MX9307777A - 7-HALO-Y 7ß, 8ß-METANO-TAXOLES, USO ANTINEOPLASTICO Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN. - Google Patents

7-HALO-Y 7ß, 8ß-METANO-TAXOLES, USO ANTINEOPLASTICO Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN.

Info

Publication number
MX9307777A
MX9307777A MX9307777A MX9307777A MX9307777A MX 9307777 A MX9307777 A MX 9307777A MX 9307777 A MX9307777 A MX 9307777A MX 9307777 A MX9307777 A MX 9307777A MX 9307777 A MX9307777 A MX 9307777A
Authority
MX
Mexico
Prior art keywords
cancer
taxoles
halo
methane
contain
Prior art date
Application number
MX9307777A
Other languages
English (en)
Inventor
Eldon G Nidy
Jackson B Hester Jr
Roy A Johnson
Robert C Kelly
Harvey I Skulnick
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27486333&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX9307777(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of MX9307777A publication Critical patent/MX9307777A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Esta invención provee análogos de 7-desoxi-taxol de la fórmula I: Los compuestos de la fórmula I (incluyendo II y III) son útiles para los mismos tipos de cáncer en los cuales los taxoles han demostrado actividad, incluyendo en humanos el cáncer ovárico, cáncer de la mama y melanoma maligno, como también el cáncer pulmonar, cáncer gástrico, cáncer de colon, cáncer de cabeza y cuello y la leucemia.
MX9307777A 1992-12-15 1993-12-09 7-HALO-Y 7ß, 8ß-METANO-TAXOLES, USO ANTINEOPLASTICO Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN. MX9307777A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US99057992A 1992-12-15 1992-12-15
US1382693A 1993-02-02 1993-02-02
US7633793A 1993-06-11 1993-06-11
US12297493A 1993-09-17 1993-09-17

Publications (1)

Publication Number Publication Date
MX9307777A true MX9307777A (es) 1994-07-29

Family

ID=27486333

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9307777A MX9307777A (es) 1992-12-15 1993-12-09 7-HALO-Y 7ß, 8ß-METANO-TAXOLES, USO ANTINEOPLASTICO Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN.

Country Status (26)

Country Link
US (1) US6911549B1 (es)
EP (1) EP0674630B1 (es)
JP (1) JP3441458B2 (es)
KR (1) KR100317015B1 (es)
CN (2) CN1062561C (es)
AT (1) ATE226576T1 (es)
AU (1) AU687027B2 (es)
CA (1) CA2149021A1 (es)
CZ (1) CZ291177B6 (es)
DE (1) DE69332438T2 (es)
DK (1) DK0674630T3 (es)
ES (1) ES2187519T3 (es)
FI (1) FI111633B (es)
HU (1) HUT74447A (es)
IL (1) IL107950A (es)
LV (1) LV13023B (es)
MX (1) MX9307777A (es)
MY (1) MY116473A (es)
NO (1) NO313801B1 (es)
NZ (1) NZ259196A (es)
PL (1) PL185042B1 (es)
PT (1) PT674630E (es)
RU (1) RU2125996C1 (es)
SK (1) SK281897B6 (es)
TW (1) TW389758B (es)
WO (1) WO1994013655A1 (es)

Families Citing this family (45)

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US5710287A (en) 1991-09-23 1998-01-20 Florida State University Taxanes having an amino substituted side-chain and pharmaceutical compositions containing them
US5998656A (en) * 1991-09-23 1999-12-07 Florida State University C10 tricyclic taxanes
FR2697752B1 (fr) 1992-11-10 1995-04-14 Rhone Poulenc Rorer Sa Compositions antitumorales contenant des dérivés du taxane.
US5814658A (en) 1992-12-09 1998-09-29 Rhone-Poulenc Rorer S.A. Taxoids, their preparation and pharmaceutical compositions containing them
FR2698871B1 (fr) * 1992-12-09 1995-02-24 Rhone Poulenc Rorer Sa Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
US5973160A (en) 1992-12-23 1999-10-26 Poss; Michael A. Methods for the preparation of novel sidechain-bearing taxanes
FR2712288B1 (fr) * 1993-11-08 1996-01-05 Rhone Poulenc Rorer Sa Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
GB9409131D0 (en) * 1994-05-09 1994-06-29 Erba Carlo Spa Unsaturated taxane compounds
FR2726272B1 (fr) * 1994-10-26 1996-12-06 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
EP0738266A1 (en) * 1994-11-04 1996-10-23 PHARMACIA S.p.A. Taxane derivatives
IT1275936B1 (it) * 1995-03-17 1997-10-24 Indena Spa Derivati della 10-deacetilbaccatina iii e della 10-deacetil-14b- idrossibaccatina iii loro metodo di preparazione e formulazioni
FR2732342B1 (fr) * 1995-04-03 1997-04-30 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2742751B1 (fr) * 1995-12-22 1998-01-30 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
US5635531A (en) * 1996-07-08 1997-06-03 Bristol-Myers Squibb Company 3'-aminocarbonyloxy paclitaxels
US5773464A (en) * 1996-09-30 1998-06-30 Bristol-Myers Squibb Company C-10 epoxy taxanes
US6410756B1 (en) 1996-10-24 2002-06-25 Institut National De La Recherche Scientifique Family of Canadensol taxanes, the semi-synthetic preparation and therapeutic use thereof
US6017935A (en) * 1997-04-24 2000-01-25 Bristol-Myers Squibb Company 7-sulfur substituted paclitaxels
US6156789A (en) * 1998-03-17 2000-12-05 Rhone-Poulenc Rorer S.A. Method for treating abnormal cell proliferation in the brain
WO2001057013A1 (en) * 2000-02-02 2001-08-09 Florida State University Research Foundation, Inc. Taxane formulations having improved solubility
CN1186340C (zh) 2000-02-02 2005-01-26 佛罗里达州立大学研究基金有限公司 用作抗肿瘤剂的c10碳酸酯取代的紫杉烷
AU776122B2 (en) 2000-02-02 2004-08-26 Florida State University Research Foundation, Inc. C7 carbonate substituted taxanes as antitumor agents
US6649632B2 (en) 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes
JP2004525860A (ja) 2000-09-22 2004-08-26 ブリストル−マイヤーズ スクイブ カンパニー 併用化学療法剤の毒性を低下させる方法
CA2354478A1 (en) * 2001-07-31 2003-01-31 Florida State University Research Foundation, Inc. C10 carbonate substituted taxanes
SG125888A1 (en) * 2001-08-01 2006-10-30 Univ Florida State Res Found C10 carbonate substituted taxanes
WO2004033442A2 (en) * 2002-10-09 2004-04-22 Chatham Biotec Ltd. Novel taxanes and methods related to use and preparation thereof
US8703982B2 (en) 2003-03-17 2014-04-22 Phyton Holdings Llc Purification of taxanes
PE20050693A1 (es) 2004-02-13 2005-09-27 Univ Florida State Res Found Taxanos sustituidos con esteres de ciclopentilo en c10
AU2012202903B2 (en) * 2005-02-18 2014-12-11 Abraxis Bioscience, Inc. Drugs with improved hydrophobicity for incorporation in medical devices
WO2006089207A2 (en) * 2005-02-18 2006-08-24 Abraxis Bioscience, Inc. Drugs with improved hydrophobicity for incorporation in medical devices
SI2233156T1 (sl) 2005-07-15 2013-09-30 Angiochem Inc. Uporaba polipeptidov aprotinina kot nosilce v farmacevtskih konjugatih
AU2007357451B2 (en) * 2006-10-12 2012-11-15 Bhi Limited Partnership. Methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid
WO2008144919A1 (en) 2007-05-29 2008-12-04 Angiochem, Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
CN101835769A (zh) * 2007-08-22 2010-09-15 6570763加拿大有限公司 将9-二氢-13-乙酰基浆果赤霉素ⅲ转化为多烯紫杉醇或太平洋紫杉醇的方法
DK2080764T3 (da) 2008-01-18 2012-09-24 Indena Spa Faste former af ortataxel
WO2009145981A1 (en) 2008-03-31 2009-12-03 Florida State University Research Foundation, Inc. C(10) ethyl ester and c(10) cyclopropyl ester substituted taxanes
KR101014438B1 (ko) * 2008-09-26 2011-02-14 동아제약주식회사 탁산 유도체의 제조방법
CN101648973B (zh) * 2009-09-03 2012-05-30 漆又毛 水溶性紫杉烷及制备方法
JP2013530993A (ja) 2010-07-02 2013-08-01 アンジオケム インコーポレーテッド 治療用コンジュゲートのための短く且つｄ−アミノ酸を含有するポリペプチドおよびその使用
US8791279B2 (en) * 2010-12-13 2014-07-29 Yung Shin Pharm. Ind. Co., Ltd. Process for preparing taxoids from baccatin derivatives using lewis acid catalyst
US20140303134A1 (en) 2011-10-26 2014-10-09 H. Lee Moffitt Cancer Center & Research Institute, Inc. Platinum compounds that inhibit constitutive stat3 signaling and induce cell cycle arrest and apoptosis of malignant cells
WO2016205367A1 (en) 2015-06-15 2016-12-22 Angiochem Inc. Methods for the treatment of leptomeningeal carcinomatosis
CN111138386A (zh) * 2019-12-30 2020-05-12 重庆市碚圣医药科技股份有限公司 一种多西他赛的半合成方法
CN111763179A (zh) * 2020-07-08 2020-10-13 云南汉德生物技术有限公司 一种紫杉醇侧链的合成方法
CN115260130A (zh) * 2022-07-07 2022-11-01 上海卓鼎生物技术有限公司 一种10-脱乙酰基紫杉醇的制备方法

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FR2601675B1 (fr) 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2601676B1 (fr) 1986-07-17 1988-09-23 Rhone Poulenc Sante Procede de preparation du taxol et du desacetyl-10 taxol
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FR2629818B1 (fr) 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
FR2629819B1 (fr) 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
US4960790A (en) 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
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FR2658513B1 (fr) 1990-02-21 1994-02-04 Rhone Poulenc Sante Procede de preparation de l'acide cis-beta-phenylglycidique-(2r,3r).
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US5380751A (en) 1992-12-04 1995-01-10 Bristol-Myers Squibb Company 6,7-modified paclitaxels
CA2109861C (en) 1992-12-04 1999-03-16 Shu-Hui Chen 6,7-modified paclitaxels
FR2698871B1 (fr) 1992-12-09 1995-02-24 Rhone Poulenc Rorer Sa Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
LV13023B (en) 2003-12-20
FI952920A (fi) 1995-06-14
CA2149021A1 (en) 1994-06-23
RU95114377A (ru) 1997-06-10
PL185042B1 (pl) 2003-02-28
MY116473A (en) 2004-02-28
CZ291177B6 (cs) 2003-01-15
ATE226576T1 (de) 2002-11-15
HUT74447A (en) 1996-12-30
US6911549B1 (en) 2005-06-28
DE69332438T2 (de) 2003-06-18
PL309392A1 (en) 1995-10-02
CZ143795A3 (en) 1995-11-15
KR100317015B1 (ko) 2002-06-22
AU687027B2 (en) 1998-02-19
JP3441458B2 (ja) 2003-09-02
DK0674630T3 (da) 2003-02-24
RU2125996C1 (ru) 1999-02-10
FI952920A0 (fi) 1995-06-14
CN1261072A (zh) 2000-07-26
KR950704288A (ko) 1995-11-17
ES2187519T3 (es) 2003-06-16
NO313801B1 (no) 2002-12-02
CN1062561C (zh) 2001-02-28
PT674630E (pt) 2003-03-31
AU5741194A (en) 1994-07-04
EP0674630A1 (en) 1995-10-04
HU9501733D0 (en) 1995-08-28
DE69332438D1 (de) 2002-11-28
JPH08506568A (ja) 1996-07-16
IL107950A (en) 2001-04-30
NO952351L (no) 1995-08-14
SK281897B6 (sk) 2001-09-11
TW389758B (en) 2000-05-11
CN1095377A (zh) 1994-11-23
IL107950A0 (en) 1994-04-12
WO1994013655A1 (en) 1994-06-23
NO952351D0 (no) 1995-06-14
EP0674630B1 (en) 2002-10-23
NZ259196A (en) 1998-08-26
FI111633B (fi) 2003-08-29
SK78895A3 (en) 1995-12-06

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