TW427988B - Process for the preparation of taxane derivatives - Google Patents

Process for the preparation of taxane derivatives

Info

Publication number
TW427988B
TW427988B TW082109008A TW82109008A TW427988B TW 427988 B TW427988 B TW 427988B TW 082109008 A TW082109008 A TW 082109008A TW 82109008 A TW82109008 A TW 82109008A TW 427988 B TW427988 B TW 427988B
Authority
TW
Taiwan
Prior art keywords
radical
formula
phenyl
hydroxyl
alkyl
Prior art date
Application number
TW082109008A
Other languages
English (en)
Inventor
Denis Jean-Noel
Andrew Greene
Alice Kanazaea
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Application granted granted Critical
Publication of TW427988B publication Critical patent/TW427988B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
TW082109008A 1992-10-30 1993-10-28 Process for the preparation of taxane derivatives TW427988B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9213000A FR2697522B1 (fr) 1992-10-30 1992-10-30 Procédé de préparation de dérivés du taxane.

Publications (1)

Publication Number Publication Date
TW427988B true TW427988B (en) 2001-04-01

Family

ID=9435013

Family Applications (1)

Application Number Title Priority Date Filing Date
TW082109008A TW427988B (en) 1992-10-30 1993-10-28 Process for the preparation of taxane derivatives

Country Status (24)

Country Link
US (3) US5686623A (zh)
EP (1) EP0666857B1 (zh)
JP (1) JP3030088B2 (zh)
KR (1) KR100255460B1 (zh)
AT (1) ATE180258T1 (zh)
AU (1) AU679947B2 (zh)
CA (1) CA2148103C (zh)
CZ (1) CZ287805B6 (zh)
DE (1) DE69325031T2 (zh)
DK (1) DK0666857T3 (zh)
ES (1) ES2133418T3 (zh)
FI (1) FI109798B (zh)
FR (1) FR2697522B1 (zh)
GR (1) GR3030268T3 (zh)
HU (1) HUT73780A (zh)
MX (1) MX9306606A (zh)
NO (2) NO304114B1 (zh)
NZ (1) NZ257578A (zh)
PL (1) PL177746B1 (zh)
RU (2) RU2118958C1 (zh)
SK (1) SK281045B6 (zh)
TW (1) TW427988B (zh)
WO (1) WO1994010169A1 (zh)
ZA (1) ZA938012B (zh)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9307777A (es) 1992-12-15 1994-07-29 Upjohn Co 7-HALO-Y 7ß, 8ß-METANO-TAXOLES, USO ANTINEOPLASTICO Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN.
PT982301E (pt) * 1993-06-11 2004-02-27 Upjohn Co Utilizacao antineoplasica de delta-6,7-taxois e composicoes farmaceuticas que oscontem
IL127599A (en) * 1994-01-28 2004-06-01 Upjohn Co Process for preparing isotaxol analogs
CA2170661A1 (en) * 1995-03-22 1996-09-23 John K. Thottathil Novel methods for the preparation of taxanes using oaxzolidine intermediates
EP1099696A3 (en) * 1995-06-06 2001-05-23 Dr. Reddy's Research Foundation Preparation of oxazolidine
AU4768797A (en) 1996-10-24 1998-05-15 Institute Armand-Frappier A family of canadensol taxanes, the semi-synthetic preparation and therapeutic use thereof
US6150537A (en) * 1997-12-12 2000-11-21 Emory University Methods for the esterification of alcohols and compounds useful therefor as potential anticancer agents
EP0982028A1 (en) * 1998-08-20 2000-03-01 Aventis Pharma S.A. New use of taxoid derivatives
WO2000010547A2 (en) * 1998-08-20 2000-03-02 Aventis Pharma S.A. New use of taxoid derivatives
JP4502338B2 (ja) * 1999-09-17 2010-07-14 株式会社横浜国際バイオ研究所 タキソイド化合物の製造法
CA2385528C (en) 1999-10-01 2013-12-10 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
AU2000261768A1 (en) * 2000-08-08 2002-02-18 Dr. Reddy's Research Foundation An improved process for the preparation of docetaxel
JP2002088935A (ja) 2000-09-14 2002-03-27 Nichiha Corp 外装材の縦目地ジョイナー
US8338617B2 (en) 2004-11-19 2012-12-25 Dr. Reddy's Laboratories Limited Process for preparing oxazolidine derivatives
CZ298332B6 (cs) * 2005-09-26 2007-08-29 Zentiva, A. S Zpusob prípravy kyseliny (4S,5R)-2,4-difenyloxazolin-4,5-dihydro-5-karboxylové
AU2006331674A1 (en) * 2005-12-21 2007-07-05 Tapestry Pharmaceuticals, Inc. Processes for taxane derivatives and intermediates useful therein
WO2008074178A1 (fr) * 2006-11-23 2008-06-26 Shanghai Bailing Pharmaceutical Technology Co., Ltd Nouveau procédé de préparation de paclitaxel semi-synthétique
CN101020672B (zh) * 2006-12-28 2010-08-25 上海百灵医药科技有限公司 多烯紫杉醇的合成方法
PL388144A1 (pl) 2009-05-29 2010-12-06 Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie
KR101379694B1 (ko) * 2011-09-30 2014-03-31 주식회사 삼양바이오팜 탁산유도체의 제조방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9102128A (es) * 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
FR2696459B1 (fr) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
FR2696458B1 (fr) * 1992-10-05 1994-11-10 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
FR2696460B1 (fr) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
FR2696464B1 (fr) * 1992-10-05 1994-11-10 Rhone Poulenc Rorer Sa Nouveau procédé d'estérification de la baccatine III et de la désacétyl-10 baccatine III.
PT982301E (pt) * 1993-06-11 2004-02-27 Upjohn Co Utilizacao antineoplasica de delta-6,7-taxois e composicoes farmaceuticas que oscontem

Also Published As

Publication number Publication date
EP0666857A1 (fr) 1995-08-16
ES2133418T3 (es) 1999-09-16
RU2118958C1 (ru) 1998-09-20
US20030013889A1 (en) 2003-01-16
FR2697522B1 (fr) 1994-11-25
MX9306606A (es) 1994-04-29
CA2148103C (fr) 2002-11-26
KR100255460B1 (ko) 2000-05-01
DK0666857T3 (da) 1999-11-08
US6433180B1 (en) 2002-08-13
NO951587D0 (no) 1995-04-26
WO1994010169A1 (fr) 1994-05-11
FI109798B (fi) 2002-10-15
SK281045B6 (sk) 2000-11-07
ATE180258T1 (de) 1999-06-15
ZA938012B (en) 1994-06-09
GR3030268T3 (en) 1999-08-31
PL177746B1 (pl) 2000-01-31
FI952059A (fi) 1995-04-28
US5686623A (en) 1997-11-11
NO981813D0 (no) 1998-04-22
FI952059A0 (fi) 1995-04-28
AU5423794A (en) 1994-05-24
CA2148103A1 (fr) 1994-05-11
RU2188198C2 (ru) 2002-08-27
CZ109295A3 (en) 1995-10-18
DE69325031D1 (de) 1999-06-24
NO951587L (no) 1995-04-26
FR2697522A1 (fr) 1994-05-06
RU95111381A (ru) 1996-12-27
CZ287805B6 (en) 2001-02-14
JP3030088B2 (ja) 2000-04-10
HU9501235D0 (en) 1995-06-28
PL308638A1 (en) 1995-08-21
EP0666857B1 (fr) 1999-05-19
NO981813L (no) 1995-04-26
JPH08502507A (ja) 1996-03-19
DE69325031T2 (de) 1999-10-07
KR950704307A (ko) 1995-11-17
SK55795A3 (en) 1995-10-11
NO304114B1 (no) 1998-10-26
NZ257578A (en) 1996-06-25
AU679947B2 (en) 1997-07-17
NO306062B1 (no) 1999-09-13
HUT73780A (en) 1996-09-30

Similar Documents

Publication Publication Date Title
TW427988B (en) Process for the preparation of taxane derivatives
TW372234B (en) Process for the esterification of baccatin III and 10-deacetylbaccatin III
DE69308154D1 (de) Verfahren zur herstellung von taxan-derivaten
MX9306883A (es) Nuevos derivados de taxano, procedimiento para su obtencion y composicionfarmaceutica que los contiene.
DK0687259T3 (da) Fremgangsmåde til fremstilling af taxoider

Legal Events

Date Code Title Description
GD4A Issue of patent certificate for granted invention patent
MM4A Annulment or lapse of patent due to non-payment of fees