 | 2022-12-13 | Shanghai Longwood Biopharmaceuticals Co., Ltd. | JAK kinase inhibitor and preparation method and use thereof |
WO2018167283A1 (en) | 2017-03-17 | 2018-09-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the diagnosis and treatment of pancreatic ductal adenocarcinoma associated neural remodeling |
EP3610264A1 (en) | 2017-04-13 | 2020-02-19 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the diagnosis and treatment of pancreatic ductal adenocarcinoma |
KR20200051626A (ko) | 2017-08-07 | 2020-05-13 | 조인트 스탁 컴퍼니 "바이오케드" | Cdk8/19 저해제로서 새로운 헤테로사이클릭 화합물 |
US11254668B2 (en) | 2017-08-14 | 2022-02-22 | Pfizer Inc. | Pyrazolo[1,5-A]pyrazin-4-yl and related derivatives |
US10596161B2 (en) | 2017-12-08 | 2020-03-24 | Incyte Corporation | Low dose combination therapy for treatment of myeloproliferative neoplasms |
PL3746429T3 (pl) | 2018-01-30 | 2022-06-20 | Incyte Corporation | Procesy do otrzymywania (1-(3-fluoro-2-(trifluorometylo)izonikotynoilo)piperydyn-4-onu) |
SG11202007805SA (en) | 2018-02-16 | 2020-09-29 | Incyte Corp | Jak1 pathway inhibitors for the treatment of cytokine-related disorders |
WO2019191684A1 (en) | 2018-03-30 | 2019-10-03 | Incyte Corporation | Treatment of hidradenitis suppurativa using jak inhibitors |
US20220041588A1 (en) * | 2018-09-27 | 2022-02-10 | Fochon Pharmaceuticals, Ltd. | Substituted imidazo[1,2-a]pyridine and [1,2,4]triazolo[1,5-a]pyridine compounds as ret kinase inhibitors |
EP3873608A1 (en) | 2018-10-31 | 2021-09-08 | Gilead Sciences, Inc. | Substituted 6-azabenzimidazole compounds having hpk1 inhibitory activity |
CA3117556A1 (en) | 2018-10-31 | 2020-05-07 | Gilead Sciences, Inc. | Substituted 6-azabenzimidazole compounds as hpk1 inhibitors |
WO2020092015A1 (en) | 2018-11-02 | 2020-05-07 | University Of Rochester | Therapeutic mitigation of epithelial infection |
CN111320624B (zh) * | 2018-12-14 | 2023-05-12 | 中国医药研究开发中心有限公司 | ***并吡啶类和咪唑并吡啶类化合物及其制备方法和医药用途 |
JP7256291B2 (ja) * | 2019-04-12 | 2023-04-11 | プライムジーン(ベイジン)カンパニー リミテッド | ピラゾロピラジン誘導の化合物、医薬組成物およびその使用 |
TWI826690B (zh) | 2019-05-23 | 2023-12-21 | 美商基利科學股份有限公司 | 經取代之烯吲哚酮化物及其用途 |
CN111039963B (zh) * | 2019-12-31 | 2021-03-19 | 卓和药业集团有限公司 | Wxfl10203614水溶性类似物及其合成方法 |
US11685731B2 (en) | 2020-06-02 | 2023-06-27 | Incyte Corporation | Processes of preparing a JAK1 inhibitor |
US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
EP3944859A1 (en) | 2020-07-30 | 2022-02-02 | Assistance Publique Hôpitaux de Paris | Method for treating immune toxicities induced by immune checkpoint inhibitors |
KR20230118118A (ko) | 2020-12-08 | 2023-08-10 | 인사이트 코포레이션 | 백반증의 치료를 위한 jak1 경로 저해제 |
WO2023083200A1 (zh) * | 2021-11-12 | 2023-05-19 | 南京明德新药研发有限公司 | 吡唑并环化合物及其应用 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5728536A (en) | 1993-07-29 | 1998-03-17 | St. Jude Children's Research Hospital | Jak kinases and regulation of Cytokine signal transduction |
WO2000010981A1 (en) | 1998-08-21 | 2000-03-02 | Parker Hughes Institute | Quinazoline derivatives |
JP2001302667A (ja) * | 2000-04-28 | 2001-10-31 | Bayer Ag | イミダゾピリミジン誘導体およびトリアゾロピリミジン誘導体 |
US7713973B2 (en) * | 2004-10-15 | 2010-05-11 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
MY162590A (en) | 2005-12-13 | 2017-06-30 | Incyte Holdings Corp | Heteroaryl substituted pyrrolo[2,3-b] pyridines and pyrrolo[2,3-b] pyrimidines as janus kinase inhibitors |
JP5572388B2 (ja) * | 2006-11-22 | 2014-08-13 | インサイト・コーポレイション | キナーゼ阻害剤としてのイミダゾトリアジンおよびイミダゾピリミジン |
DE102007012645A1 (de) * | 2007-03-16 | 2008-09-18 | Bayer Healthcare Ag | Substituierte Imidazo- und Triazolopyrimidine |
CL2008001709A1 (es) * | 2007-06-13 | 2008-11-03 | Incyte Corp | Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras. |
SI2288610T1 (sl) | 2008-03-11 | 2016-11-30 | Incyte Holdings Corporation | Derivati azetidina in ciklobutana kot inhibitorji jak |
JOP20190230A1 (ar) | 2009-01-15 | 2017-06-16 | Incyte Corp | طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به |
-
2011
- 2011-04-11 KR KR1020127029826A patent/KR20130094710A/ko not_active Application Discontinuation
- 2011-04-11 CA CA2796388A patent/CA2796388A1/en not_active Abandoned
- 2011-04-11 CN CN201180029128.5A patent/CN102985424B/zh not_active Expired - Fee Related
- 2011-04-11 RU RU2012148246/04A patent/RU2012148246A/ru not_active Application Discontinuation
- 2011-04-11 AU AU2011240808A patent/AU2011240808B2/en not_active Ceased
- 2011-04-11 US US13/640,099 patent/US8962596B2/en not_active Expired - Fee Related
- 2011-04-11 UA UAA201212901A patent/UA109131C2/ru unknown
- 2011-04-11 WO PCT/US2011/031896 patent/WO2011130146A1/en active Application Filing
- 2011-04-11 EP EP11715818.8A patent/EP2558468B1/en active Active
- 2011-04-11 JP JP2013504972A patent/JP2013523884A/ja not_active Ceased
- 2011-04-11 MX MX2012011941A patent/MX2012011941A/es active IP Right Grant
- 2011-04-11 SG SG2012076493A patent/SG184870A1/en unknown
- 2011-04-11 NZ NZ603446A patent/NZ603446A/en not_active IP Right Cessation
- 2011-04-13 AR ARP110101268A patent/AR081075A1/es not_active Application Discontinuation
- 2011-04-13 UY UY0001033328A patent/UY33328A/es not_active Application Discontinuation
- 2011-04-14 TW TW100113047A patent/TWI494314B/zh not_active IP Right Cessation
-
2012
- 2012-10-12 CL CL2012002882A patent/CL2012002882A1/es unknown
- 2012-11-09 CR CR20120572A patent/CR20120572A/es unknown
- 2012-11-13 CO CO12203751A patent/CO6630187A2/es active IP Right Grant
- 2012-11-13 ZA ZA2012/08544A patent/ZA201208544B/en unknown
-
2015
- 2015-06-26 JP JP2015128369A patent/JP2015205905A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
SG184870A1 (en) | 2012-11-29 |
RU2012148246A (ru) | 2014-05-20 |
CR20120572A (es) | 2013-02-20 |
MX2012011941A (es) | 2013-08-27 |
KR20130094710A (ko) | 2013-08-26 |
EP2558468A1 (en) | 2013-02-20 |
US8962596B2 (en) | 2015-02-24 |
CN102985424B (zh) | 2015-03-11 |
UY33328A (es) | 2012-10-31 |
CL2012002882A1 (es) | 2013-02-08 |
JP2013523884A (ja) | 2013-06-17 |
CO6630187A2 (es) | 2013-03-01 |
EP2558468B1 (en) | 2015-04-01 |
WO2011130146A1 (en) | 2011-10-20 |
US20130131039A1 (en) | 2013-05-23 |
CN102985424A (zh) | 2013-03-20 |
CA2796388A1 (en) | 2011-10-20 |
NZ603446A (en) | 2014-05-30 |
AR081075A1 (es) | 2012-06-06 |
TWI494314B (zh) | 2015-08-01 |
TW201134827A (en) | 2011-10-16 |
AU2011240808B2 (en) | 2015-01-22 |
ZA201208544B (en) | 2015-04-29 |
AU2011240808A1 (en) | 2012-11-29 |
JP2015205905A (ja) | 2015-11-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
UA109131C2 (ru) | 5,7-ЗАМЕЩЕННЫЕ ИМИДАЗО[1,2-c]ПИРИМИДИНЫ КАК ИНГИБИТОРЫ JAK-КИНАЗ | |
MX2014004473A (es) | Imidazo [1,2-c] pirimidinas 5,7-substituidas. | |
PH12017501032A1 (en) | 4,6-SUBSTITUTED-PYRAZOLO[1,5-a]PYRAZINES AS JANUS KINASE INHIBITORS | |
UA108222C2 (xx) | СПОЛУКИ ЗАМІЩЕНОГО N-(1H-ІНДАЗОЛ-4-ІЛ)ІМІДАЗОЛ$1,2-а]ПІРИДИН-3-КАРБОКСАМІДУ ЯК ІНГІБІТОРИ cFMS | |
PH12013501779B1 (en) | Pyrrolopyridines as kinase inhibitors | |
MX2009008510A (es) | Antagonistas de activina-actriia y usos para promover el crecimiento de huesos en pacientes con cancer. | |
TN2016000458A1 (en) | Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer. | |
TW201129565A (en) | Tricyclic heterocyclic compounds, compositions and methods of use thereof | |
UA111756C2 (uk) | Сполуки гетероарилпіридону та азапіридону як інгібітори тирозинкінази брутона | |
UA112425C2 (uk) | ЗАМІЩЕНІ N-(1H-ІНДАЗОЛ-4-ІЛ)ІМІДАЗО[1,2-a]ПІРИДИН-3-КАРБОКСАМІДНІ СПОЛУКИ ЯК ІНГІБІТОРИ РЕЦЕПТОРНОЇ ТИРОЗИНКІНАЗИ ІІІ ТИПУ | |
EA201390736A1 (ru) | Циклобутилзамещенные производные пирролопиридина и пирролопиримидина как ингибиторы jak | |
MA32272B1 (fr) | Inhibiteurs de raf de pyrazole [3,4-b]pyridine | |
SG178899A1 (en) | Raf inhibitor compounds and methods of use thereof | |
MX2013005826A (es) | Benzoxazepinas como inhibidores de fosfatidilinositol 3-cinasa/objetivo de rapamicina en mamiferos (p13k/mtor) y metodos de uso y fabricacion. | |
MX2011012353A (es) | Derivados de n-(hetero)aril-pirrolidina de pirazol-4-il-pirrolo[2, 3-d]pirimidinas y pirrol-3-il-pirrolo[2,3-d]pirimidinas como inhibidores de la cinasa janus. | |
MX2019005232A (es) | Derivados de piperidin-4-il azetidina como inhibidores de janus cinasa 1 (jak1). | |
TN2010000071A1 (en) | Fused imidazoles or cancer treatment | |
MX2014005282A (es) | Compuestos de 8-fluoroftalazin-1 (2h) -ona. | |
MX2020009397A (es) | Composiciones y metodos para inhibicion de la via jak. | |
MX2011010451A (es) | Derivados de oxadiazol. | |
MY150747A (en) | Pyrido[2,3-d] pyrimidin-7-one compounds as inhibitors of pi3k-alpha for the treatment of cancer | |
MX349550B (es) | 1,7-diazacarbazoles y metodos de uso. | |
SG178900A1 (en) | Raf inhibitor compounds and methods of use thereof | |
IN2015DN03751A (ru) | ||
TW200833342A (en) | 2-substituted pyrimidines I in therapy |